{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:13Z","timestamp":1791919693636,"version":"4.3.4"},"reference-count":213,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG035982"],"award-info":[{"award-number":["P30 AG035982"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG065487"],"award-info":[{"award-number":["K01 AG065487"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative condition characterized by clinical decline in memory and other cognitive functions. A classic AD neuropathological hallmark includes the accumulation of amyloid-\u03b2 (A\u03b2) plaques, which may precede onset of clinical symptoms by over a decade. Efforts to prevent or treat AD frequently emphasize decreasing A\u03b2 through various mechanisms, but such approaches have yet to establish compelling interventions. It is still not understood exactly why A\u03b2 accumulates in AD, but it is hypothesized that A\u03b2 and other downstream pathological events are a result of impaired bioenergetics, which can also manifest prior to cognitive decline. Evidence suggests that individuals with AD and at high risk for AD have functional brain ketone metabolism and ketotherapies (KTs), dietary approaches that produce ketone bodies for energy metabolism, may affect AD pathology by targeting impaired brain bioenergetics. Cognitively normal individuals with elevated brain A\u03b2, deemed \u201cpreclinical AD,\u201d and older adults with peripheral metabolic impairments are ideal candidates to test whether KTs modulate AD biology as they have impaired mitochondrial function, perturbed brain glucose metabolism, and elevated risk for rapid A\u03b2 accumulation and symptomatic AD. Here, we discuss the link between brain bioenergetics and A\u03b2, as well as the potential for KTs to influence AD risk and progression.<\/jats:p>","DOI":"10.3389\/fnins.2022.899612","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T05:35:40Z","timestamp":1655357740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential for Ketotherapies as Amyloid-Regulating Treatment in Individuals at Risk for Alzheimer\u2019s Disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Matthew K.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra K.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/life10070101","article-title":"Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration.","volume":"10","author":"Abramov","year":"2020","journal-title":"Life"},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11064-016-2099-2","article-title":"beta-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.","volume":"42","author":"Achanta","year":"2017","journal-title":"Neurochem. 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