{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:56:50Z","timestamp":1792691810611,"version":"4.5.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Acute sleep deprivation (SD) seriously affects cognitive functions, such as attention, memory, and response inhibition. Previous neuroimaging studies have demonstrated a close relationship between the functional activities of the precuneus (PC) and the function of alert attention. However, the specific effect of the PC on attention decline after acute SD has not been elucidated. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to study the relationship between the changes of the PC functional connectivity and alertness decline after total SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty healthy, right-handed adult men participated in the experiment. Alert attention and functional connectivity were assessed by the Psychomotor Vigilance Test and a resting-state fMRI scan before and after total SD. The region of interest to region of interest (\u201cROI-to-ROI\u201d) correlation was employed to analyze the relationship between the PC and other brain regions after acute SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants showed decreased alert attention after total SD. In addition, SD induced decreased functional connectivity between the right PC and the right middle frontal gyrus (MFG). Moreover, there was a significant correlation between the decreased PC functional connectivity and alertness decline after total SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the interruption of the connection between the right PC and the right MFG is related to the observed decline in alert attention after acute SD. These results provide evidence further elucidating the cognitive impairment model of SD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2020.530257","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T06:20:55Z","timestamp":1608531655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Decreased Functional Connectivity Between the Right Precuneus and Middle Frontal Gyrus Is Related to Attentional Decline Following Acute Sleep Deprivation"],"prefix":"10.3389","volume":"14","author":[{"given":"Bozhi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nn.2509","article-title":"A central role for the lateral prefrontal cortex in goal-directed and stimulus-driven attention.","volume":"13","author":"Asplund","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/sleep\/34.5.581","article-title":"Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss.","volume":"34","author":"Basner","year":"2011","journal-title":"Sleep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/jsr.12322","article-title":"A new likelihood ratio metric for the psychomotor vigilance test and its sensitivity to sleep loss.","volume":"24","author":"Basner","year":"2015","journal-title":"J. Sleep Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.actaastro.2011.07.015","article-title":"Validity and sensitivity of a brief psychomotor vigilance test (PVT-B) to total and partial sleep deprivation.","volume":"69","author":"Basner","year":"2011","journal-title":"Acta Astronaut."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1097\/jom.0b013e31822b8356","article-title":"Fitness for duty: a 3-minute version of the psychomotor vigilance test predicts fatigue-related declines in luggage-screening performance.","volume":"53","author":"Basner","year":"2011","journal-title":"J. Occup. Environ. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI.","volume":"37","author":"Behzadi","year":"2007","journal-title":"NeuroImage"},{"key":"B7","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41583-019-0212-7","article-title":"The brain\u2019s default network: updated anatomy, physiology and evolving insights.","volume":"20","author":"Buckner","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1162\/08989290051137585","article-title":"Imaging cognition II: an empirical review of 275 PET and fMRI studies.","volume":"12","author":"Cabeza","year":"2000","journal-title":"J. Cogn. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates.","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.neuroimage.2011.06.058","article-title":"Effects of sleep deprivation on cortical activation during directed attention in the absence and presence of visual stimuli.","volume":"58","author":"Chee","year":"2011","journal-title":"NeuroImage"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.neuroimage.2009.08.067","article-title":"Sleep deprivation and its effects on object-selective attention.","volume":"49","author":"Chee","year":"2010","journal-title":"NeuroImage"},{"key":"B12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.sleep.2018.05.040","article-title":"Dissociable effects of sleep deprivation on functional connectivity in the dorsal and ventral default mode networks.","volume":"50","author":"Chen","year":"2018","journal-title":"Sleep Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1097\/01.wnr.0000239956.45448.4c","article-title":"Functional connectivity in a baseline resting-state network in autism.","volume":"17","author":"Cherkassky","year":"2006","journal-title":"NeuroReport"},{"key":"B14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.neuron.2008.04.017","article-title":"The reorienting system of the human brain: from environment to theory of mind.","volume":"58","author":"Corbetta","year":"2008","journal-title":"Neuron"},{"key":"B15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuroimage.2015.01.037","article-title":"Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.","volume":"110","author":"Crone","year":"2015","journal-title":"NeuroImage"},{"key":"B16","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/hbm.23429","article-title":"Structural and functional connectivity of the precuneus and thalamus to the default mode network.","volume":"38","author":"Cunningham","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00067","article-title":"On the need of objective vigilance monitoring: effects of sleep loss on target detection and task-negative activity using combined EEG\/fMRI.","volume":"3","author":"Czisch","year":"2012","journal-title":"Front. Neurol."},{"key":"B18","first-page":"1059","article-title":"The neural basis of the psychomotor vigilance task.","volume":"28","author":"Drummond","year":"2005","journal-title":"Sleep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1055\/s-2005-867080","article-title":"Neurocognitive consequences of sleep deprivation.","volume":"25","author":"Durmer","year":"2005","journal-title":"Semin. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"829","DOI":"10.5665\/sleep.4684","article-title":"Trends in self-reported sleep duration among US adults from 1985 to 2012.","volume":"38","author":"Ford","year":"2015","journal-title":"Sleep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"10046","DOI":"10.1073\/pnas.0604187103","article-title":"Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems.","volume":"103","author":"Fox","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.neuroimage.2008.05.059","article-title":"The precuneus\/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis.","volume":"42","author":"Fransson","year":"2008","journal-title":"NeuroImage"},{"key":"B23","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1055\/s-0029-1237117","article-title":"Neurocognitive consequences of sleep deprivation.","volume":"29","author":"Goel","year":"2009","journal-title":"Semin. Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1093\/cercor\/bhx219","article-title":"Neural substrate for metacognitive accuracy of tactile working memory.","volume":"27","author":"Gogulski","year":"2017","journal-title":"Cereb. Cortex"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1093\/cercor\/bhp264","article-title":"Semantic, factual, and social language comprehension in adolescents with autism: an FMRI study.","volume":"20","author":"Groen","year":"2009","journal-title":"Cereb. Cortex"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1212\/wnl.0000000000001404","article-title":"Resting brain activity in disorders of consciousness: a systematic review and meta-analysis.","volume":"84","author":"Hannawi","year":"2015","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.sleh.2019.08.008","article-title":"Changes in sleep difficulties among the U.S. population from 2013 to 2017: results from the national health interview survey.","volume":"5","author":"Hisler","year":"2019","journal-title":"Sleep Health"},{"key":"B28","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10597-019-00469-7","article-title":"A single-item visual analogue scale (VAS) measure for assessing depression among college students.","volume":"56","author":"Huang","year":"2019","journal-title":"Commun. Ment. Health J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1101\/lm.919109","article-title":"Posterior parietal cortex and episodic retrieval: convergent and divergent effects of attention and memory.","volume":"16","author":"Hutchinson","year":"2009","journal-title":"Learn. Mem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.Sleep.2016.08.006","article-title":"Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression.","volume":"32","author":"Itani","year":"2017","journal-title":"Sleep Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s1053-8119(02)91132-8","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images.","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"B32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/0956797612457384","article-title":"When anger leads to rumination.","volume":"24","author":"Kelley","year":"2013","journal-title":"Psychol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1542\/peds.2014-2707","article-title":"The great sleep recession: changes in sleep duration among US adolescents, 1991-2012.","volume":"135","author":"Keyes","year":"2015","journal-title":"Pediatrics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nrn.2017.55","article-title":"The sleep-deprived human brain.","volume":"18","author":"Krause","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01001","article-title":"Brain activity correlates with cognitive performance deterioration during sleep deprivation.","volume":"13","author":"Krause Posada-Quintero","year":"2019","journal-title":"Front. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1162\/jocn_a_01426","article-title":"Developmental maturation of the precuneus as a functional core of the default mode network.","volume":"31","author":"Li","year":"2019","journal-title":"J. Cogn. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1093\/cercor\/bhq151","article-title":"A neuronal basis for task-negative responses in the human brain.","volume":"21","author":"Lin","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1196\/annals.1417.002","article-title":"Sleep deprivation and vigilant attention.","volume":"1129","author":"Lim","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3758\/bf03195580","article-title":"The validity of psychomotor vigilance tasks of less than 10-minute duration.","volume":"36","author":"Loh","year":"2004","journal-title":"Behav. Res. Methods Instrum.Comput."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.5665\/sleep.4174","article-title":"The effect of one night\u2019s sleep deprivation on adolescent neurobehavioral performance.","volume":"37","author":"Louca","year":"2014","journal-title":"Sleep"},{"key":"B41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5665\/sleep.4404","article-title":"How acute total sleep loss affects the attending brain: a meta-analysis of neuroimaging studies.","volume":"38","author":"Ma","year":"2015","journal-title":"Sleep"},{"key":"B42","first-page":"15","article-title":"Measurement of subjective phenomena in primary care research: the visual analogue scale.","volume":"13","author":"Miller","year":"1993","journal-title":"Fam. Pract. Res. J."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138994","article-title":"Functional activation during the rapid visual information processing task in a middle aged cohort: an fMRI study.","volume":"10","author":"Neale","year":"2015","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.tics.2005.03.010","article-title":"The cognitive control of emotion.","volume":"9","author":"Ochsner","year":"2005","journal-title":"Trends Cogn. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuron.2010.11.032","article-title":"Sleep state switching.","volume":"68","author":"Saper","year":"2010","journal-title":"Neuron"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy221","article-title":"Are U.S. adults reporting less sleep?: findings from sleep duration trends in the national health interview survey, 2004\u20132017.","volume":"42","author":"Sheehan","year":"2018","journal-title":"Sleep"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2019.00022","article-title":"Transcranial magnetic stimulation to the middle frontal gyrus during attention modes induced dynamic module reconfiguration in brain networks.","volume":"13","author":"Song","year":"2019","journal-title":"Front. Neuroinformatics"},{"key":"B48","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/scan\/nsy009","article-title":"Sleep quality and adolescent default mode network connectivity.","volume":"13","author":"Tashjian","year":"2018","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/cercor\/bhn073","article-title":"Impairment of attentional networks after 1 night of sleep deprivation.","volume":"19","author":"Tomasi","year":"2009","journal-title":"Cereb. Cortex"},{"key":"B50","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"B51","first-page":"829","article-title":"Visceral circuits and cingulate-mediated autonomic functions","author":"Vogt","year":"2009","journal-title":"Cingulate Neurobiology and Disease"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.00526","article-title":"Hostile attribution bias mediates the relationship between structural variations in the left middle frontal gyrus and trait angry rumination.","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Psychol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1518\/001872008x312152","article-title":"Vigilance requires hard mental work and is stressful.","volume":"50","author":"Warm","year":"2008","journal-title":"Hum. Fact."},{"key":"B54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/hbm.24468","article-title":"Beware detrending: optimal preprocessing pipeline for low-frequency fluctuation analysis.","volume":"40","author":"Woletz","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.neuroimage.2003.07.016","article-title":"Frontal activations associated with accessing and evaluating information in working memory: an fMRI study.","volume":"20","author":"Zhang","year":"2003","journal-title":"NeuroImage"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.530257\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T06:20:59Z","timestamp":1608531659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.530257\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":56,"alternative-id":["10.3389\/fnins.2020.530257"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.530257","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,21]]},"article-number":"530257"}}