{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:09:43Z","timestamp":1790683783955,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012498","name":"Alzheimer Society Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012498","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2020.00713","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T14:13:17Z","timestamp":1593785597000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["In vivo Retinal Fluorescence Imaging With Curcumin in an Alzheimer Mouse Model"],"prefix":"10.3389","volume":"14","author":[{"given":"Ahmad","family":"Sidiqi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza Faisal","family":"Beg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinko","family":"Sarunic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne A.","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"B1","year":"2004","journal-title":"Mouse Brain Atlas"},{"key":"B2","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease.","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease [7].","volume":"28","author":"Baum","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/ceo.12386","article-title":"Evaluation of the chorioretinal thickness changes in Alzheimer\u2019s disease using spectral-domain optical coherence tomography.","volume":"43","author":"Bayhan","year":"2015","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1750-3639.1991.tb00667.x","article-title":"Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer\u2019s disease: precursor-product relationships in the derangement of neuronal function.","volume":"1","author":"Beyreuther","year":"1991","journal-title":"Brain Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer\u2019s disease.","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimer\u2019s Dementia"},{"key":"B7","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1254\/jphs.CR0050014","article-title":"Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the \u03b2-amyloid precursor protein in Alzheimer\u2019s disease.","volume":"97","author":"Chang","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jalz.2013.06.004","article-title":"Alzheimer\u2019s disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers.","volume":"10","author":"Chang","year":"2014","journal-title":"Alzheimer\u2019s Dementia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/35050103","article-title":"A learning deficit related to age and \u03b2-amyloid plaques in a mouse model of alzheimer\u2019s disease.","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134750","article-title":"Optical coherence tomography in Alzheimer\u2019s disease: a meta-analysis.","volume":"10","author":"Coppola","year":"2015","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/0197-4580(93)90105-K","article-title":"Incomplete achromatopsia in alzheimer\u2019s disease.","volume":"14","author":"Cronin-Golomb","year":"1993","journal-title":"Neurobiol. Aging"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00701","article-title":"Optical coherence tomograhy in Alzheimer\u2019s disease and other neurodegenerative diseases.","volume":"8","author":"Doustar","year":"2017","journal-title":"Front. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s00417-009-1060-3","article-title":"Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer\u2019s disease.","volume":"247","author":"Dutescu","year":"2009","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007901","article-title":"Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer\u2019s disease.","volume":"6","author":"Fagan","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00287","article-title":"Improving CSF biomarkers\u2019 performance for predicting progression from mild cognitive impairment to Alzheimer\u2019s disease by considering different confounding factors: A meta-analysis.","volume":"6","author":"Ferreira","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1471-4159.2007.04613.x","article-title":"Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.","volume":"102","author":"Garcia-Alloza","year":"2007","journal-title":"J. Neurochem."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-019-0170-z","article-title":"A longitudinal assessment of retinal function and structure in the APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease.","volume":"8","author":"Georgevsky","year":"2019","journal-title":"Transl. Neurodegen."},{"key":"B18","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1017\/S0007114515004687","article-title":"Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer\u2019s disease.","volume":"115","author":"Goozee","year":"2016","journal-title":"Br. J. Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.neulet.2016.04.059","article-title":"Amyloid beta accumulation and inner retinal degenerative changes in Alzheimer\u2019s disease transgenic mice.","volume":"623","author":"Gupta","year":"2016","journal-title":"Neurosci. Lett."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12242-1","article-title":"Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer\u2019s disease.","volume":"10","author":"Hadoux","year":"2019","journal-title":"Nat. Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.3233\/JAD-179932","article-title":"Revolution of Alzheimer precision neurology: passageway of systems biology and neurophysiology.","volume":"64","author":"Hampel","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","article-title":"Amyloid deposition as the central event in the aetiology of Alzheimer\u2019s disease.","volume":"12","author":"Hardy","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis.","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1117\/1.nph.7.1.015006","article-title":"Retinal analysis of a mouse model of Alzheimer\u2019s disease with multicontrast optical coherence tomography.","volume":"7","author":"Harper","year":"2020","journal-title":"Neurophotonics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00401-016-1613-6","article-title":"Ocular indicators of Alzheimer\u2019s: exploring disease in the retina.","volume":"132","author":"Hart","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, abeta elevation and amyolid plaques in transgenic mice.","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/35050110","article-title":"A\u03b2 peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer\u2019s disease.","volume":"408","author":"Janus","year":"2000","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00055","article-title":"Visual and ocular manifestations of Alzheimer\u2019s disease and their use as biomarkers for diagnosis and progression.","volume":"7","author":"Javaid","year":"2016","journal-title":"Front. Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013127","article-title":"Viewing ageing eyes: diverse sites of amyloid beta accumulation in the ageing mouse retina and the up-regulation of macrophages.","volume":"5","author":"Kam","year":"2010","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1034\/j.1600-0420.2001.079002187.x","article-title":"An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type.","volume":"79","author":"Kergoat","year":"2001","journal-title":"Acta Ophthalmol. Scand."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00426","article-title":"Hypoxia affects neprilysin expression through caspase activation and an APP intracellular domain-dependent mechanism.","volume":"9","author":"Kerridge","year":"2015","journal-title":"Front. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.clineuro.2011.02.014","article-title":"Retinal thickness in patients with mild cognitive impairment and Alzheimer\u2019s disease.","volume":"113","author":"Kesler","year":"2011","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000335154","article-title":"Alzheimer\u2019s disease in the retina: imaging retinal A\u03b2 plaques for early diagnosis and therapy assessment.","volume":"10","author":"Koronyo","year":"2012","journal-title":"Neurodegen. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"S204","DOI":"10.1016\/j.neuroimage.2010.06.020","article-title":"Identification of amyloid plaques in retinas from Alzheimer\u2019s patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.","volume":"54","author":"Koronyo-Hamaoui","year":"2011","journal-title":"Neuroimage"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.2353\/ajpath.2009.090159","article-title":"Amyloid-peptide vaccinations reduce \u03b2-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer\u2019s transgenic mice.","volume":"175","author":"Liu","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006446","article-title":"Changes in amyloid beta and tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.","volume":"5","author":"Maia","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/00005072-200606000-00010","article-title":"Visual association pathology in preclinical Alzheimer disease.","volume":"65","author":"McKee","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1523\/JNEUROSCI.4264-11.2012","article-title":"Differential effects between \u03b3-Secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice.","volume":"32","author":"Mitani","year":"2012","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-014-1347-2","article-title":"The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.","volume":"129","author":"Nhan","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1242\/dev.108712","article-title":"Amyloid precursor protein and neural development.","volume":"141","author":"Nicolas","year":"2014","journal-title":"Development"},{"key":"B42","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1167\/iovs.08-1849","article-title":"Amyloid-\u03b2 deposits lead to retinal degeneration in a mouse model of Alzheimer disease.","volume":"49","author":"Ning","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1016\/j.neurobiolaging.2014.03.008","article-title":"Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice.","volume":"35","author":"Park","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B44","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1167\/iovs.08-2384","article-title":"Beta-amyloid deposition and functional impairment in the retina of the APPswe\/PS1DeltaE9 transgenic mouse model of Alzheimer\u2019s disease.","volume":"50","author":"Perez","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1212\/WNL.0b013e31823b9c5e","article-title":"Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.","volume":"77","author":"Rabinovici","year":"2011","journal-title":"Neurology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.neurobiolaging.2012.08.007","article-title":"Visual contrast sensitivity in Alzheimer\u2019s disease, mild cognitive impairment, and older adults with cognitive complaints.","volume":"34","author":"Risacher","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1042\/BST0351219","article-title":"Synaptic memory mechanisms: Alzheimer\u2019s disease amyloid beta-peptide-induced dysfunction.","volume":"35","author":"Rowan","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"B49","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0002-9394(87)90001-8","article-title":"Assessment of visual impairment in patients with Alzheimer\u2019s disease.","volume":"104","author":"Sadun","year":"1987","journal-title":"Am. J. Ophthalmol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/brain\/107.1.309","article-title":"Visual processing deficits as assessed by spatial frequency contrast sensitivity and backward masking in normal ageing and alzheimer\u2019s disease.","volume":"107","author":"Schlotterer","year":"1984","journal-title":"Brain"},{"key":"B51","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer\u2019s disease.","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"B52","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer\u2019s disease.","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/mp.2016.251","article-title":"Beta- amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer\u2019s disease.","volume":"22","author":"Shah","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1471-4159.2008.05606.x","article-title":"Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-D-aspartate receptor signaling.","volume":"107","author":"Shimazawa","year":"2008","journal-title":"J. Neurochem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.dadm.2016.09.001","article-title":"Nonvascular retinal imaging markers of preclinical Alzheimer\u2019s disease.","volume":"4","author":"Snyder","year":"2016","journal-title":"Alzheimer\u2019s Dementia"},{"key":"B56","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10072-007-0789-x","article-title":"Neurodegeneration and Alzheimer\u2019s disease: the lesson from tauopathies.","volume":"28","author":"Sorrentino","year":"2007","journal-title":"Neurol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.survophthal.2013.10.002","article-title":"Vision function abnormalities in Alzheimer disease.","volume":"59","author":"Tzekov","year":"2014","journal-title":"Surv. Ophthalmol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/ceo.12872","article-title":"Emerging ocular biomarkers of Alzheimer disease.","volume":"45","author":"van Wijngaarden","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature14864","article-title":"\u03c3-Secretase processing of APP inhibits neuronal activity in the hippocampus.","volume":"526","author":"Willem","year":"2015","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1474-9726.2007.00351.x","article-title":"Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice.","volume":"7","author":"Xu","year":"2008","journal-title":"Aging Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid \u03b2 oligomers and fibrils, binds plaques, and reduces amyloid in vivo.","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.tins.2010.05.004","article-title":"\u201cToo much good news\u201d - are Alzheimer mouse models trying to tell us how to prevent, not cure. Alzheimer\u2019s disease?.","volume":"33","author":"Zahs","year":"2010","journal-title":"Trends Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00713\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T14:13:21Z","timestamp":1593785601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.00713\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":62,"alternative-id":["10.3389\/fnins.2020.00713"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.00713","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]},"article-number":"713"}}