{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:45:54Z","timestamp":1776177954939,"version":"3.50.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Presbycusis and tinnitus are the two most common hearing related pathologies. Although both of these conditions presumably originate in the inner ear, there are several reports concerning their central components. Interestingly, the onset of presbycusis coincides with the highest occurrence of tinnitus. The aim of this study was to identify age, hearing loss, and tinnitus related functional changes, within the auditory system and its associated structures. Seventy-eight participants were selected for the study based on their age, hearing, and tinnitus, and they were divided into six groups: young controls (Y-NH-NT), subjects with mild presbycusis (O-NH-NT) or expressed presbycusis (O-HL-NT), young subjects with tinnitus (Y-NH-T), subjects with mild presbycusis and tinnitus (O-NH-T), and subjects with expressed presbycusis and tinnitus (O-HL-T). An MRI functional study was performed with a 3T MRI system, using an event related design (different types of acoustic and visual stimulations and their combinations). The amount of activation of the auditory cortices (ACs) was dependent on the complexity of the stimuli; higher complexity resulted in a larger area of the activated cortex. Auditory stimulation produced a slightly greater activation in the elderly, with a negative effect of hearing loss (lower activation). The congruent audiovisual stimulation led to an increased activity within the default mode network, whereas incongruent stimulation led to increased activation of the visual cortex. The presence of tinnitus increased activation of the AC, specifically in the aged population, with a slight prevalence in the left AC. The occurrence of tinnitus was accompanied by increased activity within the insula and hippocampus bilaterally. Overall, we can conclude that expressed presbycusis leads to a lower activation of the AC, compared to the elderly with normal hearing; aging itself leads to increased activity in the right AC. The complexity of acoustic stimuli plays a major role in the activation of the AC, its support by visual stimulation leads to minimal changes within the AC. Tinnitus causes changes in the activity of the limbic system, as well as in the auditory AC, where it is bound to the left hemisphere.<\/jats:p>","DOI":"10.3389\/fnins.2022.921873","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:28:30Z","timestamp":1666200510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus"],"prefix":"10.3389","volume":"16","author":[{"given":"Jakub","family":"Fuksa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Profant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Tint\u011bra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Svobodov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"T\u00f3thov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"\u0160koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Syka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"B1","first-page":"35","article-title":"A review of the cocktail party effect.","volume":"12","author":"Arons","year":"1992","journal-title":"J. Am. Voice Soc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus.","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"102166","DOI":"10.1016\/j.nicl.2020.102166","article-title":"A 7 Tesla fMRI investigation of human tinnitus percept in cortical and subcortical auditory areas.","volume":"25","author":"Berlot","year":"2020","journal-title":"Neuroimage Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.neuropsychologia.2006.03.008","article-title":"Utilizing the ventriloquism-effect to investigate audio-visual binding.","volume":"45","author":"Bischoff","year":"2007","journal-title":"Neuropsychologia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.heares.2009.06.017","article-title":"Visual influences on ferret auditory cortex.","volume":"258","author":"Bizley","year":"2009","journal-title":"Hear. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nn1409","article-title":"Hierarchical and asymmetric temporal sensitivity in human auditory cortices.","volume":"8","author":"Boemio","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fnagi.2019.00219","article-title":"Speech comprehension and its relation to other auditory parameters in elderly patients with tinnitus.","volume":"11","author":"Bure\u0161","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e876","DOI":"10.1097\/MAO.0000000000002403","article-title":"Cognitive performance in chronic tinnitus patients: a cross-sectional study using the RBANS-H.","volume":"40","author":"Cardon","year":"2019","journal-title":"Otol. Neurotol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/hbm.23525","article-title":"Tinnitus distress is linked to enhanced resting-state functional connectivity from the limbic system to the auditory cortex.","volume":"38","author":"Chen","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"B10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neubiorev.2013.03.021","article-title":"An integrative model of auditory phantom perception: tinnitus as a unified percept of interacting separable subnetworks.","volume":"44","author":"De Ridder","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B11","first-page":"240","article-title":"Test vetn\u00e9 srozumitelnosti v hovorov\u00e9m \u0161umu u osob s vadou sluchu","volume":"61","author":"Dlouh\u00e1","year":"2012","journal-title":"Otorhinolaryngol. Phoniatr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2331216519857267","DOI":"10.1177\/2331216519857267","article-title":"Age-Related hearing loss associations with changes in brain morphology.","volume":"23","author":"Eckert","year":"2019","journal-title":"Trends Hear."},{"key":"B13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/B978-0-12-805398-0.00007-4","article-title":"Chapter 7 - epidemiology and genetics of hearing loss and tinnitus","author":"Eggermont","year":"2017","journal-title":"Hearing Loss"},{"key":"B14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fnsys.2012.00053","article-title":"The neuroscience of tinnitus: understanding abnormal and normal auditory perception.","volume":"6","author":"Eggermont","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1121\/1.4921603","article-title":"Sentence intelligibility during segmental interruption and masking by speech-modulated noise: effects of age and hearing loss.","volume":"137","author":"Fogerty","year":"2015","journal-title":"J. Acoust. Soc. Am."},{"key":"B16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s00221-002-1017-9","article-title":"Redundant target effect and intersensory facilitation from visual-tactile interactions in simple reaction time.","volume":"143","author":"Forster","year":"2002","journal-title":"Exp. Brain Res."},{"key":"B17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.48095\/ccorl2021223","article-title":"Vztah mezi presbyakuz\u00ed a poruchou kognitivn\u00edch funkc\u00ed ve st\u00e1r\u00ed","volume":"70","author":"Fuksa","year":"2021","journal-title":"Otorhinolaryngol. Phoniatr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis.","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroscience.2013.10.015","article-title":"Asymmetry in primary auditory cortex activity in tinnitus patients and controls.","volume":"256","author":"Geven","year":"2014","journal-title":"Neuroscience"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00288","article-title":"Decreased speech-in-noise understanding in young adults with tinnitus.","volume":"10","author":"Gilles","year":"2016","journal-title":"Front. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00429-017-1477-0","article-title":"Neuroanatomical and resting state EEG power correlates of central hearing loss in older adults.","volume":"223","author":"Giroud","year":"2017","journal-title":"Brain Struct. Funct"},{"key":"B22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2016.08.012","article-title":"Cross-modal plasticity in developmental and age-related hearing loss: clinical implications.","volume":"343","author":"Glick","year":"2017","journal-title":"Hear. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/AUD.0b013e3181e627e7","article-title":"Processing of temporal fine structure as a function of age.","volume":"31","author":"Grose","year":"2010","journal-title":"Ear Hear."},{"key":"B24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1080\/14992020400050030","article-title":"Tinnitus impairs cognitive efficiency.","volume":"43","author":"Hallam","year":"2004","journal-title":"Int. J. Audiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0030-6665(02)00160-3","article-title":"Classification and epidemiology of tinnitus.","volume":"36","author":"Heller","year":"2003","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"B26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.nicl.2018.08.029","article-title":"Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus.","volume":"20","author":"Hofmeier","year":"2018","journal-title":"Neuroimage Clin."},{"key":"B27","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/9780470720677.ch12","article-title":"Tinnitus: surgical treatment.","volume":"85","author":"House","year":"1981","journal-title":"Ciba Found. Symp."},{"key":"B28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.heares.2015.09.010","article-title":"Neural networks of tinnitus in humans: elucidating severity and habituation.","volume":"334","author":"Husain","year":"2016","journal-title":"Hear. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1121\/1.4894719","article-title":"Reference hearing thresholds in an extended frequency range as a function of age.","volume":"136","author":"Jilek","year":"2014","journal-title":"J. Acoust. Soc. Am."},{"key":"B30","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.neuroimage.2019.01.050","article-title":"When right becomes less right: neural dedifferentiation during suprasegmental speech processing in the aging brain.","volume":"189","author":"Keller","year":"2019","journal-title":"Neuroimage"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1002\/lio2.501","article-title":"Tinnitus and cognition: can load theory help us refine our understanding?","volume":"5","author":"Khan","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"23395","DOI":"10.1038\/s41598-021-02908-6","article-title":"A large-scale diffusion imaging study of tinnitus and hearing loss.","volume":"11","author":"Khan","year":"2021","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"7190","DOI":"10.1523\/JNEUROSCI.1314-19.2020","article-title":"The neural bases of tinnitus: lessons from deafness and cochlear implants.","volume":"40","author":"Knipper","year":"2020","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1523\/JNEUROSCI.2083-19.2020","article-title":"Cortical tonotopic map changes in humans are larger in hearing loss than in additional tinnitus.","volume":"40","author":"Koops","year":"2020","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.tics.2015.08.017","article-title":"Unraveling the biology of auditory learning: a cognitive-sensorimotor-reward framework.","volume":"19","author":"Kraus","year":"2015","journal-title":"Trends Cogn. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnsys.2012.00002","article-title":"Tinnitus does not require macroscopic tonotopic map reorganization.","volume":"6","author":"Langers","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-3-319-25474-6_19","article-title":"Tinnitus- and task-related differences in resting-state networks.","volume":"894","author":"Lanting","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1037\/0096-3445.133.3.339","article-title":"Load theory of selective attention and cognitive control.","volume":"133","author":"Lavie","year":"2004","journal-title":"J. Exp. Psychol. Gen."},{"key":"B39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.heares.2015.08.005","article-title":"Auditory-limbic interactions in chronic tinnitus: challenges for neuroimaging research.","volume":"334","author":"Leaver","year":"2016","journal-title":"Hear. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1037\/a0024238","article-title":"Hearing loss and cognition in the baltimore longitudinal study of aging.","volume":"25","author":"Lin","year":"2011","journal-title":"Neuropsychology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","article-title":"Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British association of otolaryngologists, head and neck surgeons, 1999.","volume":"26","author":"McCombe","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.tics.2012.04.006","article-title":"Cortical asymmetries in speech perception: what\u2019s wrong, what\u2019s right and what\u2019s left?","volume":"16","author":"McGettigan","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"14260","DOI":"10.1523\/JNEUROSCI.5091-14.2015","article-title":"Influence of tinnitus on auditory spectral and temporal resolution and speech perception in tinnitus patients.","volume":"35","author":"Moon","year":"2015","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-25474-6_1","article-title":"Effects of age and hearing loss on the processing of auditory temporal fine structure.","volume":"894","author":"Moore","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.heares.2009.06.018","article-title":"Neuronal mechanisms, response dynamics and perceptual functions of multisensory interactions in auditory cortex.","volume":"258","author":"Musacchia","year":"2009","journal-title":"Hear. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/archotol.1996.01890140029007","article-title":"Development of the tinnitus handicap inventory.","volume":"122","author":"Newman","year":"1996","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2331216519862982","DOI":"10.1177\/2331216519862982","article-title":"Measuring speech recognition with a matrix test using synthetic speech.","volume":"23","author":"Nuesse","year":"2019","journal-title":"Trends Hear."},{"key":"B48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00441-014-2107-2","article-title":"Age-related changes in the central auditory system.","volume":"361","author":"Ouda","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1001\/jama.2020.0697","article-title":"Tinnitus.","volume":"323","author":"Piccirillo","year":"2020","journal-title":"JAMA"},{"key":"B50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/108471380601000103","article-title":"Effects of age on auditory and cognitive processing: implications for hearing aid fitting and audiologic rehabilitation.","volume":"10","author":"Pichora-Fuller","year":"2006","journal-title":"Trends Amplif."},{"key":"B51","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.exger.2013.04.012","article-title":"Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.","volume":"48","author":"Profant","year":"2013","journal-title":"Exp. Gerontol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fnagi.2019.00026","article-title":"Functional age-related changes within the human auditory system studied by audiometric examination.","volume":"11","author":"Profant","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuroscience.2013.12.010","article-title":"Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging.","volume":"260","author":"Profant","year":"2014","journal-title":"Neuroscience"},{"key":"B54","doi-asserted-by":"publisher","first-page":"553461","DOI":"10.3389\/fnagi.2020.553461","article-title":"The influence of aging, hearing, and tinnitus on the morphology of cortical gray matter, amygdala, and hippocampus.","volume":"12","author":"Profant","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0116692","DOI":"10.1371\/journal.pone.0116692","article-title":"Functional changes in the human auditory cortex in ageing.","volume":"10","author":"Profant","year":"2015","journal-title":"PLoS One"},{"key":"B56","doi-asserted-by":"publisher","first-page":"627522","DOI":"10.3389\/fneur.2021.627522","article-title":"Co-occurrence of hyperacusis accelerates with tinnitus burden over time and requires medical care.","volume":"12","author":"Refat","year":"2021","journal-title":"Front. Neurol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.cortex.2020.04.022","article-title":"Age-related hearing loss influences functional connectivity of auditory cortex for the McGurk illusion.","volume":"129","author":"Rosemann","year":"2020","journal-title":"Cortex"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e24672","DOI":"10.1371\/journal.pone.0024672","article-title":"Hemispheric asymmetries in speech perception: sense, nonsense and modulations.","volume":"6","author":"Rosen","year":"2011","journal-title":"PLoS One"},{"key":"B59","doi-asserted-by":"publisher","first-page":"13410","DOI":"10.1523\/JNEUROSCI.2592-09.2009","article-title":"Distributed and antagonistic contributions of ongoing activity fluctuations to auditory stimulus detection.","volume":"29","author":"Sadaghiani","year":"2009","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/hbm.21426","article-title":"Neural correlates of tinnitus duration and distress: a positron emission tomography study.","volume":"34","author":"Schecklmann","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"B61","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/cercor\/bhj165","article-title":"Hemispheric asymmetry for auditory processing in the human auditory brain stem, thalamus, and cortex.","volume":"17","author":"Sch\u00f6nwiesner","year":"2007","journal-title":"Cereb. Cortex"},{"key":"B62","author":"Schuknecht","year":"1974","journal-title":"Pathology of the Ear."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis.","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00234-007-0231-3","article-title":"Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus.","volume":"49","author":"Smits","year":"2007","journal-title":"Neuroradiology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1002\/hbm.20768","article-title":"Detection of differential speech-specific processes in the temporal lobe using fMRI and a dynamic \u201csound morphing\u201d technique.","volume":"30","author":"Specht","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"B66","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1044\/jshd.5503.439","article-title":"Characterization of tinnitus by tinnitus patients.","volume":"55","author":"Stouffer","year":"1990","journal-title":"J. Speech Hear. Disord."},{"key":"B67","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/physrev.00002.2002","article-title":"Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning.","volume":"82","author":"Syka","year":"2002","journal-title":"Physiol. Rev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1196\/annals.1360.011","article-title":"Neurophysiology and neuroanatomy of pitch perception: auditory cortex.","volume":"1060","author":"Tramo","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B69","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1152\/jn.00104.1999","article-title":"Functional role of auditory cortex in frequency processing and pitch perception.","volume":"87","author":"Tramo","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"117675","DOI":"10.1016\/j.neuroimage.2020.117675","article-title":"Brain aging and speech perception: effects of background noise and talker variability.","volume":"227","author":"Tremblay","year":"2021","journal-title":"Neuroimage"},{"key":"B71","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.arr.2015.06.002","article-title":"A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline.","volume":"23","author":"Wayne","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"B72","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jneumeth.2007.01.026","article-title":"LI-tool: a new toolbox to assess lateralization in functional MR-data.","volume":"163","author":"Wilke","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"B73","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.neuroimage.2006.07.010","article-title":"A combined bootstrap\/histogram analysis approach for computing a lateralization index from neuroimaging data.","volume":"33","author":"Wilke","year":"2006","journal-title":"Neuroimage"},{"key":"B74","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1121\/1.395965","article-title":"Speech understanding and aging.","volume":"83","year":"1988","journal-title":"J. Acoust. Soc. Am."},{"key":"B75","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/WNP.0b013e3181c298b1","article-title":"Multisensory interactions elicited by audiovisual stimuli presented peripherally in a visual attention task: a behavioral and event-related potential study in humans.","volume":"26","author":"Wu","year":"2009","journal-title":"J. Clin. Neurophysiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1111\/j.1460-9568.2004.03687.x","article-title":"Evidence for rapid auditory perception as the foundation of speech processing: a sparse temporal sampling fMRI study.","volume":"20","author":"Zaehle","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B77","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/cercor\/11.10.946","article-title":"Spectral and temporal processing in human auditory cortex.","volume":"11","author":"Zatorre","year":"2001","journal-title":"Cereb. Cortex"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.921873\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:28:43Z","timestamp":1666200523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.921873\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":77,"alternative-id":["10.3389\/fnins.2022.921873"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.921873","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"article-number":"921873"}}