{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:44:35Z","timestamp":1790387075839,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005024","name":"Beijing Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>This study aimed to explore brain surface-based morphometry cortical thickness changes in patients with idiopathic tinnitus before and after 24 weeks of sound therapy. In this prospective observational study, we recruited 33 tinnitus patients who had undergone 24 weeks of sound therapy and 26 matched healthy controls. For the two groups of subjects, a 3D-BRAVO pulse sequence was acquired both at baseline and at the 24th week. Structural image data preprocessing was performed using the DPABISurf toolbox. The Tinnitus Handicap Inventory (THI) score was assessed to determine the severity of tinnitus before and after treatment. Two-way mixed-model analysis of variance (ANOVA) and Pearson\u2019s correlation analysis were used in the statistical analysis. Student\u2013Newman\u2013Keuls (SNK) tests were used in the <jats:italic>post hoc<\/jats:italic> analysis. Significantly lower cortical thickness was found in the left somatosensory and motor cortex (SMC), left posterior cingulate cortex (PCC), and right orbital and polar frontal cortex (OPFC) of the participants in the tinnitus group at baseline than in the participants in the HC group at baseline and after 24 weeks; in the tinnitus group, significantly higher cortical thickness was found after the 24 weeks sound therapy in comparison to the baseline in the left SMC, bilateral superior parietal cortex (SPC), left inferior parietal cortex (IPC), left PCC, and right OPFC. In the HC group, no statistically significant difference in cortical thickness was found after the 24 weeks treatment in comparison to the baseline in the bilateral SMC, bilateral SPC, left IPC, left PCC, or right OPFC. The changes in cortical thickness before and after sound therapy can provide certain reference values for clinical tinnitus treatment. These brain regions could serve as potential targets for neuroimaging.<\/jats:p>","DOI":"10.3389\/fnins.2021.633364","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T04:40:00Z","timestamp":1614919200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cortical Thickness Alterations in Patients With Tinnitus Before and After Sound Therapy: A Surface-Based Morphometry Study"],"prefix":"10.3389","volume":"15","author":[{"given":"Xuan","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neubiorev.2014.05.013","article-title":"Neuroanatomical abnormalities in chronic tinnitus in the human brain.","volume":"45","author":"Adjamian","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00234-012-1044-6","article-title":"Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging.","volume":"54","author":"Aldhafeeri","year":"2012","journal-title":"Neuroradiology"},{"key":"B3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014the methods.","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain.","volume":"12","author":"Avants","year":"2008","journal-title":"Med. Image Anal."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1056\/NEJMcp1506631","article-title":"Tinnitus.","volume":"378","author":"Bauer","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1016\/j.cub.2010.09.044","article-title":"Sensitive period for a multimodal response in human visual motion area MT\/MST.","volume":"20","author":"Bedny","year":"2010","journal-title":"Curr. Biol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101976","article-title":"Chronic tinnitus and the limbic system: reappraising brain structural effects of distress and affective symptoms.","volume":"24","author":"Besteher","year":"2019","journal-title":"Neuroimage Clin."},{"key":"B8","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/lary.26107","article-title":"Relationships between tinnitus and the prevalence of anxiety and depression.","volume":"127","author":"Bhatt","year":"2017","journal-title":"Laryngoscope"},{"key":"B9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5152\/iao.2019.6257","article-title":"Prevalence of persistent tinnitus and dizziness in an elderly population in southern taiwan.","volume":"15","author":"Chang","year":"2019","journal-title":"J. Int. Adv. Otol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1002\/hbm.25260","article-title":"Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy.","volume":"42","author":"Chen","year":"","journal-title":"Hum. Brain Mapp."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00591","article-title":"Reorganization of brain white matter in persistent idiopathic tinnitus patients without hearing loss: evidence from baseline data.","volume":"14","author":"Chen","year":"","journal-title":"Front. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00009","article-title":"Abnormal resting-state functional connectivity of the anterior cingulate cortex in unilateral chronic tinnitus patients.","volume":"12","author":"Chen","year":"","journal-title":"Front. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.21037\/qims.2018.11.04","article-title":"Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus.","volume":"8","author":"Chen","year":"","journal-title":"Quant. Imaging Med. Surg."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00028","article-title":"A multimodal meta-analysis of structural and functional changes in the brain of tinnitus.","volume":"14","author":"Cheng","year":"2020","journal-title":"Front. Hum. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction.","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"B16","article-title":"The distressed brain: a group blind source separation analysis on tinnitus.","volume":"6","author":"Dirk","year":"2011","journal-title":"Plos One"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2019.00016","article-title":"Putting the \u201cSensory\u201d into sensorimotor control: the role of sensorimotor integration in goal-directed hand movements after stroke.","volume":"13","author":"Edwards","year":"2019","journal-title":"Front. Integr. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI.","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat. Methods"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00059","article-title":"Increased resting-state cerebellar-cerebral functional connectivity underlying chronic tinnitus.","volume":"10","author":"Feng","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3233\/RNN-2010-0500","article-title":"Plasticity of multisensory dorsal stream functions: evidence from congenitally blind and sighted adults.","volume":"28","author":"Fiehler","year":"2010","journal-title":"Restor. Neurol. Neurosci."},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1016\/S1053-8119(09)70884-5","article-title":"Unbiased nonlinear average age-appropriate brain templates from birth to adulthood.","volume":"47","author":"Fonov","year":"2009","journal-title":"NeuroImage"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.neuroimage.2008.05.059","article-title":"The precuneus\/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis.","volume":"42","author":"Fransson","year":"2008","journal-title":"Neuroimage"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0729-7","article-title":"Can neuroimaging provide reliable biomarkers for obsessive-compulsive disorder? a narrative review.","volume":"18","author":"Frydman","year":"2016","journal-title":"Curr. Psychiatry Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex.","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00013","article-title":"Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python.","volume":"5","author":"Gorgolewski","year":"2011","journal-title":"Front. Neuroinform."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00614","article-title":"Baseline functional connectivity features of neural network nodes can predict improvement after sound therapy through adjusted narrow band noise in tinnitus patients.","volume":"13","author":"Han","year":"","journal-title":"Front. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1002\/jmri.26796","article-title":"Effects of sound therapy on resting-state functional brain networks in patients with tinnitus: a graph-theoretical-based study.","volume":"50","author":"Han","year":"","journal-title":"J. Magn. Reson. Imaging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pnpbp.2015.01.013","article-title":"Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: evidence from resting-state fMRI.","volume":"59","author":"Han","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.otc.2020.03.002","article-title":"Tinnitus: an epidemiologic perspective.","volume":"53","author":"Henry","year":"2020","journal-title":"Otolaryngol. Clin. North Am."},{"key":"B30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1055\/s-0040-1716016","article-title":"Comparison of tinnitus masking and tinnitus retraining therapy.","volume":"13","author":"Henry","year":"2002","journal-title":"J. Am. Acad. Audiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.nicl.2018.08.029","article-title":"Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus.","volume":"20","author":"Hofmeier","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2010.10.095","article-title":"Neuroanatomical changes due to hearing loss and chronic tinnitus: a combined VBM and DTI study.","volume":"1369","author":"Husain","year":"2011","journal-title":"Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer\u2019s disease.","volume":"17","author":"Khan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005350","article-title":"Mindboggling morphometry of human brains.","volume":"13","author":"Klein","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00049","article-title":"Cortical reorganization in recent-onset tinnitus patients by the heidelberg model of music therapy.","volume":"9","author":"Krick","year":"2015","journal-title":"Front. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: causes and clinical management.","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00021","article-title":"Cortico-limbic morphology separates tinnitus from tinnitus distress.","volume":"6","author":"Leaver","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01123","article-title":"Changes in the resting-state cortical oscillatory activity 6 months after modified tinnitus retraining therapy.","volume":"13","author":"Lee","year":"2019","journal-title":"Front. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-020-00341-3","article-title":"Decreased cortical thickness of left premotor cortex as a treatment predictor in major depressive disorder.","author":"Liu","year":"2020","journal-title":"Brain Imaging Behav."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s11682-019-00218-0","article-title":"Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy.","volume":"14","author":"Lv","year":"2020","journal-title":"Brain Imaging Behav."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3174\/ajnr.A5527","article-title":"Resting-state functional mri: everything that nonexperts have always wanted to know.","volume":"39","author":"Lv","year":"","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.pnpbp.2017.09.020","article-title":"Lateralization effects on functional connectivity of the auditory network in patients with unilateral pulsatile tinnitus as detected by functional MRI.","volume":"81","author":"Lv","year":"","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/j.ejrad.2016.09.011","article-title":"Abnormal resting-state functional connectivity study in unilateral pulsatile tinnitus patients with single etiology: a seed-based functional connectivity study.","volume":"85","author":"Lv","year":"","journal-title":"Eur. J. Radiol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4918186","article-title":"Frequency-dependent neural activity in patients with unilateral vascular pulsatile tinnitus.","volume":"2016","author":"Lv","year":"","journal-title":"Neural. Plast."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2016.08.016","article-title":"Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area.","volume":"342","author":"Meyer","year":"2016","journal-title":"Hear. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/archotol.1996.01890140029007","article-title":"Development of the tinnitus handicap inventory.","volume":"122","author":"Newman","year":"1996","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B47","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00106-014-2975-5","article-title":"[Cochlear implants and tinnitus].","volume":"63","author":"Olze","year":"2015","journal-title":"HNO"},{"key":"B48","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/hbm.23864","article-title":"Brain stimulation-induced neuroplasticity underlying therapeutic response in phantom sounds.","volume":"39","author":"Poeppl","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"B49","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1365-2273.2004.00879.x","article-title":"Tinnitus and psychological morbidity: a cross-sectional study to investigate psychological morbidity in tinnitus patients and its relationship with severity of symptoms and illness perceptions.","volume":"29","author":"Reynolds","year":"2004","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"R1083","DOI":"10.1016\/j.cub.2018.07.018","article-title":"Orbitofrontal cortex.","volume":"28","author":"Rudebeck","year":"2018","journal-title":"Curr. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1007\/s00330-015-4034-3","article-title":"White matter integrity associated with clinical symptoms in tinnitus patients: a tract-based spatial statistics study.","volume":"26","author":"Ryu","year":"2016","journal-title":"Eur. Radiol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076488","article-title":"Default mode, dorsal attention and auditory resting state networks exhibit differential functional connectivity in tinnitus and hearing loss.","volume":"8","author":"Schmidt","year":"2013","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.nicl.2017.07.015","article-title":"Connectivity of precuneus to the default mode and dorsal attention networks: a possible invariant marker of long-term tinnitus.","volume":"16","author":"Schmidt","year":"2017","journal-title":"NeuroImage Clin."},{"key":"B54","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.brainres.2017.11.012","article-title":"Changes in gray and white matter in subgroups within the tinnitus population.","volume":"1679","author":"Schmidt","year":"2018","journal-title":"Brain Res."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01599","article-title":"A state-of-the-art review: personalization of tinnitus sound therapy.","volume":"8","author":"Searchfield","year":"2017","journal-title":"Front. Psychol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00234-018-2093-2","article-title":"Changes in the regional shape and volume of subcortical nuclei in patients with tinnitus comorbid with mild hearing loss.","volume":"60","author":"Tae","year":"2018","journal-title":"Neuroradiology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction.","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw5388","article-title":"The somatosensory cortex receives information about motor output.","volume":"5","author":"Umeda","year":"2019","journal-title":"Sci. Adv."},{"key":"B59","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.autneu.2011.06.007","article-title":"Insular lateralization in tinnitus distress.","volume":"165","author":"van der Loo","year":"2011","journal-title":"Auton Neurosci."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00031","article-title":"The auditory and non-auditory brain areas involved in tinnitus. An emergent property of multiple parallel overlapping subnetworks.","volume":"6","author":"Vanneste","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.brainres.2016.03.016","article-title":"The neural correlates of cognitive dysfunction in phantom sounds.","volume":"1642","author":"Vanneste","year":"2016","journal-title":"Brain Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ynstr.2016.11.003","article-title":"Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress.","volume":"8","author":"Vanneste","year":"2018","journal-title":"Neurobiol. Stress"},{"key":"B63","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.neuroimage.2010.04.029","article-title":"The neural correlates of tinnitus-related distress.","volume":"52","author":"Vanneste","year":"2010","journal-title":"Neuroimage"},{"key":"B64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2011.07.067","article-title":"Contralateral parahippocampal gamma-band activity determines noise-like tinnitus laterality: a region of interest analysis.","volume":"199","author":"Vanneste","year":"2011","journal-title":"Neuroscience"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.918","article-title":"The characteristics of cognitive impairment in subjective chronic tinnitus.","volume":"8","author":"Wang","year":"2018","journal-title":"Brain Behav."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00036","article-title":"Acoustic coordinated reset neuromodulation: a systematic review of a novel therapy for tinnitus.","volume":"8","author":"Wegger","year":"2017","journal-title":"Front. Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s11682-019-00051-5","article-title":"Assessing drug cue-induced brain response in heroin dependents treated by methadone maintenance and protracted abstinence measures.","volume":"14","author":"Wei","year":"","journal-title":"Brain Imaging Behav."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00911","article-title":"Neuroanatomical alterations in patients with tinnitus before and after sound therapy: a voxel-based morphometry study.","volume":"14","author":"Wei","year":"","journal-title":"Front. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00246","article-title":"Altered spatial and temporal brain connectivity in the salience network of sensorineural hearing loss and tinnitus.","volume":"13","author":"Xu","year":"2019","journal-title":"Front. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1097\/MAO.0000000000002315","article-title":"Tinnitus suppression effect of hearing aids in patients with high-frequency hearing loss: a randomized double-blind controlled trial.","volume":"40","author":"Yakunina","year":"2019","journal-title":"Otol. Neurotol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s10548-016-0511-5","article-title":"The importance of aging in gray matter changes within tinnitus patients shown in cortical thickness, surface area and volume.","volume":"29","author":"Yoo","year":"2016","journal-title":"Brain Topogr."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-12-7","article-title":"Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample.","volume":"12","author":"Zeman","year":"2014","journal-title":"Health Qual. Life Outcomes"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00405-016-4401-y","article-title":"A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.","volume":"274","author":"Zenner","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.ejrad.2015.04.006","article-title":"Impairments of thalamic resting-state functional connectivity in patients with chronic tinnitus.","volume":"84","author":"Zhang","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans. Med. Imaging"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.633364\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T04:40:11Z","timestamp":1614919211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.633364\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":75,"alternative-id":["10.3389\/fnins.2021.633364"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.633364","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"article-number":"633364"}}