{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:06:17Z","timestamp":1793505977673,"version":"4.5.0"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/50138-4"],"award-info":[{"award-number":["2015\/50138-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["347\/15"],"award-info":[{"award-number":["347\/15"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2041\/16"],"award-info":[{"award-number":["2041\/16"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2020.00023","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:26:54Z","timestamp":1580894814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":105,"title":["Complement System in Brain Architecture and Neurodevelopmental Disorders"],"prefix":"10.3389","volume":"14","author":[{"given":"Juliana","family":"Magdalon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz","family":"Teles e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Abreu","family":"de Goes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Laurato","family":"Serti\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/archpsyc.1996.01830050061010","article-title":"Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients.","volume":"53","author":"Akbarian","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00417","article-title":"Complement in the homeostatic and ischemic brain.","volume":"6","author":"Alawieh","year":"2015","journal-title":"Front. Immunol."},{"key":"B3","first-page":"321","article-title":"The cerebellum in autism.","volume":"2","author":"Allen","year":"2005","journal-title":"Clin. Neuropsychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/npp.2017.164","article-title":"Complement gene expression correlates with superior frontal cortical thickness in humans.","volume":"43","author":"Allswede","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"B6","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-11-10","article-title":"Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia.","volume":"11","author":"Arakelyan","year":"2011","journal-title":"BMC Clin. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/s0006-3223(97)00142-x","article-title":"Further evidence of abnormal cytoarchitecture of the entorhinal cortex in schizophrenia using spatial point pattern analyses.","volume":"42","author":"Arnold","year":"1997","journal-title":"Biol. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","article-title":"Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.","volume":"25","author":"Ashwood","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0345-343","article-title":"Novel MASP1 mutations are associated with an expanded phenotype in 3MC1 syndrome.","volume":"10","author":"Atik","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.15252\/embj.201591881","article-title":"Complement activation, regulation, and molecular basis for complement-related diseases.","volume":"34","author":"Bajic","year":"2015","journal-title":"EMBO J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/MCD.0000000000000256","article-title":"Novel mutation in MASP1 gene in a new family with 3MC syndrome.","volume":"28","author":"Basdemirci","year":"2019","journal-title":"Clin. Dysmorphol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1016\/j.molimm.2008.05.027","article-title":"Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.","volume":"45","author":"Benard","year":"2008","journal-title":"Mol. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1016\/j.molimm.2007.11.003","article-title":"The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb).","volume":"45","author":"Bexborn","year":"2008","journal-title":"Mol. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement.","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized.","volume":"7","author":"Bienvenu","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.014.2009","article-title":"Early-life programming of later-life brain and behavior: a critical role for the immune system.","volume":"3","author":"Bilbo","year":"2009","journal-title":"Front. Behav. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/jnr.21401","article-title":"Signaling through C5aR is not involved in basal neurogenesis.","volume":"85","author":"Bogestal","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrn3992","article-title":"From the genetic architecture to synaptic plasticity in autism spectrum disorder.","volume":"16","author":"Bourgeron","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s11064-010-0126-122","article-title":"Alternative complement pathway in schizophrenia.","volume":"35","author":"Boyajyan","year":"2010","journal-title":"Neurochem. Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-137","article-title":"Complement activation in the injured central nervous system: another dual-edged sword?","volume":"9","author":"Brennan","year":"2012","journal-title":"J. Neuroinflam."},{"key":"B22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.biopsych.2014.05.023","article-title":"Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk.","volume":"77","author":"Cannon","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1073\/pnas.052023499","article-title":"Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia.","volume":"99","author":"Cannon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.devcel.2011.10.012","article-title":"Complement fragment C3a controls mutual cell attraction during collective cell migration.","volume":"21","author":"Carmona-Fontaine","year":"2011","journal-title":"Dev. Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1212\/wnl.58.3.428","article-title":"Minicolumnar pathology in autism.","volume":"58","author":"Casanova","year":"2002","journal-title":"Neurology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology.","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"B27","doi-asserted-by":"publisher","first-page":"26058","DOI":"10.1074\/jbc.M401318200","article-title":"Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/DBP.0000000000000235","article-title":"Prevalence and characteristics of autism spectrum disorder among 4-year-old children in the autism and developmental disabilities monitoring network.","volume":"37","author":"Christensen","year":"2016","journal-title":"J. Dev. Behav. Pediatr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7975","DOI":"10.1073\/pnas.0913449107","article-title":"Enhanced synaptic connectivity and epilepsy in C1q knockout mice.","volume":"107","author":"Chu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bbi.2015.07.022","article-title":"Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders.","volume":"50","author":"Coiro","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/598342","article-title":"Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.","author":"Comer","year":"2019","journal-title":"bioRxiv[Preprint]"},{"key":"B32","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/sj.mp.4001943","article-title":"A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins.","volume":"12","author":"Corbett","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/480980","article-title":"Subclinical inflammatory status in Rett syndrome.","volume":"2014","author":"Cortelazzo","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B34","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.molimm.2018.06.271","article-title":"Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance.","volume":"101","author":"Coulthard","year":"","journal-title":"Mol. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1523\/JNEUROSCI.0525-17.2017","article-title":"Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCzeta.","volume":"37","author":"Coulthard","year":"2017","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.tins.2018.03.009","article-title":"Complement: the emerging architect of the developing brain.","volume":"41","author":"Coulthard","year":"","journal-title":"Trends Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.nbd.2014.04.006","article-title":"Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome.","volume":"68","author":"De Felice","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/gbb.12016","article-title":"Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253.","volume":"12","author":"Donohoe","year":"2013","journal-title":"Genes Brain Behav."},{"key":"B39","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.schres.2018.03.035","article-title":"Increased complement component 4 (C4) gene expression in the cingulate cortex of rats exposed to late gestation immune activation.","volume":"199","author":"Duchatel","year":"2018","journal-title":"Schizophr. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses.","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1096\/fj.13-230706","article-title":"The novel complement inhibitor human CUB and Sushi multiple domains 1 (CSMD1) protein promotes factor I-mediated degradation of C4b and C3b and inhibits the membrane attack complex assembly.","volume":"27","author":"Escudero-Esparza","year":"2013","journal-title":"FASEB J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1159\/000465523","article-title":"Complement C3 expression is decreased in autism spectrum disorder subjects and contributes to behavioral deficits in rodents.","volume":"3","author":"Fagan","year":"2017","journal-title":"Mol. Neuropsychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000154060","article-title":"Complement genetic markers in schizophrenia: C3, BF and C6 polymorphisms.","volume":"42","author":"Fananas","year":"1992","journal-title":"Hum. Hered."},{"key":"B44","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1113\/jphysiol.2001.013381","article-title":"CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b-8 as well as C5b-9.","author":"Farkas","year":"2002","journal-title":"J. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","article-title":"Adult neural stem cells bridge their niche.","volume":"10","author":"Fuentealba","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.it.2004.04.008","article-title":"Structure and activation of the C1 complex of complement: unraveling the puzzle.","volume":"25","author":"Gaboriaud","year":"2004","journal-title":"Trends Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1597\/15-151","article-title":"Familial recurrence of 3MC syndrome in consanguineous families: a clinical and molecular diagnostic approach with review of the literature.","volume":"54","author":"Gardner","year":"2017","journal-title":"Cleft Palate Craniofac. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/imr.12468","article-title":"A journey through the lectin pathway of complement-MBL and beyond.","volume":"274","author":"Garred","year":"2016","journal-title":"Immunol. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroscience.2012.04.044","article-title":"Dendritic spine pathology in schizophrenia.","volume":"251","author":"Glausier","year":"2013","journal-title":"Neuroscience"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00150","article-title":"Complement C3 affects rac1 activity in the developing brain.","volume":"11","author":"Gorelik","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15096","article-title":"Developmental activities of the complement pathway in migrating neurons.","volume":"8","author":"Gorelik","year":"","journal-title":"Nat. Commun."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00169","article-title":"Serping1\/C1 Inhibitor affects cortical development in a cell autonomous and non-cell autonomous manner.","volume":"11","author":"Gorelik","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ejmg.2018.01.016","article-title":"Biallelic intragenic deletion in MASP1 in an adult female with 3MC syndrome.","volume":"61","author":"Graul-Neumann","year":"2018","journal-title":"Eur. J. Med. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s41588-019-0344-348","article-title":"Identification of common genetic risk variants for autism spectrum disorder.","volume":"51","author":"Grove","year":"2019","journal-title":"Nat. Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1073\/pnas.1722613115","article-title":"Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning.","volume":"115","author":"Gyorffy","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/070674379704200204","article-title":"Epidemiology of schizophrenia.","volume":"42","author":"Hafner","year":"1997","journal-title":"Can. J. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neulet.2004.10.024","article-title":"Classical pathway complement activity in schizophrenia.","volume":"374","author":"Hakobyan","year":"2005","journal-title":"Neurosci. Lett."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1066-z","article-title":"The role of the complement system in traumatic brain injury: a review.","volume":"15","author":"Hammad","year":"2018","journal-title":"J. Neuroinflam."},{"key":"B60","doi-asserted-by":"publisher","first-page":"64","DOI":"10.9758\/cpn.2017.15.1.64","article-title":"Increased levels of C1q in the prefrontal cortex of adult offspring after maternal immune activation: prevention by 7,8-Dihydroxyflavone.","volume":"15","author":"Han","year":"2017","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1001\/archgenpsychiatry.2011.39","article-title":"Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years.","volume":"68","author":"Hazlett","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"10498","DOI":"10.1073\/pnas.1202588109","article-title":"Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2.","volume":"109","author":"Heja","year":"2012","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neuron.2006.07.007","article-title":"Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse.","volume":"52","author":"Hooks","year":"2006","journal-title":"Neuron"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/S0140-6736(13)62036-X","article-title":"Schizophrenia: an integrated sociodevelopmental-cognitive model.","volume":"383","author":"Howes","year":"2014","journal-title":"Lancet"},{"key":"B65","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.brainres.2009.09.120","article-title":"Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders.","volume":"1309","author":"Hutsler","year":"2010","journal-title":"Brain Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.bbrc.2018.02.131","article-title":"Increased cerebrospinal fluid complement C5 levels in major depressive disorder and schizophrenia.","volume":"497","author":"Ishii","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B67","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders.","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.schres.2014.02.017","article-title":"The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males.","volume":"154","author":"Koiliari","year":"2014","journal-title":"Schizophr. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement\u2013tapping into new sites and effector systems.","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.4049\/jimmunol.176.7.4419","article-title":"CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.","volume":"176","author":"Kraus","year":"2006","journal-title":"J. Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0065-2776(08)04004-4002","article-title":"The amplification loop of the complement pathways.","volume":"104","author":"Lachmann","year":"2009","journal-title":"Adv. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.imbio.2018.02.001","article-title":"Looking back on the alternative complement pathway.","volume":"223","author":"Lachmann","year":"2018","journal-title":"Immunobiology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/ajmg.a.32252","article-title":"Blepharophimosis, blepharoptosis, defects of the anterior chamber of the eye, caudal appendage, radioulnar synostosis, hearing loss and umbilical anomalies in sibs: 3MC syndrome?","author":"Leal","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"B74","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.psychres.2016.10.061","article-title":"Plasma levels of Th17-related cytokines and complement C3 correlated with aggressive behavior in patients with schizophrenia.","volume":"246","author":"Li","year":"2016","journal-title":"Psychiatry Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1039\/c2mb25158b","article-title":"Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia.","volume":"8","author":"Li","year":"2012","journal-title":"Mol. Biosyst."},{"key":"B76","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease.","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2746-2747","article-title":"Transcriptome analysis of human brain tissue identifies reduced expression of complement complex C1Q Genes in Rett syndrome.","volume":"17","author":"Lin","year":"2016","journal-title":"BMC Genomics"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2089-2084","article-title":"Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients.","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Psychiatry"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0165-1781(96)02915-2910","article-title":"Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs.","volume":"66","author":"Maes","year":"1997","journal-title":"Psychiatry Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","article-title":"Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism.","volume":"26","author":"Malkova","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001834","article-title":"Guiding neuronal cell migrations.","volume":"2","author":"Marin","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.neulet.2006.06.051","article-title":"Increased complement classical and mannan-binding lectin pathway activities in schizophrenia.","volume":"404","author":"Mayilyan","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B83","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15622970701227803","article-title":"Complement C4B protein in schizophrenia.","volume":"9","author":"Mayilyan","year":"2008","journal-title":"World J. Biol. Psychiatry"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005140","article-title":"Experimental Malaria in pregnancy induces neurocognitive injury in uninfected offspring via a C5a-C5a receptor dependent pathway.","volume":"11","author":"McDonald","year":"2015","journal-title":"PLoS Pathog."},{"key":"B85","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/epirev\/mxn001","article-title":"Schizophrenia: a concise overview of incidence, prevalence, and mortality.","volume":"30","author":"McGrath","year":"2008","journal-title":"Epidemiol. Rev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.","volume":"26","author":"Meyer","year":"2006","journal-title":"J. Neurosci."},{"key":"B87","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B","article-title":"Head circumference is an independent clinical finding associated with autism.","volume":"95","author":"Miles","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/868576","article-title":"High complement factor I activity in the plasma of children with autism spectrum disorders.","volume":"2012","author":"Momeni","year":"2012","journal-title":"Autism Res. Treat."},{"key":"B89","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B90","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jneuroim.2010.03.025","article-title":"The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children.","volume":"223","author":"Mostafa","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"B91","first-page":"235","article-title":"Transmembrane channel-formation by five complement proteins.","volume":"50","author":"Muller-Eberhard","year":"1985","journal-title":"Biochem. Soc Symp."},{"key":"B92","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1084\/jem.125.2.359","article-title":"Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.","volume":"125","author":"Muller-Eberhard","year":"1967","journal-title":"J. Exp. Med."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006679","article-title":"COLEC10 is mutated in 3MC patients and regulates early craniofacial development.","volume":"13","author":"Munye","year":"2017","journal-title":"PLoS Genet."},{"key":"B94","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.70","article-title":"DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways.","volume":"4","author":"Nardone","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"B96","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.humimm.2004.11.002","article-title":"Confirmation of the association of the C4B null allelle in autism.","volume":"66","author":"Odell","year":"2005","journal-title":"Hum. Immunol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jneuroim.2015.04.005","article-title":"Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-kappaB signaling in myeloid derived cells.","volume":"283","author":"O\u2019Driscoll","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00380","article-title":"Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis.","volume":"8","author":"Orsini","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.bbr.2008.12.016","article-title":"Immune involvement in schizophrenia and autism: etiology, pathology and animal models.","volume":"204","author":"Patterson","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism.","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbadis.2013.10.011","article-title":"Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth.","volume":"1842","author":"Pedroni","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B102","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.expneurol.2013.12.013","article-title":"Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.","volume":"253","author":"Perez-Alcazar","year":"2014","journal-title":"Exp. Neurol."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0181-z","article-title":"Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.","volume":"8","author":"Prasad","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/sj.emboj.7601004","article-title":"Complement: a novel factor in basal and ischemia-induced neurogenesis.","volume":"25","author":"Rahpeymai","year":"2006","journal-title":"EMBO J."},{"key":"B105","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1126\/science.3952506","article-title":"Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex.","volume":"232","author":"Rakic","year":"1986","journal-title":"Science"},{"key":"B106","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1146\/annurev-cellbio-100913-113038","article-title":"Sculpting neural circuits by axon and dendrite pruning.","volume":"31","author":"Riccomagno","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis.","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ng.757","article-title":"Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.","volume":"43","author":"Rooryck","year":"2011","journal-title":"Nat. Genet."},{"key":"B109","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000153555","article-title":"C3 and C6 complement types in schizophrenia.","volume":"35","author":"Rudduck","year":"1985","journal-title":"Hum. Hered."},{"key":"B110","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0006-3223(94)91149-91145","article-title":"Changes of immunological functions after acute exacerbation in schizophrenia.","volume":"35","author":"Sasaki","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"B111","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"B112","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/ng.940","article-title":"Genome-wide association study identifies five new schizophrenia loci.","volume":"43","year":"2011","journal-title":"Nat. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000154424","article-title":"Investigation of complement C4B deficiency in schizophrenia.","volume":"47","author":"Schroers","year":"1997","journal-title":"Hum. Hered."},{"key":"B114","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4.","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"key":"B115","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/s0006-3223(98)00281-289","article-title":"The reduced neuropil hypothesis: a circuit based model of schizophrenia.","volume":"45","author":"Selemon","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"B116","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.schres.2014.07.053","article-title":"Maternal complement C1q and increased odds for psychosis in adult offspring.","volume":"159","author":"Severance","year":"2014","journal-title":"Schizophr. Res."},{"key":"B117","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0162-3109(99)00099-5","article-title":"The possible role of plasma kallikrein-kinin system and leukocyte elastase in pathogenesis of schizophrenia.","volume":"43","author":"Shcherbakova","year":"1999","journal-title":"Immunopharmacology"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201700085","article-title":"iTRAQ-based proteomic analysis reveals protein profile in plasma from children with autism.","volume":"12","author":"Shen","year":"2018","journal-title":"Proteomics Clin. Appl."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0920-9964(01)00163-163","article-title":"A review of MRI findings in schizophrenia.","volume":"49","author":"Shenton","year":"2001","journal-title":"Schizophr. Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1002\/stem.225","article-title":"Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells.","volume":"27","author":"Shinjyo","year":"2009","journal-title":"Stem Cells"},{"key":"B121","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.ajhg.2010.09.018","article-title":"MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes.","volume":"87","author":"Sirmaci","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"B122","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1017\/s0033291700028397","article-title":"Reduced total complement haemolytic activity in schizophrenic patients.","volume":"23","author":"Spivak","year":"1993","journal-title":"Psychol. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/0006-3223(89)90091-90097","article-title":"A study of the complement system in psychiatric patients.","volume":"26","author":"Spivak","year":"1989","journal-title":"Biol. Psychiatry"},{"key":"B124","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease.","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination.","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa1307491","article-title":"Patches of disorganization in the neocortex of children with autism.","volume":"370","author":"Stoner","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"B128","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/ajmg.a.30878","article-title":"Michels syndrome, Carnevale syndrome, OSA syndrome, and Malpuech syndrome: variable expression of a single disorder (3MC syndrome)?","author":"Titomanlio","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1002\/ajmg.a.37564","article-title":"Exploring the genetic basis of 3MC syndrome: findings in 12 further families.","author":"Urquhart","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.molimm.2011.04.003","article-title":"Complement in the brain.","volume":"48","author":"Veerhuis","year":"2011","journal-title":"Mol. Immunol."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0136-132","article-title":"Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.","volume":"13","author":"Venkatraman Girija","year":"2015","journal-title":"BMC Biol."},{"key":"B132","first-page":"316","article-title":"Investigation of allotypes of HLA class III (C2, BF and C4) in patients with schizophrenia.","volume":"105","author":"Wang","year":"1992","journal-title":"Chin. Med. J. (Engl)"},{"key":"B133","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1365-2249.1991.tb05657.x","article-title":"Increased frequency of the null allele at the complement C4b locus in autism.","volume":"83","author":"Warren","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1001\/archpedi.1994.02170020066011","article-title":"Decreased plasma concentrations of the C4B complement protein in autism.","volume":"148","author":"Warren","year":"1994","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s12311-008-0043-y","article-title":"Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k.","volume":"7","author":"Whitney","year":"2008","journal-title":"Cerebellum"},{"key":"B136","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0920-9964(96)00037-30","article-title":"Acute phase proteins in male Chinese schizophrenic patients in Singapore.","volume":"22","author":"Wong","year":"1996","journal-title":"Schizophr. Res."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-126","article-title":"Association of C1QB gene polymorphism with schizophrenia in Armenian population.","volume":"12","author":"Zakharyan","year":"2011","journal-title":"BMC Med. Genet."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00023\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:26:58Z","timestamp":1580894818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00023\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":137,"alternative-id":["10.3389\/fnins.2020.00023"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.00023","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"article-number":"23"}}