{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:21:55Z","timestamp":1787728915582,"version":"build-2784847793"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The clinical outcome of patients suffering from stroke is dependent on multiple factors. The features of the lesion itself play an important role but clinical recovery is remarkably influenced by the plasticity mechanisms triggered by the stroke and occurring at a distance from the lesion. The latter translate into functional and structural changes of which cortical thickness might be easy to quantify one of the main players. However, studies on the changes of cortical thickness in brain areas beyond stroke lesion and their relationship to sensory-motor recovery are sparse.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> To evaluate the effects of cerebral stroke on cortical thickness (CT) beyond the stroke lesion and its association with sensory-motor recovery.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> Five electronic databases (PubMed, Embase, Web of Science, Scopus and the Cochrane Library) were searched. Methodological quality of the included studies was assessed with the Newcastle-Ottawa Scale for non-randomized controlled trials and the Risk of Bias Cochrane tool for randomized controlled trials.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The search strategy retrieved 821 records, 12 studies were included and risk of bias assessed. In most of the included studies, cortical thinning was seen at the ipsilesional motor area (M1). Cortical thinning can occur beyond the stroke lesion, typically in regions anatomically connected because of anterograde degeneration. Nonetheless, studies also reported cortical thickening of regions of the unaffected hemisphere, likely related to compensatory plasticity. Some studies revealed a significant correlation between changes in cortical thickness of M1 or somatosensory (S1) cortical areas and motor function recovery.<\/jats:p><jats:p><jats:bold>Discussion and Conclusions:<\/jats:bold> Following a stroke, changes in cortical thickness occur both in regions directly connected to the stroke lesion and in contralateral hemisphere areas as well as in the cerebellum. The underlying mechanisms leading to these changes in cortical thickness are still to be fully understood and further research in the field is needed.<\/jats:p><jats:p><jats:bold>Systematic Review Registration:<\/jats:bold><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42020200539<\/jats:ext-link>; PROSPERO 2020, identifier: CRD42020200539.<\/jats:p>","DOI":"10.3389\/fnins.2021.764671","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T07:33:56Z","timestamp":1635924836000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cortical Thickness of Brain Areas Beyond Stroke Lesions and Sensory-Motor Recovery: A Systematic Review"],"prefix":"10.3389","volume":"15","author":[{"given":"Anna Maria","family":"Cortese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Cacciante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lisa","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Turolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1093\/brain\/awx021","article-title":"Decreased integration and information capacity in stroke measured by whole brain models of resting state activity","volume":"140","author":"Adhikari","year":"2017","journal-title":"Brain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.brs.2016.12.005","article-title":"Cathodal transcranial direct current stimulation reduces seizure frequency in adults with drug-resistant temporal lobe epilepsy: A sham controlled study","volume":"10","author":"Assenza","year":"2017","journal-title":"Brain Stimul."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.clinph.2014.09.029","article-title":"Wakefulness delta waves increase after cortical plasticity induction","volume":"126","author":"Assenza","year":"2015","journal-title":"Clin. 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