{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:00:59Z","timestamp":1789423259405,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Age-related hearing loss (ARHL) may limit communication, which is closely associated with cognitive decline of the elderly and negatively affects their quality of life. In ARHL patients who suffer chronic otitis media (COM), hearing impairment may worsen and negatively affect the cognition and quality of life. It is currently unknown whether restoration of the conductive hearing in the mixed hearing loss through middle ear surgeries can improve both the cognitive function and quality of life of the ARHL patients. Therefore, in the present study, the ARHL patients were followed up for 6 months after middle ear surgeries for COM, and both the cognitive functions and quality of life of the patients were assessed using Montreal Cognitive Assessment and Glasgow Benefit Inventory. It was found that both the cognitive functions and quality of life were improved 6 months after middle ear surgeries. In conclusion, hearing recovery after middle ear surgeries could improve cognitive functions and quality of life of ARHL patients with COM, and surgical intervention is, hence, recommended for COM.<\/jats:p>","DOI":"10.3389\/fnins.2022.786383","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T06:24:08Z","timestamp":1645079048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Middle Ear Surgeries for Chronic Otitis Media Improve Cognitive Functions and Quality of Life of Age-Related Hearing Loss Patients"],"prefix":"10.3389","volume":"16","author":[{"given":"Juanjuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1111\/j.1532-5415.2012.04150.x","article-title":"Cochlear implant rehabilitation in older adults: literature review and proposal of a conceptual framework [J].","volume":"60","author":"Clark","year":"2012","journal-title":"J. Am. Geriat. Soc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2105\/ajph.2010.300078","article-title":"Determinants of hearing aid acquisition in older adults [J].","volume":"101","author":"Fischer","year":"2011","journal-title":"Am. J. Public Health"},{"key":"B3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.14639\/0392-100X-993","article-title":"review of new insights on the association between hearing loss and cognitive decline in ageing [J].","volume":"36","author":"Fortunato","year":"2016","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"B4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1055\/s-0035-1555117","article-title":"Mechanisms of the hearing-cognition relationship [J].","volume":"36","author":"Fulton","year":"2015","journal-title":"Sem. Hear."},{"key":"B5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.neuron.2020.08.003","article-title":"How can hearing loss cause dementia? [J].","volume":"108","author":"Griffiths","year":"2020","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1159\/000506621","article-title":"Prognostic value of a test of central auditory function in conversion from mild cognitive impairment to dementia [J].","volume":"25","author":"H\u00e4ggstr\u00f6m","year":"2020","journal-title":"Audiol. Neurootol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0404-x","article-title":"Impact of social relationships on Alzheimer\u2019s memory impairment: mechanistic studies [J].","volume":"25","author":"Hsiao","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.arr.2015.04.006","article-title":"Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies [J].","volume":"22","author":"Kuiper","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"B9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/13607863.2014.915924","article-title":"Hearing loss and dementia - who is listening? [J].","volume":"18","author":"Lin","year":"2014","journal-title":"Aging Ment. Health"},{"key":"B10","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care [J].","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1044\/2019_AJA-19-00043","article-title":"Relationship between domain-specific cognitive function and speech-in-noise performance in older adults: the atherosclerosis risk in communities hearing pilot study [J].","volume":"28","author":"Mamo","year":"2019","journal-title":"Am. J. Audiol."},{"key":"B12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/14992027.2011.611178","article-title":"What factors influence help-seeking for hearing impairment and hearing aid adoption in older adults? [J].","volume":"51","author":"Meyer","year":"2012","journal-title":"Int. J. Audiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.7326\/0003-4819-113-3-188","article-title":"Quality-of-life changes and hearing impairment. A randomized trial [J].","volume":"113","author":"Mulrow","year":"1990","journal-title":"Ann. Intern. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3233\/JAD-160793","article-title":"Efficacy of hearing aids on the cognitive status of patients with alzheimer\u2019s disease and hearing loss: a multicenter controlled randomized trial [J].","volume":"58","author":"Nguyen","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bbr.2018.01.003","article-title":"Cognitive decline and increased hippocampal p-tau expression in mice with hearing loss [J].","volume":"342","author":"Park","year":"2018","journal-title":"Behav. Brain Res."},{"key":"B16","doi-asserted-by":"crossref","first-page":"12638","DOI":"10.1523\/JNEUROSCI.2559-11.2011","article-title":"Hearing loss in older adults affects neural systems supporting speech comprehension [J].","volume":"31","author":"Peelle","year":"2011","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3233\/jad-171037","article-title":"Aging without dementia is achievable: current evidence from epidemiological research [J].","volume":"62","author":"Qiu","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B18","article-title":"Etiological investigation and analysis on hearing loss of chinese people over 60 years old [J].","volume":"22","author":"Ren","year":"2016","journal-title":"Chin. J. Rehabil. Theory Pract."},{"key":"B19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S1092852917000268","article-title":"Does treating hearing loss prevent or slow the progress of dementia? Hearing is not all in the ears, but who\u2019s listening? [J].","volume":"22","author":"Stahl","year":"2017","journal-title":"CNS Spectr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anl.2018.08.010","article-title":"Age-related hearing loss and cognitive decline - The potential mechanisms linking the two [J].","volume":"46","author":"Uchida","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"B21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/03005369609076779","article-title":"Attitude and help-seeking for hearing impairment [J].","volume":"30","author":"van den Brink","year":"1996","journal-title":"Br. J. Audiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1001\/archotol.1985.00800100057006","article-title":"Surgery in elderly patients with chronic otitis media [J].","volume":"111","author":"Vartiainen","year":"1985","journal-title":"Arch. Otolaryngol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/000348940311200116","article-title":"Validation assessment of the Chinese-version Chronic Ear Survey: a comparison between data from English and Chinese versions [J].","volume":"112","author":"Wang","year":"2003","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.arr.2015.06.002","article-title":"A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline [J].","volume":"23","author":"Wayne","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1152\/jn.00472.2016","article-title":"Transmission of auditory sensory information decreases in rate and temporal precision at the endbulb of Held synapse during age-related hearing loss [J].","volume":"116","author":"Xie","year":"2016","journal-title":"J. Neurophysiol."},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-020-01461-6","article-title":"Measuring health-related quality of life in chronic otitis media in a Chinese population: cultural adaption and validation of the Zurich Chronic Middle Ear Inventory (ZCMEI-21-Chn) [J].","volume":"18","author":"Yang","year":"2020","journal-title":"Health Qual. Life Outcomes"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.786383\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T06:24:18Z","timestamp":1645079058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.786383\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":26,"alternative-id":["10.3389\/fnins.2022.786383"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.786383","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]},"article-number":"786383"}}