{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:54:40Z","timestamp":1793260480309,"version":"4.5.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Major facilitator superfamily (MFS) is the maximum and most diversified membrane transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a good development potential in the transport of drugs for the treatment of brain diseases. The major facilitator superfamily domain containing protein 2a (Mfsd2a) is a member of MFS. Mfsd2a-knockout mice have shown a marked decrease of docosahexaenoic acid (DHA) level in brain, exhibiting neuron loss, microcephaly and cognitive deficits, as DHA acts essentially in brain growth and integrity. Mfsd2a has attracted more and more attention in the study of nervous system diseases because of its critical role in maintaining the integrity of the blood-brain barrier (BBB) and transporting DHA, including inhibiting cell transport in central nervous system endothelial cells, alleviating BBB injury, avoiding BBB injury in cerebral hemorrhage model, acting as a carrier etc. Up to now, the clinical research of Mfsd2a in nervous system diseases is rare. This article reviewed the current research progress of Mfsd2a in nervous system diseases. It summarized the physiological functions of Mfsd2a in the occurrence and development of intracranial hemorrhage (ICH), Alzheimer\u2019s disease (AD), sepsis-associated encephalopathy (SAE), autosomal recessive primary microcephaly (MCPH) and intracranial tumor, aiming to provide ideas for the basic research and clinical application of Mfsd2a.<\/jats:p>","DOI":"10.3389\/fnins.2021.730534","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T01:15:58Z","timestamp":1631236558000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["The Role of Mfsd2a in Nervous System Diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Bei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/ng.3313","article-title":"A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.","volume":"47","author":"Alakbarzade","year":"2015","journal-title":"Nat. Genet."},{"key":"B2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12974-019-1615-0","article-title":"The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus.","volume":"16","author":"Alashmali","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/mcc.0b013e328325d12c","article-title":"Medical management of acute intracerebral hemorrhage.","volume":"15","author":"Anderson","year":"2009","journal-title":"Curr. Opin. Crit. Care"},{"key":"B4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","article-title":"Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis.","volume":"94","author":"Andreone","year":"2017","journal-title":"Neuron"},{"key":"B5","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/bj20080165","article-title":"Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.","volume":"416","author":"Angers","year":"2008","journal-title":"Biochem. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.7863\/ultra.33.7.1185","article-title":"Reference charts of fetal biometric parameters in 31,476 Brazilian singleton pregnancies.","volume":"33","author":"Araujo","year":"2014","journal-title":"J. Ultrasound. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/medicina56050240","article-title":"Sepsis associated delirium.","volume":"56","author":"Atterton","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.nutres.2020.12.003","article-title":"Structured form of DHA prevents neurodegenerative disorders: a better insight into the pathophysiology and the mechanism of DHA transport to the brain.","volume":"85","author":"Balakrishnan","year":"2021","journal-title":"Nutr. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.brainresbull.2011.12.001","article-title":"Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.","volume":"87","author":"Basselin","year":"2012","journal-title":"Brain Res. Bull."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.1073\/pnas.1109035108","article-title":"Knocking out the door to tunicamycin entry.","volume":"108","author":"Bassik","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B11","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature13324","article-title":"Mfsd2a is critical for the formation and function of the blood-brain barrier.","volume":"509","author":"Ben-Zvi","year":"2014","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/ng.3348","article-title":"Lipid transport and human brain development.","volume":"47","author":"Betsholtz","year":"2015","journal-title":"Nat. Genet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e2006443","DOI":"10.1371\/journal.pbio.2006443","article-title":"The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.","volume":"16","author":"Chan","year":"2018","journal-title":"PLoS Biol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"15791","DOI":"10.1038\/srep15791","article-title":"Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain.","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1099\/mic.0.2007\/010611-0","article-title":"The phagosomal nutrient transporter (Pht) family.","volume":"154","author":"Chen","year":"2008","journal-title":"Microbiology (Reading)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/intqhc\/mzp041","article-title":"Risk stratification for predicting 30-day mortality of intracerebral hemorrhage.","volume":"21","author":"Chuang","year":"2009","journal-title":"Int. J. Qual. Health Care"},{"key":"B17","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3390\/jcm9030703","article-title":"Sepsis-associated encephalopathy: from delirium to dementia?","volume":"9","author":"Chung","year":"2020","journal-title":"J. Clin. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1365-2788.1960.tb00751.x","article-title":"The genetics and sub-classification of microcephaly.","volume":"4","author":"Cowie","year":"1960","journal-title":"J. Ment. Defic. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1136\/jmg.2009.076398","article-title":"A clinical and molecular genetic study of 112 iranian families with primary microcephaly.","volume":"47","author":"Darvish","year":"2010","journal-title":"J. Med. Genet."},{"key":"B20","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fncel.2014.00418","article-title":"Gliomas and the vascular fragility of the blood brain barrier.","volume":"8","author":"Dubois","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.expneurol.2009.07.018","article-title":"The complement cascade as a therapeutic target in intracerebral hemorrhage.","volume":"219","author":"Ducruet","year":"2009","journal-title":"Exp. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00441-014-1811-2","article-title":"Novel insights into the development and maintenance of the blood-brain barrier.","volume":"355","author":"Engelhardt","year":"2014","journal-title":"Cell Tissue Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"113203","DOI":"10.1016\/j.expneurol.2020.113203","article-title":"Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1\/Keap-1\/Nrf-2\/HO-1 pathway in a rat model of surgical brain injury.","volume":"326","author":"Eser Ocak","year":"2020","journal-title":"Exp. Neurol."},{"key":"B24","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1038\/ncomms4009","article-title":"Structure-based mechanism for Na(+)\/melibiose symport by MelB.","volume":"5","author":"Ethayathulla","year":"2014","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.bbalip.2018.12.007","article-title":"A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation.","volume":"1864","author":"Ferchaud-Roucher","year":"2019","journal-title":"Biochim. Biophys. Acta. Mol. Cell. Biol. Lipids"},{"key":"B26","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future.","volume":"44","author":"Finn","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/ng.3311","article-title":"Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.","volume":"47","author":"Guemez-Gamboa","year":"2015","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10048-018-0556-6","article-title":"Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.","volume":"19","author":"Harel","year":"2018","journal-title":"Neurogenetics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s00125-006-0485-z","article-title":"Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.","volume":"50","author":"Hawkins","year":"2007","journal-title":"Diabetologia"},{"key":"B30","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1038\/s41598-018-26500-7","article-title":"Intraperitoneal hypertension, a novel risk factor for sepsis-associated encephalopathy in sepsis mice.","volume":"8","author":"He","year":"2018","journal-title":"Sci. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s00424-020-02411-3","article-title":"Structure, function and regulation of mammalian glucose transporters of the SLC2 family.","volume":"472","author":"Holman","year":"2020","journal-title":"Pflugers Arch."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/jci0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12272-013-0272-6","article-title":"Nano-enabled delivery systems across the blood-brain barrier.","volume":"37","author":"Hwang","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"B34","first-page":"117","article-title":"[Current concept of blood-brain barrier].","volume":"65","author":"Kanda","year":"2013","journal-title":"Brain Nerve"},{"key":"B35","first-page":"247","article-title":"Intracerebral haemorrhage.","volume":"4","author":"Kase","year":"1995","journal-title":"Baillieres Clin. Neurol."},{"key":"B36","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1111\/febs.13412","article-title":"The dynamic blood-brain barrier.","volume":"282","author":"Keaney","year":"2015","journal-title":"FEBS J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/s1474-4422(12)70104-7","article-title":"Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.","volume":"11","author":"Keep","year":"2012","journal-title":"Lancet. Neurol."},{"key":"B38","first-page":"207","article-title":"Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids.","volume":"12","author":"Kidd","year":"2007","journal-title":"Altern. Med. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1517\/14728214.12.3.389","article-title":"Advances in hemorrhagic stroke therapy: conventional and novel approaches.","volume":"12","author":"Lapchak","year":"2007","journal-title":"Exp. Opin. Emerg. Drugs"},{"key":"B40","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3171\/jns.1997.86.2.0272","article-title":"Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model.","volume":"86","author":"Lee","year":"1997","journal-title":"J. Neurosurg."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.bbamem.2007.02.007","article-title":"Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses.","volume":"1768","author":"Lorca","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis.","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.3390\/nu10091250","article-title":"Short-term fish oil treatment changes the composition of phospholipids while not affecting the expression of Mfsd2a omega-3 transporter in the brain and liver of the 5xfad mouse model of Alzheimer\u2019s disease.","volume":"10","author":"Milanovic","year":"2018","journal-title":"Nutrients"},{"key":"B44","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimer\u2019s disease: a matter of blood-brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J. Exp. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s13577-016-0153-7","article-title":"A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.","volume":"30","author":"Moritake","year":"2017","journal-title":"Hum. Cell"},{"key":"B46","first-page":"22","article-title":"Blood brain barrier, exchange of metabolites and gases","author":"Nag","year":"2005","journal-title":"Pathology and Genetics: Cerebrovascular Diseases"},{"key":"B47","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S0016672318000046","article-title":"Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH).","volume":"100","author":"Naveed","year":"2018","journal-title":"Genet. Res. (Camb)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/biomedicines9050524","article-title":"Neuroinflammation in Alzheimer\u2019s disease.","volume":"9","author":"Onyango","year":"2021","journal-title":"Biomedicines"},{"key":"B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.62.1.1-34.1998","article-title":"Major facilitator superfamily.","volume":"62","author":"Pao","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1194\/jlr.m070862","article-title":"Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice.","volume":"58","author":"Pauter","year":"2017","journal-title":"J. Lipid. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4049\/jimmunol.1801585","article-title":"The Lysophosphatidylcholine transporter MFSD2A is essential for CD8(+) memory T cell maintenance and secondary response to infection.","volume":"203","author":"Piccirillo","year":"2019","journal-title":"J. Immunol."},{"key":"B53","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fnins.2020.00461","article-title":"Mfsd2a reverses spatial learning and memory impairment caused by chronic cerebral hypoperfusion via protection of the blood-brain barrier.","volume":"14","author":"Qu","year":"2020","journal-title":"Front. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"9383","DOI":"10.1074\/jbc.m116.721035","article-title":"Structural insights into the transport mechanism of the human sodium-dependent Lysophosphatidylcholine transporter MFSD2A.","volume":"291","author":"Quek","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"104096","DOI":"10.1016\/j.ejmg.2020.104096","article-title":"Novel neuroclinical findings of autosomal recessive primary microcephaly 15 in a consanguineous Iranian family.","volume":"63","author":"Razmara","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1111\/j.1742-4658.2012.08588.x","article-title":"The major facilitator superfamily (MFS) revisited.","volume":"279","author":"Reddy","year":"2012","journal-title":"FEBS J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"fow043","DOI":"10.1093\/femsyr\/fow043","article-title":"MFS transporters of Candida species and their role in clinical drug resistance.","volume":"16","author":"Redhu","year":"2016","journal-title":"FEMS Yeast Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1006\/scdb.2000.0246","article-title":"Phylogeny of multidrug transporters.","volume":"12","author":"Saier","year":"2001","journal-title":"Semin. Cell. Dev. Biol."},{"key":"B59","doi-asserted-by":"crossref","first-page":"D251","DOI":"10.1093\/nar\/gkt1097","article-title":"The transporter classification database.","volume":"42","author":"Saier","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B60","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fendo.2020.00038","article-title":"Child head circumference and placental MFSD2a expression are associated to the level of MFSD2a in maternal blood during pregnancy.","volume":"11","author":"S\u00e1nchez-Campillo","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/ijms21010070","article-title":"Decreased blood level of MFSD2a as a potential biomarker of Alzheimer\u2019s disease.","volume":"21","author":"S\u00e1nchez-Campillo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1038\/s41431-020-0669-x","article-title":"Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features.","volume":"28","author":"Scala","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"key":"B63","doi-asserted-by":"crossref","first-page":"690410","DOI":"10.3389\/fnins.2021.690410","article-title":"LPC-DHA\/EPA-enriched diets increase brain DHA and modulate behavior in mice that express human APOE4.","volume":"15","author":"Scheinman","year":"2021","journal-title":"Front. Neurosci."},{"key":"B64","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1161\/STROKEAHA.108.533125","article-title":"Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials.","volume":"40","author":"Selim","year":"2009","journal-title":"Stroke"},{"key":"B65","doi-asserted-by":"publisher","first-page":"146379","DOI":"10.1016\/j.brainres.2019.146379","article-title":"Chronic cerebral hypoperfusion alters amyloid-\u03b2 transport related proteins in the cortical blood vessels of Alzheimer\u2019s disease model mouse.","volume":"1723","author":"Shang","year":"2019","journal-title":"Brain Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.bbrc.2018.09.156","article-title":"MFSD2A expression predicts better prognosis in gastric cancer.","volume":"505","author":"Shi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B67","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.etp.2012.04.001","article-title":"Responses of brown adipose tissue to diet-induced obesity, exercise, dietary restriction and ephedrine treatment.","volume":"65","author":"Slocum","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1476-4598-9-62","article-title":"MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment.","volume":"9","author":"Spinola","year":"2010","journal-title":"Mol. Cancer"},{"key":"B69","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.bbalip.2016.05.002","article-title":"Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier.","volume":"1861","author":"Subbaiah","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B70","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1038\/s41598-017-11766-0","article-title":"Dietary docosahexaenoic acid (DHA) as Lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice.","volume":"7","author":"Sugasini","year":"2017","journal-title":"Sci. Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"108231","DOI":"10.1016\/j.jnutbio.2019.108231","article-title":"Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: Lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol.","volume":"74","author":"Sugasini","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"B72","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1038\/s41598-018-26636-6","article-title":"Metastatic brain tumors disrupt the blood-brain barrier and alter lipid metabolism by inhibiting expression of the endothelial cell fatty acid transporter Mfsd2a.","volume":"8","author":"Tiwary","year":"2018","journal-title":"Sci. Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.placenta.2012.10.012","article-title":"MFSD2a, the syncytin-2 receptor, is important for trophoblast fusion.","volume":"34","author":"Toufaily","year":"2013","journal-title":"Placenta"},{"key":"B74","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1053\/j.gastro.2017.07.048","article-title":"MFSD2A promotes endothelial generation of inflammation-resolving lipid mediators and reduces colitis in mice.","volume":"153","author":"Ungaro","year":"2017","journal-title":"Gastroenterology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.phrs.2015.12.024","article-title":"Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier.","volume":"104","author":"Wang","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"eaay8627","DOI":"10.1126\/sciadv.aay8627","article-title":"Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier.","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"B77","doi-asserted-by":"publisher","first-page":"10501","DOI":"10.1074\/jbc.m116.721340","article-title":"Mfsd2a is a transporter for the essential \u03c9-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development.","volume":"291","author":"Wong","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/s1474-4422(05)70283-0","article-title":"Mechanisms of brain injury after intracerebral haemorrhage.","volume":"5","author":"Xi","year":"2006","journal-title":"Lancet. Neurol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"8474","DOI":"10.18632\/aging.102333","article-title":"The prognostic value of major facilitator superfamily domain-containing protein 2A in patients with hepatocellular carcinoma.","volume":"11","author":"Xing","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1194\/jlr.m090464","article-title":"Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.","volume":"60","author":"Yalagala","year":"2019","journal-title":"J. Lipid Res."},{"key":"B81","doi-asserted-by":"crossref","first-page":"e005811","DOI":"10.1161\/JAHA.117.005811","article-title":"Mfsd2a (major facilitator superfamily domain containing 2a) attenuates intracerebral hemorrhage-induced blood-brain barrier disruption by inhibiting vesicular transcytosis.","volume":"6","author":"Yang","year":"2017","journal-title":"J. Am. Heart. Assoc."},{"key":"B82","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-1-60761-700-6_3","article-title":"Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters.","volume":"637","author":"Yen","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/13816810.2019.1592200","article-title":"MFSD8 gene mutations; evidence for phenotypic heterogeneity.","volume":"40","author":"Zare-Abdollahi","year":"2019","journal-title":"Ophthalmic Genet"},{"key":"B84","first-page":"828","article-title":"Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011.","volume":"125","author":"Zhang","year":"2012","journal-title":"Chin. Med. J. (Engl)"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s12975-019-00775-y","article-title":"Mfsd2a attenuates blood-brain barrier disruption after sub-arachnoid hemorrhage by inhibiting caveolae-mediated transcellular transport in rats.","volume":"11","author":"Zhao","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"eaax7142","DOI":"10.1126\/sciadv.aax7142","article-title":"Zika virus degrades the \u03c9-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis.","volume":"5","author":"Zhou","year":"2019","journal-title":"Sci. Adv."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.730534\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T01:16:16Z","timestamp":1631236576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.730534\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,10]]},"references-count":86,"alternative-id":["10.3389\/fnins.2021.730534"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.730534","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,10]]},"article-number":"730534"}}