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Neurosci."],"abstract":"<jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H<jats:sub>2<\/jats:sub>S donor, can alleviate angiotensin II (Ang II)\u2013induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng\/kg\/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1\u2013positive (Iba1<jats:sup>+<\/jats:sup>) cells in the PVN of male, Sprague\u2013Dawley rats. ICV co-infusion of NaHS (at 30 and\/or 60 nmol\/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal<jats:italic>Deltaproteobacteria<\/jats:italic>and<jats:italic>Desulfovibrionales<\/jats:italic>, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol\/h. We observed no differences in circulating H<jats:sub>2<\/jats:sub>S between the groups. Our results suggest that central H<jats:sub>2<\/jats:sub>S may alleviate rodent HTN independently from circulating H<jats:sub>2<\/jats:sub>S via effects on autonomic nervous system and PVN microglia.<\/jats:p>","DOI":"10.3389\/fnins.2021.690919","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T07:53:25Z","timestamp":1631692405000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension"],"prefix":"10.3389","volume":"15","author":[{"given":"Basak","family":"Donertas Ayaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendi L.","family":"Malphurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ty","family":"Redler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Moreira","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basar","family":"Sirmagul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasenka","family":"Zubcevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/jneurosci.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator.","volume":"16","author":"Abe","year":"1996","journal-title":"J. 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