{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:27:33Z","timestamp":1793284053540,"version":"4.5.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.01400","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:07:33Z","timestamp":1579565253000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":123,"title":["Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer\u2019s Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"XingRong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiKun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer\u2019s disease.","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"B2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jalz.2019.01.010","article-title":"2019 Alzheimer\u2019s disease facts and figures.","volume":"15","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.abb.2009.01.018","article-title":"Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms.","volume":"486","author":"Athar","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1042\/BST20051041","article-title":"Increased risk of Alzheimer\u2019s disease in type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?","author":"Biessels","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1111\/ggi.12602","article-title":"Inflammatory hypothesis as a link between Alzheimer\u2019s disease and diabetes mellitus.","volume":"16","author":"Bozluolcay","year":"2015","journal-title":"Geriatr. Gerontol. Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1089\/ars.2012.5027","article-title":"Amyloid beta-peptide (1\u201342)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression.","volume":"19","author":"Butterfield","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuint.2017.10.002","article-title":"Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress.","volume":"115","author":"Chiang","year":"2018","journal-title":"Neurochem. Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045.","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: role of polyphenols.","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"B10","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0047-6374(01)00313-X","article-title":"Inflammatory markers in Alzheimer\u2019s disease and multi-infarct dementia.","volume":"122","author":"De Luigi","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"774","DOI":"10.2337\/diabetes.55.03.06.db05-1417","article-title":"Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes.","volume":"55","author":"Devaraj","year":"2006","journal-title":"Diabetes"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/mnfr.201200067","article-title":"Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db\/db mice.","volume":"56","author":"Do","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity.","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1080\/10715760802255764","article-title":"Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer\u2019s disease.","volume":"42","author":"Greilberger","year":"2008","journal-title":"Free Radic. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"7611","DOI":"10.1073\/pnas.86.19.7611","article-title":"Brain interleukin 1 and S-100 immunoreactivity are elevated in down syndrome and Alzheimer disease.","volume":"86","author":"Griffin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3892\/etm.2018.6178","article-title":"Resveratrol provides benefits in mice with type II diabetes-induced chronic renal failure through AMPK signaling pathway.","volume":"16","author":"Guo","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRT1 in neurodevelopment and brain senescence.","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"key":"B18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11064-017-2421-7","article-title":"Resveratrol attenuates the cytotoxicity induced by amyloid-beta1-42 in PC12 cells by upregulating heme oxygenase-1 via the PI3K\/Akt\/Nrf2 pathway.","volume":"43","author":"Hui","year":"2018","journal-title":"Neurochem. Res."},{"key":"B19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3143\/geriatrics.37.207","article-title":"[Alzheimer\u2019s disease: basic aspects].","volume":"37","author":"Iwatsubo","year":"2000","journal-title":"Nihon Ronen Igakkai Zasshi"},{"key":"B20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington\u2019s disease through activation of multiple Sirt1 targets.","volume":"18","author":"Jiang","year":"2012","journal-title":"Nat. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis.","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3233\/JAD-2010-1332","article-title":"A relationship between Alzheimer\u2019s disease and type 2 diabetes mellitus through the measurement of serum amyloid-beta autoantibodies.","volume":"19","author":"Kim","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B23","first-page":"237","article-title":"SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.","volume":"16","author":"Kobayashi","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000097511","article-title":"Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.","volume":"79","author":"Kumar","year":"2007","journal-title":"Pharmacology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00016","article-title":"The role of sirtuins in Alzheimer\u2019s disease.","volume":"5","author":"Lalla","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/nn.3500","article-title":"Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.","volume":"16","author":"Lee","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/138161212798919075","article-title":"Resveratrol, a neuroprotective supplement for Alzheimer\u2019s disease.","volume":"18","author":"Li","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.3969\/j.issn.1673-5374.2013.22.004","article-title":"Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.","volume":"8","author":"Ma","year":"2013","journal-title":"Neural Regen. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"37377","DOI":"10.1074\/jbc.M508246200","article-title":"Resveratrol promotes clearance of Alzheimer\u2019s disease amyloid-beta peptides.","volume":"280","author":"Marambaud","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14712\/18059694.2019.79","article-title":"Genetic aspects of diabetes mellitus.","volume":"44","author":"Marklova","year":"2001","journal-title":"Acta Medica (Hradec Kralove)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ana.25570","article-title":"Amylin as a potential link between type 2 diabetes and Alzheimer disease.","volume":"86","author":"Martinez-Valbuena","year":"2019","journal-title":"Ann. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/cbic.200800762","article-title":"Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol.","volume":"10","author":"Mishra","year":"2009","journal-title":"Chembiochem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1016\/j.dsx.2016.01.021","article-title":"Shared links between type 2 diabetes mellitus and Alzheimer\u2019s disease: a review.","volume":"10","author":"Mittal","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1089\/ars.2012.4713","article-title":"SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a\/PGC-1alpha complex.","volume":"19","author":"Olmos","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B35","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2174\/156720209787466019","article-title":"Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection.","volume":"6","author":"Pallas","year":"2009","journal-title":"Curr. Neurovasc. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12035-013-8459-x","article-title":"Brain activation of SIRT1: role in neuropathology.","volume":"48","author":"Paraiso","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"B37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/JMN:23:1-2:097","article-title":"Cell degeneration induced by amyloid-beta peptides: implications for Alzheimer\u2019s disease.","volume":"23","author":"Pereira","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01803-6","article-title":"Resveratrol activates neuronal autophagy through AMPK in the ischemic brain.","author":"Pineda-Ramirez","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010210","article-title":"Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study.","volume":"6","author":"Sharma","year":"2016","journal-title":"BMJ Open"},{"key":"B40","first-page":"279","article-title":"[Advance of resveratrol in treating diabetes mellitus].","volume":"33","author":"Shen","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1016\/S0140-6736(14)60886-2","article-title":"The global implications of diabetes and cancer.","volume":"383","author":"Shi","year":"2014","journal-title":"Lancet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"744","DOI":"10.4239\/wjd.v6.i5.744","article-title":"Emerging links between type 2 diabetes and Alzheimer\u2019s disease.","volume":"6","author":"Sridhar","year":"2015","journal-title":"World J. Diabetes"},{"key":"B43","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1471-4159.1980.tb12511.x","article-title":"Acetyl-CoA synthesizing enzymes in cholinergic nerve terminals.","volume":"35","author":"Sterri","year":"1980","journal-title":"J. Neurochem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1007\/s12035-019-1475-8","article-title":"Mechanisms associated with type 2 diabetes as a risk factor for Alzheimer-related pathology.","volume":"56","author":"Su","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3892\/etm.2014.1542","article-title":"Effects of resveratrol on apoptosis in a rat model of vascular dementia.","volume":"7","author":"Sun","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1002\/jnr.21745","article-title":"Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid.","volume":"86","author":"Sun","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.bbadis.2014.10.013","article-title":"Resveratrol and diabetes: from animal to human studies.","volume":"1852","author":"Szkudelski","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1262\/jrd.11-138n","article-title":"Oxidative stress and redox regulation on in vitro development of mammalian embryos.","volume":"58","author":"Takahashi","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/35065638","article-title":"Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.","volume":"410","author":"Tissenbaum","year":"2001","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-S2-S6","article-title":"Therapeutic potential of resveratrol in Alzheimer\u2019s disease.","author":"Vingtdeux","year":"2008","journal-title":"BMC Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1089\/ars.2009.3064","article-title":"Antioxidant and anti-inflammatory effects of resveratrol in airway disease.","volume":"13","author":"Wood","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"B52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000328516","article-title":"Resveratrol-activated AMPK\/SIRT1\/autophagy in cellular models of Parkinson\u2019s disease.","volume":"19","author":"Wu","year":"2011","journal-title":"Neurosignals"},{"key":"B53","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phrs.2012.10.010","article-title":"Negative regulation of inflammation by SIRT1.","volume":"67","author":"Xie","year":"2013","journal-title":"Pharmacol. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12640-017-9726-9","article-title":"Resveratrol attenuates Abeta-induced early hippocampal neuron excitability impairment via recovery of function of potassium channels.","volume":"32","author":"Yin","year":"2017","journal-title":"Neurotox. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.jnutbio.2012.02.015","article-title":"Resveratrol promotes cellular glucose utilization in primary cultured cortical neurons via calcium-dependent signaling pathway.","volume":"24","author":"Zhang","year":"2013","journal-title":"J. Nutr. Biochem."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01400\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:07:36Z","timestamp":1579565256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.01400\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":55,"alternative-id":["10.3389\/fnins.2019.01400"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.01400","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"article-number":"1400"}}