{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:51:39Z","timestamp":1783129899218,"version":"3.54.6"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004572","name":"National Health and Family Planning Commission of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008832","name":"Nanjing Municipal Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the contralateral structural and functional plasticity induced by frontal gliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with left (<jats:italic>n<\/jats:italic> = 49) or right (<jats:italic>n<\/jats:italic> = 52) frontal diffuse glioma were enrolled along with 35 age- matched healthy controls (HCs). The gray-matter volumes (GMVs) of the contralesional region were measured using the voxel-based morphometry (VBM) analysis. Additionally, the amplitude of low-frequency fluctuation (ALFF) of the contralesional region was calculated via resting state functional magnetic resonance imaging (MRI) to assess functional alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The GMV of the contralateral orbitofrontal cortex of the right or left frontal gliomas was significantly larger than the corresponding GMV in the controls. In the patients with right frontal glioma, the GMV and ALFF in the left inferior frontal gyrus were significantly increased compared with those in the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glioma invasion of the frontal lobe can induce contralateral structural compensation and functional compensation, which show synergy in the left inferior frontal gyrus. Our findings explain why patients with unilateral frontal glioma can have functional balance, and offer the possibility of preserving the brain function while maximizing tumor removal.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2022.1016693","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T10:31:19Z","timestamp":1663929079000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Synergetic reorganization of the contralateral structure and function in patients with unilateral frontal glioma"],"prefix":"10.3389","volume":"16","author":[{"given":"Honglin","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1902","DOI":"10.1212\/WNL.0000000000006517","article-title":"Contralesional macrostructural plasticity of the insular cortex in patients with glioma: A VBM study.","volume":"91","author":"Almairac","year":"2018","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.canlet.2017.11.010","article-title":"Emerging role of plexins signaling in glioma progression and therapy.","volume":"414","author":"Angelopoulou","year":"2018","journal-title":"Cancer Lett."},{"key":"B3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroimage.2008.12.008","article-title":"Computing average shaped tissue probability templates.","volume":"45","author":"Ashburner","year":"2009","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","first-page":"16177","DOI":"10.1038\/s41598-020-73221-x","article-title":"Rajyoga meditation induces grey matter volume changes in regions that process reward and happiness.","volume":"10","author":"Babu","year":"2020","journal-title":"Sci. Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3389\/fnhum.2016.00393","article-title":"Contralesional cortical structural reorganization contributes to motor recovery after sub-cortical stroke: A longitudinal voxel-based morphometry study.","volume":"10","author":"Cai","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1093\/cercor\/bhs157","article-title":"Anatomical and functional enhancements of the insula after loss of large primary somatosensory fibers.","volume":"23","author":"Ceko","year":"2013","journal-title":"Cereb. Cortex"},{"key":"B7","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1093\/brain\/awl300","article-title":"Contrasting acute and slow-growing lesions: A new door to brain plasticity.","volume":"130","author":"Desmurget","year":"2007","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1017\/S0033291718001903","article-title":"Larger right inferior frontal gyrus volume and surface area in participants at genetic risk for bipolar disorders.","volume":"49","author":"Drobinin","year":"2019","journal-title":"Psychol. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00701-013-1653-9","article-title":"The \u201conco-functional balance\u201d in surgery for diffuse low-grade glioma: Integrating the extent of resection with quality of life.","volume":"155","author":"Duffau","year":"2013","journal-title":"Acta Neurochir (Wien)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1002\/hbm.24936","article-title":"Right inferior frontal gyrus: An integrative hub in tonal bilinguals.","volume":"41","author":"Gao","year":"2020","journal-title":"Hum. Brain Mapp."},{"key":"B11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/1073858413491147","article-title":"Cortical reorganization after stroke: How much and how functional?","volume":"20","author":"Grefkes","year":"2014","journal-title":"Neuroscientist"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/jmri.25869","article-title":"Advanced and amplified BOLD fluctuations in high-grade gliomas.","volume":"47","author":"Gupta","year":"2018","journal-title":"J. Magn. Reson Imaging"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1093\/cercor\/bhy049","article-title":"Functional segregation of the right inferior frontal gyrus: Evidence from coactivation-based parcellation.","volume":"29","author":"Hartwigsen","year":"2019","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1093\/cercor\/bhaa160","article-title":"Connections of the human orbitofrontal cortex and inferior frontal gyrus.","volume":"30","author":"Heather Hsu","year":"2020","journal-title":"Cereb. Cortex"},{"key":"B15","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.neuroimage.2003.09.005","article-title":"Disturbance and recovery of language function: Correlates in PET activation studies.","volume":"20","author":"Heiss","year":"2003","journal-title":"Neuroimage"},{"key":"B16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/brain\/awv394","article-title":"Mapping neuroplastic potential in brain-damaged patients.","volume":"139","author":"Herbet","year":"2016","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.biopsych.2017.10.030","article-title":"The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology.","volume":"83","author":"Hiser","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mrm.1910350312","article-title":"Movement-related effects in fMRI time-series.","volume":"35","author":"Karl","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"B19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0896-6273(02)00723-7","article-title":"Reaching for answers.","volume":"34","author":"Krauzlis","year":"2002","journal-title":"Neuron"},{"key":"B20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/neuros\/nyaa456","article-title":"Central nervous system plasticity influences language and cognitive recovery in adult glioma.","volume":"89","author":"Krishna","year":"2021","journal-title":"Neurosurgery"},{"key":"B21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroimage.2013.04.011","article-title":"Subregions of the human superior frontal gyrus and their connections.","volume":"78","author":"Li","year":"2013","journal-title":"Neuroimage"},{"key":"B22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.bbr.2011.06.022","article-title":"Diversity of the inferior frontal gyrus\u2013a meta-analysis of neuroimaging studies.","volume":"225","author":"Liakakis","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3171\/2019.11.JNS191982","article-title":"Contralesional homotopic functional plasticity in patients with temporal glioma.","volume":"134","author":"Liu","year":"2020","journal-title":"J. Neurosurg"},{"key":"B24","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature06976","article-title":"What we can do and what we cannot do with fMRI.","volume":"453","author":"Logothetis","year":"2008","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/cercor\/bhj138","article-title":"Structural brain alterations following 5 days of intervention: Dynamic aspects of neuroplasticity.","volume":"17","author":"May","year":"2007","journal-title":"Cereb. Cortex"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e105987","DOI":"10.1371\/journal.pone.0105987","article-title":"Right inferior frontal gyrus activation is associated with memory improvement in patients with left frontal low-grade glioma resection.","volume":"9","author":"Miotto","year":"2014","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017.","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro. Oncol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuropsychologia.2017.09.021","article-title":"The orbitofrontal cortex and emotion in health and disease, including depression.","volume":"128","author":"Rolls","year":"2019","journal-title":"Neuropsychologia"},{"key":"B29","doi-asserted-by":"crossref","first-page":"R1083","DOI":"10.1016\/j.cub.2018.07.018","article-title":"Orbitofrontal cortex.","volume":"28","author":"Rudebeck","year":"2018","journal-title":"Curr. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1186\/s12885-015-1939-9","article-title":"Comparative transcriptomics reveals similarities and differences between astrocytoma grades.","volume":"15","author":"Seifert","year":"2015","journal-title":"BMC Cancer"},{"key":"B31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nn.3982","article-title":"What the orbitofrontal cortex does not do.","volume":"18","author":"Stalnaker","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"117960","DOI":"10.1016\/j.neuroimage.2021.117960","article-title":"Language networks in aphasia and health: A 1000 participant activation likelihood estimation meta-analysis.","volume":"233","author":"Stefaniak","year":"2021","journal-title":"Neuroimage"},{"key":"B33","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/brain\/awaa023","article-title":"Dynamics of language reorganization after left temporo-parietal and frontal stroke.","volume":"143","author":"Stockert","year":"2020","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/jon.12275","article-title":"Corpus callosum diffusion and language lateralization in patients with brain tumors: A DTI and fMRI Study.","volume":"26","author":"Tantillo","year":"2016","journal-title":"J. Neuroimaging"},{"key":"B35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fnhum.2019.00177","article-title":"Neuroplastic effects in patients with traumatic brain injury after music-supported therapy.","volume":"13","author":"Vik","year":"2019","journal-title":"Front. Hum. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"117268","DOI":"10.1016\/j.neuroimage.2020.117268","article-title":"Evolutional and developmental anatomical architecture of the left inferior frontal gyrus.","volume":"222","author":"Wang","year":"2020","journal-title":"Neuroimage"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1002\/hbm.24953","article-title":"Convergence of distinct functional networks supporting naming and semantic recognition in the left inferior frontal gyrus.","volume":"41","author":"Xu","year":"2020","journal-title":"Hum. Brain Mapp."},{"key":"B38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: Data processing & analysis for (Resting-State) brain imaging.","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1002\/hbm.24324","article-title":"Reorganization of cerebro-cerebellar circuit in patients with left hemispheric gliomas involving language network: A combined structural and resting-state functional MRI study.","volume":"39","author":"Zhang","year":"2018","journal-title":"Hum. Brain. Mapp."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1016693\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T10:31:40Z","timestamp":1663929100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.1016693\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":39,"alternative-id":["10.3389\/fnins.2022.1016693"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.1016693","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]},"article-number":"1016693"}}