{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:32:44Z","timestamp":1790011964211,"version":"4.0.1"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003213","name":"Beijing Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003213","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Migraine is a neurovascular disease with a high disability rate. Acupuncture treatment has emerged as a safe and viable alternative prophylactic therapy that can effectively alleviate the duration and frequency of migraine attacks. However, the therapeutic mechanisms underlying the effects of acupuncture are yet to be systematically elucidated. In this study, we enrolled female patients with migraine without aura (<jats:italic>n<\/jats:italic> = 20) and healthy controls (<jats:italic>n<\/jats:italic> = 10). Patients received acupuncture treatment on DU20, DU24, bilateral GB13, GB8, and GB20, applied three times per week over the course of 4 weeks for 12 sessions in total. Blood samples were collected from the median cubital vein before and after acupuncture treatment. Proteomic and metabolomic profiling was performed using liquid chromatography-mass spectrometry to determine the characteristics of differentially expressed molecules and expression of their corresponding biological pathways as well as to elucidate the pathogenesis of migraine and the biological effects underlying the treatment of migraine with acupuncture. Proteomic and metabolomic profiling of plasma samples from patients with migraine without aura before and after acupuncture treatment revealed enrichment of immune-related pathway functions and the arginine synthesis pathway. Joint pathway analyses revealed significant enrichment of the pentose phosphate and glycolysis\/gluconeogenesis pathways in patients with migraine. The glycolysis\/gluconeogenesis and riboflavin metabolism pathways were significantly enriched after acupuncture treatment. The expression levels of various key proteins and metabolites, including \u03b1-<jats:sc>D<\/jats:sc>-glucose, flavin adenine dinucleotide, biliverdin reductase B, and L-glutamate, were significantly differentially expressed before and after acupuncture treatment in patients with migraine without aura. Treatment of migraine with acupuncture was associated with significant changes in key molecules and pathways, indicative of physiological changes in the trigeminovascular system, glutamate neurotoxicity, and other migraine-related physiological changes. Overall, our comprehensive analysis using proteomic and metabolomic profiling demonstrates that energy metabolism may serve as a key correlative link in the occurrence of migraine and the therapeutic effects of acupuncture treatment. Our findings may facilitate the identification of diagnostic and therapeutic modalities in the ongoing search for effective treatments for migraine attacks.<\/jats:p>","DOI":"10.3389\/fnins.2022.1013328","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T11:24:51Z","timestamp":1664450691000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Proteomic and metabolomic profiling of acupuncture for migraine reveals a correlative link via energy metabolism"],"prefix":"10.3389","volume":"16","author":[{"given":"Lu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianli","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongke","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/head.13301","article-title":"Migraine Burden of Disease: From the Patient\u2019s Experience to a Socio-Economic View.","volume":"58","author":"Agosti","year":"2018","journal-title":"Headache"},{"key":"B2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s10194-017-0800-8","article-title":"The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine.","volume":"18","author":"Al-Karagholi","year":"2017","journal-title":"J. Headache Pain"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine.","volume":"383","author":"Ashina","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/s0140-6736(20)32342-4","article-title":"Migraine: integrated approaches to clinical management and emerging treatments.","volume":"397","author":"Ashina","year":"","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1016\/S0140-6736(20)32162-0","article-title":"Migraine: disease characterisation, biomarkers, and precision medicine.","volume":"397","author":"Ashina","year":"","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1007\/s10072-014-1864-8","article-title":"Decreased antioxidant status in migraine patients with brain white matter hyperintensities.","volume":"35","author":"Ayta\u00e7","year":"2014","journal-title":"Neurol. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1111\/bph.12512","article-title":"The TRPA1 channel in migraine mechanism and treatment.","volume":"171","author":"Benemei","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1468-1331.2004.00813.x","article-title":"High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre.","volume":"11","author":"Boehnke","year":"2004","journal-title":"Eur. J. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1046\/j.1471-4159.1994.63030910.x","article-title":"Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes.","volume":"63","author":"Bolanos","year":"1994","journal-title":"J. Neurochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/head.13214","article-title":"The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory.","volume":"58","author":"Borkum","year":"2018","journal-title":"Headache"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s11064-021-03335-9","article-title":"Brain energy deficit as a source of oxidative stress in migraine: A molecular basis for migraine susceptibility.","volume":"46","author":"Borkum","year":"2021","journal-title":"Neurochem. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00232-014-9758-5","article-title":"Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate.","volume":"248","author":"B\u00fct\u00fcn","year":"2015","journal-title":"J. Membr. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1177\/0333102413487444","article-title":"Glutamate oxaloacetate transaminase: a new key in the dysregulation of glutamate in migraine patients.","volume":"33","author":"Campos","year":"2013","journal-title":"Cephalalgia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/s1474-4422(17)30435-0","article-title":"The pathophysiology of migraine: implications for clinical management.","volume":"17","author":"Charles","year":"2018","journal-title":"Lancet Neurol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4236","article-title":"Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine.","author":"Chi","year":"2018","journal-title":"Nat. Biotechnol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s11136-007-9217-1","article-title":"Validation of the Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ v. 2.1) for patients undergoing prophylactic migraine treatment.","volume":"16","author":"Cole","year":"2007","journal-title":"Qual. Life Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1111\/head.13673","article-title":"Pathogenesis of Cluster Headache: From Episodic to Chronic Form, the Role of Neurotransmitters and Neuromodulators.","volume":"59","author":"D\u2019Andrea","year":"2019","journal-title":"Headache"},{"key":"B19","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nrneurol.2014.14","article-title":"Altered processing of sensory stimuli in patients with migraine.","volume":"10","author":"de Tommaso","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pneurobio.2019.02.002","article-title":"Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.","volume":"177","author":"Demartini","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput.","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neulet.2016.10.054","article-title":"Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine.","volume":"636","author":"Dong","year":"2017","journal-title":"Neurosci. Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/jb\/mvaa039","article-title":"Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family.","volume":"168","author":"Duff","year":"2020","journal-title":"J. Biochem"},{"key":"B24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1177\/0333102416651454","article-title":"Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions.","volume":"37","author":"Erd\u00e9lyi-B\u00f3tor","year":"2017","journal-title":"Cephalalgia"},{"key":"B25","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/j.1468-2982.2008.01749.x","article-title":"Effective prophylactic treatments of migraine lower plasma glutamate levels.","volume":"29","author":"Ferrari","year":"2009","journal-title":"Cephalalgia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1212\/wnl.40.10.1582","article-title":"Neuroexcitatory plasma amino acids are elevated in migraine.","volume":"40","author":"Ferrari","year":"1990","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/WAD.0b013e3182420bfe","article-title":"Montreal cognitive assessment: validation study for mild cognitive impairment and Alzheimer disease.","volume":"27","author":"Freitas","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00002508-199706000-00011","article-title":"Assessing depression among persons with chronic pain using the Center for Epidemiological Studies-Depression Scale and the Beck Depression Inventory: a comparative analysis.","volume":"13","author":"Geisser","year":"1997","journal-title":"Clin. J. Pain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuroscience.2018.02.017","article-title":"Nitric Oxide and Mitochondrial Function in Neurological Diseases.","volume":"376","author":"Ghasemi","year":"2018","journal-title":"Neuroscience"},{"key":"B32","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of migraine: A disorder of sensory processing.","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ng.3598","article-title":"Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.","volume":"48","author":"Gormley","year":"2016","journal-title":"Nat. Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41582-019-0255-4","article-title":"The metabolic face of migraine - from pathophysiology to treatment.","volume":"15","author":"Gross","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/j.1468-2982.2009.01964.x","article-title":"Increased nitric oxide stress is associated with migraine.","volume":"30","author":"Gruber","year":"2010","journal-title":"Cephalalgia"},{"key":"B36","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The International Classification of Headache Disorders, 3rd edition (beta version).","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The International Classification of Headache Disorders, 3rd edition.","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s13311-018-0616-5","article-title":"Glutamate and Its Receptors as Therapeutic Targets for Migraine.","volume":"15","author":"Hoffmann","year":"2018","journal-title":"Neurotherapeutics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1212\/WNL.0b013e3182535d0c","article-title":"Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society.","volume":"78","author":"Holland","year":"2012","journal-title":"Neurology"},{"key":"B40","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/clinchem\/48.9.1571","article-title":"Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation.","volume":"48","author":"Hustad","year":"2002","journal-title":"Clin. Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","article-title":"Metabolomics: a global biochemical approach to drug response and disease.","volume":"48","author":"Kaddurah-Daouk","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s10194-018-0839-1","article-title":"Poor medical care for people with migraine in Europe - evidence from the Eurolight study.","volume":"19","author":"Katsarava","year":"2018","journal-title":"J. Headache Pain"},{"key":"B43","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1468-2982.2009.01890.x","article-title":"Interictal metabolic changes in episodic migraine: a voxel-based FDG-PET study.","volume":"30","author":"Kim","year":"2010","journal-title":"Cephalalgia"},{"key":"B44","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1089\/ars.2013.5616","article-title":"Redox regulation of transient receptor potential channels.","volume":"21","author":"Kozai","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2377-4-4","article-title":"Acute treatment of migraine. Breaking the paradigm of monotherapy.","volume":"4","author":"Krymchantowski","year":"2004","journal-title":"BMC Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jphs.2017.02.004","article-title":"l-Citrulline ameliorates cerebral blood flow during cortical spreading depression in rats: Involvement of nitric oxide- and prostanoids-mediated pathway.","volume":"133","author":"Kurauchi","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s10194-021-01271-1","article-title":"Migraine and neuroinflammation: the inflammasome perspective.","volume":"22","author":"Kursun","year":"2021","journal-title":"J. Headache Pain"},{"key":"B48","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration.","volume":"460","author":"Lau","year":"2010","journal-title":"Pflugers Arch."},{"key":"B49","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.janxdis.2005.05.004","article-title":"Examination of the utility of the Beck Anxiety Inventory and its factors as a screener for anxiety disorders.","volume":"20","author":"Leyfer","year":"2006","journal-title":"J. Anxiety Disord."},{"key":"B50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1129-2377-14-55","article-title":"The omics in migraine.","volume":"14","author":"Lionetto","year":"2013","journal-title":"J. Headache Pain"},{"key":"B51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s10194-018-0877-8","article-title":"Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing (18)FDG-PET and visual evoked potentials.","volume":"19","author":"Lisicki","year":"2018","journal-title":"J. Headache Pain"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5286","DOI":"10.1021\/ac404246w","article-title":"pQuant improves quantitation by keeping out interfering signals and evaluating the accuracy of calculated ratios.","volume":"86","author":"Liu","year":"2014","journal-title":"Anal. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.aca.2018.08.002","article-title":"statTarget: A streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data.","volume":"1036","author":"Luan","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"B54","doi-asserted-by":"publisher","first-page":"D1211","DOI":"10.1093\/nar\/gky869","article-title":"iProX: an integrated proteome resource.","volume":"47","author":"Ma","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1098\/rstb.1999.0471","article-title":"Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.","volume":"354","author":"Magistretti","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fneur.2017.00333","article-title":"Riboflavin has neuroprotective potential: Focus on Parkinson\u2019s disease and migraine.","volume":"8","author":"Marashly","year":"2017","journal-title":"Front. Neurol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1046\/j.1468-2982.1993.1302089.x","article-title":"Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks.","volume":"13","author":"Mart\u00ednez","year":"1993","journal-title":"Cephalalgia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.nbd.2017.01.005","article-title":"Neuroendocrine signaling modulates specific neural networks relevant to migraine.","volume":"101","author":"Martins-Oliveira","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1212\/wnl.44.4.666","article-title":"31P-magnetic resonance spectroscopy in migraine without aura.","volume":"44","author":"Montagna","year":"1994","journal-title":"Neurology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1007\/s12035-020-02030-0","article-title":"Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival.","volume":"57","author":"Mori","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.3390\/ijms21113847","article-title":"Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism.","volume":"21","author":"Mosegaard","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights.","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3988\/jcn.2021.17.2.164","article-title":"The role of endothelial dysfunction in the pathophysiology and cerebrovascular effects of migraine: A narrative review.","volume":"17","author":"Paolucci","year":"2021","journal-title":"J. Clin. Neurol."},{"key":"B64","first-page":"S1","article-title":"Canadian Headache Society guideline for migraine prophylaxis.","volume":"39","author":"Pringsheim","year":"2012","journal-title":"Can. J. Neurol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"146670","DOI":"10.1016\/j.brainres.2020.146670","article-title":"Electro-acupuncture inhibits C-fiber-evoked WDR neuronal activity of the trigeminocervical complex: Neurophysiological hypothesis of a complementary therapy for acute migraine modeled rats.","volume":"1730","author":"Qu","year":"2020","journal-title":"Brain Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"691208","DOI":"10.3389\/fmolb.2021.691208","article-title":"Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B.","volume":"8","author":"Redzic","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s10072-017-2970-1","article-title":"High asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in migraine patients.","volume":"38","author":"Reyhani","year":"2017","journal-title":"Neurol. Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1177\/0333102412452048","article-title":"Magnetic resonance spectroscopy in migraine: what have we learned so far?","volume":"32","author":"Reyngoudt","year":"2012","journal-title":"Cephalalgia"},{"key":"B69","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1212\/wnl.50.2.466","article-title":"Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial.","volume":"50","author":"Schoenen","year":"1998","journal-title":"Neurology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s41467-019-09550-x","article-title":"Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics.","volume":"10","author":"Shen","year":"2019","journal-title":"Nat. Commun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1129-2377-15-31","article-title":"The impact of headache in Europe: principal results of the Eurolight project.","volume":"15","author":"Steiner","year":"2014","journal-title":"J. Headache Pain"},{"key":"B72","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00438-012-0723-7","article-title":"A possible role for mitochondrial dysfunction in migraine.","volume":"287","author":"Stuart","year":"2012","journal-title":"Mol. Genet. Genom."},{"key":"B73","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41576-020-0268-2","article-title":"Genetics meets proteomics: perspectives for large population-based studies.","volume":"22","author":"Suhre","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/0333102411417901","article-title":"Guidelines for controlled trials of drugs in migraine: third edition. A guide for investigators.","volume":"32","author":"Tfelt-Hansen","year":"2012","journal-title":"Cephalalgia"},{"key":"B75","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/jcpt.12548","article-title":"Prophylaxis of migraine headaches with riboflavin: A systematic review.","volume":"42","author":"Thompson","year":"2017","journal-title":"J. Clin. Pharm. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e21345","DOI":"10.1097\/MD.0000000000021345","article-title":"Acupuncture reduced the medical expenditure in migraine patients: Real-world data of a 10-year national cohort study.","volume":"99","author":"Tsai","year":"2020","journal-title":"Medicine"},{"key":"B77","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s10194-018-0836-4","article-title":"PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord.","volume":"19","author":"Wang","year":"2018","journal-title":"J. Headache Pain"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/j.pain.2011.04.006","article-title":"Efficacy of acupuncture for migraine prophylaxis: a single-blinded, double-dummy, randomized controlled trial.","volume":"152","author":"Wang","year":"2011","journal-title":"Pain"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1093\/nar\/gkaa498","article-title":"NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses.","volume":"48","author":"Wang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1212\/wnl.39.4.538","article-title":"Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy.","volume":"39","author":"Welch","year":"1989","journal-title":"Neurology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes.","volume":"99","author":"Wishart","year":"2019","journal-title":"Physiol. Rev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1177\/0333102414566200","article-title":"The place of corticosteroids in migraine attack management: A 65-year systematic review with pooled analysis and critical appraisal.","volume":"35","author":"Woldeamanuel","year":"2015","journal-title":"Cephalalgia"},{"key":"B83","doi-asserted-by":"publisher","first-page":"m697","DOI":"10.1136\/bmj.m697","article-title":"Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial.","volume":"368","author":"Xu","year":"2020","journal-title":"BMJ"},{"key":"B84","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/0333102410379890","article-title":"Validation of the Headache Impact Test (HIT-6\u2122) across episodic and chronic migraine.","volume":"31","author":"Yang","year":"2011","journal-title":"Cephalalgia"},{"key":"B85","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12967-014-0351-6","article-title":"Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study.","volume":"12","author":"Yang","year":"2014","journal-title":"J. Transl. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters.","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B87","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/jamainternmed.2016.9378","article-title":"The long-term effect of acupuncture for migraine prophylaxis: A randomized clinical trial.","volume":"177","author":"Zhao","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2147\/jpr.S225431","article-title":"Electroacupuncture Inhibits Hyperalgesia by Alleviating Inflammatory Factors in a Rat Model of Migraine.","volume":"13","author":"Zhao","year":"2020","journal-title":"J. Pain Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41392-020-00399-x","article-title":"Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation.","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal. Transduct. Target Ther."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1039\/c6mb00424e","article-title":"Metabolomic changes in CSF of migraine patients measured with (1)H-NMR spectroscopy.","volume":"12","author":"Zielman","year":"2016","journal-title":"Mol. Biosyst."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1013328\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T11:25:06Z","timestamp":1664450706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1013328\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":90,"alternative-id":["10.3389\/fnins.2022.1013328"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.1013328","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"article-number":"1013328"}}