{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:11:23Z","timestamp":1787793083481,"version":"build-2784847793"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS096398-02"],"award-info":[{"award-number":["NS096398-02"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","award":["PF-FBS-1899"],"award-info":[{"award-number":["PF-FBS-1899"]}],"id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["9605"],"award-info":[{"award-number":["9605"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Resting state beta band (13\u201330 Hz) oscillations represent pathological neural activity in Parkinson\u2019s disease (PD). It is unknown how the peak frequency or dynamics of beta oscillations may change among fine, limb, and axial movements and different disease phenotypes. This will be critical for the development of personalized closed loop deep brain stimulation (DBS) algorithms during different activity states.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Subthalamic (STN) and local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa\n                    <jats:sup>\u00ae<\/jats:sup>\n                    PC + S, Medtronic PLC.) in fourteen PD participants (six tremor-dominant and eight akinetic-rigid) off medication\/off STN DBS during 30 s of repetitive alternating finger tapping, wrist-flexion extension, stepping in place, and free walking. Beta power peaks and beta burst dynamics were identified by custom algorithms and were compared among movement tasks and between tremor-dominant and akinetic-rigid groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Beta power peaks were evident during fine, limb, and axial movements in 98% of movement trials; the peak frequencies were similar during each type of movement. Burst power and duration were significantly larger in the high beta band, but not in the low beta band, in the akinetic-rigid group compared to the tremor-dominant group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The conservation of beta peak frequency during different activity states supports the feasibility of patient-specific closed loop DBS algorithms driven by the dynamics of the same beta band during different activities. Akinetic-rigid participants had greater power and longer burst durations in the high beta band than tremor-dominant participants during movement, which may relate to the difference in underlying pathophysiology between phenotypes.\n                  <\/jats:p>","DOI":"10.3389\/fnins.2021.733203","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T01:06:01Z","timestamp":1636592761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Differential Effects of Pathological Beta Burst Dynamics Between Parkinson\u2019s Disease Phenotypes Across Different Movements"],"prefix":"10.3389","volume":"15","author":[{"given":"Raumin S.","family":"Neuville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B.","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross W.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Velisar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Bronte-Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1016\/j.brs.2019.03.019","article-title":"Proceedings #61: subthalamic neural closed-loop deep brain stimulation for bradykinesia in Parkinson\u2019s disease.","volume":"12","author":"Afzal","year":"2019","journal-title":"Brain Stimul."},{"key":"B2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.neuroimage.2017.07.012","article-title":"Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson\u2019s disease.","volume":"158","author":"Akram","year":"2017","journal-title":"Neuroimage"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108811","article-title":"A novel method for calculating beta band burst durations in Parkinson\u2019s disease using a physiological baseline.","volume":"343","author":"Anderson","year":"2020","journal-title":"J. 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