{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:40:58Z","timestamp":1779370858148,"version":"3.53.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obtaining accurate axial length (AL) is very important for the establishment of animal models of myopia. The purpose of this study is to compare the accuracy of Quantel A-B scan, OD-1 A scan, and vernier caliper in measuring AL in Sprague Dawley (SD) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 60 5-week-old SD rats were divided into female rat group (<jats:italic>n<\/jats:italic> = 30) and male rat group (<jats:italic>n<\/jats:italic> = 30). Quantel A-B scan and OD-1 A scan were, respectively, used to measure the AL of both eyes of each living rat, and vernier caliper was used to measure the anterior-posterior diameter of each rat\u2019s eyeball. Besides, the correlation between refractive error (RE) and AL measured by different instruments was evaluated, and the accuracy of the three measurement methods was compared according to gender and left\/right eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in AL and diopter of SD rats at the same age (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). the AL of male rats was greater than that of female rats, while diopter (D) was the opposite; There was no significant difference in AL and D between left and right eyes in the same SD rats (<jats:italic>p<\/jats:italic> &amp;gt; 0.05); There were statistical differences among the three measurement methods (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), AL measured by vernier caliper was the largest, followed by Quantel A-B scan, OD-1 A scan; Difference in AL between male and female was not statistically significant between the results obtained by Quantel A-B scan and vernier caliper (<jats:italic>p<\/jats:italic> &amp;gt; 0.05), but there were statistically significant differences between the other two measurement methods (<jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex is the influencing factor of AL and RE. Imaging measurement can accurately measure the AL in living small rodents. Compared with OD-1 A scan, Quantel A-B scan may be more accurate.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2022.1106904","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T20:40:41Z","timestamp":1673037641000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the accuracy of axial length measurement by different imaging methods in Sprague Dawley rats"],"prefix":"10.3389","volume":"16","author":[{"given":"Yajun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia.","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/opo.12812","article-title":"Axial length targets for myopia control.","volume":"41","author":"Chamberlain","year":"2021","journal-title":"Ophthalmic Physiol Opt."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-021-01264-8","article-title":"DNAH17 is essential for rat spermatogenesis and fertility.","volume":"100","author":"Chen","year":"2021","journal-title":"J Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e460","DOI":"10.1111\/aos.14080","article-title":"Amphiregulin and ocular axial length.","volume":"97","author":"Dong","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/0042-6989(94)00292-T","article-title":"In vitro changes in back vertex distance of chick and pigeon lenses: species differences and the effects of aging.","volume":"35","author":"Glasser","year":"1995","journal-title":"Vision Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1097\/j.jcrs.0000000000000149","article-title":"Change in optical axial length after cataract surgery.","volume":"46","author":"Goto","year":"","journal-title":"Journal of Cataract &amp; Refractive Surgery."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61391-7","article-title":"Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography.","volume":"10","author":"Goto","year":"","journal-title":"Sci Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/jama.2015.10803","article-title":"Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China: A Randomized Clinical Trial.","volume":"314","author":"He","year":"2015","journal-title":"JAMA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050.","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3928\/1081597X-20190109-01","article-title":"Comprehensive Comparison of Axial Length Measurement With Three Swept-Source OCT-Based Biometers and Partial Coherence Interferometry.","volume":"35","author":"Huang","year":"2019","journal-title":"J Refract Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1167\/iovs.08-2463","article-title":"Spontaneous axial myopia and emmetropization in a strain of wild-type guinea pig (Cavia porcellus).","volume":"50","author":"Jiang","year":"2009","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.visres.2013.10.020","article-title":"Interactions of chromatic and lens-induced defocus during visual control of eye growth in guinea pigs (Cavia porcellus).","volume":"94","author":"Jiang","year":"2014","journal-title":"Vision Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1167\/iovs.12-10480","article-title":"What factors are associated with myopia in young adults? 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