{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:33:54Z","timestamp":1793734434160,"version":"4.6.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Scho 849\/6-2"],"award-info":[{"award-number":["Scho 849\/6-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC\/TR 296"],"award-info":[{"award-number":["CRC\/TR 296"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:title>Graphical Abstract<\/jats:title><jats:p>The pathophysiology of traumatic spinal cord injury (TSCI) can be divided into two major phases. <jats:bold>(A)<\/jats:bold> The mechanical trauma is followed within minutes by a secondary phase consisting of local complex and intertwined acute responses, intercellular signaling and cell activity regulating pathways. Inflammatory processes, oxidative stress and hypoxia, leading to cell damage and death, and specific cell contents are released into the circulation <jats:bold>(B)<\/jats:bold>. The motor and sensory deficits upon TSCI are assessed by using the American Spinal Injury Association (ASIA) impairment scale (AIS), ranging from AIS A as a complete absence of any motor and sensory functions under the lesion site, to AIS E with complete preservation of motor and sensory functions. <jats:bold>(C)<\/jats:bold> The concentrations of serum SELENBP1 were elevated in patients classified as AIS A as compared to less severely affected patients classified as AIS B, C or D. A cut-off was deduced [(SELENBP1) &amp;gt; 30.2 \u03bcg\/L], reliably predicting whether a patient belongs to the group showing neurological recovery (G1) or not (G0) within 3 months after the trauma. The figure was created by using <jats:ext-link>https:\/\/biorender.com<\/jats:ext-link>.<\/jats:p><jats:p\/>","DOI":"10.3389\/fnins.2021.680240","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T18:28:02Z","timestamp":1634149682000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Selenium-Binding Protein 1 (SELENBP1) as Biomarker for Adverse Clinical Outcome After Traumatic Spinal Cord Injury"],"prefix":"10.3389","volume":"15","author":[{"given":"Julian","family":"Seelig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raban Arved","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Haubruck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Georg Klingenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hackler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Lucia","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schomburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Biglari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/nu10091203","article-title":"Selenium, selenoproteins, and immunity.","volume":"10","author":"Avery","year":"2018","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1089\/neu.2006.23.318","article-title":"Pharmacological approaches to repair the injured spinal cord.","volume":"23","author":"Baptiste","year":"2006","journal-title":"J. Neurotrauma."},{"key":"B3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00775-016-1335-1","article-title":"The yin and yang of copper during infection.","volume":"21","author":"Besold","year":"2016","journal-title":"J. Biol. Inorg. Chem."},{"key":"B4","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1097\/00007632-200112151-00023","article-title":"Establishing prognosis and maximizing functional outcomes after spinal cord injury: a review of current and future directions in rehabilitation management.","volume":"26","author":"Burns","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1089\/neu.2009.1156","article-title":"A systematic review of intensive cardiopulmonary management after spinal cord injury.","volume":"28","author":"Casha","year":"2011","journal-title":"J. Neurotrauma."},{"key":"B6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fneur.2018.00493","article-title":"Non-linear dynamical analysis of intraspinal pressure signal predicts outcome after spinal cord injury.","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.3390\/nu7053938","article-title":"The subcellular location of selenoproteins and the impact on their function.","volume":"7","author":"Diamond","year":"2015","journal-title":"Nutrients"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.3390\/ijms19113437","article-title":"Selenium-binding protein 1 in human health and disease.","volume":"19","author":"Elhodaky","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B9","first-page":"456","article-title":"Global incidence and prevalence of traumatic spinal cord injury.","volume":"40","author":"Furlan","year":"2013","journal-title":"Canad. J. Neurol. Sci. Le J. Canad. Des Sci. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"126437","DOI":"10.1016\/j.jtemb.2019.126437","article-title":"Copper and selenium status as biomarkers of neonatal infections.","volume":"58","author":"Hackler","year":"2020","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1089\/neu.2014.3778","article-title":"Mean arterial blood pressure correlates with neurological recovery after human spinal cord injury: analysis of high frequency physiologic data.","volume":"32","author":"Hawryluk","year":"2015","journal-title":"J. Neurotrauma."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/sc.2017.69","article-title":"CCL-2 as a possible early marker for remission after traumatic spinal cord injury.","volume":"55","author":"Heller","year":"2017","journal-title":"Spinal Cord."},{"key":"B13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jtemb.2018.10.006","article-title":"Relation of selenium status to neuro-regeneration after traumatic spinal cord injury.","volume":"51","author":"Heller","year":"2019","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3390\/antiox9050421","article-title":"Zinc concentration dynamics indicate neurological impairment odds after traumatic spinal cord injury.","volume":"9","author":"Heller","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1158\/1078-0432.ccr-12-0183","article-title":"Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness.","volume":"18","author":"Huang","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"B16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3945\/ajcn.116.131672","article-title":"Prediagnostic selenium status and hepatobiliary cancer risk in the european prospective investigation into cancer and nutrition cohort.","volume":"104","author":"Hughes","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3390\/nu10111812","article-title":"Expression of selenoprotein genes and association with selenium status in colorectal adenoma and colorectal cancer.","volume":"10","author":"Hughes","year":"2018","journal-title":"Nutrients"},{"key":"B18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.redox.2016.12.025","article-title":"Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P.","volume":"11","author":"Hybsier","year":"2017","journal-title":"Redox Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"411","DOI":"10.5483\/bmbrep.2014.47.7.104","article-title":"Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1alpha and suppresses the malignant characteristics of prostate cancer cells.","volume":"47","author":"Jeong","year":"2014","journal-title":"BMB Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.4097\/kjae.2013.64.5.402","article-title":"The prevention and handling of the missing data.","volume":"64","author":"Kang","year":"2013","journal-title":"Korean. J. Anesthesiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.17219\/acem\/67222","article-title":"Selenium - a fascinating antioxidant of protective properties.","volume":"27","author":"Kielczykowska","year":"2018","journal-title":"Adv Clin Exp Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.pain.2010.02.025","article-title":"Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation.","volume":"149","author":"Kiguchi","year":"2010","journal-title":"Pain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jtemb.2019.01.005","article-title":"Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death.","volume":"52","author":"K\u00fchn","year":"2019","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.3390\/nu11092005","article-title":"Selenium-binding protein 1 indicates myocardial stress and risk for adverse outcome in cardiac surgery.","volume":"11","author":"Kuhn-Heid","year":"2019","journal-title":"Nutrients"},{"key":"B25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40560-020-00443-6","article-title":"Spinal cord autoregulation using near-infrared spectroscopy under normal, hypovolemic, and post-fluid resuscitation conditions in a swine model: a comparison with cerebral autoregulation.","volume":"8","author":"Kurita","year":"2020","journal-title":"J. Intensive Care."},{"key":"B26","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41393-019-0319-8","article-title":"Neurochemical biomarkers in spinal cord injury.","volume":"57","author":"Kwon","year":"2019","journal-title":"Spinal Cord."},{"key":"B27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2015.04.008","article-title":"Large animal and primate models of spinal cord injury for the testing of novel therapies.","volume":"269","author":"Kwon","year":"2015","journal-title":"Exp. Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.spinee.2003.07.007","article-title":"Pathophysiology and pharmacologic treatment of acute spinal cord injury.","volume":"4","author":"Kwon","year":"2004","journal-title":"Spine J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1524-475x.2006.00179.x","article-title":"Zinc in wound healing: theoretical, experimental, and clinical aspects.","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"key":"B30","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1753-4887.2005.tb00130.x","article-title":"Zinc supplementation: neuroprotective or neurotoxic?","volume":"63","author":"Levenson","year":"2005","journal-title":"Nutr. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e13036","DOI":"10.1111\/eci.13036","article-title":"The copper-zinc superoxide dismutase activity in selected diseases.","volume":"49","author":"Lewandowski","year":"2019","journal-title":"Eur. J. Clin. Invest."},{"key":"B32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuro.2018.10.002","article-title":"Differential copper-induced death and regeneration of olfactory sensory neuron populations and neurobehavioral function in larval zebrafish.","volume":"69","author":"Ma","year":"2018","journal-title":"Neurotoxicology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/bf02221591","article-title":"A comprehensive classification of thoracic and lumbar injuries.","volume":"3","author":"Magerl","year":"1994","journal-title":"Eur. Spine J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc requirements and the risks and benefits of zinc supplementation.","volume":"20","author":"Maret","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.3390\/ijms16047900","article-title":"Posttraumatic inflammation as a key to neuroregeneration after traumatic spinal cord injury.","volume":"16","author":"Moghaddam","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.psychres.2018.04.036","article-title":"Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia.","volume":"265","author":"Mohammadi","year":"2018","journal-title":"Psychiatry Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1742-2094-4-12","article-title":"Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1\/CCL2) and MCP-5 (Ccl12) in astrocytes.","volume":"4","author":"Mojsilovic-Petrovic","year":"2007","journal-title":"J. Neuroinflammation."},{"key":"B38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1089\/089771504323004575","article-title":"The pathology of human spinal cord injury: defining the problems.","volume":"21","author":"Norenberg","year":"2004","journal-title":"J. Neurotrauma."},{"key":"B39","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1089\/neu.2014.3668","article-title":"Expansion duroplasty improves intraspinal pressure, spinal cord perfusion pressure, and vascular pressure reactivity index in patients with traumatic spinal cord injury: injured spinal cord pressure evaluation study.","volume":"32","author":"Phang","year":"2015","journal-title":"J. Neurotrauma."},{"key":"B40","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41588-017-0006-7","article-title":"Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis.","volume":"50","author":"Pol","year":"2018","journal-title":"Nat. Genet."},{"key":"B41","year":"2015","journal-title":"R: A Language and Environment for Statistical Computing."},{"key":"B42","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/FOC.2008.25.11.E2","article-title":"Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon.","volume":"25","author":"Rowland","year":"2008","journal-title":"Neurosurg Focus."},{"key":"B43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1227\/NEU.0b013e318276ee16","article-title":"The acute cardiopulmonary management of patients with cervical spinal cord injuries.","volume":"72","author":"Ryken","year":"2013","journal-title":"Neurosurgery"},{"key":"B44","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s13311-019-00820-6","article-title":"Targeted perfusion therapy in spinal cord trauma.","volume":"17","author":"Saadoun","year":"2020","journal-title":"Neurotherapeutics"},{"key":"B45","doi-asserted-by":"publisher","first-page":"10445","DOI":"10.18632\/oncotarget.23853","article-title":"Selenium-binding protein 1 is down-regulated in malignant melanoma.","volume":"9","author":"Schott","year":"2018","journal-title":"Oncotarget"},{"key":"B46","doi-asserted-by":"publisher","first-page":"126415","DOI":"10.1016\/j.jtemb.2019.126415","article-title":"Selenium and copper status - potential signposts for neurological remission after traumatic spinal cord injury.","volume":"57","author":"Seelig","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1089\/neu.2018.6208","article-title":"Optical assessment of spinal cord tissue oxygenation using a miniaturized near infrared spectroscopy sensor.","volume":"36","author":"Shadgan","year":"2019","journal-title":"J. Neurotrauma."},{"key":"B48","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/antiox8110509","article-title":"The role of magnesium in the secondary phase after traumatic spinal cord injury. a prospective clinical observer study.","volume":"8","author":"Sperl","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"B49","year":"2016","journal-title":"Facts and Figures at a Glance."},{"key":"B50","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.redox.2018.11.004","article-title":"Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes.","volume":"20","author":"Steinbrenner","year":"2019","journal-title":"Redox Biol."},{"key":"B51","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1227\/01.NEU.0000245591.16087.89","article-title":"Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations.","volume":"59","author":"Tator","year":"2006","journal-title":"Neurosurgery"},{"key":"B52","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"61","author":"von Elm","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"B53","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-98141-3","author":"Wickham","year":"2009","journal-title":"ggplot2: Elegant Graphics for Data Analysis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"8682","DOI":"10.1523\/jneurosci.18-21-08682.1998","article-title":"Purification from bovine serum of a survival-promoting factor for cultured central neurons and its identification as selenoprotein-P.","volume":"18","author":"Yan","year":"1998","journal-title":"J. Neurosci."},{"key":"B55","article-title":"Selenium restores synaptic deficits by modulating NMDA receptors and selenoprotein k in an alzheimer\u2019s disease model.","author":"Zhang","year":"2020","journal-title":"Antioxid Redox Signal"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.680240\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T18:28:12Z","timestamp":1634149692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.680240\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":55,"alternative-id":["10.3389\/fnins.2021.680240"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.680240","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"article-number":"680240"}}