{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:43:43Z","timestamp":1793879023576,"version":"4.7.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> The central nervous mechanism of acute tinnitus is different from that of chronic tinnitus, which may be related to the difference of cerebral blood flow (CBF) perfusion in certain regions. To verify this conjecture, we used arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in this study to compare the CBF alterations of patients with acute and chronic tinnitus.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The current study included patients with chronic tinnitus (<jats:italic>n<\/jats:italic> = 35), acute tinnitus (<jats:italic>n<\/jats:italic> = 30), and healthy controls (<jats:italic>n<\/jats:italic> = 40) who were age-, sex-, and education-matched. All participants underwent MRI scanning and then ASL images were obtained to measure CBF of the entire brain and analyze the differences between groups as well as the correlations with tinnitus characteristics.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The chronic tinnitus group showed increased z-CBF in the right superior temporal gyrus (STG) and superior frontal gyrus (SFG) when compared with the acute tinnitus patients. Further connectivity analysis found enhanced CBF connectivity between the right STG and fusiform gyrus (FG), the right SFG and left middle occipital gyrus (MOG), as well as the right parahippocampal gyrus (PHG). Moreover, in the chronic tinnitus group, the tinnitus handicap questionnaire (THQ) score was positively correlated with the normalized z-CBF of right STG (<jats:italic>r<\/jats:italic> = 0.440, <jats:italic>p<\/jats:italic> = 0.013).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our results confirmed that the CBF changes in some brain regions were different between acute and chronic tinnitus patients, which was correlated with certain tinnitus characteristics. This is of great value to further research on chronicity of tinnitus, and ASL has a promising application in the measurement of CBF.<\/jats:p>","DOI":"10.3389\/fnins.2021.752419","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T05:54:48Z","timestamp":1633413288000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study"],"prefix":"10.3389","volume":"15","author":[{"given":"Jinghua","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2019an","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00234-012-1044-6","article-title":"Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging.","volume":"54","author":"Aldhafeeri","year":"2012","journal-title":"Neuroradiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pscychresns.2009.04.015","article-title":"Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder.","volume":"174","author":"Almeida","year":"2009","journal-title":"Psychiatry Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1080\/00016480050218717","article-title":"Regional cerebral blood flow during tinnitus: a PET case study with lidocaine and auditory stimulation.","volume":"120","author":"Andersson","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.neuron.2011.05.040","article-title":"Differences between neural activity in prefrontal cortex and striatum during learning of novel abstract categories.","volume":"71","author":"Antzoulatos","year":"2011","journal-title":"Neuron"},{"key":"B5","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.mri.2010.03.037","article-title":"On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow.","volume":"28","author":"Aslan","year":"2010","journal-title":"Magn. Reson. Imaging"},{"key":"B6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s11682-018-9877-1","article-title":"Arterial spin labeling reveals relationships between resting cerebral perfusion and motor learning in Parkinson\u2019s disease.","volume":"13","author":"Barzgari","year":"2019","journal-title":"Brain Imaging Behav."},{"key":"B7","doi-asserted-by":"publisher","first-page":"102166","DOI":"10.1016\/j.nicl.2020.102166","article-title":"A 7 Tesla fMRI investigation of human tinnitus percept in cortical and subcortical auditory areas.","volume":"25","author":"Berlot","year":"2020","journal-title":"NeuroImage"},{"key":"B8","doi-asserted-by":"publisher","first-page":"101976","DOI":"10.1016\/j.nicl.2019.101976","article-title":"Chronic tinnitus and the limbic system: reappraising brain structural effects of distress and affective symptoms.","volume":"24","author":"Besteher","year":"2019","journal-title":"Neuroimage"},{"key":"B9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.heares.2019.02.008","article-title":"Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages.","volume":"377","author":"Biswas","year":"2019","journal-title":"Hear. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2202-13-3","article-title":"Altered networks in bothersome tinnitus: a functional connectivity study.","volume":"13","author":"Burton","year":"2012","journal-title":"BMC Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.3389\/fnins.2019.01314","article-title":"Abnormal spontaneous neural activity of the central auditory system changes the functional connectivity in the tinnitus brain: a resting-state functional MRI study.","volume":"13","author":"Cai","year":"2019","journal-title":"Front. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"700670","DOI":"10.3389\/fnins.2021.700670","article-title":"Editorial: neuroimaging approaches to the study of tinnitus and hyperacusis.","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fnagi.2016.00174","article-title":"Disrupted brain functional network architecture in chronic tinnitus patients.","volume":"8","author":"Chen","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B14","doi-asserted-by":"crossref","first-page":"e06576","DOI":"10.7554\/eLife.06576","article-title":"Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network.","volume":"4","author":"Chen","year":"","journal-title":"Elife"},{"key":"B15","first-page":"475382","article-title":"Altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus.","volume":"2015","author":"Chen","year":"","journal-title":"Neural Plast."},{"key":"B16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3389\/fncir.2015.00067","article-title":"Frequency-specific alternations in the amplitude of low-frequency fluctuations in chronic tinnitus.","volume":"9","author":"Chen","year":"","journal-title":"Front. Neural Circuits"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/hbm.23525","article-title":"Tinnitus distress is linked to enhanced resting-state functional connectivity from the limbic system to the auditory cortex.","volume":"38","author":"Chen","year":"","journal-title":"Hum. Brain Mapp."},{"key":"B18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fnhum.2017.00022","article-title":"Resting-state brain abnormalities in chronic subjective tinnitus: a meta-analysis.","volume":"11","author":"Chen","year":"","journal-title":"Front. Hum. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.21037\/qims.2018.11.04","article-title":"Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus.","volume":"8","author":"Chen","year":"2018","journal-title":"Quant. Imaging Med. Surg."},{"key":"B20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.nicl.2014.09.011","article-title":"Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI.","volume":"6","author":"Chen","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00106-019-0633-7","article-title":"A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment.","volume":"67","author":"Cima","year":"2019","journal-title":"HNO"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.11.002","article-title":"Interaction of language, auditory and memory brain networks in auditory verbal hallucinations.","volume":"148","author":"\u0106ur\u010di\u0107-Blake","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1080\/03655230600895580","article-title":"Amygdalohippocampal involvement in tinnitus and auditory memory.","volume":"126","author":"De Ridder","year":"2006","journal-title":"Acta OtoLaryngol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/s1388-2457(02)00038-x","article-title":"Technical aspects and utility of fMRI using BOLD and ASL.","volume":"113","author":"Detre","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1176\/appi.ajp.2009.09040456","article-title":"Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia.","volume":"167","author":"Diederen","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/s0385-8146(02)00122-0","article-title":"Central tinnitus.","volume":"30","author":"Eggermont","year":"2003","journal-title":"Auris Nasus Larynx"},{"key":"B27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus.","volume":"27","author":"Eggermont","year":"2004","journal-title":"Trends Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fnagi.2018.00059","article-title":"Increased resting-state cerebellar-cerebral functional connectivity underlying chronic tinnitus.","volume":"10","author":"Feng","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.diii.2013.06.010","article-title":"Arterial spin labeling (ASL) perfusion: techniques and clinical use.","volume":"94","author":"Ferr\u00e9","year":"2013","journal-title":"Diagn. Interv. Imaging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroscience.2013.10.015","article-title":"Asymmetry in primary auditory cortex activity in tinnitus patients and controls.","volume":"256","author":"Geven","year":"2014","journal-title":"Neuroscience"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s00234-018-2087-0","article-title":"Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study.","volume":"60","author":"Han","year":"2018","journal-title":"Neuroradiology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1177\/0284185117752552","article-title":"Arterial spin labeling: a technical overview.","volume":"59","author":"Havsteen","year":"2018","journal-title":"Acta Radiol."},{"key":"B33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.otc.2020.03.002","article-title":"Tinnitus: an epidemiologic perspective.","volume":"53","author":"Henry","year":"2020","journal-title":"Otolaryngol. Clin. North Am."},{"key":"B34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainres.2015.05.010","article-title":"Alterations to the attention system in adults with tinnitus are modality specific.","volume":"1620","author":"Husain","year":"2015","journal-title":"Brain Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1177\/1971400920977031","article-title":"A pictorial review of brain arterial spin labelling artefacts and their potential remedies in clinical studies.","volume":"34","author":"Jaganmohan","year":"2021","journal-title":"Neuroradiol. J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuroimage.2014.11.028","article-title":"Functional connectivity in BOLD and CBF data: similarity and reliability of resting brain networks.","volume":"106","author":"Jann","year":"2015","journal-title":"Neuroimage"},{"key":"B37","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0168-0102(90)90031-9","article-title":"Phantom auditory perception (tinnitus): mechanisms of generation and perception.","volume":"8","author":"Jastreboff","year":"1990","journal-title":"Neurosci. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1159\/000067570","article-title":"Psychometric normalization of a hyperacusis questionnaire.","volume":"64","author":"Khalfa","year":"2002","journal-title":"ORL"},{"key":"B39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jocn.2018.10.098","article-title":"Preoperative localization of the sensorimotor cortex and measurement of tumor perfusion in a single acquisition using ASL technique.","volume":"59","author":"Kim","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/00003446-199012000-00005","article-title":"The psychometric properties of a tinnitus handicap questionnaire.","volume":"11","author":"Kuk","year":"1990","journal-title":"Ear Hear."},{"key":"B41","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/hbm.25238","article-title":"Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.","volume":"42","author":"Lan","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2009.06.009","article-title":"Neural activity underlying tinnitus generation: results from PET and fMRI.","volume":"255","author":"Lanting","year":"2009","journal-title":"Hear. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e87839","DOI":"10.1371\/journal.pone.0087839","article-title":"Memory networks in tinnitus: a functional brain image study.","volume":"9","author":"Laureano","year":"2014","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2174371","article-title":"Cerebral blood flow and its connectivity deficits in mild traumatic brain injury at the acute stage.","volume":"2020","author":"Li","year":"2020","journal-title":"Neural Plast."},{"key":"B45","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fnhum.2020.591260","article-title":"Lateralization effects on cerebral blood flow in patients with unilateral pulsatile tinnitus measured With arterial spin labeling.","volume":"14","author":"Li","year":"2020","journal-title":"Front. Hum. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"20200990","DOI":"10.1259\/bjr.20200990","article-title":"Altered cerebral blood flow in patients with unilateral venous pulsatile tinnitus: an arterial spin labeling study.","volume":"94","author":"Li","year":"2021","journal-title":"Br. J. Radiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bandc.2009.09.009","article-title":"The right parahippocampal gyrus contributes to the formation and maintenance of bound information in working memory.","volume":"72","author":"Luck","year":"2010","journal-title":"Brain Cogn."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/j.neuroscience.2009.05.028","article-title":"Activity-dependent depression of medial prefrontal cortex inputs to accumbens neurons by the basolateral amygdala.","volume":"162","author":"McGinty","year":"2009","journal-title":"Neuroscience"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1523\/jneurosci.4623-06.2007","article-title":"Synchronization of neural activity across cortical areas correlates with conscious perception.","volume":"27","author":"Melloni","year":"2007","journal-title":"J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/s0079-6123(07)66003-8","article-title":"The role of neural plasticity in tinnitus","author":"M\u00f8ller","year":"2007","journal-title":"Progress in Brain Research"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1371\/journal.pmed.0020153","article-title":"Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography.","volume":"2","author":"Nathan","year":"2005","journal-title":"PLoS Med."},{"key":"B52","first-page":"171","article-title":"Hearing loss and the elderly-a primer.","volume":"3","author":"Olaosun","year":"2013","journal-title":"Population"},{"key":"B53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40134-017-0199-7","article-title":"Pulsatile tinnitus: differential diagnosis and radiological work-up.","volume":"5","author":"Pegge","year":"2017","journal-title":"Curr. Radiol. Rep."},{"key":"B54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain\u2019s default mode network.","volume":"38","author":"Raichle","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","article-title":"Tuning out the noise: limbic-auditory interactions in tinnitus.","volume":"66","author":"Rauschecker","year":"2010","journal-title":"Neuron"},{"key":"B56","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.tics.2015.08.002","article-title":"Frontostriatal gating of tinnitus and chronic pain.","volume":"19","author":"Rauschecker","year":"2015","journal-title":"Trends Cogn. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s0378-5955(02)00346-5","article-title":"Brain imaging of the effects of lidocaine on tinnitus.","volume":"171","author":"Reyes","year":"2002","journal-title":"Hear. Res."},{"key":"B58","doi-asserted-by":"crossref","first-page":"436146","DOI":"10.1155\/2014\/436146","article-title":"Reduced variability of auditory alpha activity in chronic tinnitus.","volume":"2014","author":"Schlee","year":"2014","journal-title":"Neural Plast."},{"key":"B59","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.nicl.2017.07.015","article-title":"Connectivity of precuneus to the default mode and dorsal attention networks: a possible invariant marker of long-term tinnitus.","volume":"16","author":"Schmidt","year":"2017","journal-title":"Neuroimage Clin."},{"key":"B60","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.brainres.2017.11.012","article-title":"Changes in gray and white matter in subgroups within the tinnitus population.","volume":"1679","author":"Schmidt","year":"2018","journal-title":"Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/s0079-6123(07)66043-9","article-title":"Object identification and attention training for treating tinnitus","author":"Searchfield","year":"2007","journal-title":"Progress in Brain Research"},{"key":"B62","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/hbm.25223","article-title":"Motor asymmetry related cerebral perfusion patterns in Parkinson\u2019s disease: an arterial spin labeling study.","volume":"42","author":"Shang","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/jmri.24751","article-title":"Arterial spin labeling MRI: clinical applications in the brain.","volume":"41","author":"Telischak","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"B64","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neulet.2018.11.037","article-title":"Cortico-limbic pain mechanisms.","volume":"702","author":"Thompson","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e0137291","DOI":"10.1371\/journal.pone.0137291","article-title":"Alterations of regional cerebral blood flow in tinnitus patients as assessed using single-photon emission computed tomography.","volume":"10","author":"Ueyama","year":"2015","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1460-9568.2011.07793.x","article-title":"The neural network of phantom sound changes over time: a comparison between recent-onset and chronic tinnitus patients.","volume":"34","author":"Vanneste","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3389\/fneur.2020.00997","article-title":"From acute to chronic tinnitus: pilot data on predictors and progression.","volume":"11","author":"Vielsmeier","year":"2020","journal-title":"Front. Neurol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3389\/fneur.2017.00605","article-title":"Transition from acute to chronic tinnitus: predictors for the development of chronic distressing tinnitus.","volume":"8","author":"Wallh\u00e4usser-Franke","year":"2017","journal-title":"Front. Neurol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.mri.2007.07.003","article-title":"Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx.","volume":"26","author":"Wang","year":"2008","journal-title":"Magn. Reson. Imaging"},{"key":"B70","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuropsychologia.2015.06.033","article-title":"The anatomical and functional specialization of the fusiform gyrus.","volume":"83","author":"Weiner","year":"2016","journal-title":"Neuropsychologia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"623520","DOI":"10.3389\/fnins.2020.623520","article-title":"Glucose control has an impact on cerebral blood flow alterations in chronic tinnitus patients.","volume":"14","author":"Xia","year":"2020","journal-title":"Front. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/nbm.1462","article-title":"Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer\u2019s disease.","volume":"23","author":"Xu","year":"2010","journal-title":"NMR Biomed."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.3389\/fnins.2019.01299","article-title":"Chronic tinnitus exhibits bidirectional functional dysconnectivity in frontostriatal circuit.","volume":"13","author":"Xu","year":"2019","journal-title":"Front. Neurosci."},{"key":"B74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s10194-021-01280-0","article-title":"Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study.","volume":"22","author":"Xu","year":"2021","journal-title":"J. Headache Pain"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.neuron.2019.04.023","article-title":"The encoding of speech sounds in the superior temporal gyrus.","volume":"102","author":"Yi","year":"2019","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.ejrad.2015.04.006","article-title":"Impairments of thalamic resting-state functional connectivity in patients with chronic tinnitus.","volume":"84","author":"Zhang","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neubiorev.2016.11.023","article-title":"Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer\u2019s disease.","volume":"72","author":"Zhang","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B78","doi-asserted-by":"publisher","first-page":"738","DOI":"10.3389\/fnins.2019.00738","article-title":"Disrupted regional cerebral blood flow, functional activity and connectivity in Alzheimer\u2019s disease: a combined ASL perfusion and resting state fMRI study.","volume":"13","author":"Zheng","year":"2019","journal-title":"Front. Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1162\/netn_a_00053","article-title":"Dissociating tinnitus patients from healthy controls using resting-state cyclicity analysis and clustering.","volume":"3","author":"Zimmerman","year":"2019","journal-title":"Netw. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.752419\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T05:55:04Z","timestamp":1633413304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.752419\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":79,"alternative-id":["10.3389\/fnins.2021.752419"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.752419","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"article-number":"752419"}}