{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:21:41Z","timestamp":1760710901870,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic tinnitus is a clinically multidimensional phenomenon that entails audiological, psychological and somatosensory components. Previous research has demonstrated age and female gender as potential risk factors, although studies to this regard are heterogeneous. Moreover, whilst recent research has begun to identify clinical \u201cphenotypes,\u201d little is known about differences in patient population profiles at geographically separated and specialized treatment centers. Identifying such differences might prevent potential biases in joint randomized controlled trials (RCTs) and allow for population-specific treatment adaptations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two German tinnitus treatment centers were compared regarding pre-treatment data distributions of their patient population bases. To identify overlapping as well as center-specific factors, juxtaposition-, similarity-, and meta-data-based methods were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between centers, significant differences emerged. One center demonstrated some predictive power of the patients of the other center with regard to questionnaire score after treatment, indicating similarities in treatment response across center populations. Furthermore, adherence to the completion of the questionnaires was found to be an important factor in predicting post-treatment data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Differential age and gender distributions per center should be considered as regards RCT design and individualized treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2022.818686","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T22:51:56Z","timestamp":1648507916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Juxtaposing Medical Centers Using Different Questionnaires Through Score Predictors"],"prefix":"10.3389","volume":"16","author":[{"given":"Clara","family":"Puga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miro","family":"Schleicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uli","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Unnikrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Boecking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Brueggemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Simoes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Langguth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Schlee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Mazurek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myra","family":"Spiliopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1026\/0012-1924\/a000068","article-title":"Messung der gesundheitsbezogenen lebensqualit\u00e4t mit dem sf-8","volume":"58","author":"Beierlein","year":"2012","journal-title":"Diagnostica"},{"key":"B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/7854_2020_154","article-title":"\u201cPrevalence, incidence, and risk factors for tinnitus,\u201d","volume-title":"The Behavioral Neuroscience of Tinnitus","author":"Biswas","year":"2020"},{"key":"B3","first-page":"14","article-title":"Scaling of psychosomatic by means of the giessen inventory (gbb)(author's transl)","volume":"29","author":"Br\u00e4hler","year":"1979","journal-title":"Psychotherapie Medizinische Psychologie"},{"key":"B4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/01.psy.0000151491.80178.78","article-title":"The perceived stress questionnaire (psq) reconsidered: validation and reference values from different clinical and healthy adult samples","volume":"67","author":"Fliege","year":"2005","journal-title":"Psychosomatic Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/s0960-9822(03)00290-2","article-title":"Superior underwater vision in a human population of sea gypsies","volume":"13","author":"Gisl\u00e9n","year":"2003","journal-title":"Curr. Biol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/3-540-27491-X_10","article-title":"\u201cPsychiatrische komorbidit\u00e4t bei tinnitus,\u201d","volume-title":"Tinnitus","author":"Goebel","year":"2005"},{"volume-title":"Tinnitus-Fragebogen:(TF); ein Instrument zur Erfassung von Belastung und Schweregrad bei Tinnitus; Handanweisung","year":"1998","author":"Goebel","key":"B7"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/2331554","article-title":"The probable error of a mean","volume":"6","author":"Gosset","year":"1908","journal-title":"Biometrika"},{"key":"B9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s001060050382","article-title":"Ist tinnitus messbar? methoden zur erfassung tinnitusspezifischer beeintr\u00e4chtigungen und pr\u00e4sentation des tinnitus-beeintr\u00e4chtigungs-fragebogens (tbf-12)","volume":"47","author":"Greimel","year":"1999","journal-title":"HNO"},{"volume-title":"ADS, Allgemeine Depressions Skala. Manual.","year":"1993","author":"Hautzinger","key":"B10"},{"key":"B11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.heares.2015.06.004","article-title":"Tinnitus functional index: development, validation, outcomes research, and clinical application","volume":"334","author":"Henry","year":"2016","journal-title":"Hearing Res."},{"key":"B12","first-page":"27","article-title":"Testing the invariance and hierarchy of a multidimensional model of mood by means of repeated measurement with student and patient sample","volume":"1","author":"Hoerhold","year":"1993","journal-title":"Z Med. Psychol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","article-title":"The development of the dizziness handicap inventory","volume":"116","author":"Jacobson","year":"1990","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0168-0102(90)90031-9","article-title":"Phantom auditory perception (tinnitus): mechanisms of generation and perception","volume":"8","author":"Jastreboff","year":"1990","journal-title":"Neurosci. Res."},{"key":"B15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0022-3999(93)90120-5","article-title":"Development of the perceived stress questionnaire: a new tool for psychosomatic research","volume":"37","author":"Levenstein","year":"1993","journal-title":"J. Psychosomatic Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/AUD.0b013e31822f67c0","article-title":"The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus","volume":"33","author":"Meikle","year":"2012","journal-title":"Ear Hearing"},{"key":"B17","first-page":"1656","author":"Neuh\u00e4user","year":"2011","journal-title":"Wilcoxon\u2013Mann\u2013Whitney Test"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2020.00487","article-title":"Gender-specific differences in patients with chronic tinnitus\u2014baseline characteristics and treatment effects","volume":"14","author":"Niemann","year":"2020","journal-title":"Front. Neurosci."},{"key":"B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/DSAA53316.2021.9564158","article-title":"\u201cDiscovery of patient phenotypes through multi-layer network analysis on the example of tinnitus,\u201d","volume-title":"2021 IEEE 8th International Conference on Data Science and Advanced Analytics (DSAA)","author":"Puga","year":"2021"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e28999","DOI":"10.2196\/28999","article-title":"Exploratory data mining techniques (decision tree models) for examining the impact of internet-based cognitive behavioral therapy for tinnitus: Machine learning approach","volume":"23","author":"Rodrigo","year":"2021","journal-title":"J. Med. Internet Res."},{"key":"B21","first-page":"175","author":"Schlee","year":"2021","journal-title":"Using Big Data to Develop a Clinical Decision Support System for Tinnitus Treatment"},{"key":"B22","first-page":"275","article-title":"Questionnaire of self-efficacy, optimism and pessimism: reconstruction, selection of items and validation of an instrument by means of examinations of clinical samples","volume":"49","author":"Scholler","year":"1999","journal-title":"Psychotherapie Psychosomatik Medizinische Psychologie"},{"key":"B23","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1097\/AUD.0b013e31828149f2","article-title":"Gender and chronic tinnitus","volume":"34","author":"Seydel","year":"2013","journal-title":"Ear and Hearing"},{"key":"B24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"B25","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1145\/3219819.3219991","article-title":"\u201cNetLSD: hearing the shape of a graph,\u201d","volume-title":"Proceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining","author":"Tsitsulin","year":"2018"},{"key":"B26","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/0194599811403882","article-title":"Tinnitus handicap inventory for evaluating treatment effects: which changes are clinically relevant?","volume":"145","author":"Zeman","year":"2011","journal-title":"Otolaryngol. Head Neck Surg."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.818686\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T04:38:28Z","timestamp":1726893508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.818686\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":26,"alternative-id":["10.3389\/fnins.2022.818686"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.818686","relation":{},"ISSN":["1662-453X"],"issn-type":[{"type":"electronic","value":"1662-453X"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"article-number":"818686"}}