{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:06Z","timestamp":1790888646374,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072772"],"award-info":[{"award-number":["32072772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>The enteric nervous system (ENS) is important for the intestinal barrier to defend and regulate inflammation in the intestine. The aim of this study was to investigate the effect of pyrroloquinoline quinone (PQQ) on regulating neuropeptide secretion by ENS neurons of rats challenged with lipopolysaccharide (LPS) to create enteritis. Thirty Sprague Dawley rats were divided into five groups, namely, basal (CTRL), basal plus LPS challenge (LPS), basal with 2.5 mg\/kg b.w.\/day of PQQ plus challenge with LPS (PQQ 2.5), basal with 5.0 mg\/kg b.w.\/day PQQ plus challenge with LPS (PQQ 5), and basal with 10.0 mg\/kg b.w.\/day PQQ plus challenge with LPS (PQQ 10). After treatment with basal diet or PQQ for 14 days, rats were challenged with LPS except for the CTRL group. Rats were euthanized 6 h after the LPS challenge. Rats showed an increased average daily gain in PQQ treatment groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Compared with the LPS group, PQQ 5 and PQQ 10 rats showed increased villus height and villus height\/crypt depth of jejunum (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). In PQQ treatment groups, concentrations of IL-1\u03b2 and TNF-\u03b1 in serum and intestine of rats were decreased, and IL-10 concentration was increased in serum compared with the LPS group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Compared with the LPS group, the concentration of neuropeptide Y (NPY), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), and brain-derived neurotropic factor (BDNF) in serum were decreased in PQQ treatment groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Compared with the LPS group, ileal mRNA levels of BDNF, NPY, and NGF were decreased in PQQ treatment groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Jejunal concentrations of SP, CGRP, VIP, BDNF, NPY, and NGF were decreased in PQQ treatment groups compared with the LPS group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Compared with the LPS group, phosphor-protein kinase B (p-Akt)\/Akt levels in jejunum and colon were decreased in PQQ treatment groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). In conclusion, daily treatment with PQQ improved daily gain, jejunal morphology, immune responses. PQQ-regulated enteric neurochemical plasticity of ENS <jats:italic>via<\/jats:italic> the Akt signaling pathway of weaned rats suffering from enteritis.<\/jats:p>","DOI":"10.3389\/fnins.2022.878541","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T13:17:55Z","timestamp":1651583875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Pyrroloquinoline Quinone Regulates Enteric Neurochemical Plasticity of Weaned Rats Challenged With Lipopolysaccharide"],"prefix":"10.3389","volume":"16","author":[{"given":"Chenyu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/306584a0","article-title":"Neuropeptide Y distribution in human brain.","volume":"306","author":"Adrian","year":"1983","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.regpep.2007.09.021","article-title":"Vasoactive intestinal peptide rescues cultured rat myenteric neurons from lipopolysaccharide induced cell death.","volume":"146","author":"Arciszewski","year":"2008","journal-title":"Regul. 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