{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:09:33Z","timestamp":1768410573940,"version":"3.49.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["the Science and Technology Planning Project of Guangzhou (grant number: 202102021268)"],"award-info":[{"award-number":["the Science and Technology Planning Project of Guangzhou (grant number: 202102021268)"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Post-traumatic stress disorder (PTSD) can develop after stroke attacks, and its rate ranges from 4 to 37% in the stroke population. Suffering from PTSD not only decreases stroke patient\u2019s quality of life, but also relates to their non-adherence of treatment. Since strokes often recur and progress, long-term medical management is especially important. However, previous studies generally focused on the epidemiological characteristics of post-stroke PTSD, while there are literally no studies on the psychological intervention. In our study, 170 patients with a first-ever stroke during the acute phase were recruited. They were randomized into Psycho-therapy group 1 and Control group 1, and were administered with preventive intervention for PTSD or routine health education, respectively. At 2-month follow-up, PTSD symptoms were evaluated. Participants who were diagnosed with post-stroke PTSD were further randomized into Psycho-therapy group 2 and Control group 2, and received supportive therapy or routine health counseling, respectively. At 6-month follow-up (1\u00b0month after the therapy was completed), PTSD symptoms were re-evaluated. Our results showed that at 2-month, the PTSD incidence in our series was 11.69%, and the severity of stroke was the only risk factor for PTSD development. The preventive intervention was not superior to routine health education for PTSD prevention. At 6-month, results indicated the supportive therapy did have a fine effect in ameliorating symptoms for diagnosed PTSD patients, superior to routine health counseling. Thus, our study was the first to provide evidence that the supportive therapy was effective in treating post-stroke PTSD early after its diagnosis. This clinical trial was preregistered on <jats:ext-link>www.chictr.org.cn<\/jats:ext-link> (ChiCTR2100048411).<\/jats:p>","DOI":"10.3389\/fnins.2022.1007571","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:29:15Z","timestamp":1665062955000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Supportive psychological therapy can effectively treat post-stroke post-traumatic stress disorder at the early stage"],"prefix":"10.3389","volume":"16","author":[{"given":"Che","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhensheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenggang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiwu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaoquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1080\/14656566.2021.1935871","article-title":"Advances in the pharmacotherapeutic management of post-traumatic stress disorder.","volume":"22","author":"Akhtar","year":"2021","journal-title":"Expert Opin. Pharmacother."},{"key":"B2","year":"2013","journal-title":"Diagnostic and statistical manual of mental disorders"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1161\/STROKEAHA.121.036635","article-title":"Posttraumatic stress symptoms after stroke: The effects of anatomy and coping style.","volume":"53","author":"Assayag","year":"2022","journal-title":"Stroke"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-019-0673-5","article-title":"Pharmacological prevention and early treatment of post-traumatic stress disorder and acute stress disorder: A systematic review and meta-analysis.","volume":"9","author":"Astill Wright","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neurol.2015.07.013","article-title":"Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives.","volume":"172","author":"B\u00e9jot","year":"2016","journal-title":"Rev. Neurol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2021.102004","article-title":"Preventing the onset of post traumatic stress disorder.","volume":"86","author":"Bisson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.infbeh.2014.08.003","article-title":"Effects of an early intervention on maternal post-traumatic stress symptoms and the quality of mother-infant interaction: The case of preterm birth.","volume":"37","author":"Borghini","year":"2014","journal-title":"Infant Behav. Dev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1212\/01.wnl.0000194210.98757.49","article-title":"Chronic posttraumatic stress symptoms after nonsevere stroke.","volume":"66","author":"Bruggimann","year":"2006","journal-title":"Neurology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1164\/rccm.201704-0720OC","article-title":"Effects of a telephone- and web-based coping skills training program compared with an education program for survivors of critical illness and their family members a randomized clinical trial.","volume":"197","author":"Cox","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1164\/rccm.201505-0900OC","article-title":"Randomized trial of communication facilitators to reduce family distress and intensity of end-of-life care.","volume":"193","author":"Curtis","year":"2016","journal-title":"Am. J. Respir. Crit. Med."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03303-1","article-title":"Prevalence and influencing factors of chronic post-traumatic stress disorder in patients with myocardial infarction, transient ischemic attack (TIA) and stroke - an exploratory, descriptive study.","volume":"21","author":"Dollenberg","year":"2021","journal-title":"BMC Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/bjhp.12022","article-title":"Concerns about medications mediate the association of posttraumatic stress disorder with adherence to medication in stroke survivors.","volume":"18","author":"Edmondson","year":"","journal-title":"Br. J. Health Psychol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066435","article-title":"Prevalence of PTSD in survivors of stroke and transient ischemic attack: A meta-analytic review.","volume":"8","author":"Edmondson","year":"","journal-title":"PLoS One"},{"key":"B14","author":"Foa","year":"2010","journal-title":"Effective treatments for PTSD: Practice guidelines from the international society for traumatic stress studies."},{"key":"B15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.0730-7659.2005.00340.x","article-title":"Effectiveness of a counseling intervention after a traumatic childbirth: A randomized controlled trial.","volume":"32","author":"Gamble","year":"2005","journal-title":"Birth"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2019.105657","article-title":"Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage.","volume":"190","author":"Garton","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/STROKEAHA.116.015234","article-title":"Post-stroke posttraumatic stress disorder: A review.","volume":"48","author":"Garton","year":"2017","journal-title":"Stroke"},{"key":"B18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brat.2017.03.018","article-title":"Reducing intrusive traumatic memories after emergency caesarean section: A proof-of-principle randomized controlled study.","volume":"94","author":"Horsch","year":"2017","journal-title":"Behav. Res. Ther."},{"key":"B19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1097\/PSY.0b013e31820afc63","article-title":"A randomized controlled trial of cognitive behavior therapy tailored to psychological adaptation to an implantable cardioverter defibrillator.","volume":"73","author":"Irvine","year":"2011","journal-title":"Psychosom. Med."},{"key":"B20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1891\/1933-3196.5.3.82","article-title":"The EMDR protocol for recent critical incidents: Application in a disaster mental health continuum of care context.","volume":"5","author":"Jarero","year":"2011","journal-title":"J. EMDR Pract. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00134-016-4522-1","article-title":"A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: A multicenter randomized controlled trial, the RAPIT study.","volume":"42","author":"Jensen","year":"2016","journal-title":"Intensive Care Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/23279095.2018.1451334","article-title":"Posttraumatic stress disorder after a first-ever intracerebral hemorrhage in the Chinese population: A pilot study.","volume":"27","author":"Jiang","year":"2020","journal-title":"Appl. Neuropsychol. Adult"},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1186\/cc9260","article-title":"Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: A randomised, controlled trial.","volume":"14","author":"Jones","year":"2010","journal-title":"Crit. Care"},{"key":"B24","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/jpepsy\/jsi051","article-title":"Feasibility and preliminary outcomes from a pilot study of a brief psychological intervention for families of children newly diagnosed with cancer.","volume":"30","author":"Kazak","year":"2005","journal-title":"J. Pediatr. Psychol."},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2017.1353383","article-title":"Trauma and PTSD in the WHO world mental health surveys.","author":"Kessler","year":"2017","journal-title":"Eur. J. Psychotraumatol."},{"key":"B26","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","article-title":"Posttraumatic stress disorder in the National comorbidity survey.","volume":"52","author":"Kessler","year":"1995","journal-title":"Arch. Gen. Psychiatry"},{"key":"B27","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1161\/STROKEAHA.113.004459","article-title":"Increased prevalence of posttraumatic stress disorder in patients after transient ischemic attack.","volume":"45","author":"Kiphuth","year":"2014","journal-title":"Stroke"},{"key":"B28","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/STROKEAHA.112.655209","article-title":"Posttraumatic stress disorder and adherence to medications in survivors of strokes and transient ischemic attacks.","volume":"43","author":"Kronish","year":"2012","journal-title":"Stroke"},{"key":"B29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.2044-8341.1996.tb01849.x","article-title":"The influence of psychological debriefing on emotional adaptation in women following early miscarriage: A preliminary study.","author":"Lee","year":"1996","journal-title":"Br. J. Med. Psychol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/da.22645","article-title":"Internet-based guided self-help for posttraumatic stress disorder (PTSD): Randomized controlled trial.","volume":"34","author":"Lewis","year":"2017","journal-title":"Depress. Anxiety"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2018.1468710","article-title":"DSM-5 posttraumatic stress symptom dimensions and health-related quality of life among Chinese earthquake survivors.","volume":"9","author":"Li","year":"2018","journal-title":"Eur. J. Psychotraumatol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.janxdis.2016.07.010","article-title":"The from survivor to thriver program: RCT of an online therapist-facilitated program for rape-related PTSD.","volume":"43","author":"Littleton","year":"2016","journal-title":"J. Anxiety Disord."},{"key":"B33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1161\/STROKEAHA.120.031109","article-title":"Medications as traumatic reminders in patients with stroke\/transient ischemic attack-induced posttraumatic stress disorder.","volume":"52","author":"Liyanage-Don","year":"2021","journal-title":"Stroke"},{"key":"B34","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2015.8370","article-title":"Psychotherapy for military-related PTSD: A review of randomized clinical trials.","volume":"314","author":"Maria","year":"2015","journal-title":"JAMA"},{"key":"B35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12028-018-0641-6","article-title":"Preventing chronic emotional distress in stroke survivors and their informal caregivers.","volume":"30","author":"McCurley","year":"2019","journal-title":"Neurocrit. Care"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2010.tb00254.x","article-title":"The long-term costs of traumatic stress: Intertwined physical and psychological consequences.","volume":"9","author":"McFarlene","year":"2010","journal-title":"World Psychiatry"},{"key":"B37","author":"McManus","year":"2007","journal-title":"Adult psychiatric morbidity in England, 2007: Results of a household survey."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258170","article-title":"Early psychological interventions for prevention and treatment of post-traumatic stress disorder (PTSD) and post-traumatic stress symptoms in post-partum women: A systematic review and meta-analysis.","volume":"16","author":"Miller","year":"2021","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/16506073.2016.1169626","article-title":"Internet-provided cognitive behaviour therapy of posttraumatic stress symptoms following childbirth-a randomized controlled trial.","volume":"45","author":"Nieminen","year":"2016","journal-title":"Cogn. Behav. Ther."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1227\/01.NEU.0000327580.91345.78","article-title":"Posttraumatic stress disorder explains reduced quality of life in subarachnoid hemorrhage patients in both the short and long term.","volume":"63","author":"Noble","year":"2008","journal-title":"Neurosurgery"},{"key":"B41","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/NMD.0000000000000563","article-title":"Pilot study of a telehealth-delivered medication-augmented exposure therapy protocol for PTSD.","volume":"205","author":"Olden","year":"2017","journal-title":"J. Nerv. Ment. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.genhosppsych.2021.03.004","article-title":"Relationship between NIH stroke symptoms and post-traumatic stress disorder in patients evaluated for transient ischemic attack\/stroke.","volume":"70","author":"Pedowitz","year":"2021","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1682\/jrrd.2011.08.0152","article-title":"Review of exposure therapy: A gold standard for PTSD treatment.","volume":"49","author":"Rauch","year":"2012","journal-title":"J. Rehabil. Res. Dev."},{"key":"B44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13760-019-01200-9","article-title":"Prevalence and correlates of post-traumatic stress disorder after ischaemic stroke.","volume":"121","author":"Rutovic","year":"2021","journal-title":"Acta Neurol. Belg."},{"key":"B45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.erap.2012.09.003","article-title":"EMDR and early psychological intervention following trauma.","volume":"62","author":"Shapiro","year":"2012","journal-title":"Eur. Rev. Appl. Psychol."},{"key":"B46","doi-asserted-by":"crossref","first-page":"e886","DOI":"10.1542\/peds.2013-1331","article-title":"Prevention of traumatic stress in mothers with preterm infants: A randomized controlled trial.","volume":"132","author":"Shaw","year":"2013","journal-title":"Paediatrics"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2174\/1872208316666220617110402","article-title":"Impact of COVID-19 on brain and psychological health, its possible mechanisms, and coping strategies.","author":"Simnani","year":"2022","journal-title":"Recent Pat. Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jad.2014.03.009","article-title":"Internet-based trauma-focused cognitive behavioural therapy for PTSD with and without exposure components: A randomised controlled trial.","volume":"162","author":"Spence","year":"2014","journal-title":"J. Affect. Disord."},{"key":"B49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2015.8370","article-title":"Psychotherapy for military-related PTSD: A review of randomized clinical trials.","volume":"314","author":"Steenkamp","year":"2015","journal-title":"JAMA"},{"key":"B50","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1080\/01612840.2016.1224282","article-title":"Early psychological preventive intervention for workplace violence: A randomized controlled explorative and comparative study between EMDR-recent event and critical incident stress debriefing.","volume":"37","author":"Tarquinio","year":"2016","journal-title":"Issues Ment. Health Nurs."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1161\/STR.0000000000000113","article-title":"Poststroke depression: A scientific statement for healthcare professionals from the American Heart Association\/American Stroke Association.","volume":"48","author":"Towfighi","year":"2017","journal-title":"Stroke"},{"key":"B52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3109\/10673229409017088","article-title":"The body keeps the score: Memory and the evolving psychobiology of posttraumatic stress.","volume":"1","author":"Van der Kolk","year":"1994","journal-title":"Harv. Rev. Psychiatry"},{"key":"B53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000486099","article-title":"Early psychological counseling for the prevention of posttraumatic stress induced by acute coronary syndrome: The MI-SPRINT randomized controlled trial.","volume":"87","author":"von K\u00e4nel","year":"2018","journal-title":"Psychother. Psychosom."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1017\/S0033291716000945","article-title":"Selective prevention of combat-related post-traumatic stress disorder using attention bias modification training: A randomized controlled trial.","volume":"46","author":"Wald","year":"2016","journal-title":"Psychol. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.janxdis.2017.07.001","article-title":"Factor structure of DSM-5 PTSD symptoms in trauma-exposed adolescents: Examining stability across time.","volume":"52","author":"Wang","year":"2017","journal-title":"J. Anxiety Disord."},{"key":"B56","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1037\/pas0000486","article-title":"The clinician administered PTSD scale for DSM-5 (CAPS-5): Development and initial psychometric evaluation in military veterans.","volume":"30","author":"Weathers","year":"2018","journal-title":"Psychol. Assess."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1007571\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:29:37Z","timestamp":1665062977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1007571\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":56,"alternative-id":["10.3389\/fnins.2022.1007571"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.1007571","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"article-number":"1007571"}}