{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:51:41Z","timestamp":1790610701657,"version":"4.1.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.01212","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T04:28:36Z","timestamp":1573619316000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Tactile Stimulation for Expectation, Perceived Treatment Assignment and the Placebo Effect in an Experimental Nausea Paradigm"],"prefix":"10.3389","volume":"13","author":[{"given":"Simone","family":"Aichner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Olliges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias H.","family":"Tsch\u00f6p","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3109\/10601331003777444","article-title":"Blinding assessment in clinical trials: a review of statistical methods and a proposal of blinding assessment protocol.","volume":"27","author":"Bang","year":"2010","journal-title":"Clin. Res. Regul. Aff."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1250","article-title":"Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus.","volume":"7","author":"Benedetti","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00213-011-2233-4","article-title":"Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo.","volume":"215","author":"Bjorkedal","year":"2011","journal-title":"Psychopharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/ana.25387","article-title":"Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation.","volume":"85","author":"Burke","year":"2019","journal-title":"Ann. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1136\/aim.24.4.169","article-title":"Role of C tactile fibres in touch and emotion\u2013clinical and research relevance to acupuncture.","volume":"24","author":"Campbell","year":"2006","journal-title":"Acupunct. Med."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00243","article-title":"How placebo needles differ from placebo pills?","volume":"9","author":"Chae","year":"2018","journal-title":"Front. Psychiatr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1098\/rstb.2010.0398","article-title":"How placebo responses are formed: a learning perspective.","volume":"366","author":"Colloca","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1126\/science.1060937","article-title":"Expectation and dopamine release: mechanism of the placebo effect in Parkinson\u2019s disease.","volume":"293","author":"De la Fuente-Fern\u00e1ndez","year":"2001","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002285.pub2","article-title":"Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting.","volume":"2","author":"Ezzo","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev-neuro-072116-031132","article-title":"The cognitive neuroscience of placebo effects: concepts, predictions, and physiology.","volume":"40","author":"Geuter","year":"2017","journal-title":"Ann. Rev. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/s0022-3999(01)00201-x","article-title":"Relationship of gastric myoelectrical and cardiac parasympathetic activity to chemotherapy-induced nausea.","volume":"50","author":"Gianaros","year":"2001","journal-title":"J. Psychosom. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/s0361-9230(98)00091-4","article-title":"Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness.","volume":"47","author":"Golding","year":"1998","journal-title":"Brain Res. Bull."},{"key":"B13","first-page":"453","article-title":"Diagnostic criteria for grading the severity of acute motion sickness.","volume":"39","author":"Graybiel","year":"1968","journal-title":"Aerosp. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/bs.irn.2018.01.001","article-title":"Placebo effects in the immune system.","volume":"138","author":"Hadamitzky","year":"2018","journal-title":"Int. Rev. Neurobiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.autneu.2010.07.027","article-title":"Autonomic and subjective responses to real and sham acupuncture stimulation.","volume":"159","author":"Kang","year":"2011","journal-title":"Auton. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/bmj.38726.603310.55","article-title":"Sham device v inert pill: randomised controlled trial of two placebo treatments.","volume":"332","author":"Kaptchuk","year":"2006","journal-title":"BMJ"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00424","article-title":"Mechanisms of perceived treatment assignment and subsequent expectancy effects in a double blind placebo controlled RCT of major depression.","volume":"9","author":"Laferton","year":"2018","journal-title":"Front. Psychiatr."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003281.pub3","article-title":"Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting.","volume":"2","author":"Lee","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/01.psy.0000221377.52036.50","article-title":"The effects of manipulating expectations through placebo and nocebo administration on gastric tachyarrhythmia and motion-induced nausea.","volume":"68","author":"Levine","year":"2006","journal-title":"Psychosom. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1001\/archgenpsychiatry.2010.88","article-title":"Effects of expectation on placebo-induced dopamine release in Parkinson disease.","volume":"67","author":"Lidstone","year":"2010","journal-title":"Arch. Gen. Psychiatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000320374","article-title":"Are sham acupuncture interventions more effective than (other) placebos? A re-analysis of data from the cochrane review on placebo effects.","volume":"17","author":"Linde","year":"","journal-title":"Forsch. Komplementmed."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-75","article-title":"How large are the nonspecific effects of acupuncture? A meta-analysis of randomized controlled trials.","volume":"8","author":"Linde","year":"","journal-title":"BMC Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.pain.2006.12.006","article-title":"The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain.","volume":"128","author":"Linde","year":"2007","journal-title":"Pain"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093739","article-title":"Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis.","volume":"9","author":"MacPherson","year":"2014","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jpsychores.2008.09.004","article-title":"Effects of placebo interventions on gastric motility and general autonomic activity.","volume":"66","author":"Meissner","year":"2009","journal-title":"J. Psychosom. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1098\/rstb.2010.0403","article-title":"The placebo effect and the autonomic nervous system: evidence for an intimate relationship.","volume":"366","author":"Meissner","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-3-662-44519-8-11","article-title":"Placebo responses on cardiovascular, gastrointestinal, and respiratory organ functions.","volume":"225","author":"Meissner","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"16117","DOI":"10.1523\/JNEUROSCI.4099-11.2011","article-title":"The placebo effect: advances from different methodological approaches.","volume":"31","author":"Meissner","year":"2011","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1001\/jamainternmed.2013.10391","article-title":"Differential effectiveness of placebo treatments: a systematic review of migraine prophylaxis.","volume":"173","author":"Meissner","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/bs.irn.2018.07.014","article-title":"Are blue pills better than green? How treatment features modulate placebo effects.","volume":"139","author":"Meissner","year":"2018","journal-title":"Int. Rev. Neurobiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.autneu.2011.06.006","article-title":"Organ-specificity of placebo effects on blood pressure.","volume":"164","author":"Meissner","year":"2011","journal-title":"Auton. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"7365","DOI":"10.1523\/JNEUROSCI.4793-14.2015","article-title":"Neural mechanisms of placebo anxiolysis.","volume":"35","author":"Meyer","year":"2015","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jpsychores.2016.09.012","article-title":"Effectiveness of a placebo intervention on visually induced nausea in women\u2013A randomized controlled pilot study.","volume":"91","author":"M\u00fcller","year":"2016","journal-title":"J. Psychosom. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/cercor\/bhs073","article-title":"The brain circuitry underlying the temporal evolution of nausea in humans.","volume":"23","author":"Napadow","year":"2012","journal-title":"Cereb. Cortex"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1001\/jamapsychiatry.2015.1335","article-title":"Association between placebo-activated neural systems and antidepressant responses: neurochemistry of placebo effects in major depression.","volume":"72","author":"Peci\u00f1a","year":"2015","journal-title":"JAMA Psychiatr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12160-014-9670-3","article-title":"Placebo interventions for nausea: a systematic review.","volume":"49","author":"Quinn","year":"2014","journal-title":"Ann. Behav. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/PSY.0000000000000265","article-title":"Sources of placebo-induced relief from nausea: the role of instruction and conditioning.","volume":"78","author":"Quinn","year":"2016","journal-title":"Psychosom. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.edurev.2010.12.001","article-title":"Eta squared and partial eta squared as measures of effect size in educational research.","volume":"6","author":"Richardson","year":"2011","journal-title":"Educ. Res. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1016\/j.pain.2012.09.007","article-title":"The hidden effects of blinded, placebo-controlled randomized trials: an experimental investigation.","volume":"153","author":"Rief","year":"2012","journal-title":"Pain"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0767-3","article-title":"Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial.","volume":"15","author":"Rief","year":"2017","journal-title":"BMC Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.ahj.2011.06.016","article-title":"Effects of verbal suggestion on coronary arteries: results of a randomized controlled experimental investigation during coronary angiography.","volume":"162","author":"Ronel","year":"2011","journal-title":"Am. Heart J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1176\/appi.ajp.2016.16020225","article-title":"Patient expectancy as a mediator of placebo effects in antidepressant clinical trials.","volume":"174","author":"Rutherford","year":"2016","journal-title":"Am. J. Psychiatr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1001\/archinternmed.2012.3654","article-title":"Acupuncture for chronic pain: individual patient data meta-analysis.","volume":"172","author":"Vickers","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jpain.2017.11.005","article-title":"Acupuncture for chronic pain: update of an individual patient data meta-analysis.","volume":"19","author":"Vickers","year":"2018","journal-title":"J. Pain"},{"key":"B45","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1365-2982.2012.01877.x","article-title":"Stimulation of gastric slow waves with manual acupuncture at acupuncture points ST36 and PC6\u2013a randomized single blind controlled trial.","volume":"24","author":"Witt","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140825","article-title":"Placebo devices as effective control methods in acupuncture clinical trials: a systematic review.","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale.","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01212\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T04:28:38Z","timestamp":1573619318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01212\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":47,"alternative-id":["10.3389\/fnins.2019.01212"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.01212","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"article-number":"1212"}}