{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:52:34Z","timestamp":1792857154855,"version":"4.5.0"},"reference-count":406,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2020.579953","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:52:43Z","timestamp":1603673563000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":200,"title":["Excitotoxicity: Still Hammering the Ischemic Brain in 2020"],"prefix":"10.3389","volume":"14","author":[{"given":"Dennis W.","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0092-8674(03)01017-1011","article-title":"A key role for TRPM7 channels in anoxic neuronal death.","volume":"115","author":"Aarts","year":"2003","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.","volume":"298","author":"Aarts","year":"2002","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejphar.2009.11.066","article-title":"d-Cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window.","volume":"629","author":"Adeleye","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1046\/j.1471-4159.2000.0751878.x","article-title":"Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release.","volume":"75","author":"Aizenman","year":"2000","journal-title":"J. Neurochem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.1073\/pnas.0600554103","article-title":"Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.","volume":"103","author":"Alano","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","first-page":"5080","article-title":"Nitric oxide-mediated apoptosis in murine peritoneal macrophages.","volume":"1950","author":"Albina","year":"1993","journal-title":"J. Immunol. Baltim. Md"},{"key":"B7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1113\/jphysiol.2002.020297","article-title":"Modulation of ASIC channels in rat cerebellar purkinje neurons by ischaemia-related signals.","volume":"543","author":"Allen","year":"2002","journal-title":"J. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J."},{"key":"B9","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.","volume":"78","author":"Ames","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","article-title":"Inflammation and stroke: an overview.","volume":"13","author":"Anrather","year":"2016","journal-title":"Neurotherapeutics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.03.015","article-title":"NXY-059, a failed stroke neuroprotectant, offers no protection to stem cell-derived human neurons.","volume":"27","author":"Antonic","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1111\/j.1460-9568.2009.07026.x","article-title":"Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia: Zinc in Kv2.1 modulation after ischemia.","volume":"30","author":"Aras","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1084\/jem.20161673","article-title":"Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations.","volume":"214","author":"Bading","year":"2017","journal-title":"J. Exp. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/aps.2018.5","article-title":"Discovery and development of NA-1 for the treatment of acute ischemic stroke.","volume":"39","author":"Ballarin","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1152\/physiol.00048.2005","article-title":"Cell-cell communication beyond connexins: the pannexin channels.","volume":"21","author":"Barbe","year":"2006","journal-title":"Physiology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1002\/glia.23670","article-title":"Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes.","volume":"67","author":"Barron","year":"2019","journal-title":"Glia"},{"key":"B17","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0006-8993(80)90316-90319","article-title":"The role of epileptic activity in hippocampal and \u2018remote\u2019 cerebral lesions induced by kainic acid.","volume":"191","author":"Ben-Ari","year":"1980","journal-title":"Brain Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"9679","DOI":"10.1523\/JNEUROSCI.22-22-09679.2002","article-title":"Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.","volume":"22","author":"Benquet","year":"2002","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1111\/j.1471-4159.1984.tb05396.x","article-title":"Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis.","volume":"43","author":"Benveniste","year":"1984","journal-title":"J. Neurochem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0304-3940(83)90489-90485","article-title":"Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.","volume":"36","author":"Berdichevsky","year":"1983","journal-title":"Neurosci. Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-5793(97)00150-156","article-title":"Nitric oxide mediates intracytoplasmic and intranuclear zinc release.","volume":"405","author":"Berendji","year":"1997","journal-title":"FEBS Lett."},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000522","article-title":"Stim2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.","volume":"2","author":"Berna-Erro","year":"2009","journal-title":"Sci. Signal."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009755","article-title":"Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons.","volume":"5","author":"Bertaso","year":"2010","journal-title":"PLoS One"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1523\/JNEUROSCI.5093-08.2009","article-title":"Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus.","volume":"29","author":"Besser","year":"2009","journal-title":"J. Neurosci."},{"key":"B27","first-page":"459","article-title":"Calcium as mediator of isoproterenol-induced myocardial necrosis.","volume":"69","author":"Bloom","year":"1972","journal-title":"Am. J. Pathol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/glia.1048","article-title":"Rapid astrocyte death induced by transient hypoxia, acidosis, and extracellular ion shifts.","volume":"34","author":"Bondarenko","year":"2001","journal-title":"Glia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","article-title":"Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures.","volume":"92","author":"Bonfoco","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","first-page":"199","article-title":"Roles of phospholipases A2 in brain cell and tissue injury associated with ischemia and excitotoxicity\u2019.","volume":"16","author":"Bonventre","year":"1997","journal-title":"J Lipid Mediat. Cell Signal."},{"key":"B31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.abb.2007.01.020","article-title":"Cell shrinkage and monovalent cation fluxes: role in apoptosis.","volume":"462","author":"Bortner","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"B32","doi-asserted-by":"publisher","first-page":"32436","DOI":"10.1074\/jbc.272.51.32436","article-title":"A primary role for K+ and Na+ efflux in the activation of apoptosis.","volume":"272","author":"Bortner","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1258\/ebm.2010.009258","article-title":"Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro.","volume":"235","author":"Bozym","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bcp.2012.04.009","article-title":"G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptors.","volume":"84","author":"Bradley","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/347768a0","article-title":"Localization of nitric oxide synthase indicating a neural role for nitric oxide.","volume":"347","author":"Bredt","year":"1990","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/s0092-8674(00)81053-81053","article-title":"Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.","volume":"84","author":"Brenman","year":"1996","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nn.2334","article-title":"NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.","volume":"12","author":"Brennan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B38","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1038\/cddis.2013.111","article-title":"Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death.","volume":"4","author":"Brennan-Minnella","year":"2013","journal-title":"Cell Death Dis."},{"key":"B39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1476-5381.1996.tb15971.x","article-title":"Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells.","volume":"119","author":"Bresink","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1111\/j.1460-9568.1995.tb00712.x","article-title":"Activation of Class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration.","volume":"7","author":"Bruno","year":"","journal-title":"Eur. J. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/0028-3908(95)00077-J","article-title":"Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.","volume":"34","author":"Bruno","year":"","journal-title":"Neuropharmacology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0028-3908(98)00159-152","article-title":"Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors.","volume":"38","author":"Bruno","year":"1999","journal-title":"Neuropharmacology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1523\/JNEUROSCI.10-01-00311.1990","article-title":"Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia.","volume":"10","author":"Buchan","year":"1990","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00001756-199108000-199108016","article-title":"Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.","volume":"2","author":"Buchan","year":"1991","journal-title":"NeuroReport"},{"key":"B45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0896-6273(92)90120-3","article-title":"Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit.","volume":"8","author":"Burnashev","year":"1992","journal-title":"Neuron"},{"key":"B46","doi-asserted-by":"publisher","first-page":"9903","DOI":"10.1523\/JNEUROSCI.1713-04.2004","article-title":"Late calcium EDTA rescues hippocampal ca1 neurons from global ischemia-induced death.","volume":"24","author":"Calderone","year":"2004","journal-title":"J. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1523\/JNEUROSCI.23-06-02112.2003","article-title":"Ischemic insults derepress the gene silencer REST in neurons destined to die.","volume":"23","author":"Calderone","year":"2003","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.nbd.2003.10.013","article-title":"Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockade.","volume":"15","author":"Canzoniero","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"B49","doi-asserted-by":"crossref","first-page":"12315","DOI":"10.1073\/pnas.1705034114","article-title":"NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.","volume":"114","author":"Casas","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102450","article-title":"Glial cell AMPA receptors in nervous system health, injury and disease.","volume":"20","author":"Ceprian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1474-4422(14)70054-7","article-title":"Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b\/3 trial.","volume":"13","author":"Chamorro","year":"2014","journal-title":"Lancet Neurol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0079-6123(08)61986-X","article-title":"Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury","author":"Chan","year":"1985","journal-title":"Progress in Brain Research"},{"key":"B53","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s12035-013-8538-z","article-title":"MMP-9 inhibition: a therapeutic strategy in ischemic stroke.","volume":"49","author":"Chaturvedi","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.yexcr.2016.12.028","article-title":"Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke.","volume":"351","author":"Chen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"B55","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/jcbfm.2015.16","article-title":"Tat-NR2B9c prevents excitotoxic neuronal superoxide production.","volume":"35","author":"Chen","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1046\/j.1471-4159.1998.71062401.x","article-title":"Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons.","volume":"71","author":"Cheng","year":"1998","journal-title":"J. Neurochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0301-0082(90)90034-E","article-title":"The regulation and modulation of pH in the nervous system.","volume":"34","author":"Chesler","year":"1990","journal-title":"Prog. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1056\/NEJM198606263142604","article-title":"Calcium and ischemic injury.","volume":"314","author":"Cheung","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1358\/dnp.2010.23.9.1513493","article-title":"Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke.","volume":"23","author":"Cho","year":"2010","journal-title":"Drug News Perspect."},{"key":"B60","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1523\/JNEUROSCI.07-02-00369.1987","article-title":"Ionic dependence of glutamate neurotoxicity.","volume":"7","author":"Choi","year":"1987","journal-title":"J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-90166","article-title":"Glutamate neurotoxicity and diseases of the nervous system.","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"key":"B62","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1523\/JNEUROSCI.08-01-00185.1988","article-title":"Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.","volume":"8","author":"Choi","year":"1988","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1523\/JNEUROSCI.07-02-00357.1987","article-title":"Glutamate neurotoxicity in cortical cell culture.","volume":"7","author":"Choi","year":"1987","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0304-3940(85)90069-90062","article-title":"Glutamate neurotoxicity in cortical cell culture is calcium dependent.","volume":"58","author":"Choi","year":"1985","journal-title":"Neurosci. Lett."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/neu.480230915","article-title":"Excitotoxic cell death.","volume":"23","author":"Choi","year":"1992","journal-title":"J. Neurobiol."},{"key":"B66","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0166-2236(95)80018-W","article-title":"Calcium: still center-stage in hypoxic-ischemic neuronal death.","volume":"18","author":"Choi","year":"1995","journal-title":"Trends Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/s0959-4388(96)80101-80102","article-title":"Ischemia-induced neuronal apoptosis.","volume":"6","author":"Choi","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.neuron.2014.10.027","article-title":"Medicines for the mind: policy-based \u201cpull\u201d incentives for creating breakthrough CNS drugs.","volume":"84","author":"Choi","year":"2014","journal-title":"Neuron"},{"key":"B69","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1146\/annurev.neuro.21.1.347","article-title":"Zinc and brain injury.","volume":"21","author":"Choi","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1523\/JNEUROSCI.17-01-00107.1997","article-title":"A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors.","volume":"17","author":"Clark","year":"1997","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083347","article-title":"Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons.","volume":"8","author":"Clausen","year":"2013","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jacbts.2018.11.006","article-title":"Perioperatively inhaled hydrogen gas diminishes neurologic injury following experimental circulatory arrest in swine.","volume":"4","author":"Cole","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuropharm.2008.06.063","article-title":"A nomenclature for ligand-gated ion channels.","volume":"56","author":"Collingridge","year":"2009","journal-title":"Neuropharmacology"},{"key":"B74","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1523\/JNEUROSCI.1889-07.2007","article-title":"The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration\/neuroprotection.","volume":"27","author":"Corti","year":"2007","journal-title":"J. Neurosci."},{"key":"B75","first-page":"1","article-title":"An overview of glutamate as a neurotransmitter.","volume":"27","author":"Cotman","year":"1981","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/263244a0","article-title":"Lesion of striatal neurones with kainic acid provides a model for Huntington\u2019s chorea.","volume":"263","author":"Coyle","year":"1976","journal-title":"Nature"},{"key":"B77","first-page":"25","article-title":"Edaravone (Radicava).","volume":"43","author":"Cruz","year":"2018","journal-title":"Pharm. Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0006-8993(98)00463-466","article-title":"Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya.","volume":"799","author":"Cuajungco","year":"1998","journal-title":"Brain Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1113\/jphysiol.1960.sp006410","article-title":"The chemical excitation of spinal neurones by certain acidic amino acids.","volume":"150","author":"Curtis","year":"1960","journal-title":"J. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1021\/acs.jmedchem.8b01610","article-title":"A survey of the structures of US FDA approved combination drugs.","volume":"62","author":"Das","year":"2019","journal-title":"J. Med. Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"6368","DOI":"10.1073\/pnas.88.14.6368","article-title":"Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.","volume":"88","author":"Dawson","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B82","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0022-2828(91)91642-5","article-title":"Protons in ischemia: where do they come from; Where do they go to?","volume":"23","author":"Dennis","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1111\/j.1471-4159.1993.tb13427.x","article-title":"Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture.","volume":"60","author":"Dessi","year":"1993","journal-title":"J. Neurochem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2217\/fnl.11.55","article-title":"A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke.","volume":"6","author":"Dhawan","year":"2011","journal-title":"Future Neurol."},{"key":"B85","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2014.08.029","article-title":"The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.","volume":"77","author":"Dohare","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/glia.22441","article-title":"Zn 2+ -induced ERK activation mediates PARP-1-dependent ischemic-reoxygenation damage to oligodendrocytes.","volume":"61","author":"Domercq","year":"2013","journal-title":"Glia"},{"key":"B87","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/glia.20958","article-title":"P2X7 receptors mediate ischemic damage to oligodendrocytes.","volume":"58","author":"Domercq","year":"2010","journal-title":"Glia"},{"key":"B88","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pnpbp.2018.02.006","article-title":"Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension.","volume":"84","author":"Domin","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B89","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/00004647-199603000-199603003","article-title":"Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis?","volume":"16","author":"Du","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B90","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1523\/JNEUROSCI.15-10-06377.1995","article-title":"Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate.","volume":"15","author":"Dugan","year":"1995","journal-title":"J. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1159\/000069318","article-title":"Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction.","volume":"15","year":"2003","journal-title":"Cerebrovasc. Dis."},{"key":"B92","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0092-8674(86)90004-90008","article-title":"Genetic control of programmed cell death in the nematode C. elegans.","volume":"44","author":"Ellis","year":"1986","journal-title":"Cell"},{"key":"B93","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/00004647-199803000-199803002","article-title":"Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.","volume":"18","author":"Endres","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/0306-4522(79)90185-90184","article-title":"The uptake and release of putative amino acid neurotransmitters.","volume":"4","author":"Fagg","year":"1979","journal-title":"Neuroscience"},{"key":"B95","first-page":"1171","article-title":"NMDA-stimulated expression of BDNF mRNA in cultured cerebellar granule neurones.","volume":"4","author":"Favaron","year":"1993","journal-title":"Neuroreport"},{"key":"B96","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1101\/261420","article-title":"Non-canonical activation of CREB mediates neuroprotection in a C. elegans model of excitotoxic necrosis.","volume":"148","author":"Feldmann","year":"2018","journal-title":"Neuroscience"},{"key":"B97","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neulet.2018.11.031","article-title":"Glutamate receptors and white matter stroke.","volume":"694","author":"Fern","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1161\/STROKEAHA.108.541128","article-title":"Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations.","volume":"40","author":"Fisher","year":"2009","journal-title":"Stroke"},{"key":"B99","first-page":"21","article-title":"Key role of Ca in the production of noncoronarogenic myocardial necroses.","volume":"6","author":"Fleckenstein","year":"1975","journal-title":"Recent Adv. Stud. Cardiac Struct. Metab."},{"key":"B100","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s004010050977","article-title":"Inducible nitric oxide synthase expression in human cerebral infarcts.","volume":"97","author":"Forster","year":"1999","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"B101","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0074-7742(08)60279-60272","article-title":"Neurobiology of zinc and zinc-containing neurons","author":"Frederickson","year":"1989","journal-title":"International Review of Neurobiology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease.","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/1073858403255840","article-title":"Zinc and excitotoxic brain injury: a new model.","volume":"10","author":"Frederickson","year":"2004","journal-title":"Neuroscientist"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1177\/002215540205001210","article-title":"Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitro.","volume":"50","author":"Frederickson","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death.","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134315","article-title":"Intracellular labile zinc is a determinant of vulnerability of cultured astrocytes to oxidative stress.","volume":"707","author":"Furuta","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B107","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.brainres.2004.05.046","article-title":"Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons.","volume":"1017","author":"Gao","year":"2004","journal-title":"Brain Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic.","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B109","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/336385a0","article-title":"Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain.","volume":"336","author":"Garthwaite","year":"1988","journal-title":"Nature"},{"key":"B110","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.molmed.2020.03.001","article-title":"NMDARs in cell survival and death: implications in stroke pathogenesis and treatment.","volume":"26","author":"Ge","year":"2020","journal-title":"Trends Mol. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0006-8993(90)90670-90677","article-title":"Selective vulnerability of cultured cortical glia to injury by extracellular acidosis.","volume":"530","author":"Giffard","year":"","journal-title":"Brain Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0006-8993(90)91276-M","article-title":"Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures.","volume":"506","author":"Giffard","year":"","journal-title":"Brain Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1523\/JNEUROSCI.07-10-03343.1987","article-title":"Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil.","volume":"7","author":"Gill","year":"1987","journal-title":"J. Neurosci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.neuropharm.2007.12.007","article-title":"Neuroprotection for ischemic stroke: past, present and future.","volume":"55","author":"Ginsberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.coph.2005.11.001","article-title":"Glutamate-based therapeutic approaches: NR2B receptor antagonists.","volume":"6","author":"Gogas","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"B116","first-page":"784","article-title":"N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.","volume":"243","author":"Goldberg","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B117","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/jcbfm.1989.70","article-title":"The effects of extracellular acidosis on neurons and glia in vitro.","volume":"9","author":"Goldman","year":"1989","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"B118","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1074\/jbc.M400005200","article-title":"Inhibitory mechanism of store-operated Ca 2+ channels by zinc.","volume":"279","author":"Gore","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B119","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0006-8993(90)90144-Z","article-title":"Effects of cycloheximide on delayed neuronal death in rat hippocampus.","volume":"534","author":"Goto","year":"1990","journal-title":"Brain Res."},{"key":"B120","first-page":"1211","article-title":"Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.","volume":"247","author":"Gotti","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B121","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.nbd.2015.04.010","article-title":"Intracellular zinc is a critical intermediate in the excitotoxic cascade.","volume":"81","author":"Granzotto","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B122","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0304-3940(82)90421-90429","article-title":"Intracelular sites of early calcium accumulation in the rat hippocampus during status epilepticus.","volume":"30","author":"Griffiths","year":"1982","journal-title":"Neurosci. Lett."},{"key":"B123","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/NEN.0b013e3182358e4e","article-title":"Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.","volume":"70","author":"Guemez-Gamboa","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0306-4522(98)00508-509","article-title":"Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons.","volume":"90","author":"Gwag","year":"1999","journal-title":"Neuroscience"},{"key":"B125","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0306-4522(96)00473-473","article-title":"Slowly triggered excitotoxicity occurs by necrosis in cortical cultures.","volume":"77","author":"Gwag","year":"1997","journal-title":"Neuroscience"},{"key":"B126","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0306-4522(95)00232-238","article-title":"Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro.","volume":"68","author":"Gwag","year":"1995","journal-title":"Neuroscience"},{"key":"B127","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1177\/107385849700300114","article-title":"Lazaroids: mechanisms of action and implications for disorders of the CNS.","volume":"3","author":"Hall","year":"1997","journal-title":"Neuroscientist"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1111\/j.1471-4159.1992.tb10990.x","article-title":"Reactive oxygen species and the central nervous system.","volume":"59","author":"Halliwell","year":"1992","journal-title":"J. Neurochem."},{"key":"B129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease.","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem. J."},{"key":"B130","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1152\/physrev.1985.65.1.101","article-title":"Effect of anoxia on ion distribution in the brain.","volume":"65","author":"Hansen","year":"1985","journal-title":"Physiol. Rev."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19925.1","article-title":"NMDA receptor C-terminal signaling in development, plasticity, and disease.","volume":"8","author":"Hardingham","year":"2019","journal-title":"F1000Research"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1042\/BST0371147","article-title":"Coupling of the NMDA receptor to neuroprotective and neurodestructive events.","volume":"37","author":"Hardingham","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"B133","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1152\/jn.01169.2007","article-title":"Recruiting extrasynaptic NMDA receptors augments synaptic signaling.","volume":"99","author":"Harris","year":"2008","journal-title":"J. Neurophysiol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/jcbfm.1981.21","article-title":"Changes in extracellular calcium activity in cerebral ischaemia.","volume":"1","author":"Harris","year":"1981","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1523\/JNEUROSCI.13-05-01993.1993","article-title":"Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.","volume":"13","author":"Hartley","year":"1993","journal-title":"J. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1523\/JNEUROSCI.13-11-04690.1993","article-title":"Changes in intracellular pH associated with glutamate excitotoxicity.","volume":"13","author":"Hartley","year":"1993","journal-title":"J. Neurosci."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006726","article-title":"mGluR1\/TRPC3-mediated synaptic transmission and calcium signaling in mammalian central neurons.","volume":"3","author":"Hartmann","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B139","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1074\/jbc.M409803200","article-title":"Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca 2+\/calmodulin-dependent protein kinase II.","volume":"280","author":"Haskew-Layton","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2302\/kjm.3.183","article-title":"Effects of sodium glutamate on the nervous system.","volume":"3","author":"Hayashi","year":"1954","journal-title":"Keio J. Med."},{"key":"B141","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1016\/S0021-9258(19)38985-9","article-title":"A specific requirement for protein kinase C in activation of the respiratory burst oxidase of fertilization.","volume":"265","author":"Heinecke","year":"1990","journal-title":"J. Biol. Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF00237788","article-title":"Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of aminoacids.","volume":"40","author":"Heinemann","year":"1980","journal-title":"Exp. Brain Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ceca.2017.01.007","article-title":"Crosstalk between calcium and reactive oxygen species signaling in cancer.","volume":"63","author":"Hempel","year":"2017","journal-title":"Cell Calcium"},{"key":"B144","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0959-437X(94)90076-F","article-title":"Programmed cell death in Caenorhabditis elegans.","volume":"4","author":"Hengartner","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B145","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(94)90362-X","article-title":"Selective potentiation of NMDA-induced neuronal injury following induction of astrocytk iNOS.","volume":"13","author":"Hewett","year":"1994","journal-title":"Neuron"},{"key":"B146","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0006-8993(98)01329-1328","article-title":"Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia.","volume":"819","author":"Hicks","year":"1999","journal-title":"Brain Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-30250","article-title":"Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet"},{"key":"B148","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S1474-4422(12)70225-70229","article-title":"Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.","volume":"11","author":"Hill","year":"2012","journal-title":"Lancet Neurol."},{"key":"B149","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors.","volume":"17","author":"Hollmann","year":"1994","journal-title":"Ann. Rev. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-2746-2749","article-title":"Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial.","volume":"19","author":"Hong","year":"2018","journal-title":"Trials"},{"key":"B151","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1073\/pnas.88.7.2811","article-title":"Neuronal NADPH diaphorase is a nitric oxide synthase.","volume":"88","author":"Hope","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B152","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2174\/1566524043479248","article-title":"The rise and fall of NMDA antagonists for ischemic stroke.","volume":"4","author":"Hoyte","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1126\/science.7522345","article-title":"Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.","volume":"265","author":"Huang","year":"1994","journal-title":"Science"},{"key":"B154","doi-asserted-by":"publisher","first-page":"30567","DOI":"10.1074\/jbc.272.48.30567","article-title":"Intracellular K+ suppresses the activation of apoptosis in lymphocytes.","volume":"272","author":"Hughes","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ceca.2017.07.006","article-title":"Calcium signaling and cell cycle: progression or death.","volume":"70","author":"Humeau","year":"2018","journal-title":"Cell Calcium"},{"key":"B156","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1523\/JNEUROSCI.17-17-06669.1997","article-title":"Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.","volume":"17","author":"Hyrc","year":"1997","journal-title":"J. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"R286","DOI":"10.1152\/ajpregu.1995.268.1.R286","article-title":"Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage.","volume":"268","author":"Iadecola","year":"1995","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"7092","DOI":"10.1523\/JNEUROSCI.6062-08.2009","article-title":"Pannexin 1: the molecular substrate of astrocyte \u201chemichannels.\u201d.","volume":"29","author":"Iglesias","year":"2009","journal-title":"J. Neurosci."},{"key":"B159","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/00001756-199111000-199111004","article-title":"Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.","volume":"2","author":"Ignatowicz","year":"1991","journal-title":"Neuroreport"},{"key":"B160","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain.","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"key":"B161","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-163","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"B162","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2006.8.1583","article-title":"NADPH oxidases of the brain: distribution, regulation, and function.","volume":"8","author":"Infanger","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.2174\/0929867322666150209153750","article-title":"Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological\/pathophysiological significance.","volume":"22","author":"Inoue","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1523\/JNEUROSCI.14-03-01352.1994","article-title":"N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons.","volume":"14","author":"Irwin","year":"1994","journal-title":"J. Neurosci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s10571-010-9516-x","article-title":"Acidosis-induced zinc-dependent death of cultured cerebellar granule neurons.","volume":"30","author":"Isaev","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuropharm.2008.08.023","article-title":"Kainate receptors: pharmacology, function and therapeutic potential.","volume":"56","author":"Jane","year":"2009","journal-title":"Neuropharmacology"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1516-1512","article-title":"Neuroinflammation: friend and foe for ischemic stroke.","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B168","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1038\/jcbfm.2011.77","article-title":"Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.","volume":"31","author":"Jia","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B169","doi-asserted-by":"crossref","first-page":"28183","DOI":"10.1074\/jbc.272.45.28183","article-title":"Calmodulin activates phosphatidylinositol 3-kinase.","volume":"272","author":"Joyal","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/09593330802468848","article-title":"Effect of pH on Fenton and Fenton-like oxidation.","volume":"30","author":"Jung","year":"2009","journal-title":"Environ. Technol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"15749","DOI":"10.1073\/pnas.1512296112","article-title":"AMPA receptor inhibition by synaptically released zinc.","volume":"112","author":"Kalappa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B172","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1254\/jphs.FP0060128","article-title":"A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.","volume":"101","author":"Kaneko","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124232","article-title":"An inhibitor of the sodium-hydrogen exchanger-1 (NHE-1), amiloride, reduced zinc accumulation and hippocampal neuronal death after ischemia.","volume":"21","author":"Kang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.neuroscience.2006.08.070","article-title":"Neurotransmitter receptors in the life and death of oligodendrocytes.","volume":"145","author":"K\u00e1rad\u00f3ttir","year":"2007","journal-title":"Neuroscience"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/nature04302","article-title":"NMDA receptors are expressed in oligodendrocytes and activated in ischaemia.","volume":"438","author":"K\u00e1rad\u00f3ttir","year":"2005","journal-title":"Nature"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.cell.2013.02.002","article-title":"Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus.","volume":"152","author":"Karpova","year":"2013","journal-title":"Cell"},{"key":"B177","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1055\/s-0038-1649503","article-title":"Global burden of stroke.","volume":"38","author":"Katan","year":"2018","journal-title":"Semin. Neurol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/jcbfm.1991.109","article-title":"Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis.","volume":"11","author":"Katsura","year":"1991","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B179","doi-asserted-by":"publisher","first-page":"L646","DOI":"10.1152\/ajplung.00164.2012","article-title":"Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.","volume":"304","author":"Kawamura","year":"2013","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1469-7793.2000.00039.x","article-title":"Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones.","volume":"528","author":"Kerchner","year":"2000","journal-title":"J. Physiol."},{"key":"B181","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature02162","article-title":"Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.","volume":"426","author":"Kim","year":"2003","journal-title":"Nature"},{"key":"B182","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1006\/exnr.2002.7990","article-title":"The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture.","volume":"177","author":"Kim","year":"2002","journal-title":"Exp. Neurol."},{"key":"B183","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/glia.20174","article-title":"Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy.","volume":"50","author":"Kimelberg","year":"2005","journal-title":"Glia"},{"key":"B184","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0006-8993(82)90833-90832","article-title":"Delayed neuronal death in the gerbil hippocampus following ischemia.","volume":"239","author":"Kirino","year":"1982","journal-title":"Brain Res."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1818-1814","article-title":"Site-specific phosphorylation of Fbxw7 by Cdk5\/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity.","volume":"10","author":"Ko","year":"2019","journal-title":"Cell Death Dis."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1523\/JNEUROSCI.14-05-02585.1994","article-title":"Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient.","volume":"14","author":"Koch","year":"1994","journal-title":"J. Neurosci."},{"key":"B187","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1001\/archneur.1988.00520260034016","article-title":"Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia.","volume":"45","author":"Kochhar","year":"1988","journal-title":"Arch. Neurol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1523\/JNEUROSCI.10-02-00693.1990","article-title":"Non-NMDA receptor-mediated neurotoxicity in cortical culture.","volume":"10","author":"Koh","year":"1990","journal-title":"J. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/science.7725105","article-title":"Potentiated necrosis of cultured cortical neurons by neurotrophins.","volume":"268","author":"Koh","year":"1995","journal-title":"Science"},{"key":"B190","first-page":"1013","article-title":"The role of zinc in selective neuronal death after transient global cerebral ischemia.","volume":"272","author":"Koh","year":"1996","journal-title":"Sci. New Ser."},{"key":"B191","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1161\/STROKEAHA.113.000780","article-title":"Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis.","volume":"44","author":"Kohler","year":"2013","journal-title":"Stroke"},{"key":"B192","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.1073\/pnas.86.16.6421","article-title":"Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.","volume":"86","author":"Koike","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B193","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1073\/pnas.88.9.3892","article-title":"Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.","volume":"88","author":"Koike","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B194","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/sj.jcbfm.9600040","article-title":"Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice.","volume":"25","author":"Koistinaho","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B195","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/jcbfm.1987.80","article-title":"Hydrogen ions kill brain at concentrations reached in ischemia.","volume":"7","author":"Kraig","year":"1987","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"B196","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(85)91127-8","article-title":"Hydrogen ion buffering during complete brain ischemia.","volume":"342","author":"Kraig","year":"1985","journal-title":"Brain Res."},{"key":"B197","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/284064a0","article-title":"New class of glutamate agonist structurally related to ibotenic acid.","volume":"284","author":"Krogsgaard-Larsen","year":"1980","journal-title":"Nature"},{"key":"B198","doi-asserted-by":"publisher","first-page":"15184","DOI":"10.1073\/pnas.2336254100","article-title":"A critical role of neural-specific JNK3 for ischemic apoptosis.","volume":"100","author":"Kuan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B199","author":"Kuhn","year":"1962","journal-title":"The Structure of Scientific Revolutions"},{"key":"B200","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0006-291X(91)91330-F","article-title":"Glutamate triggers internucleosomal DNA cleavage in neuronal cells.","volume":"179","author":"Kure","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B201","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/00004647-199907000-199907008","article-title":"Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.","volume":"19","author":"Kuroda","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B202","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/364535a0","article-title":"NMDA-dependent superoxide production and neurotoxicity.","volume":"364","author":"Lafon-Cazal","year":"1993","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","first-page":"14423","DOI":"10.1096\/fj.201900417R","article-title":"The receptor-receptor interaction between mGluR1 receptor and NMDA receptor: a potential therapeutic target for protection against ischemic stroke.","volume":"33","author":"Lai","year":"2019","journal-title":"FASEB J."},{"key":"B204","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.molmed.2010.12.008","article-title":"Stroke intervention pathways: NMDA receptors and beyond.","volume":"17","author":"Lai","year":"2011","journal-title":"Trends Mol. Med."},{"key":"B205","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection.","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B206","doi-asserted-by":"crossref","first-page":"E4362","DOI":"10.1073\/pnas.1313029110","article-title":"Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase.","volume":"110","author":"Lam","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1212\/01.wnl.0000277487.04281.db","article-title":"Minocycline treatment in acute stroke: an open-label, evaluator-blinded study.","volume":"69","author":"Lampl","year":"2007","journal-title":"Neurology"},{"key":"B208","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1517\/14656566.2010.493558","article-title":"A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?","volume":"11","author":"Lapchak","year":"2010","journal-title":"Expert Opin. Pharmacother."},{"key":"B209","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1113\/jphysiol.2006.121848","article-title":"Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats: extracellular zinc chelation and seizures.","volume":"578","author":"Lavoie","year":"2007","journal-title":"J. Physiol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/jnr.22818","article-title":"The Na+\/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload.","volume":"90","author":"Lee","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"B211","doi-asserted-by":"publisher","first-page":"A7","DOI":"10.1038\/399a007","article-title":"The changing landscape of ischaemic brain injury mechanisms.","volume":"399","author":"Lee","year":"1999","journal-title":"Nature"},{"key":"B212","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0306-4522(02)00513-514","article-title":"Zinc translocation accelerates infarction after mild transient focal ischemia.","volume":"115","author":"Lee","year":"2002","journal-title":"Neuroscience"},{"key":"B213","doi-asserted-by":"publisher","first-page":"RC171","DOI":"10.1523\/JNEUROSCI.21-20-j0002.2001","article-title":"Protection by pyruvate against transient forebrain ischemia in rats.","volume":"21","author":"Lee","year":"2001","journal-title":"J. Neurosci."},{"key":"B214","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/STROKEAHA.111.000013","article-title":"Results of membrane-activated chelator stroke intervention randomized trial of DP-b99 in acute ischemic stroke.","volume":"44","author":"Lees","year":"2013","journal-title":"Stroke"},{"key":"B215","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.pneurobio.2013.12.008","article-title":"Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?","volume":"115","author":"Leng","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1365-2184.1991.tb01150.x","article-title":"Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.","volume":"24","author":"Lennon","year":"1991","journal-title":"Cell Prolif."},{"key":"B217","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1083\/jcb.82.3.811","article-title":"Agonist-induced myopathy at the neuromuscular junction is mediated by calcium.","volume":"82","author":"Leonard","year":"1979","journal-title":"J. Cell Biol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1517\/14728222.2015.1021781","article-title":"Non-NMDAR neuronal Ca 2+ -permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage.","volume":"19","author":"Li","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1042\/AN20130002","article-title":"Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia.","volume":"5","author":"Li","year":"2013","journal-title":"ASN NEURO"},{"key":"B220","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1073\/pnas.89.2.648","article-title":"Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.","volume":"89","author":"Lindvall","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B221","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1161\/01.str.24.12.2002","article-title":"Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.","volume":"24","author":"Linnik","year":"1993","journal-title":"Stroke"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004556","article-title":"Protein kinase C: the \u201cmasters\u201d of calcium and lipid.","volume":"3","author":"Lipp","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B223","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1602\/neurorx.1.1.101","article-title":"Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.","volume":"1","author":"Lipton","year":"2004","journal-title":"NeuroRx"},{"key":"B224","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.cr.7290262","article-title":"Role of JNK activation in apoptosis: a double-edged sword.","volume":"15","author":"Liu","year":"2005","journal-title":"Cell Res."},{"key":"B225","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.tins.2007.01.006","article-title":"Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death.","volume":"30","author":"Liu","year":"2007","journal-title":"Trends Neurosci."},{"key":"B226","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"key":"B227","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0006-8993(74)91049-X","article-title":"Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia.","volume":"73","author":"Ljunggren","year":"1974","journal-title":"Brain Res."},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0604-607","article-title":"Administration of Uric Acid in the Emergency Treatment of Acute Ischemic Stroke.","volume":"16","author":"Llull","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B229","first-page":"797","article-title":"Zinc-induced neuronal death in cortical neurons.","volume":"46","author":"Lobner","year":"2000","journal-title":"Cell. Mol. Biol. Noisy\u2013Gd. Fr."},{"key":"B230","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/bies.200900005","article-title":"Switching Akt: from survival signaling to deadly response.","volume":"31","author":"Los","year":"2009","journal-title":"BioEssays News Rev. Mol. Cell. Dev. Biol."},{"key":"B231","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1001\/archopht.1957.00940010205006","article-title":"The toxic effect of sodium L-glutamate on the inner layers of the retina.","volume":"58","author":"Lucas","year":"1957","journal-title":"Arch. Ophthalmol."},{"key":"B232","doi-asserted-by":"crossref","first-page":"11256","DOI":"10.1523\/JNEUROSCI.3271-05.2005","article-title":"Decreased neuronal death in Na+\/H+ exchanger isoform 1-null mice after in vitro and in vivo ischemia.","volume":"25","author":"Luo","year":"2005","journal-title":"J. Neurosci."},{"key":"B233","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0150-7","article-title":"NADPH oxidase in brain injury and neurodegenerative disorders.","volume":"12","author":"Ma","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B234","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/321519a0","article-title":"NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.","volume":"321","author":"MacDermott","year":"1986","journal-title":"Nature"},{"key":"B235","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00001756-199401120-00031","article-title":"DNA damage consistent with apoptosis in transient focal ischaemic neocortex.","volume":"5","author":"MacManus","year":"1994","journal-title":"Neuroreport"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09873-9876","article-title":"Expansion of the dimensions in the current management of acute ischemic stroke.","author":"Malik","year":"2020","journal-title":"J. Neurol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/exnr.1997.6510","article-title":"Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells.","volume":"146","author":"Manev","year":"1997","journal-title":"Exp. Neurol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"11055","DOI":"10.1073\/pnas.191353598","article-title":"Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.","volume":"98","author":"Manzerra","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B239","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1073\/pnas.91.1.237","article-title":"Oxidative metal release from metallothionein via zinc-thiol\/disulfide interchange.","volume":"91","author":"Maret","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112285","article-title":"Zinc in cellular regulation: the nature and significance of \u201czinc signals.\u201d.","volume":"18","author":"Maret","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B241","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1161\/01.STR.29.1.152","article-title":"Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.","volume":"29","author":"Markgraf","year":"1998","journal-title":"Stroke"},{"key":"B242","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1523\/JNEUROSCI.07-12-04034.1987","article-title":"Calcium regulation of neurite elongation and growth cone motility.","volume":"7","author":"Mattson","year":"1987","journal-title":"J. Neurosci."},{"key":"B243","doi-asserted-by":"crossref","first-page":"8830","DOI":"10.1073\/pnas.94.16.8830","article-title":"Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes.","volume":"94","author":"Matute","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B244","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.","volume":"309","author":"Mayer","year":"1984","journal-title":"Nature"},{"key":"B245","doi-asserted-by":"publisher","first-page":"13988","DOI":"10.1073\/pnas.1306238110","article-title":"Convergent Ca 2+ and Zn 2+ signaling regulates apoptotic Kv2.1 K + currents.","volume":"110","author":"McCord","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B246","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nm0398-291","article-title":"Oligodendrocytes from forebrain are highly vulnerable to AMPA\/kainate receptor-mediated excitotoxicity.","volume":"4","author":"McDonald","year":"1998","journal-title":"Nat. Med."},{"key":"B247","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/263517a0","article-title":"Duplication of biochemical changes of Huntington\u2019s chorea by intrastriatal injections of glutamic and kainic acids.","volume":"263","author":"Mcgeer","year":"1976","journal-title":"Nature"},{"key":"B248","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0301-0082(83)90004-90007","article-title":"Receptors for the excitatory amino acids in the mammalian central nervous system.","volume":"20","author":"McLennan","year":"1983","journal-title":"Prog. Neurobiol."},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17161","article-title":"Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.","volume":"6","author":"McQueen","year":"2017","journal-title":"eLife"},{"key":"B250","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1523\/JNEUROSCI.4604-08.2009","article-title":"Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.","volume":"29","author":"Medvedeva","year":"2009","journal-title":"J. Neurosci."},{"key":"B251","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1042\/cs0680113","article-title":"Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.","volume":"68","author":"Meldrum","year":"1985","journal-title":"Clin. Sci."},{"key":"B252","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.pharmthera.2015.06.002","article-title":"Neuroprotective peptides fused to arginine-rich cell penetrating peptides: neuroprotective mechanism likely mediated by peptide endocytic properties.","volume":"153","author":"Meloni","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"B253","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35725-5","article-title":"Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling.","volume":"8","author":"Minnella","year":"2018","journal-title":"Sci. Rep."},{"key":"B254","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1085\/jgp.20028740","article-title":"TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions.","volume":"121","author":"Monteilh-Zoller","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0006-8993(89)90179-90170","article-title":"Glucose deprivation neuronal injury in cortical culture.","volume":"483","author":"Monyer","year":"1989","journal-title":"Brain Res."},{"key":"B256","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0896-6273(90)90302-v","article-title":"21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.","volume":"5","author":"Monyer","year":"1990","journal-title":"Neuron"},{"key":"B257","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1073\/pnas.91.9.3954","article-title":"The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.","volume":"91","author":"Moon","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0158-152","article-title":"Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.","volume":"8","author":"Motolese","year":"2015","journal-title":"Mol. Brain"},{"key":"B259","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0140-6736(04)15490-15491","article-title":"Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial.","volume":"363","author":"Muir","year":"2004","journal-title":"Lancet"},{"key":"B260","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-90043","article-title":"Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.","volume":"2","author":"Murphy","year":"1989","journal-title":"Neuron"},{"key":"B261","doi-asserted-by":"publisher","first-page":"773","DOI":"10.4103\/1673-5374.268898","article-title":"Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review.","volume":"15","author":"Naderi","year":"2019","journal-title":"Neural Regen. Res."},{"key":"B262","doi-asserted-by":"publisher","first-page":"13858","DOI":"10.3390\/ijms140713858","article-title":"Death associated protein kinases: molecular structure and brain injury.","volume":"14","author":"Nair","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B263","year":"2008","journal-title":"Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants."},{"key":"B264","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1523\/JNEUROSCI.11-08-02489.1991","article-title":"Acid-induced death in neurons and glia.","volume":"11","author":"Nedergaard","year":"1991","journal-title":"J. Neurosci."},{"key":"B265","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1523\/JNEUROSCI.5449-03.2004","article-title":"Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.","volume":"24","author":"Ning","year":"2004","journal-title":"J. Neurosci."},{"key":"B266","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0301-0082(79)90016-90019","article-title":"Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates???.","volume":"13","author":"Nistri","year":"1979","journal-title":"Prog. Neurobiol."},{"key":"B267","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s10571-017-0489-x","article-title":"The orally active noncompetitive AMPAR antagonist perampanel attenuates focal cerebral ischemia injury in rats.","volume":"38","author":"Niu","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"B268","doi-asserted-by":"crossref","first-page":"RC111","DOI":"10.1523\/JNEUROSCI.20-23-j0001.2000","article-title":"Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes.","volume":"20","author":"Noh","year":"2000","journal-title":"J. Neurosci."},{"key":"B269","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/307462a0","article-title":"Magnesium gates glutamate-activated channels in mouse central neurones.","volume":"307","author":"Nowak","year":"1984","journal-title":"Nature"},{"key":"B270","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"B271","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2014.04.006","article-title":"Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.","volume":"144","author":"Ohta","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"B272","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1523\/JNEUROSCI.13-04-01441.1993","article-title":"Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention.","volume":"13","author":"Oka","year":"1993","journal-title":"J. Neurosci."},{"key":"B273","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1126\/science.164.3880.719","article-title":"Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.","volume":"164","author":"Olney","year":"1969","journal-title":"Science"},{"key":"B274","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00006982-198200000-00020","article-title":"The toxic effects of glutamate and related compounds in the retina and the brain.","volume":"2","author":"Olney","year":"1982","journal-title":"Retina"},{"key":"B275","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0006-8993(74)90640-90644","article-title":"Kainic acid: a powerful neurotoxic analogue of glutamate.","volume":"77","author":"Olney","year":"1974","journal-title":"Brain Res."},{"key":"B276","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/S0028-3908(99)00250-256","article-title":"LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia.","volume":"39","author":"O\u2019Neill","year":"2000","journal-title":"Neuropharmacology"},{"key":"B277","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0165-6147(89)90029-90021","article-title":"Role of Ca2+ in toxic cell killing.","volume":"10","author":"Orrenius","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"B278","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/jcbfm.1988.18","article-title":"Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat.","volume":"8","author":"Ozyurt","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B279","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4103\/0028-3886.93584","article-title":"Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled trial.","volume":"60","author":"Padma Srivastava","year":"2012","journal-title":"Neurol. India"},{"key":"B280","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/cns.12098","article-title":"Zinc promotes the death of hypoxic astrocytes by upregulating hypoxia-induced hypoxia-inducible factor-1alpha expression via poly(ADP-ribose) polymerase-1.","volume":"19","author":"Pan","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"B281","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1177\/1073858407305833","article-title":"The dichotomy of NMDA receptor signaling.","volume":"13","author":"Papadia","year":"2007","journal-title":"Neuroscientist"},{"key":"B282","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1093\/ajcn\/22.9.1222","article-title":"Zinc metalloenzymes: characteristics and significance in biology and medicine.","volume":"22","author":"Parisi","year":"1969","journal-title":"Am. J. Clin. Nutr."},{"key":"B283","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/jcbfm.1988.124","article-title":"Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.","volume":"8","author":"Park","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B284","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","article-title":"Extrasynaptic NMDA receptor involvement in central nervous system disorders.","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"B285","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0028-3908(99)00097-90","article-title":"Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms.","volume":"38","author":"Pellegrini-Giampietro","year":"1999","journal-title":"Neuropharmacology"},{"key":"B286","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.1073\/pnas.89.21.10499","article-title":"Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.","volume":"89","author":"Pellegrini-Giampietro","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B287","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1126\/science.2883728","article-title":"Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.","volume":"236","author":"Peters","year":"1987","journal-title":"Science"},{"key":"B288","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0028-3908(94)00129-G","article-title":"The metabotropic glutamate receptors: structure and functions.","volume":"34","author":"Pin","year":"1995","journal-title":"Neuropharmacology"},{"key":"B289","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1016\/j.cellsig.2015.08.006","article-title":"Calcium signaling and cell proliferation.","volume":"27","author":"Pinto","year":"2015","journal-title":"Cell. Signal."},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3034","article-title":"Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.","volume":"4","author":"Qiu","year":"2013","journal-title":"Nat. Commun."},{"key":"B291","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1089\/ars.2012.4797","article-title":"Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.","volume":"18","author":"Radermacher","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B292","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/S0021-9258(18)49907-3","article-title":"Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+\/ H+ exchanger.","volume":"266","author":"Raley-Susman","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B293","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.chembiol.2020.03.007","article-title":"The chemical biology of ferroptosis in the central nervous system.","volume":"27","author":"Ratan","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"B294","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0197-0186(95)00115-118","article-title":"Serum deprivation inhibits glutathione depletion-induced death in embryonic cortical neurons: evidence against oxidative stress as a final common mediator of neuronal apoptosis.","volume":"29","author":"Ratan","year":"1996","journal-title":"Neurochem. Int."},{"key":"B295","doi-asserted-by":"publisher","first-page":"14426","DOI":"10.1073\/pnas.1312982110","article-title":"AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.","volume":"110","author":"Rathje","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B296","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1523\/JNEUROSCI.15-05-03318.1995","article-title":"Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation.","volume":"15","author":"Reynolds","year":"1995","journal-title":"J. Neurosci."},{"key":"B297","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn1134","article-title":"PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.","volume":"6","author":"Rong","year":"2003","journal-title":"Nat. Neurosci."},{"key":"B298","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1523\/JNEUROSCI.12-01-00056.1992","article-title":"Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture.","volume":"12","author":"Rosenberg","year":"1992","journal-title":"J. Neurosci."},{"key":"B299","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake.","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"B300","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1126\/science.6836300","article-title":"Synaptic activity mediates death of hypoxic neurons.","volume":"220","author":"Rothman","year":"1983","journal-title":"Science"},{"key":"B301","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1523\/JNEUROSCI.04-07-01884.1984","article-title":"Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death.","volume":"4","author":"Rothman","year":"1984","journal-title":"J. Neurosci."},{"key":"B302","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/nature04301","article-title":"NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.","volume":"438","author":"Salter","year":"2005","journal-title":"Nature"},{"key":"B303","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1126\/science.284.5421.1845","article-title":"Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.","volume":"284","author":"Sattler","year":"1999","journal-title":"Science"},{"key":"B304","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1523\/JNEUROSCI.20-01-00022.2000","article-title":"Distinct Roles of Synaptic and Extrasynaptic NMDA receptors in excitotoxicity.","volume":"20","author":"Sattler","year":"2000","journal-title":"J. Neurosci."},{"key":"B305","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/15257770802138558","article-title":"Uric acid: the oxidant-antioxidant paradox.","volume":"27","author":"Sautin","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"B306","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1056\/NEJMoa1408827","article-title":"Prehospital use of magnesium sulfate as neuroprotection in acute stroke.","volume":"372","author":"Saver","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B307","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1126\/science.386513","article-title":"Calcium dependence of toxic cell death: a final common pathway.","volume":"206","author":"Schanne","year":"1979","journal-title":"Science"},{"key":"B308","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/0165-6147(90)90052-A","article-title":"Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors.","volume":"11","author":"Schoepp","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"B309","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7742(08)60289-60285","article-title":"Transport and metabolism of glutamate and GABA in neurons and glial cells","author":"Schousboe","year":"1981","journal-title":"International Review of Neurobiology"},{"key":"B310","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2174\/1566524043479211","article-title":"Rethinking the excitotoxic ionic milieu: the emerging role of Zn2+ in ischemic neuronal injury.","volume":"4","author":"Sensi","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"B311","doi-asserted-by":"publisher","first-page":"9554","DOI":"10.1523\/JNEUROSCI.17-24-09554.1997","article-title":"Measurement of intracellular free zinc in living cortical neurons: routes of entry.","volume":"17","author":"Sensi","year":"1997","journal-title":"J. Neurosci."},{"key":"B312","doi-asserted-by":"publisher","first-page":"6157","DOI":"10.1073\/pnas.1031598100","article-title":"Modulation of mitochondrial function by endogenous Zn2+ pools.","volume":"100","author":"Sensi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092289","article-title":"STIM proteins and glutamate receptors in neurons: role in neuronal physiology and neurodegenerative diseases.","volume":"20","author":"Serwach","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B314","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1126\/science.2154034","article-title":"2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.","volume":"247","author":"Sheardown","year":"1990","journal-title":"Science"},{"key":"B315","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1523\/JNEUROSCI.20-09-03139.2000","article-title":"Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD+ and inhibition of glycolysis.","volume":"20","author":"Sheline","year":"2000","journal-title":"J. Neurosci."},{"key":"B316","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/nbdi.2002.0497","article-title":"Depolarization-induced 65zinc influx into cultured cortical neurons.","volume":"10","author":"Sheline","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"B317","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3940(90)90182-90189","article-title":"Reduction of delayed neuronal death by inhibition of protein synthesis.","volume":"120","author":"Shigeno","year":"1990","journal-title":"Neurosci. Lett."},{"key":"B318","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/jcbfm.1981.18","article-title":"Cell damage in the brain: a speculative synthesis.","volume":"1","author":"Siesj\u00f6","year":"1981","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B319","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/jcbfm.1984.52","article-title":"Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: an electron microscopy study in the rat.","volume":"4","author":"Simon","year":"1984","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B320","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.6093256","article-title":"Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.","volume":"226","author":"Simon","year":"1984","journal-title":"Science"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020309","article-title":"NMDA receptors in astrocytes: in search for roles in neurotransmission and astrocytic homeostasis.","volume":"20","author":"Skowro\u0144ska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B322","doi-asserted-by":"publisher","first-page":"C448","DOI":"10.1152\/ajpcell.00048.2017","article-title":"Cross talk between increased intracellular zinc (Zn 2+) and accumulation of reactive oxygen species in chemical ischemia.","volume":"313","author":"Slepchenko","year":"2017","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"B323","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0006-8993(85)90017-90014","article-title":"A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation.","volume":"330","author":"Sloviter","year":"1985","journal-title":"Brain Res."},{"key":"B324","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0301-0082(94)90082-90085","article-title":"Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc.","volume":"42","author":"Smart","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"B325","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1046\/j.0953-816x.2001.01867.x","article-title":"NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neurons: proteasome inhibitor-induced neuronal death.","volume":"15","author":"Snider","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B326","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1523\/JNEUROSCI.4289-06.2007","article-title":"Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain.","volume":"27","author":"Sokka","year":"2007","journal-title":"J. Neurosci."},{"key":"B327","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1089\/ars.2009.2578","article-title":"NOX enzymes in the central nervous system: from signaling to disease.","volume":"11","author":"Sorce","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"B328","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/ajcn\/59.2.423","article-title":"Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid concentrations and body composition in hyperlipidemic patients.","volume":"59","author":"Stanko","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"B329","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1523\/JNEUROSCI.1774-19.2020","article-title":"Neuronal glutamatergic synaptic clefts alkalinize rather than acidify during neurotransmission.","volume":"40","author":"Stawarski","year":"2020","journal-title":"J. Neurosci."},{"key":"B330","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0304-3940(88)90380-90381","article-title":"Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia.","volume":"89","author":"Steinberg","year":"1988","journal-title":"Neurosci. Lett."},{"key":"B331","doi-asserted-by":"publisher","first-page":"10430","DOI":"10.1523\/JNEUROSCI.1588-06.2006","article-title":"Intracellular zinc elevation measured with a \u201ccalcium-specific\u201d indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload.","volume":"26","author":"Stork","year":"2006","journal-title":"J. Neurosci."},{"key":"B332","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0306-4522(98)00441-442","article-title":"High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations.","volume":"89","author":"Stout","year":"1999","journal-title":"Neuroscience"},{"key":"B333","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1111\/j.1460-9568.1998.00291.x","article-title":"Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.","volume":"10","author":"Strasser","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"B334","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1161\/01.STR.30.12.2752","article-title":"Recommendations for standards regarding preclinical neuroprotective and restorative drug development.","volume":"30","year":"1999","journal-title":"Stroke"},{"key":"B335","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1523\/JNEUROSCI.12-02-00430.1992","article-title":"Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na+-Ca2+ exchanger.","volume":"12","author":"Stys","year":"1992","journal-title":"J. Neurosci."},{"key":"B336","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/325531a0","article-title":"A new type of glutamate receptor linked to inositol phospholipid metabolism.","volume":"325","author":"Sugiyama","year":"1987","journal-title":"Nature"},{"key":"B337","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s12272-016-0814-819","article-title":"A novel mechanism for the pyruvate protection against zinc-induced cytotoxicity: mediation by the chelating effect of citrate and isocitrate.","volume":"39","author":"Sul","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"B338","doi-asserted-by":"publisher","first-page":"H969","DOI":"10.1152\/ajpheart.00400.2008","article-title":"Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling.","volume":"295","author":"Sumagin","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B339","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1161\/STROKEAHA.107.506048","article-title":"Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.","volume":"39","author":"Sun","year":"2008","journal-title":"Stroke"},{"key":"B340","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1152\/jn.90286.2008","article-title":"Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns.","volume":"101","author":"Sun","year":"2009","journal-title":"J. Neurophysiol."},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00168","article-title":"Phased treatment strategies for cerebral ischemia based on glutamate receptors.","volume":"13","author":"Sun","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B342","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1747-4949.2012.00770.x","article-title":"Neuroprotection for ischaemic stroke: translation from the bench to the bedside.","volume":"7","author":"Sutherland","year":"2012","journal-title":"Int. J. Stroke"},{"key":"B343","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/(SICI)1098-1136(199709)21:1<142::AID-GLIA16<3.0.CO;2-S","article-title":"Astrocyte energetics, function, and death under conditions of incomplete ischemia: a mechanism of glial death in the penumbra.","volume":"21","author":"Swanson","year":"1997","journal-title":"Glia"},{"key":"B344","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.bbagen.2016.02.013","article-title":"How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?","volume":"1860","author":"Tajeddine","year":"2016","journal-title":"Biochim. Biophys. Acta BBA Gen. Subj."},{"key":"B345","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1046\/j.1471-4159.1999.0730548.x","article-title":"Apoptotic cell death and caspase-3 activation induced by N-methyl-D-aspartate receptor antagonists and their prevention by insulin-like growth factor I.","volume":"73","author":"Takadera","year":"1999","journal-title":"J. Neurochem."},{"key":"B346","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1073\/pnas.87.16.6445","article-title":"Modulation of the N-methyl-D-aspartate channel by extracellular H+.","volume":"87","author":"Tang","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B347","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/ana.22476","article-title":"Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.","volume":"70","author":"Tang","year":"2011","journal-title":"Ann. Neurol."},{"key":"B348","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/0896-6273(89)90042-90041","article-title":"Traumatic neuronal injury in vitro is attenuated by NMDA antagonists.","volume":"2","author":"Tecoma","year":"1989","journal-title":"Neuron"},{"key":"B349","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1523\/JNEUROSCI.21-12-04237.2001","article-title":"AMPA\/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter.","volume":"21","author":"Tekk\u00f6k","year":"2001","journal-title":"J. Neurosci."},{"key":"B350","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1152\/jn.00771.2005","article-title":"Synaptic and extrasynaptic nmda receptor nr2 subunits in cultured hippocampal neurons.","volume":"95","author":"Thomas","year":"2006","journal-title":"J. Neurophysiol."},{"key":"B351","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1126\/science.1126241","article-title":"Ischemia opens neuronal gap junction hemichannels.","volume":"312","author":"Thompson","year":"2006","journal-title":"Science"},{"key":"B352","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0006-8993(90)91277-N","article-title":"Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation.","volume":"506","author":"Tombaugh","year":"1990","journal-title":"Brain Res."},{"key":"B353","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0304-3940(90)90002-Q","article-title":"Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat.","volume":"109","author":"T\u00f8nder","year":"1990","journal-title":"Neurosci. Lett."},{"key":"B354","doi-asserted-by":"publisher","first-page":"9150","DOI":"10.1523\/JNEUROSCI.0829-13.2013","article-title":"Triheteromeric NMDA receptors at hippocampal synapses.","volume":"33","author":"Tovar","year":"2013","journal-title":"J. Neurosci."},{"key":"B355","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function.","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"B356","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1152\/jappl.1991.71.4.1185","article-title":"Oxygen radical mechanisms of brain injury following ischemia and reperfusion.","volume":"71","author":"Traystman","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"B357","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.cell.2009.12.055","article-title":"DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.","volume":"140","author":"Tu","year":"2010","journal-title":"Cell"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0929-927","article-title":"Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke.","volume":"9","author":"Tuo","year":"2018","journal-title":"Cell Death Dis."},{"key":"B359","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1523\/JNEUROSCI.13-05-02085.1993","article-title":"Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons.","volume":"13","author":"Tymianski","year":"1993","journal-title":"J. Neurosci."},{"key":"B360","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ceca.2009.02.008","article-title":"PKC and PLA2: probing the complexities of the calcium network.","volume":"45","author":"van Rossum","year":"2009","journal-title":"Cell Calcium"},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123017","article-title":"Anti-cancer agents in proliferation and cell death: the calcium connection.","volume":"20","author":"Varghese","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B362","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels.","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"B363","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.tiv.2012.12.011","article-title":"Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage.","volume":"27","author":"Visavadiya","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"B364","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.02.005","article-title":"A molecular view of the function and pharmacology of acid-sensing ion channels.","volume":"154","author":"Vullo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B365","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1161\/01.STR.28.11.2252","article-title":"Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.","volume":"28","author":"Walder","year":"1997","journal-title":"Stroke"},{"key":"B366","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2174\/1568007053544183","article-title":"NMDA\/NR2B selective antagonists in the treatment of ischemic brain injury.","volume":"4","author":"Wang","year":"2005","journal-title":"Curr. Drug Target -CNS Neurol. Disord."},{"key":"B367","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nn1119","article-title":"Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.","volume":"6","author":"Wang","year":"2003","journal-title":"Nat. Neurosci."},{"key":"B368","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.nbd.2009.07.018","article-title":"Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.","volume":"36","author":"Wang","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B369","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3164\/jcbn.17-62","article-title":"How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?","volume":"62","author":"Watanabe","year":"2018","journal-title":"J. Clin. Biochem. Nutr."},{"key":"B370","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pa.21.040181.001121","article-title":"Excitatory amino acid transmitters.","volume":"21","author":"Watkins","year":"1981","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"B371","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1038\/sj.bjp.0706444","article-title":"The glutamate story.","volume":"147","author":"Watkins","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"B372","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1161\/01.STR.0000065828.18661.FE","article-title":"Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo.","volume":"34","author":"Wei","year":"2003","journal-title":"Stroke"},{"key":"B373","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nn.4236","article-title":"Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity.","volume":"19","author":"Weilinger","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B374","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","article-title":"Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.","volume":"32","author":"Weilinger","year":"2012","journal-title":"J. Neurosci."},{"key":"B375","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0006-8993(86)91447-91442","article-title":"Ketamine protects cultured neocortical neurons from hypoxic injury.","volume":"380","author":"Weiss","year":"1986","journal-title":"Brain Res."},{"key":"B376","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0304-3940(94)91035-91039","article-title":"AMPA\/kainate receptor-mediated damage to NADPH-diaphorase-containing neurons is Ca2+ dependent.","volume":"167","author":"Weiss","year":"1994","journal-title":"Neurosci. Lett."},{"key":"B377","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/328640a0","article-title":"Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.","volume":"328","author":"Westbrook","year":"1987","journal-title":"Nature"},{"key":"B378","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1126\/science.2996146","article-title":"Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.","volume":"230","author":"Wieloch","year":"1985","journal-title":"Science"},{"key":"B379","doi-asserted-by":"publisher","first-page":"L165","DOI":"10.1152\/ajplung.00459.2005","article-title":"Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide.","volume":"292","author":"Wiseman","year":"2007","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"B380","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-018-0357-358","article-title":"Targeting NMDA receptors in stroke: new hope in neuroprotection.","volume":"11","author":"Wu","year":"2018","journal-title":"Mol. Brain"},{"key":"B381","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-62318","article-title":"Cell death: the significance of apoptosis","author":"Wyllie","year":"1980","journal-title":"International Review of Cytology"},{"key":"B382","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/path.1711420112","article-title":"Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.","volume":"142","author":"Wyllie","year":"1984","journal-title":"J. Pathol."},{"key":"B383","doi-asserted-by":"publisher","first-page":"11246","DOI":"10.1523\/JNEUROSCI.2488-10.2010","article-title":"Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.","volume":"30","author":"Xia","year":"2010","journal-title":"J. Neurosci."},{"key":"B384","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function.","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"B385","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","article-title":"Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"key":"B386","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.neuron.2006.12.020","article-title":"Calpain-mediated mGlur1\u03b1 truncation: a key step in excitotoxicity.","volume":"53","author":"Xu","year":"2007","journal-title":"Neuron"},{"key":"B387","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/39899","article-title":"Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.","volume":"389","author":"Yang","year":"1997","journal-title":"Nature"},{"key":"B388","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2019.03.029","article-title":"Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission and promotes brain damage in stroke.","volume":"102","author":"Yang","year":"2019","journal-title":"Neuron"},{"key":"B389","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00128-011-0317-319","article-title":"Zinc ions induce inflammatory responses in vascular endothelial cells.","volume":"87","author":"Yeh","year":"2011","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"B390","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia.","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B391","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15004","article-title":"Pannexin-1 in the CNS: emerging concepts in health and disease.","volume":"12","author":"Yeung","year":"2020","journal-title":"J. Neurochem."},{"key":"B392","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.nbd.2006.12.007","article-title":"Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia.","volume":"26","author":"Yi","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"B393","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0304-3940(86)90646-90644","article-title":"Brief exposure to zinc is toxic to cortical neurons.","volume":"71","author":"Yokoyama","year":"1986","journal-title":"Neurosci. Lett."},{"key":"B394","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1471-4159.2003.01724.x","article-title":"Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway: the causative role of Ca2+ deficiency.","volume":"85","author":"Yoon","year":"2003","journal-title":"J. Neurochem."},{"key":"B395","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1046\/j.1471-4159.1995.64062442.x","article-title":"\u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage.","volume":"64","author":"Yoshioka","year":"1995","journal-title":"J. Neurochem."},{"key":"B396","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1113\/jphysiol.1997.sp021964","article-title":"Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1\/5 in cultured mouse cortical neurons.","volume":"499","author":"Yu","year":"1997","journal-title":"J. Physiol."},{"key":"B397","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1126\/science.284.5412.336","article-title":"NMDA receptor-mediated K+ efflux and neuronal apoptosis.","volume":"284","author":"Yu","year":"1999","journal-title":"Science"},{"key":"B398","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/(SICI)1097-4547(19980901)53:5<613::AID-JNR11>3.0.CO;2-1","article-title":"Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo.","volume":"53","author":"Yu","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"B399","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.neuron.2015.02.008","article-title":"Context-dependent GluR2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.","volume":"85","author":"Yuan","year":"2015","journal-title":"Neuron"},{"key":"B400","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1089\/neu.2005.22.1428","article-title":"The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury.","volume":"22","author":"Yurkewicz","year":"2005","journal-title":"J. Neurotrauma"},{"key":"B401","doi-asserted-by":"publisher","first-page":"4793","DOI":"10.1523\/JNEUROSCI.12-12-04793.1992","article-title":"Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes.","volume":"12","author":"Zafra","year":"1992","journal-title":"J. Neurosci."},{"key":"B402","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1002\/jnr.21675","article-title":"Role for nitric oxide in permeability of hippocampal neuronal hemichannels during oxygen glucose deprivation.","volume":"86","author":"Zhang","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"B403","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.febslet.2006.12.055","article-title":"Critical role of PTEN in the coupling between PI3K\/Akt and JNK1\/2 signaling in ischemic brain injury.","volume":"581","author":"Zhang","year":"2007","journal-title":"FEBS Lett."},{"key":"B404","doi-asserted-by":"publisher","first-page":"9460","DOI":"10.1074\/jbc.M510650200","article-title":"Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes.","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B405","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1750-3639.2000.tb00247.x","article-title":"Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia.","volume":"10","author":"Zoppo","year":"2000","journal-title":"Brain Pathol."},{"key":"B406","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00125","article-title":"Inhibition of cathepsins B induces neuroprotection against secondary degeneration in ipsilateral substantia nigra after focal cortical infarction in adult male rats.","volume":"10","author":"Zuo","year":"2018","journal-title":"Front. Aging Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.579953\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T08:07:34Z","timestamp":1618042054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.579953\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":406,"alternative-id":["10.3389\/fnins.2020.579953"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2020.579953","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,26]]},"article-number":"579953"}}