{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:01:12Z","timestamp":1783065672238,"version":"3.54.6"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tumors of the central nervous system (CNS) are the most common solid childhood malignancy. Over the last decades, treatment developments have strongly contributed to the improved overall 5-year survival rate, which is now approaching 75%. However, children now face significant long-term morbidity with late-effects including sleep disorders that may have detrimental impact on everyday functioning and quality of life. The aims of this study were to (1) describe the symptoms that lead to polysomnographic evaluation; (2) describe the nature of sleep disorders diagnosed in survivors of childhood CNS tumor using polysomnography (PSG); and (3) explore the association between tumor location and diagnosed sleep disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An extensive literature search following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines (PRISMA) was conducted. Inclusion criteria were children and adolescents diagnosed with a CNS tumor age &amp;lt;20 years having a PSG performed after end of tumor treatment. The primary outcome was sleep disorder confirmed by PSG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,658 studies identified, 11 met the inclusion criteria. All the included articles were appraised for quality and included in the analysis. Analyses indicated that sleep disorders commonly occur among childhood CNS tumor survivors. Symptoms prior to referral for PSG were excessive daytime sleepiness (EDS), fatigue, irregular breathing during sleep and snoring. The most common sleep disorders diagnosed were sleep-related breathing disorders (i.e., obstructive sleep apnea) and central disorders of hypersomnolence (i.e., narcolepsy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings point to the potential benefit of systematically registering sleep disorder symptoms among CNS tumor patients together with tumor type and treatment information, so that at-risk patients can be identified early. Moreover, future rigorous and larger scale controlled observational studies that include possible modifiable confounders of sleep disorders such as fatigue and obesity are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42021243866<\/jats:ext-link>, identifier [CRD42021243866].<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2022.808398","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T07:37:14Z","timestamp":1645515434000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Systematic Review: Sleep Disorders Based on Objective Data in Children and Adolescents Treated for a Brain Tumor"],"prefix":"10.3389","volume":"16","author":[{"given":"Anne Sophie Lind","family":"Helligsoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine Synne","family":"Weile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Kenborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Tram","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Lassen-Ramshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Maria","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette Falck","family":"Winther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Mathiasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"B1","first-page":"393","article-title":"\u201cChapter 26 - The multiple sleep latency test,\u201d","volume-title":"Handbook of Clinical Neurology","author":"Arand","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J. Clin. Sleep Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1196\/annals.1308.032","article-title":"Regulation of adolescent sleep: implications for behavior","volume":"1021","author":"Carskadon","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/sbr.12028","article-title":"Severe central apnea and hypoxia treated with acetazolamide in a toddler with brainstem ganglioglioma","volume":"11","author":"Chuang","year":"2013","journal-title":"Sleep Biol. Rhythms"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.1007\/s00415-021-10794-1","article-title":"Sleep disturbances in craniopharyngioma: a challenging diagnosis","volume":"268","author":"Cordani","year":"2021","journal-title":"J. Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"A342","DOI":"10.1007\/s00520-014-2356-3","article-title":"Changes in sleep and fatigue in newly treated pediatric oncology patients","volume":"33","author":"Crabtree","year":"2010","journal-title":"Sleep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/j.1365-2265.2011.03993.x","article-title":"Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable","volume":"74","author":"Crowley","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/jayao.2017.0006","article-title":"Sleep in adolescents and young adults in the year after cancer treatment","volume":"6","author":"Daniel","year":"2017","journal-title":"J. Adolesc. Young Adult Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1378\/chest.08-2568","article-title":"Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy","volume":"136","author":"Dayyat","year":"2009","journal-title":"Chest"},{"key":"B10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.5664\/jcsm.3372","article-title":"Two-year-old with post-surgical hypoglossal nerve injury and obstructive sleep apnea","volume":"10","author":"Delrosso","year":"2014","journal-title":"J. Clin. Sleep Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"101697","DOI":"10.1016\/j.canep.2020.101697","article-title":"Infant cancers in France: incidence and survival (2000-2014)","volume":"65","author":"Desandes","year":"2020","journal-title":"Cancer Epidemiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1378\/chest.06.2287","article-title":"Central sleep apnea: pathophysiology and treatment","volume":"131","author":"Eckert","year":"2007","journal-title":"Chest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/bf01963567","article-title":"Polygraphic sleep patterns and growth hormone secretion in children after cranial irradiation","volume":"150","author":"Fagioli","year":"1991","journal-title":"Eur. J. Pediatr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nrn1871","article-title":"Looking for inspiration: new perspectives on respiratory rhythm","volume":"7","author":"Feldman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1002\/ijc.31789","article-title":"Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes","volume":"144","author":"Frederiksen","year":"2019","journal-title":"Int. J. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5\u2013a population-based study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1378\/chest.107.4.963","article-title":"Snoring, apneic episodes, and nocturnal hypoxemia among children 6 months to 6 years old. An epidemiologic study of lower limit of prevalence","volume":"107","author":"Gislason","year":"1995","journal-title":"Chest"},{"key":"B18","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1080\/0284186x.2020.1725239","article-title":"Incidence and time trends of childhood cancer in Denmark, 1943\u20132014","volume":"59","author":"Grabas","year":"2020","journal-title":"Acta Oncol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1207\/s15402010bsm0301_3","article-title":"Health-related quality of life among children presenting to a pediatric sleep disorders clinic","volume":"3","author":"Hart","year":"2005","journal-title":"Behav. Sleep Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1210\/jc.2002-021797","article-title":"Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity","volume":"88","author":"Harz","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B21","unstructured":"\u201cAssessing risk of bias in included studies,\u201d\n            HigginsJ. P. T.\n            AltmanD. G.\n            SterneJ. A. C.\n          Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.02017"},{"key":"B22","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1188\/07.Onf.393-402","article-title":"Nocturnal awakenings, sleep environment interruptions, and fatigue in hospitalized children with cancer","volume":"34","author":"Hinds","year":"2007","journal-title":"Oncol. Nurs. Forum"},{"key":"B23","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Disorders","author":"Iber","year":"2007"},{"key":"B24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0165-5876(96)01375-4","article-title":"Pediatric brain stem gliomas with the predominant symptom of sleep apnea","volume":"37","author":"Ito","year":"1996","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1097\/PSY.0b013e3182359e77","article-title":"Psychosocial factors and sleep efficiency: discrepancies between subjective and objective evaluations of sleep","volume":"73","author":"Jackowska","year":"2011","journal-title":"Psychosom. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/nop\/npaa081","article-title":"Understanding sleep disturbance in the context of malignant brain tumors: a qualitative analysis","volume":"8","author":"Jeon","year":"2021","journal-title":"Neurooncol. Pract."},{"key":"B27","doi-asserted-by":"publisher","first-page":"A18","DOI":"10.1093\/sleep\/zsaa056.044","article-title":"Biobehavioral markers for sleep\/wake disturbance and fatigue in young childhood brain tumor survivors","volume":"43","author":"Johnson","year":"2020","journal-title":"Sleep"},{"key":"B28","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/s0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/00004691-199605000-00002","article-title":"Normal sleep architecture in infants and children","volume":"13","author":"Kahn","year":"1996","journal-title":"J. Clin. Neurophysiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.spen.2012.02.013","article-title":"Sleep disorders in children with cancer","volume":"19","author":"Kaleyias","year":"2012","journal-title":"Semin. Pediatr. Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"340","DOI":"10.11251\/ojjscn1969.38.340","article-title":"Symptomatic hypersomnia due to orexin deficiency in hypothalamic lesions","volume":"38","author":"Kanbayashi","year":"2006","journal-title":"No To Hattatsu"},{"key":"B32","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/neuonc\/noy094","article-title":"Neurologic disorders in 4858 survivors of central nervous system tumors in childhood-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study","volume":"21","author":"Kenborg","year":"2019","journal-title":"Neuro Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"iii4","DOI":"10.1093\/neuonc\/nox036","article-title":"Risk factors for hypersomnia and narcolepsy and response to therapy in survivors of childhood brain tumors","volume":"19","author":"Khan","year":"2017","journal-title":"Neuro Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1212\/01.wnl.0000265816.44697.b4","article-title":"Scholastic achievements of children with brain tumors at the end of comprehensive education - a nationwide, register-based study","volume":"69","author":"Lahteenmaki","year":"2007","journal-title":"Neurology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1111\/j.1651-2227.2009.01417.x","article-title":"Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005","volume":"98","author":"Lannering","year":"2009","journal-title":"Acta Paediatr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.5664\/jcsm.9198","article-title":"Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype","volume":"17","author":"Lividini","year":"2021","journal-title":"J. Clin. Sleep Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/sleep\/30.1.13","article-title":"The epidemiology of narcolepsy","volume":"30","author":"Longstreth","year":"2007","journal-title":"Sleep"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00520-021-06498-x","article-title":"Concordance between self-reported sleep and actigraphy-assessed sleep in adult survivors of childhood cancer: the impact of psychological and neurocognitive late effects","volume":"30","author":"Lubas","year":"2021","journal-title":"Support Care Cancer"},{"key":"B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/0883073820954617","article-title":"Secondary narcolepsy in children","volume":"36","author":"Madan","year":"2021","journal-title":"J. Child Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/pbc.23311","article-title":"Excessive daytime sleepiness and sleep-disordered breathing disturbances in survivors of childhood central nervous system tumors","volume":"58","author":"Mandrell","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"B41","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s11060-012-0859-7","article-title":"Sleep dysfunction in long term survivors of craniopharyngioma","volume":"108","author":"Manley","year":"2012","journal-title":"J. Neuro Oncol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/sleep\/25.4.427","article-title":"Secondary narcolepsy in children with brain tumors","volume":"25","author":"Marcus","year":"2002","journal-title":"Sleep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.chc.2009.04.013","article-title":"Normal sleep in children and adolescents","volume":"18","author":"McLaughlin Crabtree","year":"2009","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"B44","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1136\/jnnp.55.9.860","article-title":"Pavor nocturnus from a brainstem glioma","volume":"55","author":"Mendez","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1177\/1559827616681725","article-title":"Sleep disruption in pediaric cancer survivors: conceptual framework and opportunities for clinical assessment and behavioral treatment","volume":"12","author":"Merz","year":"2018","journal-title":"Am. J. Lifestyle Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/brainsci10070411","article-title":"Neurodevelopmental consequences of pediatric cancer and its treatment: the role of sleep","volume":"10","author":"Mogavero","year":"2020","journal-title":"Brain Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.3390\/cancers13112612","article-title":"Focus on the complex interconnection between cancer, narcolepsy and other neurodegenerative diseases: a possible case of orexin-dependent inverse comorbidity","volume":"13","author":"Mogavero","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/070674371105600905","article-title":"Prevalence of insomnia and its treatment in Canada","volume":"56","author":"Morin","year":"2011","journal-title":"Can. J. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1055\/s-2006-974095","article-title":"Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients","volume":"1","author":"M\u00fcller","year":"2006","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"B50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/sleep\/31.2.271","article-title":"Fatigue and sleep disturbance in adult survivors of childhood cancer: a report from the childhood cancer survivor study (CCSS)","volume":"31","author":"Mulrooney","year":"2008","journal-title":"Sleep"},{"key":"B51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.pedneo.2012.11.011","article-title":"A review of normal values of infant sleep polysomnography","volume":"54","author":"Ng","year":"2013","journal-title":"Pediatr. Neonatol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1176\/appi.ajp.161.11.2126","article-title":"Functional neuroimaging evidence for hyperarousal in insomnia","volume":"161","author":"Nofzinger","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1210\/jc.2009-2003","article-title":"Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls","volume":"95","author":"O'Gorman","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.sleep.2009.07.008","article-title":"Epidemiological and clinical relevance of insomnia diagnosis algorithms according to the DSM-IV and the International Classification of Sleep Disorders (ICSD)","volume":"10","author":"Ohayon","year":"2009","journal-title":"Sleep Med."},{"key":"B55","first-page":"990","article-title":"[A case of unilateral brain-stem tumor and impaired ventilatory response]","volume":"32","author":"Osanai","year":"1994","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e921","DOI":"10.1542\/peds.2014-1696","article-title":"Insufficient sleep in adolescents and young adults: an update on causes and consequences","volume":"134","author":"Owens","year":"2014","journal-title":"Pediatrics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"326","DOI":"10.23736\/s0026-4946.17.04914-3","article-title":"Insufficient sleep in adolescents: causes and consequences","volume":"69","author":"Owens","year":"2017","journal-title":"Minerva Pediatr."},{"key":"B58","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"B59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1055\/s-2008-1071310","article-title":"Sleep and wakefulness after treatment for craniopharyngioma in childhood: influence on the quality and maturation of sleep","volume":"23","author":"Palm","year":"1992","journal-title":"Neuropediatrics"},{"key":"B60","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s11060-013-1128-0","article-title":"Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma","volume":"113","author":"Park","year":"2013","journal-title":"J. Neurooncol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s11325-017-1574-6","article-title":"Polysomnographic findings in craniopharyngioma patients","volume":"21","author":"Pickering","year":"2017","journal-title":"Sleep Breath"},{"key":"B62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.sleep.2021.09.016","article-title":"Brain tumours result in sleep disorders in children and adolescents","volume":"88","author":"Pickering","year":"2021","journal-title":"Sleep Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"S189","DOI":"10.1002\/pbc.27989","article-title":"Sleep disorder in children treated for brain tumour. a polysomnography study","volume":"66","author":"Pilotto","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s1389-9457(02)00235-6","article-title":"Sleep architecture in normal Caucasian and Hispanic children aged 6-11 years recorded during unattended home polysomnography: experience from the Tucson Children's Assessment of Sleep Apnea Study (TuCASA)","volume":"4","author":"Quan","year":"2003","journal-title":"Sleep Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00520-010-0921-y","article-title":"Sleep in children with cancer: case review of 70 children evaluated in a comprehensive pediatric sleep center","volume":"19","author":"Rosen","year":"2011","journal-title":"Support. Care Cancer"},{"key":"B66","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2169\/internalmedicine.51.6101","article-title":"Possible mechanism of secondary narcolepsy with a long sleep time following surgery for craniopharyngioma","volume":"51","author":"Sakuta","year":"2012","journal-title":"Intern. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1212\/01.Con.0000427215.07715.73","article-title":"The neurobiology of sleep","volume":"19","author":"Saper","year":"2013","journal-title":"Continuum (Minneap Minn)"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition: highlights and modifications","volume":"146","author":"Sateia","year":"2014","journal-title":"Chest"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.neuroimage.2011.08.065","article-title":"Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study","volume":"59","author":"Stoodley","year":"2012","journal-title":"Neuroimage"},{"key":"B71","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0197-0070(88)90014-9","article-title":"Delayed sleep phase syndrome in adolescents","volume":"9","author":"Thorpy","year":"1988","journal-title":"J. Adolesc. Health Care"},{"key":"B72","doi-asserted-by":"publisher","first-page":"pkaa008","DOI":"10.1093\/jncics\/pkaa008","article-title":"Insomnia and neurocognitive functioning in adult survivors of childhood cancer","volume":"4","author":"Tonning Olsson","year":"2020","journal-title":"JNCI Cancer Spectr."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e0204409","DOI":"10.1371\/journal.pone.0204409","article-title":"Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness","volume":"13","author":"Tsukada","year":"2018","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012681.pub2","article-title":"Severe fatigue after treatment for childhood cancer","author":"van Deuren","year":"2020","journal-title":"Cochr. Database Syst. Rev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1365-2869.2011.00971.x","article-title":"Sleep disorders in children after treatment for a CNS tumour","volume":"21","author":"Verberne","year":"2012","journal-title":"J. Sleep Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1002\/pon.5460","article-title":"Factors associated with social functioning among long-term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults","volume":"29","author":"Walsh","year":"2020","journal-title":"Psychooncology"},{"key":"B77","article-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses","author":"Wells","year":"2021"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.808398\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T07:37:23Z","timestamp":1645515443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.808398\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":77,"alternative-id":["10.3389\/fnins.2022.808398"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.808398","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"article-number":"808398"}}