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Neurosci."],"abstract":"<jats:p>The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-activated protein kinase (AMPK) inhibition and activation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR). Changes in these signaling pathways would control phosphorylation of transcription factors cAMP response-element binding protein (CREB), forkhead box01 (FoxO1), and brain homeobox transcription factor (BSX) leading to food intake inhibition through changes in the expression of neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opio melanocortin (POMC), and cocaine and amphetamine-related transcript (CART). The present mini-review summarizes information on the topic and identifies gaps for future research.<\/jats:p>","DOI":"10.3389\/fnins.2021.653928","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T02:30:15Z","timestamp":1614306615000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Integration of Nutrient Sensing in Fish Hypothalamus"],"prefix":"10.3389","volume":"15","author":[{"given":"Jos\u00e9 L.","family":"Soengas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cbpa.2019.04.023","article-title":"Expression of messenger RNA encoding two cellular metabolic regulators, AMP-activated protein kinase (AMPK) and O-GlcNAc transferase (OGT), in channel catfish: their tissue distribution and relationship with changes in food intake.","volume":"235","author":"Abernathy","year":"2019","journal-title":"Comp. 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