{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:51:10Z","timestamp":1789167070240,"version":"build-2803163510"},"reference-count":345,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG065240"],"award-info":[{"award-number":["R01AG065240"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS115903"],"award-info":[{"award-number":["R01NS115903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS107897"],"award-info":[{"award-number":["R21NS107897"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008590","name":"Dr. Ralph and Marian Falk Medical Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial integrity by targeting specific mitochondrial quality control pathways in neurodegenerative diseases, such as Parkinson\u2019s disease, Huntington\u2019s disease, and Alzheimer\u2019s disease. In addition to ATP synthesis, mitochondria are critical regulators of ROS production, lipid metabolism, calcium buffering, and cell death. The mitochondrial unfolded protein response, mitochondrial dynamics, and mitophagy are the three main quality control mechanisms responsible for maintaining mitochondrial proteostasis and bioenergetics. The proper functioning of these complex processes is necessary to surveil and restore mitochondrial homeostasis and the healthy pool of mitochondria in cells. Mitochondrial dysfunction occurs early and causally in disease pathogenesis. A significant accumulation of mitochondrial damage resulting from compromised quality control pathways leads to the development of neuropathology. Moreover, genetic or pharmaceutical manipulation targeting the mitochondrial quality control mechanisms can sufficiently rescue mitochondrial integrity and ameliorate disease progression. Thus, therapies that can improve mitochondrial quality control have great promise for the treatment of neurodegenerative diseases. In this review, we summarize recent progress in the field that underscores the essential role of impaired mitochondrial quality control pathways in the pathogenesis of neurodegenerative diseases. We also discuss the translational approaches targeting mitochondrial function, with a focus on the restoration of mitochondrial integrity, including mitochondrial dynamics, mitophagy, and mitochondrial proteostasis.<\/jats:p>","DOI":"10.3389\/fnins.2021.746873","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T06:59:11Z","timestamp":1636700351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?"],"prefix":"10.3389","volume":"15","author":[{"given":"Di","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000874","article-title":"Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements.","volume":"2","author":"Aldridge","year":"2007","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.irn.2020.02.008","article-title":"Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.","volume":"155","author":"Aman","year":"2020","journal-title":"Int. Rev. Neurobiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.201308006","article-title":"The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.","volume":"204","author":"Anand","year":"2014","journal-title":"J. Cell Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00401-019-01989-y","article-title":"ALS\/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response.","volume":"138","author":"Anderson","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1089\/ars.2011.4085","article-title":"Mitochondrial regulation of cell cycle and proliferation.","volume":"16","author":"Antico Arciuch","year":"2012","journal-title":"Antioxid. Redox. Signal."},{"key":"B6","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/embj.201386474","article-title":"Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.","volume":"33","author":"Baker","year":"2014","journal-title":"EMBO J."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00218","article-title":"Parkinson\u2019s disease and the environment.","volume":"10","author":"Ball","year":"2019","journal-title":"Front. Neurol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0352-4","article-title":"Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.","volume":"10","author":"Bartolome","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"B9","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/1567205013666151221145445","article-title":"Evidence for mitochondrial upr gene activation in familial and sporadic Alzheimer\u2019s disease.","volume":"13","author":"Beck","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1534\/genetics.106.061580","article-title":"Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.","volume":"174","author":"Benedetti","year":"2006","journal-title":"Genetics"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30963-z","article-title":"UBXD1 is a mitochondrial recruitment factor for p97\/VCP and promotes mitophagy.","volume":"8","author":"Bento","year":"2018","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"14304","DOI":"10.1523\/jneurosci.0930-14.2014","article-title":"Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.","volume":"34","author":"Berthet","year":"2014","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1172\/jci24761","article-title":"The genetic epidemiology of neurodegenerative disease.","volume":"115","author":"Bertram","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07181-0","article-title":"Mitochondrial division inhibitor-1 is neuroprotective in the A53T-alpha-synuclein rat model of Parkinson\u2019s disease.","volume":"7","author":"Bido","year":"2017","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.1523\/JNEUROSCI.22-14-05840.2002","article-title":"Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.","volume":"22","author":"Billups","year":"2002","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature13418","article-title":"The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.","volume":"510","author":"Bingol","year":"2014","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/ana.21019","article-title":"Localization of LRRK2 to membranous and vesicular structures in mammalian brain.","volume":"60","author":"Biskup","year":"2006","journal-title":"Ann. Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1139\/o06-064","article-title":"Distinct functional contributions of 2 GABP-NRF-2 recognition sites within the context of the human TOMM70 promoter.","volume":"84","author":"Blesa","year":"2006","journal-title":"Biochem. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.02.061","article-title":"Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.","volume":"31","author":"Boecker","year":"2021","journal-title":"Curr. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1093\/hmg\/ddz004","article-title":"LRRK2 impairs PINK1\/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson\u2019s disease.","volume":"28","author":"Bonello","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"B21","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1124\/jpet.107.123000","article-title":"Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.","volume":"322","author":"Bordet","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"B22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0896-6273(00)80272-x","article-title":"ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.","volume":"18","author":"Bruijn","year":"1997","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/bs.pbr.2020.09.005","article-title":"Is the ALS a motor neuron disease or a hematopoietic stem cell disease?","volume":"258","author":"Bryukhovetskiy","year":"2020","journal-title":"Prog. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1212\/01.wnl.0000436610.28210.a5","article-title":"Feedback interaction of research, advocacy, and clinical care applied to ALS research in South America.","volume":"81","author":"Bucheli","year":"2013","journal-title":"Neurology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.expneurol.2009.03.006","article-title":"Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson\u2019s disease.","volume":"218","author":"Bueler","year":"2009","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.103","article-title":"Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.","volume":"5","author":"Burbulla","year":"2014","journal-title":"Cell Death Dis."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67229-6","article-title":"Overexpression of PGC-1alpha influences the mitochondrial unfolded protein response (mtUPR) induced by MPP(+) in human SH-SY5Y neuroblastoma cells.","volume":"10","author":"Cai","year":"2020","journal-title":"Sci. Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer\u2019s disease.","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease.","volume":"11","author":"Calvo","year":"2010","journal-title":"Ann. Rev. Genom. Hum. Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cm.21585","article-title":"Orchestrating mitochondria in neurons: cytoskeleton as the conductor.","volume":"77","author":"Cardanho-Ramos","year":"2020","journal-title":"Cytoskeleton"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56614-5","article-title":"Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer\u2019s disease and mild cognitive impairment.","volume":"9","author":"Castellazzi","year":"2019","journal-title":"Sci. Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1091\/mbc.E16-05-0313","article-title":"Amyloid beta-peptides interfere with mitochondrial preprotein import competence by a coaggregation process.","volume":"27","author":"Cenini","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease.","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.nbd.2005.12.007","article-title":"Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.","volume":"22","author":"Chang","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1093\/hmg\/ddw310","article-title":"PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.","volume":"25","author":"Chen","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104741","article-title":"Mitochondrial fission in Huntington\u2019s disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca(2+) efflux and reactive oxygen species (ROS) homeostasis.","volume":"136","author":"Cherubini","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-Nitrosylation of Drp1 mediates beta-Amyloid-Related mitochondrial fission and neuronal injury.","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03102-8","article-title":"Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis.","volume":"11","author":"Choi","year":"2020","journal-title":"Cell Death Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"10814","DOI":"10.1074\/jbc.m110.132514","article-title":"Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy.","volume":"286","author":"Choubey","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion.","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1212\/01.wnl.0000244345.49809.36","article-title":"Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.","volume":"67","author":"Clark","year":"2006","journal-title":"Neurology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuroscience.2014.01.001","article-title":"Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer\u2019s disease-linked presenilin 1 A246e mutation can be reversed with camp.","volume":"263","author":"Coffey","year":"2014","journal-title":"Neuroscience"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16637-2","article-title":"Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson\u2019s disease models.","volume":"7","author":"Cooper","year":"2017","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awr365","article-title":"Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72.","volume":"135","author":"Cooper-Knock","year":"2012","journal-title":"Brain"},{"key":"B45","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature18015","article-title":"Synchronized mitochondrial and cytosolic translation programs.","volume":"533","author":"Couvillion","year":"2016","journal-title":"Nature"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009313","article-title":"Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.","volume":"5","author":"Crews","year":"2010","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899360","article-title":"Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria.","volume":"38","author":"Cummins","year":"2019","journal-title":"EMBO J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.cmet.2012.03.019","article-title":"Elevated PGC-1 alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.","volume":"15","author":"Da Cruz","year":"2012","journal-title":"Cell Metab."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005357","article-title":"FUS interacts with HSP60 to promote mitochondrial damage.","volume":"11","author":"Deng","year":"2015","journal-title":"PLoS Genetics"},{"key":"B51","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1523\/JNEUROSCI.1469-06.2006","article-title":"Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer\u2019s disease brain is associated with mitochondrial dysfunction.","volume":"26","author":"Devi","year":"2006","journal-title":"J. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1002\/pro.3839","article-title":"Miro: a molecular switch at the center of mitochondrial regulation.","volume":"29","author":"Eberhardt","year":"2020","journal-title":"Protein Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1083\/jcb.143.3.777","article-title":"Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer\u2019s disease.","volume":"143","author":"Ebneth","year":"1998","journal-title":"J. Cell Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s13311-012-0112-2","article-title":"Huntington\u2019s disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease.","volume":"9","author":"Ehrlich","year":"2012","journal-title":"Neurotherapeutics"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0518-0","article-title":"Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.","volume":"6","author":"Ehrnhoefer","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158333","article-title":"Effects of urolithin a on mitochondrial parameters in a cellular model of early Alzheimer disease.","volume":"22","author":"Esselun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.3233\/JAD-180987","article-title":"The effect of human HSP70 administration on a mouse model of Alzheimer\u2019s disease strongly depends on transgenicity and age.","volume":"67","author":"Evgen\u2019ev","year":"2019","journal-title":"J. Alzheimers. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease.","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00016","article-title":"Mitochondrial function in neuronal cells depends on p97\/VCP\/Cdc48-mediated quality control.","volume":"9","author":"Fang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B60","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4246350","article-title":"Alpha-Synuclein preserves mitochondrial fusion and function in neuronal cells.","volume":"2019","author":"Faustini","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41586-020-2076-4","article-title":"A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.","volume":"579","author":"Fessler","year":"2020","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/srep32656","article-title":"Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson\u2019s disease model induced by MPTP.","volume":"6","author":"Filichia","year":"2016","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/10409238.2017.1291577","article-title":"Integrating the UPRmt into the mitochondrial maintenance network.","volume":"52","author":"Fiorese","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The transcription factor ATF5 mediates a mammalian mitochondrial UPR.","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.","volume":"17","author":"Franco-Iborra","year":"2021","journal-title":"Autophagy"},{"key":"B66","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division.","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.bbadis.2019.02.015","article-title":"Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.","volume":"1865","author":"Fu","year":"2019","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nj7526-299a","article-title":"Neurodegenerative disease: brain windfall.","volume":"515","author":"Gammon","year":"2014","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tcb.2020.09.008","article-title":"Mitochondrial fusion: the machineries in and out.","volume":"31","author":"Gao","year":"2021","journal-title":"Trends Cell Biol."},{"key":"B70","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"16","year":"2017","journal-title":"Lancet Neurol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1093\/hmg\/ddq419","article-title":"Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1\/parkin-dependent manner upon induction of mitophagy (vol 19, pg 4861, 2010).","volume":"22","author":"Gegg","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1.","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"58","DOI":"10.15252\/emmm.201505496","article-title":"CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.","volume":"8","author":"Genin","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics.","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.626117","article-title":"Mitochondrial OMA1 and OPA1 as gatekeepers of organellar structure\/function and cellular stress response.","volume":"9","author":"Gilkerson","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.578993","article-title":"Interaction of alpha-synuclein with lipids: mitochondrial cardiolipin as a critical player in the pathogenesis of Parkinson\u2019s disease.","volume":"14","author":"Gilmozzi","year":"2020","journal-title":"Front. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium.","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6245","article-title":"Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.","volume":"5","author":"Godena","year":"2014","journal-title":"Nat. Commun."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.neurobiolaging.2012.12.005","article-title":"Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1 alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer\u2019s mouse models.","volume":"34","author":"Gong","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B81","doi-asserted-by":"publisher","first-page":"E2634","DOI":"10.1073\/pnas.1713849115","article-title":"Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinson\u2019s disease.","volume":"115","author":"Grassi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B82","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/embor.2012.14","article-title":"Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.","volume":"13","author":"Greene","year":"2012","journal-title":"EMBO Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/cdd.2012.18","article-title":"Inhibition of Drp1 provides neuroprotection in vitro and in vivo.","volume":"19","author":"Grohm","year":"2012","journal-title":"Cell Death. Differ."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00271-2","article-title":"Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer disease: a randomized, double-blind trial.","author":"Gu","year":"2021","journal-title":"Neurol. Ther."},{"key":"B85","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1523\/jneurosci.2507-13.2014","article-title":"alpha-Synuclein is localized to mitochondria-associated ER membranes.","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114874","article-title":"p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T alpha-synuclein model of Parkinson\u2019s disease.","volume":"388","author":"Gui","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054914","article-title":"Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer\u2019s neurons.","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"B88","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington\u2019s disease-associated neurodegeneration.","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington\u2019s disease.","volume":"7","author":"Guo","year":"2016","journal-title":"Nat. Commun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41586-020-2078-2","article-title":"Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.","volume":"579","author":"Guo","year":"2020","journal-title":"Nature"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008638","article-title":"Autophagy compensates for defects in mitochondrial dynamics.","volume":"16","author":"Haeussler","year":"2020","journal-title":"PLoS Genet"},{"key":"B92","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1073\/pnas.1909814117","article-title":"Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.","volume":"117","author":"Ham","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B93","doi-asserted-by":"publisher","first-page":"26224","DOI":"10.1073\/pnas.1912954116","article-title":"Alzheimer\u2019s disease: a clinical perspective and future nonhuman primate research opportunities.","volume":"116","author":"Haque","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025053118","article-title":"ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.","volume":"118","author":"Harding","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104940","article-title":"ALS and Parkinson\u2019s disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons.","volume":"141","author":"Harjuhaahto","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B96","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy.","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.devcel.2007.07.016","article-title":"ClpP mediates activation of a mitochondrial unfolded protein response in C-elegans.","volume":"13","author":"Haynes","year":"2007","journal-title":"Dev. Cell"},{"key":"B98","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.cell.2013.07.030","article-title":"A Neo-substrate that amplifies catalytic activity of Parkinson\u2019s-disease-related kinase PINK1.","volume":"154","author":"Hertz","year":"2013","journal-title":"Cell"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1093\/hmg\/ddt501","article-title":"Parkin overexpression ameliorates hippocampal long-term potentiation and beta-amyloid load in an Alzheimer\u2019s disease mouse model.","volume":"23","author":"Hong","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000835","article-title":"The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response.","volume":"2","author":"Horibe","year":"2007","journal-title":"PLoS One"},{"key":"B101","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12188","article-title":"Mitonuclear protein imbalance as a conserved longevity mechanism.","volume":"497","author":"Houtkooper","year":"2013","journal-title":"Nature"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.023","article-title":"Miro1 marks Parkinson\u2019s disease subset and miro1 reducer rescues neuron loss in Parkinson\u2019s models.","volume":"30","author":"Hsieh","year":"2019","journal-title":"Cell Metab."},{"key":"B103","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson\u2019s disease.","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25651-y","article-title":"Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington\u2019s disease.","volume":"12","author":"Hu","year":"","journal-title":"Nat. Commun."},{"key":"B105","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbrc.2021.06.079","article-title":"UPR(mt) activation protects against MPP(+)-induced toxicity in a cell culture model of Parkinson\u2019s disease.","volume":"569","author":"Hu","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00401-019-01993-2","article-title":"Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.","volume":"137","author":"Hu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.15252\/emmm.201505256","article-title":"Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington\u2019s disease.","volume":"7","author":"Hwang","year":"2015","journal-title":"EMBO Mol. Me"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00503","article-title":"Evaluation of models of parkinson\u2019s disease.","volume":"9","author":"Jagmag","year":"2015","journal-title":"Front. Neurosci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1093\/hmg\/ddv188","article-title":"CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.","volume":"24","author":"Jahani-Asl","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update.","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2174\/1567205013666151218150004","article-title":"SS31, a small molecule antioxidant peptide, attenuates beta-amyloid elevation, mitochondrial\/synaptic deterioration and cognitive deficit in SAMP8 mice.","volume":"13","author":"Jia","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.4161\/auto.26122","article-title":"The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2\/Parkin-mediated mitophagy of polarized mitochondria.","volume":"9","author":"Jin","year":"2013","journal-title":"Autophagy"},{"key":"B113","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neuron.2011.01.009","article-title":"Exome sequencing reveals VCP mutations as a cause of familial ALS.","volume":"69","author":"Johnson","year":"2011","journal-title":"Neuron"},{"key":"B114","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/jpet.112.192138","article-title":"Mitochondrial dysfunction in neurodegenerative diseases.","volume":"342","author":"Johri","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington\u2019s disease.","volume":"21","author":"Johri","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B116","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.18632\/oncotarget.23640","article-title":"Drp1\/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer\u2019s disease.","volume":"9","author":"Joshi","year":"","journal-title":"Oncotarget"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708166","article-title":"Inhibition of Drp1\/Fis1 interaction slows progression of amyotrophic lateral sclerosis.","volume":"10","author":"Joshi","year":"","journal-title":"EMBO Mol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1042\/bst0360105","article-title":"Roles of VCP in human neurodegenerative disorders.","volume":"36","author":"Kakizuka","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"B119","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by DRP1.","volume":"558","author":"Kalia","year":"2018","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1038\/emboj.2010.223","article-title":"Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1.","volume":"29","author":"Kamp","year":"2010","journal-title":"Parkin and DJ-1. EMBO J."},{"key":"B121","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1083\/jcb.201402104","article-title":"PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.","volume":"205","author":"Kane","year":"2014","journal-title":"J. Cell Biol."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf0971","article-title":"Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.","volume":"7","author":"Kaspar","year":"2021","journal-title":"Sci. Adv."},{"key":"B123","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/ana.21743","article-title":"Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III.","volume":"66","author":"Kaufmann","year":"2009","journal-title":"Ann. Neurol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/febs.13127","article-title":"PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson\u2019s disease.","volume":"282","author":"Kazlauskaite","year":"2015","journal-title":"FEBS J."},{"key":"B125","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1038\/onc.2017.52","article-title":"Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis.","volume":"36","author":"Kenny","year":"2017","journal-title":"Oncogene"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00509","article-title":"Huntington\u2019s disease as neurodevelopmental disorder: altered chromatin regulation, coding, and non-coding RNA transcription.","volume":"9","author":"Kerschbamer","year":"2016","journal-title":"Front. Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/hmg\/ddr526","article-title":"LRRK2 Parkinson disease mutations enhance its microtubule association.","volume":"21","author":"Kett","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B128","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neurobiolaging.2017.02.016","article-title":"Enhancing Mitofusin\/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.","volume":"54","author":"Khalil","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.581","article-title":"PINK1-induced mitophagy promotes neuroprotection in Huntington\u2019s disease.","volume":"6","author":"Khalil","year":"2015","journal-title":"Cell Death Dis."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.4103\/1673-5374.211179","article-title":"Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?","volume":"12","author":"Khalil","year":"2017","journal-title":"Neural Regen. Res."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-016-0270-y","article-title":"A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death.","volume":"17","author":"Kim","year":"2017","journal-title":"BMC Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"7212","DOI":"10.1523\/JNEUROSCI.0711-11.2011","article-title":"The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons.","volume":"31","author":"Kim-Han","year":"2011","journal-title":"J. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis.","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"B134","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1228360","article-title":"An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.","volume":"339","author":"Korobova","year":"2013","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1242\/jcs.199562","article-title":"The constriction and scission machineries involved in mitochondrial fission.","volume":"130","author":"Kraus","year":"2017","journal-title":"J. Cell Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1093\/hmg\/ddx226","article-title":"Aqua-soluble DDQ reduces the levels of Drp1 and Abeta and inhibits abnormal interactions between Abeta and Drp1 and protects Alzheimer\u2019s disease neurons from Abeta- and Drp1-induced mitochondrial and synaptic toxicities.","volume":"26","author":"Kuruva","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B137","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neuro.2018.11.009","article-title":"Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1\/DREAM\/PDYN pathway.","volume":"71","author":"Laudati","year":"2019","journal-title":"Neurotoxicology"},{"key":"B138","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase parkin.","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev. Cell"},{"key":"B139","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s13238-017-0469-4","article-title":"Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.","volume":"9","author":"Lee","year":"2018","journal-title":"Protein Cell"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12679","article-title":"SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer\u2019s disease.","volume":"17","author":"Lee","year":"2018","journal-title":"Aging Cell"},{"key":"B141","doi-asserted-by":"crossref","first-page":"E8844","DOI":"10.1073\/pnas.1721136115","article-title":"Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models.","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B142","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/hmg\/ddr445","article-title":"IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.","volume":"21","author":"Lee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02475-x","article-title":"FTLD patient-derived fibroblasts show defective mitochondrial function and accumulation of p62.","author":"Leskela","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf5549","article-title":"ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells.","volume":"353","author":"Lewis","year":"2016","journal-title":"Science"},{"key":"B145","article-title":"Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"B146","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1021\/bi010616g","article-title":"Effect of familial Parkinson\u2019s disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein.","volume":"40","author":"Li","year":"2001","journal-title":"Biochemistry"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085815","article-title":"Human A53T alpha-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9341018","article-title":"Salidroside protects dopaminergic neurons by enhancing PINK1\/Parkin-Mediated mitophagy.","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107902","article-title":"Mitochondria-Associated Degradation Pathway (MAD) function beyond the outer membrane.","volume":"32","author":"Liao","year":"2020","journal-title":"Cell Rep."},{"key":"B150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2017.04.004","article-title":"Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions.","volume":"94","author":"Lin","year":"2017","journal-title":"Neuron"},{"key":"B151","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/nature17989","article-title":"Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.","volume":"533","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"B152","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070712","article-title":"Mitophagy in Parkinson\u2019s disease: from pathogenesis to treatment.","volume":"8","author":"Liu","year":"2019","journal-title":"Cells"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112213","article-title":"Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson\u2019s disease.","volume":"247","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131834","article-title":"Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.","volume":"5","author":"Liu","year":"2020","journal-title":"JCI Insight"},{"key":"B155","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"B156","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.mcn.2017.03.006","article-title":"Developmental changes in trak-mediated mitochondrial transport in neurons.","volume":"80","author":"Loss","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1056\/NEJM200005253422103","article-title":"Association between early-onset Parkinson\u2019s disease and mutations in the parkin gene.","volume":"342","author":"Lucking","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082112","article-title":"Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model.","volume":"8","author":"Luo","year":"2013","journal-title":"PLoS One"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13666","article-title":"Pharmacological inhibition of USP30 activates tissue-specific mitophagy.","volume":"232","author":"Luo","year":"2021","journal-title":"Acta Physiol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.","volume":"23","author":"Magrane","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B161","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1093\/hmg\/ddp421","article-title":"Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.","volume":"18","author":"Magrane","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B162","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s13311-013-0253-y","article-title":"Resveratrol improves motoneuron function and extends survival in SOD1(G93A) ALS mice.","volume":"11","author":"Mancuso","year":"2014","journal-title":"Neurotherapeutics"},{"key":"B163","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer\u2019s disease: implications for neuronal damage.","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B164","doi-asserted-by":"publisher","first-page":"7308","DOI":"10.1093\/hmg\/ddv429","article-title":"Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington\u2019s disease.","volume":"24","author":"Manczak","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00373","article-title":"Axonal transport and mitochondrial function in neurons.","volume":"13","author":"Mandal","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1089\/jmf.2009.0243","article-title":"A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis.","volume":"13","author":"Markert","year":"2010","journal-title":"J. Med. Food"},{"key":"B167","first-page":"568","article-title":"Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.","volume":"13","author":"Martin","year":"2010","journal-title":"Idrugs"},{"key":"B168","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1523\/jneurosci.4308-05.2006","article-title":"Parkinson\u2019s disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.","volume":"26","author":"Martin","year":"2006","journal-title":"J. Neurosci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1093\/hmg\/ddv616","article-title":"PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer\u2019s disease.","volume":"25","author":"Martin-Maestro","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B170","doi-asserted-by":"publisher","first-page":"8220","DOI":"10.1007\/s12035-019-01665-y","article-title":"Autophagy induction by bexarotene promotes mitophagy in presenilin 1 familial Alzheimer\u2019s disease iPSC-Derived neural stem cells.","volume":"56","author":"Martin-Maestro","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/17482968.2010.545952","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis.","volume":"465","author":"Maruyama","year":"2010","journal-title":"Nature"},{"key":"B172","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.neuron.2008.10.010","article-title":"Mitochondria in neuroplasticity and neurological disorders.","volume":"60","author":"Mattson","year":"2008","journal-title":"Neuron"},{"key":"B173","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism.","volume":"62","author":"Mayer","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32866","article-title":"Mfn2 ubiquitination by PINK1\/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.","volume":"7","author":"McLelland","year":"2018","journal-title":"eLife"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1922982","article-title":"VCP\/p97 cofactor UBXN1\/SAKS1 regulates mitophagy by modulating MFN2 removal from mitochondria.","author":"Mengus","year":"2021","journal-title":"Autophagy."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.cell.2016.04.012","article-title":"Two conserved histone demethylases regulate mitochondrial stress-induced longevity.","volume":"165","author":"Merkwirth","year":"2016","journal-title":"Cell"},{"key":"B177","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ncb2407","article-title":"Emerging functions of the VCP\/p97 AAA-ATPase in the ubiquitin system.","volume":"14","author":"Meyer","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2014.03.011","article-title":"Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.","volume":"19","author":"Mishra","year":"2014","journal-title":"Cell Metab."},{"key":"B179","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1523\/JNEUROSCI.6248-09.2010","article-title":"Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro\/Milton complex.","volume":"30","author":"Misko","year":"2010","journal-title":"J. Neurosci."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12382-4","article-title":"Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.","volume":"10","author":"Modi","year":"2019","journal-title":"Nat. Commun."},{"key":"B181","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.1074\/jbc.TM117.000893","article-title":"Mitochondrial proteostasis in the context of cellular and organismal health and aging.","volume":"294","author":"Moehle","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B182","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1093\/hmg\/ddx348","article-title":"Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.","volume":"26","author":"Moller","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B183","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0154-3","article-title":"Therapeutic potential of autophagy-enhancing agents in Parkinson\u2019s disease.","volume":"12","author":"Moors","year":"2017","journal-title":"Mol. Neurodegenerat."},{"key":"B184","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/emmm.200900006","article-title":"Parkinson\u2019s disease mutations in PINK1 result in decreased complex I activity and deficient synaptic function.","volume":"1","author":"Morais","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"B185","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","article-title":"Mitochondrial dysfunction is a trigger of Alzheimer\u2019s disease pathophysiology.","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13781-3","article-title":"ROCK inhibitors upregulate the neuroprotective parkin-mediated mitophagy pathway.","volume":"11","author":"Moskal","year":"2020","journal-title":"Nat. Commun."},{"key":"B187","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.cmet.2014.07.024","article-title":"Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.","volume":"20","author":"Mossmann","year":"2014","journal-title":"Cell Metab."},{"key":"B188","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD(+)\/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling.","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.581849","article-title":"The mitochondrial unfolded protein response: a hinge between healthy and pathological aging.","volume":"12","author":"Munoz-Carvajal","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00422","article-title":"ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast.","volume":"2","author":"Murley","year":"2013","journal-title":"eLife"},{"key":"B191","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2020.11.031","article-title":"Mitochondrial SIRT3 confers neuroprotection in Huntington\u2019s disease by regulation of oxidative challenges and mitochondrial dynamics.","volume":"163","author":"Naia","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146480","article-title":"A metabolic study of Huntington\u2019s disease.","volume":"11","author":"Nambron","year":"2016","journal-title":"PLoS One"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033944","article-title":"Signaling and regulation of the mitochondrial unfolded protein response.","volume":"11","author":"Naresh","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.molcel.2015.02.008","article-title":"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).","volume":"58","author":"Nargund","year":"2015","journal-title":"Mol. Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1223560","article-title":"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.","volume":"337","author":"Nargund","year":"2012","journal-title":"Science"},{"key":"B196","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"B197","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1016\/j.bbamcr.2015.02.022","article-title":"Mitochondrial autophagy: origins, significance, and role of BNIP3 and NIX.","volume":"1853","author":"Ney","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B198","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.redox.2014.11.006","article-title":"Mitochondrial dynamics and mitochondrial quality control.","volume":"4","author":"Ni","year":"2015","journal-title":"Redox Biol."},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0287-x","article-title":"TBK1: a new player in ALS linking autophagy and neuroinflammation.","volume":"10","author":"Oakes","year":"2017","journal-title":"Mol. Brain"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-0279-y","article-title":"Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.","volume":"6","author":"Obergasteiger","year":"2020","journal-title":"Cell Death Discov."},{"key":"B201","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1097\/MAO.0000000000000192","article-title":"Mitochondria-Targeted antioxidant MitoQ reduces gentamicin-induced ototoxicity.","volume":"35","author":"Ojano-Dirain","year":"2014","journal-title":"Otol. Neurotol."},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0316-5","article-title":"Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.","volume":"4","author":"Onesto","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"B203","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuron.2017.11.036","article-title":"alpha-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton.","volume":"97","author":"Ordonez","year":"2018","journal-title":"Neuron"},{"key":"B204","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1111\/bph.14585","article-title":"Mitochondrial dysfunction in Alzheimer\u2019s disease: role in pathogenesis and novel therapeutic opportunities.","volume":"176","author":"Ortiz","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1021\/acs.jmedchem.6b01897","article-title":"Kinetin riboside and its protides activate the Parkinson\u2019s disease associated PTEN-induced putative kinase 1 (PINK1) independent of mitochondrial depolarization.","volume":"60","author":"Osgerby","year":"2017","journal-title":"J. Med. Chem."},{"key":"B206","doi-asserted-by":"publisher","first-page":"616","DOI":"10.2174\/1567205017666201006162538","article-title":"Alterations in mitochondrial dynamic-related genes in the peripheral blood of Alzheimer\u2019s disease patients.","volume":"17","author":"Pakpian","year":"2020","journal-title":"Curr. Alzheimer Res."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery.","volume":"12","author":"Palmer","year":"2011","journal-title":"EMBO Rep."},{"key":"B209","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.neuroscience.2009.08.014","article-title":"Rapamycin protects against rotenone-induced apoptosis through autophagy induction.","volume":"164","author":"Pan","year":"2009","journal-title":"Neuroscience"},{"key":"B210","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mito.2020.10.005","article-title":"Miro (Mitochondrial Rho GTPase), a key player of mitochondrial axonal transport and mitochondrial dynamics in neurodegenerative diseases.","volume":"56","author":"Panchal","year":"2021","journal-title":"Mitochondrion"},{"key":"B211","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1128\/mcb.00190-14","article-title":"SirT3 regulates the mitochondrial unfolded protein response.","volume":"34","author":"Papa","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009118","article-title":"Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression.","volume":"16","author":"Pareek","year":"2020","journal-title":"PLoS Genetics"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/srep21772","article-title":"Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"B214","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/jnc.12361","article-title":"Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells.","volume":"127","author":"Park","year":"2013","journal-title":"J. Neurochem."},{"key":"B215","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.15252\/embj.201488349","article-title":"OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.","volume":"33","author":"Patten","year":"2014","journal-title":"EMBO J."},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0807-4","article-title":"Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer\u2019s disease-like pathology in human cerebral organoids.","author":"Perez","year":"2020","journal-title":"Mol. Psychiatry."},{"key":"B217","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/j.neurobiolaging.2013.03.011","article-title":"Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer\u2019s disease.","volume":"34","author":"Perez-Gonzalez","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B218","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance.","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease.","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"B220","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1073\/pnas.0709336105","article-title":"The PINK1\/Parkin pathway regulates mitochondrial morphology.","volume":"105","author":"Poole","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B221","article-title":"Limitations of animal models of Parkinson\u2019s disease.","volume":"2011","author":"Potashkin","year":"2010","journal-title":"Parkinsons Dis."},{"key":"B222","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.1073\/pnas.1713129115","article-title":"alpha-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.","volume":"115","author":"Prots","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B223","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1242\/jcs.114439","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.","volume":"126","author":"Qi","year":"2013","journal-title":"J. Cell Sci."},{"key":"B224","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/archneurol.2008.588","article-title":"PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.","volume":"66","author":"Qin","year":"2009","journal-title":"Arch. Neurol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"13500","DOI":"10.1074\/jbc.r117.791061","article-title":"The mitochondrial unfolded protein response: signaling from the powerhouse.","volume":"292","author":"Qureshi","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6244","article-title":"Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.","volume":"5","author":"Rappold","year":"2014","journal-title":"Nat. Commun."},{"key":"B227","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1212\/01.wnl.0000260965.20021.47","article-title":"Focality of upper and lower motor neuron degeneration at the clinical onset of ALS.","volume":"68","author":"Ravits","year":"2007","journal-title":"Neurology"},{"key":"B228","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/hmg\/ddab091","article-title":"Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer\u2019s disease.","volume":"30","author":"Reddy","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx129","article-title":"Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer\u2019s disease.","volume":"26","author":"Reddy","year":"","journal-title":"Hum. Mol. Genet."},{"key":"B230","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3233\/JAD-170051","article-title":"Mitochondria-Division inhibitor 1 protects against amyloid-beta induced mitochondrial fragmentation and synaptic damage in Alzheimer\u2019s disease.","volume":"58","author":"Reddy","year":"","journal-title":"J. Alzheimers. Dis."},{"key":"B231","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3233\/JAD-170988","article-title":"Synergistic protective effects of mitochondrial division inhibitor 1 and mitochondria-targeted small peptide SS31 in Alzheimer\u2019s disease.","volume":"62","author":"Reddy","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/hmg\/ddx049","article-title":"Sex specific activation of the ERalpha axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.","volume":"26","author":"Riar","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B233","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.","volume":"113","author":"Richter","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B234","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.bbrc.2018.01.114","article-title":"Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington\u2019s disease.","volume":"496","author":"Roe","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2018.00051","article-title":"Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection.","volume":"5","author":"Roe","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"B236","doi-asserted-by":"publisher","first-page":"6019","DOI":"10.1523\/JNEUROSCI.1251-06.2006","article-title":"Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.","volume":"26","author":"Rong","year":"2006","journal-title":"J. Neurosci."},{"key":"B237","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: a clinical review.","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"B238","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease.","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"B239","doi-asserted-by":"publisher","first-page":"E8294","DOI":"10.1073\/pnas.1704294114","article-title":"Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS.","volume":"114","author":"Rudnick","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000768","article-title":"USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.","volume":"3","author":"Rusilowicz-Jones","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102061","article-title":"Early death of ALS-linked CHCHD10-R15L transgenic mice with central nervous system, skeletal muscle, and cardiac pathology.","volume":"24","author":"Ryan","year":"2021","journal-title":"iScience"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03241-9","article-title":"Cardiolipin exposure on the outer mitochondrial membrane modulates alpha-synuclein.","volume":"9","author":"Ryan","year":"2018","journal-title":"Nat. Commun."},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01024","article-title":"Optineurin: a coordinator of membrane-associated cargo trafficking and autophagy.","volume":"9","author":"Ryan","year":"2018","journal-title":"Front. Immunol."},{"key":"B244","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrm3658","article-title":"Chaperone machines for protein folding, unfolding and disaggregation.","volume":"14","author":"Saibil","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B245","first-page":"2095","article-title":"The axonal transport of mitochondria.","volume":"125","author":"Saxton","year":"2012","journal-title":"J. Cell Sci."},{"key":"B246","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1152\/physrev.00025.2007","article-title":"Transcriptional paradigms in mammalian mitochondrial biogenesis and function.","volume":"88","author":"Scarpulla","year":"2008","journal-title":"Physiol. Rev."},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02776-4","article-title":"Altered mitochondrial dynamics and function in APOE4-expressing astrocytes.","volume":"11","author":"Schmukler","year":"2020","journal-title":"Cell Death Dis."},{"key":"B248","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1073\/pnas.86.5.1548","article-title":"Dynein is the motor for retrograde axonal-transport of organelles.","volume":"86","author":"Schnapp","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B249","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism.","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell."},{"key":"B250","first-page":"65","article-title":"The biological function of the Huntingtin protein and its relevance to Huntington\u2019s disease pathology.","volume":"5","author":"Schulte","year":"2011","journal-title":"Curr. Trends Neurol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00401-018-1873-4","article-title":"Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson\u2019s models.","volume":"136","author":"Shaltouki","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B252","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.molcel.2015.08.009","article-title":"SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.","volume":"60","author":"Shanmughapriya","year":"2015","journal-title":"Mol. Cell."},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00568","article-title":"Activation of mitochondrial unfolded protein response in SHSY5Y expressing APP cells and APP\/PS1 mice.","volume":"13","author":"Shen","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B254","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00568","article-title":"Activation of mitochondrial unfolded protein response in SHSY5Y expressing APP cells and APP\/PS1 mice.","volume":"13","author":"Shen","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"B255","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B256","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.bbadis.2010.05.008","article-title":"Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport.","volume":"1802","author":"Shi","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20597-z","article-title":"LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.","volume":"12","author":"Shin","year":"2021","journal-title":"Nat. Commun."},{"key":"B258","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington\u2019s disease: implications for selective neuronal damage.","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B259","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.nbd.2009.02.005","article-title":"Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia.","volume":"34","author":"Silva","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B260","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF03033565","article-title":"The 6-hydroxydopamine model of Parkinson\u2019s disease.","volume":"11","author":"Simola","year":"2007","journal-title":"Neurotox. Res."},{"key":"B261","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.brainres.2018.06.010","article-title":"LRRK2 and mitochondria: recent advances and current views.","volume":"1702","author":"Singh","year":"2019","journal-title":"Brain Res."},{"key":"B262","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2017.06.052","article-title":"The role of mitochondria in amyotrophic lateral sclerosis.","volume":"710","author":"Smith","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B263","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease.","volume":"25","author":"Snow","year":"2010","journal-title":"Mov. Disord."},{"key":"B264","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.bbadis.2012.07.009","article-title":"The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson\u2019s disease.","volume":"1832","author":"Solesio","year":"2013","journal-title":"Biochimica Biophys. Acta-Mol. Basis Dis."},{"key":"B265","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"key":"B266","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.nbd.2012.07.004","article-title":"Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1alpha.","volume":"51","author":"Song","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B267","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1091\/mbc.e09-03-0252","article-title":"Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.","volume":"20","author":"Song","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"B268","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity.","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.31.446345","article-title":"Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.","author":"Soto","year":"2021","journal-title":"bioRxiv [preprint]."},{"key":"B270","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1091\/mbc.E11-08-0674","article-title":"YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation.","volume":"23","author":"Stiburek","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"B271","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/hmg\/ddab078","article-title":"Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses.","volume":"30","author":"Straub","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B272","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1093\/hmg\/ddt301","article-title":"Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.","volume":"22","author":"Su","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113842","article-title":"Valosin-Containing protein, a calcium-associated ATPase protein, in endoplasmic reticulum and mitochondrial function and its implications for diseases.","volume":"21","author":"Sun","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B274","doi-asserted-by":"publisher","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B275","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/nn.2372","article-title":"Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.","volume":"12","author":"Tain","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.3390\/cells5010001","article-title":"MIRO GTPases in mitochondrial transport.","volume":"5","author":"Tang","year":"2016","journal-title":"Homeostasis Pathol. Cells"},{"key":"B277","doi-asserted-by":"publisher","first-page":"10613","DOI":"10.1523\/JNEUROSCI.0042-15.2015","article-title":"VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson\u2019s disease.","volume":"35","author":"Tang","year":"2015","journal-title":"J. Neurosci."},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113820","article-title":"Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis. import, and assembly pathways.","volume":"21","author":"Tang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B279","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/NEN.0b013e318275df4b","article-title":"Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS.","volume":"71","author":"Thau","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/hmg\/ddq430","article-title":"DJ-1 acts in parallel to the PINK1\/parkin pathway to control mitochondrial function and autophagy.","volume":"20","author":"Thomas","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004279","article-title":"PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.","volume":"10","author":"Thomas","year":"2014","journal-title":"PLoS Genetics"},{"key":"B282","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.cell.2016.04.011","article-title":"Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt.","volume":"165","author":"Tian","year":"2016","journal-title":"Cell"},{"key":"B283","doi-asserted-by":"publisher","first-page":"10528","DOI":"10.1074\/jbc.M116.719286","article-title":"Trehalose alters subcellular trafficking and the metabolism of the alzheimer-associated amyloid precursor protein.","volume":"291","author":"Tien","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.612757","article-title":"Defective autophagy and mitophagy in aging and Alzheimer\u2019s disease.","volume":"14","author":"Tran","year":"2020","journal-title":"Front. Neurosci."},{"key":"B285","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2013.05.002","article-title":"SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.","volume":"63","author":"Tseng","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1alpha rescues Huntington\u2019s disease proteotoxicity by preventing oxidative stress and promoting TFEB function.","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00930","article-title":"Intracellular and intercellular mitochondrial dynamics in Parkinson\u2019s disease.","volume":"13","author":"Valdinocci","year":"2019","journal-title":"Front. Neurosci."},{"key":"B288","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin.","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"B290","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/ana.25273","article-title":"CHCHD10 variants in amyotrophic lateral sclerosis: where is the evidence?","volume":"84","author":"Veldink","year":"2018","journal-title":"Ann. Neurol."},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60273-2","article-title":"In vitro CRISPR\/Cas9-Directed gene editing to model LRRK2 G2019S Parkinson\u2019s disease in common marmosets.","volume":"10","author":"Vermilyea","year":"2020","journal-title":"Sci. Rep."},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.613211","article-title":"Bexarotene impairs cognition and produces hypothyroidism in a mouse model of down syndrome and Alzheimer\u2019s disease.","volume":"12","author":"Vidal","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B293","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mito.2021.04.005","article-title":"Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer\u2019s disease.","volume":"59","author":"Vijayan","year":"2021","journal-title":"Mitochondrion"},{"key":"B294","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","article-title":"VPS35 mutations in Parkinson disease.","volume":"89","author":"Vilarino-Guell","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B295","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","article-title":"Activation of the human mitochondrial transcription factor a gene by nuclear respiratory factors - a potential regulatory link between nuclear and mitochondrial gene-expression in organelle biogenesis.","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B296","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.0911187107","article-title":"PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.","volume":"107","author":"Vives-Bauza","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B297","doi-asserted-by":"publisher","first-page":"30317","DOI":"10.1074\/jbc.M112.365890","article-title":"Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.","volume":"287","author":"Walls","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B298","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1460-9568.2007.05663.x","article-title":"Nortriptyline delays disease onset in models of chronic neurodegeneration.","volume":"26","author":"Wang","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B299","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.cmet.2018.06.011","article-title":"Mitofusin 2 regulates axonal transport of calpastatin to prevent neuromuscular synaptic elimination in skeletal muscles.","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Metab."},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007947","article-title":"TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.","volume":"15","author":"Wang","year":"2019","journal-title":"PLoS Genet"},{"key":"B301","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/cns.13140","article-title":"Mechanisms and roles of mitophagy in neurodegenerative diseases.","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"B302","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B303","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B304","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm.3983","article-title":"Parkinson\u2019s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"B305","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature14859","article-title":"A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death.","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"B306","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cell.2008.11.046","article-title":"The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility.","volume":"136","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"B307","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer\u2019s disease.","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"B308","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1523\/jneurosci.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer\u2019s disease.","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"B309","doi-asserted-by":"publisher","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins.","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B310","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins.","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B311","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.cell.2011.10.018","article-title":"PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.","volume":"147","author":"Wang","year":"2011","journal-title":"Cell"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117322","article-title":"Parkin overexpression attenuates a beta-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy.","volume":"244","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"B313","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1007\/s12035-020-01955-w","article-title":"Upregulation of AMPK ameliorates Alzheimer\u2019s disease-like tau pathology and memory impairment.","volume":"57","author":"Wang","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B314","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/15548627.2019.1603548","article-title":"LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.","volume":"16","author":"Wauters","year":"2020","journal-title":"Autophagy"},{"key":"B315","doi-asserted-by":"publisher","first-page":"613","DOI":"10.2174\/1570159X18666200123165002","article-title":"A new vision of mitochondrial unfolded protein response to the sirtuin family.","volume":"18","author":"Weng","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"B316","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.immuni.2017.02.018","article-title":"The ubiquitin binding protein TAX1BP1 mediates autophagasome induction and the metabolic transition of activated T cells.","volume":"46","author":"Whang","year":"2017","journal-title":"Immunity"},{"key":"B317","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature14951","article-title":"Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.","volume":"524","author":"Wrobel","year":"2015","journal-title":"Nature"},{"key":"B318","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.bbadis.2018.05.018","article-title":"MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1alpha.","volume":"1864","author":"Xi","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"B319","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuroscience.2013.10.011","article-title":"Inhibition of mitochondrial fission attenuates a beta-induced microglia apoptosis.","volume":"256","author":"Xie","year":"2014","journal-title":"Neuroscience"},{"key":"B320","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11011-018-0346-8","article-title":"Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer\u2019s disease model mice.","volume":"34","author":"Xie","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"B321","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-3-319-49969-7_9","article-title":"Models of LRRK2-Associated Parkinson\u2019s disease.","volume":"14","author":"Xiong","year":"2017","journal-title":"Adv. Neurobiol."},{"key":"B322","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1523\/JNEUROSCI.1630-10.2010","article-title":"Wild-Type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.","volume":"30","author":"Xu","year":"2010","journal-title":"J. Neurosci."},{"key":"B323","doi-asserted-by":"publisher","first-page":"16593","DOI":"10.1073\/pnas.1904101116","article-title":"Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.","volume":"116","author":"Yablonska","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B324","doi-asserted-by":"publisher","first-page":"300","DOI":"10.15252\/embr.201541486","article-title":"The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.","volume":"17","author":"Yamano","year":"2016","journal-title":"EMBO Rep."},{"key":"B325","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3 beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer\u2019s disease.","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B326","doi-asserted-by":"publisher","first-page":"16852","DOI":"10.18632\/aging.103578","article-title":"Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans.","volume":"12","author":"Yang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B327","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/hmg\/ddv056","article-title":"Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer\u2019s disease patient brains.","volume":"24","author":"Ye","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B328","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1530\/JME-18-0005","article-title":"The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases.","volume":"61","author":"Yi","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"B329","doi-asserted-by":"publisher","first-page":"18947","DOI":"10.1074\/jbc.M113.466870","article-title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cdelta (PKCdelta) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury.","volume":"288","author":"Yogalingam","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B330","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.jmb.2018.07.027","article-title":"Mechanisms orchestrating mitochondrial dynamics for energy homeostasis.","volume":"430","author":"Yu","year":"2018","journal-title":"J. Mol. Biol."},{"key":"B331","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1002\/2211-5463.13273","article-title":"Activation of ERK-Drp1 signaling promotes hypoxia-induced Abeta accumulation by upregulating mitochondrial fission and BACE1 activity.","volume":"11","author":"Yuan","year":"2021","journal-title":"FEBS Open Bio"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00078","article-title":"Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts.","volume":"6","author":"Zanellati","year":"2015","journal-title":"Front. Genet."},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1038\/srep18725","article-title":"Altered brain energetics induces mitochondrial fission arrest in Alzheimer\u2019s disease.","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"B334","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1089\/ars.2016.6634","article-title":"The essential role of drp1 and its regulation by S-Nitrosylation of parkin in dopaminergic neurodegeneration: implications for Parkinson\u2019s disease.","volume":"25","author":"Zhang","year":"2016","journal-title":"Antioxid. Redox. Signal."},{"key":"B335","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.neuropharm.2017.12.021","article-title":"Citalopram restores short-term memory deficit and non-cognitive behaviors in APP\/PS1 mice while halting the advance of Alzheimer\u2019s disease-like pathology.","volume":"131","author":"Zhang","year":"2018","journal-title":"Neuropharmacology"},{"key":"B336","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.gendis.2020.08.011","article-title":"The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): a promising biomarker and potential therapeutic target of human diseases.","volume":"8","author":"Zhang","year":"2021","journal-title":"Genes Dis."},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1238687","article-title":"Citalopram ameliorates impairments in spatial memory and synaptic plasticity in female 3xTgAD mice.","volume":"2017","author":"Zhang","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb8680","article-title":"Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer\u2019s disease.","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci. Adv."},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7593608","article-title":"Berberine alleviates amyloid beta-induced mitochondrial dysfunction and synaptic loss.","volume":"2019","author":"Zhao","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09291-x","article-title":"ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a mitochondria-targeted hydrogen sulfide donor, supports cellular bioenergetics and protects against Alzheimer\u2019s disease by preserving mitochondrial function in APP\/PS1 mice and neurons.","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B342","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells.","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO J."},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001059","article-title":"PGC-1 alpha, a potential therapeutic target for early intervention in Parkinson\u2019s disease.","volume":"2","author":"Zheng","year":"2010","journal-title":"Sci. Trans. Med."},{"key":"B344","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/cns.13122","article-title":"Mitochondrial transport serves as a mitochondrial quality control strategy in axons: implications for central nervous system disorders.","volume":"25","author":"Zheng","year":"2019","journal-title":"CNS Neurosci. Therapeut."},{"key":"B345","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2020.12.013","article-title":"Mitochondrial unfolded protein response: an emerging pathway in human diseases.","volume":"163","author":"Zhu","year":"2021","journal-title":"Free Radical Biol. Med."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.746873\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T14:52:19Z","timestamp":1699800739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.746873\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":345,"alternative-id":["10.3389\/fnins.2021.746873"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.746873","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,12]]},"article-number":"746873"}}