{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:44:12Z","timestamp":1788385452832,"version":"build-2803163510"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22120210192"],"award-info":[{"award-number":["22120210192"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22120210368"],"award-info":[{"award-number":["22120210368"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101486"],"award-info":[{"award-number":["82101486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s and Parkinson\u2019s diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (A\u03b2) and \u03b1-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs\/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of A\u03b2 and \u03b1-synuclein in mediating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnins.2021.781722","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T06:01:40Z","timestamp":1637215300000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies"],"prefix":"10.3389","volume":"15","author":[{"given":"Jinwen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.15252\/embj.201593411","article-title":"Tunneling nanotubes spread fibrillar alpha-synuclein by intercellular trafficking of lysosomes.","volume":"35","author":"Abounit","year":"2016","journal-title":"EMBO J."},{"key":"B2","doi-asserted-by":"crossref","first-page":"1647.e19","DOI":"10.1016\/j.cell.2019.11.025","article-title":"Wide gene expression and cell atlas of the developing human heart.","volume":"179","author":"Asp","year":"2019","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nm.3885","article-title":"Inhibition of amyloid-beta plaque formation by alpha-synuclein.","volume":"21","author":"Bachhuber","year":"2015","journal-title":"Nat. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/mds.27902","article-title":"Prevalence and clinical aspects of mild cognitive impairment in Parkinson\u2019s disease: a meta-analysis.","volume":"35","author":"Baiano","year":"2020","journal-title":"Mov. Disord."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192193","article-title":"alpha-Synuclein modulates tau spreading in mouse brains.","volume":"218","author":"Bassil","year":"2021","journal-title":"J. Exp. Med."},{"key":"B6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-beta deposition.","volume":"14","author":"Bero","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease.","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer\u2019s disease in individuals under thirty.","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease.","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00401-016-1538-0","article-title":"Axonal transport and secretion of fibrillar forms of alpha-synuclein, Abeta42 peptide and HTTExon 1.","volume":"131","author":"Brahic","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8138","DOI":"10.1523\/JNEUROSCI.0319-07.2007","article-title":"Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration.","volume":"27","author":"Caudle","year":"2007","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1021\/ja9066207","article-title":"Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis.","volume":"132","author":"Chen","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1523\/JNEUROSCI.3602-07.2008","article-title":"Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.","volume":"28","author":"Chen","year":"2008","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"976.e19","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer\u2019s disease.","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.pneurobio.2016.07.002","article-title":"Expanding the repertoire of L-DOPA\u2019s actions: a comprehensive review of its functional neurochemistry.","volume":"151","author":"De Deurwaerdere","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/acn3.338","article-title":"Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.","volume":"3","author":"Fairfoul","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B18","first-page":"217","article-title":"Electron microscopy of Lewy bodies in the amygdala-parahippocampal region. Comparison with inclusion bodies in the MPTP-treated squirrel monkey.","volume":"69","author":"Forno","year":"1996","journal-title":"Adv. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/ana.23747","article-title":"Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport.","volume":"72","author":"Freundt","year":"2012","journal-title":"Ann. Neurol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0537-x","article-title":"alpha-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons.","volume":"6","author":"Froula","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255555","article-title":"NEURODEGENERATION. Alzheimer\u2019s and Parkinson\u2019s diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein.","volume":"349","author":"Goedert","year":"2015","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.celrep.2016.06.059","article-title":"Cellular taxonomy of the mouse striatum as revealed by single-cell RNA-Seq.","volume":"16","author":"Gokce","year":"2016","journal-title":"Cell Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation.","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1196\/annals.1379.003","article-title":"Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer\u2019s disease.","volume":"1097","author":"Grutzendler","year":"2007","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cell.2013.05.057","article-title":"Distinct alpha-synuclein strains differentially promote tau inclusions in neurons.","volume":"154","author":"Guo","year":"2013","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nm.3457","article-title":"Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.","volume":"20","author":"Guo","year":"2014","journal-title":"Nat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"E3138","DOI":"10.1073\/pnas.1301440110","article-title":"Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.","volume":"110","author":"Holmes","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2642-12.2013","article-title":"Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer\u2019s-like tauopathy.","volume":"33","author":"Iba","year":"2013","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"13482","DOI":"10.1074\/jbc.M117.780296","article-title":"Selective imaging of internalized proteopathic alpha-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.","volume":"292","author":"Karpowicz","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"crossref","first-page":"1276.e17","DOI":"10.1016\/j.cell.2017.05.018","article-title":"Type associated with restricting development of Alzheimer\u2019s disease.","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nbt.4038","article-title":"Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.","volume":"36","author":"Lake","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"93.e6","DOI":"10.1016\/j.stem.2018.10.023","article-title":"Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies hdac4 as a regulator of parkinson cell phenotypes.","volume":"24","author":"Lang","year":"2019","journal-title":"Cell Stem Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00401-018-1829-8","article-title":"Differential alpha-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.","volume":"135","author":"Luna","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B35","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah3374","article-title":"Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3.","volume":"353","author":"Mao","year":"2016","journal-title":"Science"},{"key":"B36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease.","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/brain\/awu043","article-title":"Association of brain amyloid-beta with cerebral perfusion and structure in Alzheimer\u2019s disease and mild cognitive impairment.","volume":"137","author":"Mattsson","year":"2014","journal-title":"Brain"},{"key":"B38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jprot.2016.03.022","article-title":"Identification of proteins that are differentially expressed in brains with Alzheimer\u2019s disease using iTRAQ labeling and tandem mass spectrometry.","volume":"139","author":"Minjarez","year":"2016","journal-title":"J. Proteomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.1073\/pnas.1017275108","article-title":"Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells.","volume":"108","author":"Munch","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B40","doi-asserted-by":"publisher","first-page":"324","DOI":"10.5607\/en.2014.23.4.324","article-title":"Protein transmission, seeding and degradation: key steps for alpha-synuclein prion-like propagation.","volume":"23","author":"Oueslati","year":"2014","journal-title":"Exp. Neurobiol."},{"key":"B41","article-title":"Generation of alpha-synuclein preformed fibrils from monomers and use in vivo.","volume":"2019","author":"Patterson","year":"2019","journal-title":"J. Vis. Exp."},{"key":"B42","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41586-018-0104-4","article-title":"Cellular milieu imparts distinct pathological alpha-synuclein strains in alpha-synucleinopathies.","volume":"557","author":"Peng","year":"2018","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/msj.20157","article-title":"Neuropathology of Alzheimer\u2019s disease.","volume":"77","author":"Perl","year":"2010","journal-title":"Mt Sinai J. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2323.e1","DOI":"10.1016\/j.neurobiolaging.2010.05.025","article-title":"LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier.","volume":"32","author":"Pflanzner","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0199-x","article-title":"Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer\u2019s disease.","volume":"3","author":"Pooler","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nn.4366","article-title":"Disentangling neural cell diversity using single-cell transcriptomics.","volume":"19","author":"Poulin","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jalz.2016.03.002","article-title":"Testing and disclosures related to amyloid imaging and Alzheimer\u2019s disease: common questions and fact sheet summary.","volume":"12","author":"Rabinovici","year":"2016","journal-title":"Alzheimers Dement."},{"key":"B48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/ncb1830","article-title":"Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates.","volume":"11","author":"Ren","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1126\/science.aaw1219","article-title":"Slide-seq: a scalable technology for measuring genome-wide expression at high spatial resolution.","volume":"363","author":"Rodriques","year":"2019","journal-title":"Science"},{"key":"B50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-4939-8820-4_2","article-title":"Ultrasensitive RT-QuIC seed amplification assays for disease-associated tau, alpha-synuclein, and prion aggregates.","volume":"1873","author":"Saijo","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00401-019-02080-2","article-title":"4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.","volume":"139","author":"Saijo","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1038\/s41596-018-0045-2","article-title":"Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections.","volume":"13","author":"Salmen","year":"2018","journal-title":"Nat. Protoc."},{"key":"B53","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years.","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory.","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1080\/01616412.2016.1209337","article-title":"Alzheimer\u2019s disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.","volume":"38","author":"Sharma","year":"2016","journal-title":"Neurol. Res."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice.","volume":"9","author":"Shi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neulet.2015.03.070","article-title":"A novel brain-derived neurotrophic factor-modulating peptide attenuates Abeta1-42-induced neurotoxicity in vitro.","volume":"595","author":"Shin","year":"2015","journal-title":"Neurosci. Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.","volume":"353","author":"Stahl","year":"2016","journal-title":"Science"},{"key":"B59","doi-asserted-by":"publisher","first-page":"11025","DOI":"10.1073\/pnas.1206555109","article-title":"Purified and synthetic Alzheimer\u2019s amyloid beta (Abeta) prions.","volume":"109","author":"Stohr","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainresbull.2009.09.015","article-title":"Conformational diseases: looking into the eyes.","volume":"81","author":"Surguchev","year":"2010","journal-title":"Brain Res. Bull."},{"key":"B61","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2007.03.008","article-title":"D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.","volume":"30","author":"Surmeier","year":"2007","journal-title":"Trends Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell.","volume":"6","author":"Tang","year":"2009","journal-title":"Nat. Methods"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0386-4","article-title":"Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.","volume":"4","author":"Tardivel","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1212\/wnl.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD.","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"B65","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jns.2016.08.053","article-title":"Differences between the behavioral and psychological symptoms of Alzheimer\u2019s disease and Parkinson\u2019s disease.","volume":"369","author":"Tokuchi","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/nn1335","article-title":"Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.","volume":"7","author":"Tsai","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature19470","article-title":"Alzheimer\u2019s disease: structure of aggregates revealed.","volume":"537","author":"Tycko","year":"2016","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in situ tissue profiling.","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat. Methods"},{"key":"B69","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0143-y","article-title":"The release and trans-synaptic transmission of Tau via exosomes.","volume":"12","author":"Wang","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","article-title":"Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.","volume":"288","author":"Wu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in vivo.","volume":"19","author":"Wu","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00401-020-02227-6","article-title":"Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.","volume":"140","author":"Wu","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1523\/JNEUROSCI.0060-19.2019","article-title":"alpha-Synuclein (alphaSyn) preformed fibrils induce endogenous alphaSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons.","volume":"39","author":"Wu","year":"2019","journal-title":"J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00401-015-1477-1","article-title":"Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer\u2019s disease.","volume":"130","author":"Xiang","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1523\/JNEUROSCI.2531-15.2016","article-title":"Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity.","volume":"36","author":"Yuan","year":"2016","journal-title":"J. Neurosci."},{"key":"B78","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer\u2019s disease.","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"cycle of beta amyloid-dependent neuronal hyperactivation.","volume":"365","author":"Zott","year":"2019","journal-title":"Science"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.781722\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T06:01:58Z","timestamp":1637215318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.781722\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":79,"alternative-id":["10.3389\/fnins.2021.781722"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2021.781722","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]},"article-number":"781722"}}