{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:54:58Z","timestamp":1790189698372,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272495"],"award-info":[{"award-number":["81272495"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["16JC2DJC32200"],"award-info":[{"award-number":["16JC2DJC32200"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Parkinson\u2019s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This paper constructed a simulation model of TMAS based on volunteer\u2019s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W\u22c5cm<jats:sup>\u20132<\/jats:sup> sound intensity can effectively modulate PD states with RI \u2265 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W\u22c5cm<jats:sup>\u20132<\/jats:sup>. And the sound pressure level is in the range of \u22121 dB (the induced current difference is less than or equal to 0.019 \u03bcA\u22c5cm<jats:sup>\u20132<\/jats:sup>). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> TMAS can modulates the state of PD.<\/jats:p>","DOI":"10.3389\/fnins.2021.761720","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:34:39Z","timestamp":1634754879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Yanqiu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichao","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqi","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1016\/j.jhep.2008.01.010","article-title":"Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis.","volume":"48","author":"Angeli","year":"2008","journal-title":"J. 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