{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:29Z","timestamp":1753891829080,"version":"3.41.2"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Corticobasal syndrome (CBS) is clinically characterized by progressive asymmetric rigidity and apraxia together with symptoms suggestive of cortical involvement and basal ganglia dysfunction. The spectrum of neurodegenerative diseases that can manifest with CBS is wide. The associations of CBS with corticobasal degeneration, progressive supranuclear palsy, Alzheimer's disease, frontotemporal lobar degenerations, Creutzfeldt\u2013Jakob disease, or diffuse Lewy body pathology have been reported. We describe the case of a 71-year-old woman with CBS. The histopathological examination of brain tissue revealed concomitant pathology corresponding to the limbic stage of Lewy-related pathology and the intermediate stage of Alzheimer's-type pathology. To date, there have been only a few cases with a similar combination of pathology manifesting with the CBS phenotype that have been described in the literature. The extent and distribution of pathological changes in these cases were somewhat different from ours, and significance for clinical manifestation was attributed to only one of these pathologies. In our case, we assume that both types of pathology contributed to the development of the disease, considering the presumed specific spread of both types of pathological processes according to Braak's staging. Our case expands the spectrum of neurodegenerative pathological processes that may manifest with the typical CBS phenotype. Also, it points out the importance of identifying specific biomarkers that would enable more accurate <jats:italic>in vivo<\/jats:italic> differential diagnosis and more accurate determination of the underlying pathological processes of these diseases.<\/jats:p>","DOI":"10.3389\/fnins.2021.742042","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T06:39:41Z","timestamp":1635921581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Concomitant Alzheimer's and Lewy-Related Pathology Extending the Spectrum of Underlying Pathologies of Corticobasal Syndrome"],"prefix":"10.3389","volume":"15","author":[{"given":"Michaela","family":"Kaiserov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Men\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Tu\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Hlu\u0161t\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Ka\u0148ovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s12031-011-9624-1","article-title":"The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study","volume":"45","author":"Boeve","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer's disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1007\/s00415-005-0880-2","article-title":"Familial autosomal dominant corticobasal degeneration with the P301S mutation in the tau gene: an example of phenotype variability","volume":"252","author":"Casseron","year":"2005","journal-title":"J. Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1212\/WNL.0000000000003770","article-title":"Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer's disease","volume":"88","author":"Day","year":"2017","journal-title":"Neurology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF00314108","article-title":"Ideomotor apraxia in patients with dementia of Alzheimer type","volume":"234","author":"Della Sala","year":"1987","journal-title":"J. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1001\/archneur.55.5.689","article-title":"Pathologic correlates of apraxia in Alzheimer disease","volume":"55","author":"Giannakopoulos","year":"1998","journal-title":"Arch. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/002383099200500205","article-title":"Motor cortex involvement in presenile dementia: report of a case","volume":"5","author":"Golaz","year":"1992","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1001\/archneur.1996.00550100158027","article-title":"Alzheimer Disease and non-fluent Progressive Aphasia","volume":"53","author":"Greene","year":"1996","journal-title":"Arch. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s11910-008-0078-y","article-title":"Update on apraxia","volume":"8","author":"Gross","year":"2008","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1212\/WNL.36.9.1226","article-title":"Seizures and myoclonus in patients with Alzheimer's disease","volume":"36","author":"Hauser","year":"1986","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s004010051087","article-title":"Alzheimer's disease pathology in motor cortex in dementia with Lewy bodies clinically mimicking corticobasal degeneration","volume":"98","author":"Horoupian","year":"1999","journal-title":"Acta Neuropathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/mds.21877","article-title":"Corticobasal syndrome with Alzheimer's disease pathology","volume":"24","author":"Imamura","year":"2009","journal-title":"Mov. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnagi.2013.00006","article-title":"Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease","volume":"5","author":"Irwin","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1212\/WNL.40.1.14","article-title":"Focal Alzheimer's disease","volume":"40","author":"Jagust","year":"1990","journal-title":"Neurology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e279","DOI":"10.1212\/WNL.0000000000005828","article-title":"Diffuse Lewy body disease manifesting as corticobasal syndrome. A rare form of Lewy body disease","volume":"91","author":"Kasanuki","year":"2018","journal-title":"Neurology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jns.2009.08.036","article-title":"Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy","volume":"289","author":"Kertesz","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1093\/brain\/awq123","article-title":"Does corticobasal degeneration exist? A clinicopathological re-evaluation","volume":"133","author":"Ling","year":"2010","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1590\/0004-282x20170077","article-title":"Cognitive dysfunction in corticobasal degeneration","volume":"75","author":"Machado de Oliveira","year":"2017","journal-title":"Arq. Neuropsiquiatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1212\/WNL.46.3.720","article-title":"Neuropsychological functioning in cortical-basal ganglionic degeneration: differentiation from Alzheimer's disease","volume":"46","author":"Massman","year":"1996","journal-title":"Neurology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/jnnp-2011-300875","article-title":"Diagnostic criteria for corticobasal syndrome: a comparative study","volume":"83","author":"Mathew","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1212\/CON.0000000000000687","article-title":"Early-onset Alzheimer disease and its variants","volume":"25","author":"Mendez","year":"2019","journal-title":"Continuum"},{"key":"B25","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"40","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0006-8993(96)00983-3","article-title":"Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex","volume":"741","author":"Nielson","year":"1996","journal-title":"Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.2169\/internalmedicine.2496-18","article-title":"Mixed Alzheimer's and Lewy-related pathology can cause corticobasal syndrome with visual hallucinations","volume":"58","author":"Nishida","year":"2019","journal-title":"Intern. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1001\/archneurol.2008.521","article-title":"Olfactory function in corticobasal syndrome and frontotemporal dementia","volume":"66","author":"Pardini","year":"2009","journal-title":"Arch. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1212\/WNL.45.8.1477","article-title":"The neuropsychological pattern of corticobasal degeneration: comparison with progressive supranuclear palsy and Alzheimer's disease","volume":"45","author":"Pillon","year":"1995","journal-title":"Neurology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jns.2014.05.052","article-title":"Tau protein, beta-amyloid1-42, and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia","volume":"343","author":"P\u0159ikrylova-Vranova","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1006\/brcg.1995.1018","article-title":"Progressive ideomotor apraxia: evidence for a selective impairment of the action production system","volume":"27","author":"Rapcsak","year":"1995","journal-title":"Brain Cogn."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1212\/WNL.40.8.1203","article-title":"Cortical-basal ganglionic degeneration","volume":"40","author":"Riley","year":"1990","journal-title":"Neurology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/brain\/117.5.1183","article-title":"Corticobasal degeneration: a clinical study of 36 cases","volume":"117","author":"Rinne","year":"1994","journal-title":"Brain"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1212\/WNL.0000000000003165","article-title":"Aphasic variant of Alzheimer disease: clinical, anatomic and genetic features","volume":"87","author":"Rogalski","year":"2016","journal-title":"Neurology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/bs.irn.2019.10.014","article-title":"Corticobasal degeneration","volume":"149","author":"Saranza","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00401-009-0605-1","article-title":"Sporadic corticobasal syndrome due to FTLD-TDP","volume":"119","author":"Tartaglia","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/mds.20478","article-title":"Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome","volume":"20","author":"Tsuboi","year":"2005","journal-title":"Mov. Disord."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1002\/mds.21570","article-title":"Sparing of the substantia nigra in sporadic Creutzfeldt-Jakob disease presenting as an acute corticobasal syndrome","volume":"22","author":"Vandenberghe","year":"2007","journal-title":"Mov. Disord."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.742042\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T06:39:44Z","timestamp":1635921584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.742042\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":39,"alternative-id":["10.3389\/fnins.2021.742042"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.742042","relation":{},"ISSN":["1662-453X"],"issn-type":[{"type":"electronic","value":"1662-453X"}],"subject":[],"published":{"date-parts":[[2021,11,3]]},"article-number":"742042"}}