{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:50:01Z","timestamp":1791849001344,"version":"4.3.4"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600330"],"award-info":[{"award-number":["81600330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770426"],"award-info":[{"award-number":["81770426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600333"],"award-info":[{"award-number":["81600333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800372"],"award-info":[{"award-number":["81800372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700373"],"award-info":[{"award-number":["81700373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["No. 2018JQ3047"],"award-info":[{"award-number":["No. 2018JQ3047"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2016M590957"],"award-info":[{"award-number":["No. 2016M590957"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009996","name":"Shaanxi Province Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2016BSHEDZZ89"],"award-info":[{"award-number":["No. 2016BSHEDZZ89"]}],"id":[{"id":"10.13039\/501100009996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.01138","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:21:53Z","timestamp":1571876513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Exercise Training Attenuates Hypertension Through TLR4\/MyD88\/NF-\u03baB Signaling in the Hypothalamic Paraventricular Nucleus"],"prefix":"10.3389","volume":"13","author":[{"given":"Jie","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Tian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai B.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.taap.2017.08.012","article-title":"Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats.","volume":"333","author":"Bai","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2016.02.055","article-title":"Exercise training activates neuregulin 1\/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model.","volume":"149","author":"Cai","year":"2016","journal-title":"Life Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.amjcard.2017.02.011","article-title":"Prevalence and management of systemic hypertension in athletes.","volume":"119","author":"Caselli","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"C175","DOI":"10.1152\/ajpcell.00148.2018","article-title":"HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.","volume":"316","author":"Dai","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0242-7","article-title":"Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension.","volume":"12","author":"Dange","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"H1075","DOI":"10.1152\/ajpheart.00822.2016","article-title":"Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension.","volume":"313","author":"Huber","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1476-5381.2012.02040.x","article-title":"Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: role of autophagy.","volume":"167","author":"Kandadi","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s00395-011-0215-7","article-title":"NF-kappaB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure.","volume":"106","author":"Kang","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/cvr\/cvp073","article-title":"Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension.","volume":"82","author":"Kang","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.taap.2013.12.001","article-title":"Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines.","volume":"274","author":"Kang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1161\/01.res.0000244092.95152.86","article-title":"Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure.","volume":"99","author":"Kang","year":"2006","journal-title":"Circ. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.taap.2016.06.014","article-title":"TLR4\/MyD88\/NF-kappaB signaling and PPAR-gamma within the paraventricular nucleus are involved in the effects of telmisartan in hypertension.","volume":"305","author":"Li","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.taap.2014.06.004","article-title":"Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension.","volume":"279","author":"Li","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijcard.2018.12.020","article-title":"Silencing salusin beta ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK\/NF-kappaB pathways in the paraventricular nucleus.","volume":"280","author":"Li","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.amepre.2018.01.009","article-title":"Effectiveness of user- and expert-driven web-based hypertension programs: an RCT.","volume":"54","author":"Liu","year":"2018","journal-title":"Am. J. Prev. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1161\/01.hyp.0000175812.03322.59","article-title":"Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain.","volume":"46","author":"Martins","year":"2005","journal-title":"Hypertension"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122850","article-title":"Toll-Like receptor 4 promotes autonomic dysfunction, inflammation and microglia activation in the hypothalamic paraventricular nucleus: role of endoplasmic reticulum stress.","volume":"10","author":"Masson","year":"","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"H1115","DOI":"10.1152\/ajpheart.00349.2015","article-title":"Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR.","volume":"309","author":"Masson","year":"","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1161\/01.hyp.0000086201.27420.33","article-title":"Training-induced, pressure-lowering effect in SHR: wide effects on circulatory profile of exercised and nonexercised muscles.","volume":"42","author":"Melo","year":"2003","journal-title":"Hypertension"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1985-5","article-title":"Acute and chronic effects of aerobic exercise on blood pressure in resistant hypertension: study protocol for a randomized controlled trial.","volume":"18","author":"Nascimento","year":"2017","journal-title":"Trials"},{"key":"B21","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.ijcard.2015.11.066","article-title":"Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines.","volume":"203","author":"Nogueira-Ferreira","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s12012-015-9344-9","article-title":"NF-kappaB Blockade in hypothalamic paraventricular nucleus inhibits high-salt-induced hypertension through NLRP3 and caspase-1.","volume":"16","author":"Qi","year":"","journal-title":"Cardiovasc. Toxicol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12012-015-9338-7","article-title":"Targeting interleukin-1 beta to suppress sympathoexcitation in hypothalamic paraventricular nucleus in dahl salt-sensitive hypertensive rats.","volume":"16","author":"Qi","year":"","journal-title":"Cardiovasc. Toxicol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/ajh\/hpv160","article-title":"Effect of moderate exercise on mitochondrial proteome in heart tissue of spontaneous hypertensive rats.","volume":"29","author":"Rocha","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"B25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1748-1716.2011.02313.x","article-title":"Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats.","volume":"203","author":"Shi","year":"2011","journal-title":"Acta Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"H1027","DOI":"10.1152\/ajpheart.00697.2018","article-title":"Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways.","volume":"316","author":"Singh","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.taap.2014.09.004","article-title":"Inhibition of TNF-alpha in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.","volume":"281","author":"Song","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s12264-018-0292-9","article-title":"Intermedin in Paraventricular nucleus attenuates sympathoexcitation and decreases TLR4-mediated sympathetic activation via adrenomedullin receptors in rats with obesity-related hypertension.","volume":"35","author":"Sun","year":"2019","journal-title":"Neurosci. Bull."},{"key":"B29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.phymed.2018.09.206","article-title":"Chronic infusion of berberine into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation via the ROS\/Erk1\/2\/iNOS pathway.","volume":"52","author":"Tian","year":"2019","journal-title":"Phytomedicine"},{"key":"B30","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s10753-018-00953-4","article-title":"Umbelliferone alleviates lipopolysaccharide-induced inflammatory responses in acute lung injury by down-regulating TLR4\/MyD88\/NF-kappaB signaling.","volume":"42","author":"Wang","year":"2019","journal-title":"Inflammation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuroscience.2016.04.050","article-title":"Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension.","volume":"329","author":"Wang","year":"2016","journal-title":"Neuroscience"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/ajh\/hpy074","article-title":"Blockade of TLR4 within the paraventricular nucleus attenuates blood pressure by regulating ros and inflammatory cytokines in prehypertensive rats.","volume":"31","author":"Wang","year":"2018","journal-title":"Am. J. Hypertens."},{"key":"B33","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.yjmcc.2018.04.009","article-title":"Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy.","volume":"119","author":"Wang","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.toxlet.2015.04.008","article-title":"Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates neurohormonal excitation in high salt-induced hypertension.","volume":"235","author":"Zhang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep37467","article-title":"Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus.","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01138\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:21:56Z","timestamp":1571876516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01138\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":35,"alternative-id":["10.3389\/fnins.2019.01138"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.01138","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,24]]},"article-number":"1138"}}