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Neurosci."],"abstract":"<jats:p>Frontotemporal dementia (FTD), hallmarked by antero-temporal degeneration in the human brain, is the second most common early onset dementia. FTD is a diverse disease with three main clinical presentations, four different identified proteinopathies and many disease-associated genes. The exact pathophysiology of FTD remains to be elucidated. One common characteristic all forms of FTD share is the dysregulation of glucose metabolism in patients\u2019 brains. The brain consumes around 20% of the body\u2019s energy supply and predominantly utilizes glucose as a fuel. Glucose metabolism dysregulation could therefore be extremely detrimental for neuronal health. Research into the association between glucose metabolism and dementias has recently gained interest in Alzheimer\u2019s disease. FTD also presents with glucose metabolism dysregulation, however, this remains largely an unexplored area. A better understanding of the link between FTD and glucose metabolism may yield further insight into FTD pathophysiology and aid the development of novel therapeutics. Here we review our current understanding of FTD and glucose metabolism in the brain and discuss the evidence of impaired glucose metabolism in FTD. Lastly, we review research potentially suggesting a causal relationship between FTD proteinopathies and impaired glucose metabolism in FTD.<\/jats:p>","DOI":"10.3389\/fnins.2022.812222","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:29:54Z","timestamp":1645619394000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Frontotemporal Dementia and Glucose Metabolism"],"prefix":"10.3389","volume":"16","author":[{"given":"Liam Rodney","family":"Garrett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Niccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1093\/brain\/awr119","article-title":"Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.","volume":"134","author":"Acosta-Cabronero","year":"2011","journal-title":"Brain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1212\/WNL.0000000000000993","article-title":"Systemic metabolism in frontotemporal dementia.","volume":"83","author":"Ahmed","year":"2014","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-41040-4","article-title":"Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.","volume":"9","author":"Ajmone-Cat","year":"2019","journal-title":"Sci. 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