{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:09:37Z","timestamp":1792652977363,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2020.00555","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T07:24:32Z","timestamp":1591169072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["MRI Features in a Rat Model of H-ABC Tubulinopathy"],"prefix":"10.3389","volume":"14","author":[{"given":"Angeles","family":"Garduno-Robles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milvia","family":"Alata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Eguibar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Pantano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1074\/jbc.M113.496844","article-title":"Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of \u03b2-tubulin.","volume":"289","author":"Antony","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mcn.2017.03.002","article-title":"Tubulins and brain development \u2013 The origins of functional specification.","volume":"84","author":"Breuss","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/cm.21290","article-title":"The emerging role of the tubulin code: from the tubulin molecule to neuronal function and disease.","volume":"73","author":"Chakraborti","year":"2016","journal-title":"Cytoskeleton"},{"key":"B4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/jnnp.2007.139287","article-title":"White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis.","volume":"80","author":"Concha","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/syn.20188","article-title":"Characterization of the spontaneous and gripping-induced immobility episodes ontaiep rats.","volume":"58","author":"Cort\u00e9s","year":"2005","journal-title":"Synapse"},{"key":"B6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/(SICI)1097-4547(19970315)47:6<573::AID-JNR2>3.0.CO;2-A","article-title":"Binding of microtubules to transitional elements in oligodendrocytes of the myelin mutant taiep rat.","volume":"47","author":"Couve","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4506","DOI":"10.1093\/hmg\/ddx338","article-title":"TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes.","volume":"26","author":"Curiel","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/ana.24930","article-title":"A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.","volume":"81","author":"Duncan","year":"2017","journal-title":"Ann. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1007\/BF01191684","article-title":"The taiep rat: a myelin mutant with an associated oligodendrocyte microtubular defect.","volume":"21","author":"Duncan","year":"1992","journal-title":"J. Neurocytol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.pbb.2012.03.020","article-title":"Dopaminergic D2-like agonists produce yawning in the myelin mutant taiep and Sprague\u2013Dawley rats.","volume":"102","author":"Eguibar","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B11","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/mds.26129","article-title":"H-ABC syndrome and DYT4: variable expressivity or pleiotropy of TUBB4 mutations: H-ABC syndrome and DYT4.","volume":"30","author":"Erro","year":"2015","journal-title":"Mov. Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/syn.20622","article-title":"Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat.","volume":"63","author":"Fuenzalida","year":"2009","journal-title":"Synapse"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252304","article-title":"Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.","volume":"344","author":"Gibson","year":"2014","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/RMR.0000000000000188","article-title":"Tubulinopathies.","volume":"27","author":"Gon\u00e7alves","year":"2018","journal-title":"Top. Mag. Reson. Imaging"},{"key":"B15","first-page":"226","article-title":"Sprague Dawley rat mutant with tremor, ataxia, tonic immobility episodes, epilepsy and paralysis.","volume":"39","author":"Holmgren","year":"1989","journal-title":"Lab. Anim. Sci."},{"key":"B16","year":"2020"},{"key":"B17","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/ng.380","article-title":"Mutations in the \u03b2-tubulin gene TUBB2B result in asymmetrical polymicrogyria.","volume":"41","author":"Jaglin","year":"2009","journal-title":"Nat. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1101\/gr.1970304","article-title":"Comparative recombination rates in the rat, mouse, and human genomes.","volume":"14","author":"Jensen-Seaman","year":"2004","journal-title":"Genome Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/cm.10122","article-title":"Requirement for the \u03b2 I and \u03b2 IV tubulin isotypes in mammalian cilia: \u03b2 Tubulin isotypes in Cilia.","volume":"55","author":"Jensen-Smith","year":"2003","journal-title":"Cell Motil. Cytoskelet."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188869","article-title":"Hypomyelinating disorders in China: the clinical and genetic heterogeneity in 119 patients.","volume":"13","author":"Ji","year":"2018","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jnen\/nly105","article-title":"Severe TUBB4A -related hypomyelination with atrophy of the basal ganglia and cerebellum: novel neuropathological findings.","volume":"78","author":"Joyal","year":"2019","journal-title":"J. Neuropathol. Exper. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cell.2006.12.017","article-title":"Mutations in \u03b1-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.","volume":"128","author":"Keays","year":"2007","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10482-018-1142-5","article-title":"Prokaryotic cytoskeletons: in situ and ex situ structures and cellular locations.","volume":"112","author":"Kim","year":"2019","journal-title":"Antonie Van Leeuwenhoek"},{"key":"B24","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s00415-004-0306-6","article-title":"Water content and myelin water fraction in multiple sclerosis.","volume":"251","author":"Laule","year":"2004","journal-title":"J. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.brainres.2006.08.097","article-title":"Increased nitric oxide levels and nitric oxide synthase isoform expression in the cerebellum of the taiep rat during its severe demyelination stage.","volume":"1121","author":"Leon-Chavez","year":"2006","journal-title":"Brain Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00335-003-2302-z","article-title":"Mapping of taiep rat phenotype to rat chromosome 9.","volume":"14","author":"Li","year":"2003","journal-title":"Mamm. Genome"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1006\/jmbi.2001.5077","article-title":"Refined structure of \u03b1\u03b2-tubulin at 3.5 \u00c5 resolution.","volume":"313","author":"L\u00f6we","year":"2001","journal-title":"J. Mol. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1023\/A:1018548400536","article-title":"The temporal progression of the myelination defect in the taiep rat.","volume":"26","author":"Lunn","year":"1997","journal-title":"J. Neurocytol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neures.2017.04.002","article-title":"Towards an understanding of the isotype-specific functions of tubulin in neurons: technical advances in tubulin expression and purification.","volume":"122","author":"Minoura","year":"2017","journal-title":"Neurosci. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nn.4521","article-title":"Fostering reproducible fMRI research.","volume":"20","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ceb.2006.02.009","article-title":"Structural intermediates in microtubule assembly and disassembly: how and why?","volume":"18","author":"Nogales","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/brain\/awu348","article-title":"Exome sequencing in undiagnosed inherited and sporadic ataxias.","volume":"138","author":"Pyle","year":"2015","journal-title":"Brain"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1529\/biophysj.108.132233","article-title":"Microtubule assembly of isotypically purified tubulin and its mixtures.","volume":"95","author":"Rezania","year":"2008","journal-title":"Biophys. J."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00069","article-title":"Understanding suicidal behavior: the contribution of recent resting-state fMRI techniques.","volume":"7","author":"Serafini","year":"2016","journal-title":"Front. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22024","article-title":"Juvenile Taiep rats have shorter dendritic trees in the dorsal field of the hippocampus without spatial learning disabilities.","volume":"72","author":"Silva-G\u00f3mez","year":"2018","journal-title":"Synapse"},{"key":"B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-1136(20010101)33:1<1::AID-GLIA1001>3.0.CO;2-Q","article-title":"Selective myelin defects in the anterior medullary velum of the taiep mutant rat.","volume":"33","author":"Song","year":"2001","journal-title":"Glia"},{"key":"B37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cell.2009.12.011","article-title":"Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.","volume":"140","author":"Tischfield","year":"2010","journal-title":"Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1042\/BSR20100025","article-title":"Distinct \u03b1- and \u03b2-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the \u2018multi-tubulin\u2019 hypothesis.","volume":"30","author":"Tischfield","year":"2010","journal-title":"Biosci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/ng0508-523","article-title":"What everybody should know about the rat genome and its online resources.","volume":"40","author":"Twigger","year":"2008","journal-title":"Nat. Genet."},{"key":"B40","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/glia.23256","article-title":"Origin and dynamics of oligodendrocytes in the developing brain: implications for perinatal white matter injury.","volume":"66","author":"van Tilborg","year":"2018","journal-title":"Glia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ijdevneu.2011.02.012","article-title":"The developing oligodendrocyte: key cellular target in brain injury in the premature infant.","volume":"29","author":"Volpe","year":"2011","journal-title":"Intern. J. Dev. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00555\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T07:24:35Z","timestamp":1591169075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00555\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":41,"alternative-id":["10.3389\/fnins.2020.00555"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.00555","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,3]]},"article-number":"555"}}