{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:12:28Z","timestamp":1770455548735,"version":"3.49.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2020.573509","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T04:56:31Z","timestamp":1600145791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cold Exposure After Exercise Impedes the Neuroprotective Effects of Exercise on Thermoregulation and UCP4 Expression in an MPTP-Induced Parkinsonian Mouse Model"],"prefix":"10.3389","volume":"14","author":[{"given":"Yi-Ju","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Cih","family":"Jhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Hong","family":"Ching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ching","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsin","family":"Ching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih-Ing","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.pbb.2009.06.009","article-title":"Performance-enhancing and thermoregulatory effects of intracerebroventricular dopamine in running rats.","volume":"93","author":"Balthazar","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1152\/japplphysiol.00425.2011","article-title":"Long-term treadmill exercise induces neuroprotective molecular changes in rat brain.","volume":"111","author":"Bayod","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neuro.2012.02.001","article-title":"Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.","volume":"33","author":"Benskey","year":"2012","journal-title":"Neurotoxicology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.neuroscience.2006.11.028","article-title":"Relationships between locomotor activation and alterations in brain temperature during selective blockade and stimulation of dopamine transmission.","volume":"145","author":"Brown","year":"2007","journal-title":"Neuroscience"},{"key":"B5","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.freeradbiomed.2008.12.015","article-title":"Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression.","volume":"46","author":"Chu","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1126\/science.1132191","article-title":"Transgenic mice with a reduced core body temperature have an increased life span.","volume":"314","author":"Conti","year":"2006","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00292","article-title":"The Role of PGC-1alpha\/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain.","volume":"13","author":"de Oliveira Bristot","year":"2019","journal-title":"Front. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"10766","DOI":"10.1523\/jneurosci.2744-08.2008","article-title":"Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation.","volume":"28","author":"Dietrich","year":"2008","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111501","article-title":"Hypothalamic temperature of rats subjected to treadmill running in a cold environment.","volume":"9","author":"Fonseca","year":"2014","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0006-8993(95)00529-y","article-title":"MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice.","volume":"688","author":"Freyaldenhoven","year":"1995","journal-title":"Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1249\/mss.0000000000000292","article-title":"Water immersion in the treatment of exertional hyperthermia: physical determinants.","volume":"46","author":"Friesen","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1113\/expphysiol.2011.058065","article-title":"Postexercise hypotension and sustained postexercise vasodilatation: what happens after we exercise?","volume":"98","author":"Halliwill","year":"2013","journal-title":"Exp. Physiol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9349487","article-title":"Dynamic changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson\u2019s Disease.","volume":"2017","author":"Huang","year":"2017","journal-title":"Parkinsons Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3233\/jpd-140424","article-title":"Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or paraquat on core temperature in C57BL\/6J Mice.","volume":"5","author":"Jiao","year":"2015","journal-title":"J. Parkinsons Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1152\/japplphysiol.00517.2016","article-title":"Restoration of thermoregulation after exercise.","volume":"122","author":"Kenny","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2741\/3608","article-title":"Brain temperature homeostasis: physiological fluctuations and pathological shifts.","volume":"15","author":"Kiyatkin","year":"2010","journal-title":"Front. Biosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7754","DOI":"10.1523\/jneurosci.0506-14.2014","article-title":"Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.","volume":"34","author":"Kiyatkin","year":"2014","journal-title":"J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.exger.2017.01.001","article-title":"Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson\u2019s disease.","volume":"89","author":"Koo","year":"2017","journal-title":"Exp. Gerontol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1590\/1414-431x20143561","article-title":"Association between the increase in brain temperature and physical performance at different exercise intensities and protocols in a temperate environment.","volume":"47","author":"Kunstetter","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.freeradbiomed.2010.06.017","article-title":"Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity.","volume":"49","author":"Kwok","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3988\/jcn.2010.6.3.127","article-title":"Melatonin potentiates the neuroprotective properties of resveratrol against beta-amyloid-induced neurodegeneration by modulating amp-activated protein kinase pathways.","volume":"6","author":"Kwon","year":"2010","journal-title":"J. Clin. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00421-013-2774-9","article-title":"Neck cooling and cognitive performance following exercise-induced hyperthermia.","volume":"114","author":"Lee","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1385\/nmm","article-title":"Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.","volume":"8","author":"Liu","year":"2006","journal-title":"Neuromol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12640-020-00182-4","article-title":"MPTP-induced impairment of cardiovascular function.","volume":"38","author":"Liu","year":"2020","journal-title":"Neurotox. Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00258","article-title":"Whole-body cryotherapy in athletes: from therapy to stimulation. an updated review of the literature.","volume":"8","author":"Lombardi","year":"2017","journal-title":"Front. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.neuroscience.2015.06.027","article-title":"Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers.","volume":"301","author":"Marques-Aleixo","year":"2015","journal-title":"Neuroscience"},{"key":"B27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bbr.2015.11.017","article-title":"Ambient temperature influences the neural benefits of exercise.","volume":"299","author":"Maynard","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.pmrj.2018.04.009","article-title":"Cardiovascular responses during resistance exercise in patients with Parkinson Disease.","volume":"10","author":"Miyasato","year":"2018","journal-title":"Pm r"},{"key":"B29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1113\/expphysiol.2011.062273","article-title":"Brain temperature and exercise performance.","volume":"97","author":"Nybo","year":"2012","journal-title":"Exp. Physiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208453","article-title":"Effects of cold on murine brain mitochondrial function.","volume":"13","author":"Pamenter","year":"2018","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/jcbfm.2014.38","article-title":"The brain is hypothermic in patients with mitochondrial diseases.","volume":"34","author":"Rango","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/mds.26548","article-title":"Abnormal brain temperature in early-onset Parkinson\u2019s disease.","volume":"31","author":"Rango","year":"2016","journal-title":"Mov. Disord."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042200","article-title":"Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson\u2019s disease.","volume":"12","author":"Roostalu","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"B34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neulet.2019.01.003","article-title":"The effect of physical stimuli on the expression level of key elements in mitochondrial biogenesis.","volume":"698","author":"Salamon","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B35","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s11604-017-0616-0","article-title":"Assessment of brain core temperature using MR DWI-thermometry in Alzheimer disease patients compared to healthy subjects.","volume":"35","author":"Sparacia","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.340","article-title":"Intraventricular cerebrospinal fluid temperature analysis using MR diffusion-weighted imaging thermometry in Parkinson\u2019s disease patients, multiple system atrophy patients, and healthy subjects.","volume":"5","author":"Sumida","year":"2015","journal-title":"Brain Behav."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00150","article-title":"Glia maturation factor and mitochondrial uncoupling proteins 2 and 4 expression in the temporal cortex of Alzheimer\u2019s Disease brain.","volume":"9","author":"Thangavel","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.expneurol.2014.09.021","article-title":"Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity.","volume":"263","author":"Tsou","year":"2015","journal-title":"Exp. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2016.03.024","article-title":"Impaired thermoregulation and beneficial effects of thermoneutrality in the 3xTg-AD model of Alzheimer\u2019s disease.","volume":"43","author":"Vandal","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuroscience.2014.06.060","article-title":"Hippocampal UCP2 is essential for cognition and resistance to anxiety but not required for the benefits of exercise.","volume":"277","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1096\/fj.14-255802","article-title":"UCP4A protects against mitochondrial dysfunction and degeneration in pink1\/parkin models of Parkinson\u2019s disease.","volume":"28","author":"Wu","year":"2014","journal-title":"FASEB J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbi.2010.09.006","article-title":"Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway.","volume":"25","author":"Wu","year":"2011","journal-title":"Brain. Behav. Immun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jnc.14297","article-title":"Parkinson\u2019s disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.","volume":"145","author":"Xu","year":"2018","journal-title":"J. Neurochem"},{"key":"B44","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1096\/fj.99-0834com","article-title":"Characterization of novel UCP5\/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.","volume":"14","author":"Yu","year":"2000","journal-title":"FASEB J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1080\/17461391.2015.1111938","article-title":"Central dopaminergic neurotransmission plays an important role in thermoregulation and performance during endurance exercise.","volume":"16","author":"Zheng","year":"2016","journal-title":"Eur. J. Sport Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jtherbio.2017.11.003","article-title":"Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment.","volume":"71","author":"Zheng","year":"2018","journal-title":"J. Therm. Biol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.573509\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T04:56:32Z","timestamp":1600145792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2020.573509\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":46,"alternative-id":["10.3389\/fnins.2020.573509"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.573509","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]},"article-number":"573509"}}