{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:35:39Z","timestamp":1789086939868,"version":"build-2803163510"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AT009347"],"award-info":[{"award-number":["AT009347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.01049","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:25:02Z","timestamp":1570163102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Adenosine Receptor A2a, but Not A1 in the rVLM Participates Along With Opioids in Acupuncture-Mediated Inhibition of Excitatory Cardiovascular Reflexes"],"prefix":"10.3389","volume":"13","author":[{"given":"Shaista","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Samaniego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"B1","first-page":"31","article-title":"The functional background in acupuncture effects.","volume":"29","author":"Andersson","year":"1993","journal-title":"Scand. J. Rehabil. Med. Suppl."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1152\/physrev.00049.2017","article-title":"Pharmacology of adenosine receptors: the state of the art.","volume":"98","author":"Borea","year":"2018","journal-title":"Physiol. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission.","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jneuroim.2010.07.025","article-title":"Intracerebroventricular injection of an agonist-like monoclonal antibody to adenosine A(2A) receptor has antinociceptive effects in mice.","volume":"230","author":"By","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1111\/j.1476-5381.1989.tb12589.x","article-title":"Apparent affinity of 1,3-dipropyl-8-cyclopentylxanthine for adenosine A1 and A2 receptors in isolated tissues from guinea-pigs.","volume":"27","author":"Collis","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1152\/japplphysiol.01282.2004","article-title":"Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats.","volume":"98","author":"Crisostomo","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/s0028-3908(99)00237-3","article-title":"Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals.","volume":"39","author":"Cunha","year":"2000","journal-title":"Neuropharmacology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1152\/physrev.1994.74.2.323","article-title":"Functional organization of central pathways regulating the cardiovascular system.","volume":"74","author":"Dampney","year":"1994","journal-title":"Physiol. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nn.2562","article-title":"Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.","volume":"13","author":"Goldman","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"R655","DOI":"10.1152\/ajpregu.00405.2017","article-title":"Role of TRPV1 in acupuncture modulation of reflex excitatory cardiovascular responses.","volume":"314","author":"Guo","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.brainres.2018.12.009","article-title":"Acupuncture activates a direct pathway from the nucleus tractus solitarii to the rostral ventrolateral medulla.","volume":"1708","author":"Guo","year":"2019","journal-title":"Brain Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainres.2004.09.059","article-title":"Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons.","volume":"1030","author":"Guo","year":"2004","journal-title":"Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"H1479","DOI":"10.1152\/ajpheart.00209.2009","article-title":"Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflex: role of synthase isoforms.","volume":"297","author":"Guo","year":"2009","journal-title":"Am. J. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neulet.2010.12.026","article-title":"Adenosine reduces GABAergic IPSC frequency via presynaptic A(1) receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla.","volume":"490","author":"Han","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B15","first-page":"269","author":"Hua","year":"1994","journal-title":"Acupuncture Manual for Small Animals Experimental Acupuncture"},{"key":"B16","doi-asserted-by":"publisher","first-page":"H1058","DOI":"10.1152\/ajpheart.00906.2008","article-title":"Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity.","volume":"296","author":"Ichinose","year":"2009","journal-title":"Am. J. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.lfs.2011.06.003","article-title":"Adenosine A(2A)R modulates cardiovascular function by activating ERK1\/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats.","volume":"89","author":"Jiang","year":"2011","journal-title":"Life Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.autneu.2012.07.001","article-title":"Repetitive electroacupuncture causes prolonged increased met-enkephalin expression in the rVLM of conscious rats.","volume":"170","author":"Li","year":"2012","journal-title":"Auton. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"R404","DOI":"10.1152\/ajpregu.00196.2013","article-title":"Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide.","volume":"305","author":"Li","year":"2013","journal-title":"Am. J. Physiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep35791","article-title":"Repetitive electroacupuncture attenuates cold-induced hypertension through enkephalin in the rostral ventral lateral medulla.","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neulet.2010.04.025","article-title":"Electroacupuncture enhances preproenkephalin mRNA expression in rostral ventrolateral medulla of rats.","volume":"477","author":"Li","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.autneu.2010.03.015","article-title":"Neural mechanism of electroacupuncture\u2019s hypotensive effects.","volume":"157","author":"Li","year":"2010","journal-title":"Auton. Neurosci."},{"key":"B23","first-page":"R1335","article-title":"Effect of electroacupuncture on pressor reflex during gastric distention.","volume":"283","author":"Li","year":"2002","journal-title":"Am. J. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1089\/acu.2015.1106","article-title":"Long-lasting reduction of blood pressure by electroacupuncture in patients with hypertension: randomized controlled trial.","volume":"27","author":"Li","year":"2015","journal-title":"Med. Acupunct."},{"key":"B25","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1152\/japplphysiol.91277.2008","article-title":"Long-loop pathways in cardiovascular electroacupuncture responses.","volume":"106","author":"Li","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/s1566-0702(01)00247-8","article-title":"Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.","volume":"89","author":"Li","year":"2001","journal-title":"Auton. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/B978-0-12-411545-3.00013-4","article-title":"Acupuncture regulation of blood pressure: two decades of research.","volume":"111","author":"Longhurst","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1152\/japplphysiol.00477.2009","article-title":"Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture.","volume":"108","author":"Moazzami","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1124\/jpet.107.129692","article-title":"Brainstem phosphorylated extracellular signal-regulated kinase 1\/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats.","volume":"324","author":"Nassar","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1124\/jpet.108.143883","article-title":"Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1\/2-dependent hypotensive action of clonidine in conscious normotensive rats.","volume":"328","author":"Nassar","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1471-4159.1995.65010125.x","article-title":"Differential regulation of D1 dopamine receptor- and of A2a adenosine receptor-stimulated adenylyl cyclase by mu-, delta 1-, and delta 2-opioid agonists in rat caudate putamen.","volume":"65","author":"Noble","year":"1995","journal-title":"J. Neurochem."},{"key":"B32","author":"Paxinos","year":"2005","journal-title":"The Rat Brain in Stereotaxic Coordinates"},{"key":"B33","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/s0301-0082(02)00155-7","article-title":"Adenosine receptors in the nervous system: pathophysiological implications.","volume":"68","author":"Ribeiro","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"B34","first-page":"H2453","article-title":"Adenosine receptors located in the NTS contribute to renal sympathoinhibition during hypotensive phase of severe hemorrhage in anesthetized rats.","volume":"291","author":"Scislo","year":"2006","journal-title":"Am. J. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1440-1681.1997.tb02125.x","article-title":"Central nervous system control of cardiovascular function: neural mechanisms and novel modulators.","volume":"24","author":"Spyer","year":"1997","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1476-5381.1996.tb15187.x","article-title":"Role of brainstem adenosine A1 receptors in the cardiovascular response to hypothalamic defence area stimulation in the anaesthetized rat.","volume":"117","author":"St Lambert","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1111\/j.1476-5381.1996.tb15187.x","article-title":"A source of adenosine involved in cardiovascular responses to defense area stimulation.","volume":"272","author":"St Lambert","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1113\/expphysiol.1996.sp003919","article-title":"The role of adenosine receptors in the rostral ventrolateral medulla in the cardiovascular response to defence area stimulation in the rat.","volume":"81","author":"Thomas","year":"1996","journal-title":"Exp. Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/s0306-4522(98)00296-6","article-title":"A novel influence of adenosine on ongoing activity in rat rostral ventrolateral medulla.","volume":"88","author":"Thomas","year":"1999","journal-title":"Neuroscience"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/srep25910","article-title":"Paraventricular Nucleus Modulates Excitatory Cardiovascular Reflexes during Electroacupuncture.","volume":"6","author":"Tjen-A-Looi","year":"2016","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"R321","DOI":"10.1152\/ajpregu.00451.2012","article-title":"Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats.","volume":"304","author":"Tjen-A-Looi","year":"2013","journal-title":"Am. J. Physiol."},{"key":"B42","first-page":"R852","article-title":"Medullary substrate and differential cardiovascular response during stimulation of specific acupoints.","volume":"287","author":"Tjen-A-Looi","year":"2004","journal-title":"Am. J. Physiol."},{"key":"B43","first-page":"H3627","article-title":"Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats.","volume":"293","author":"Tjen-A-Looi","year":"2007","journal-title":"Am. J. Physiol."},{"key":"B44","first-page":"H1868","article-title":"Role of glutamate in rostral ventrolateral medulla in acupuncture-related modulation of visceral reflex sympathoexcitation.","volume":"292","author":"Zhou","year":"2007","journal-title":"Am. J. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1152\/japplphysiol.01079.2004","article-title":"Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses.","volume":"98","author":"Zhou","year":"","journal-title":"J. Appl. Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1152\/japplphysiol.01365.2004","article-title":"Brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats.","volume":"99","author":"Zhou","year":"","journal-title":"J. Appl. Physiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01049\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:25:05Z","timestamp":1570163105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01049\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,4]]},"references-count":46,"alternative-id":["10.3389\/fnins.2019.01049"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.01049","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,4]]},"article-number":"1049"}}