{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:15:28Z","timestamp":1788347728983,"version":"build-2803163510"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>The \u03b54 allele of the apolipoprotein E (<jats:italic>APOE<\/jats:italic>4+) genotype is a major genetic risk factor for Alzheimer\u2019s disease (AD), but the mechanisms underlying its influence remain incompletely understood. The study aimed to investigate the possible effect of the <jats:italic>APOE<\/jats:italic> genotype on spontaneous electroencephalogram (EEG) alpha characteristics, resting-state functional MRI (fMRI) connectivity (rsFC) in large brain networks and the interrelation of alpha rhythm and rsFC characteristics in non-demented adults during aging. We examined the EEG alpha subband\u2019s relative power, individual alpha peak frequency (IAPF), and fMRI rsFC in non-demented volunteers (age range 26\u201379 years) stratified by the <jats:italic>APOE<\/jats:italic> genotype. The presence of the <jats:italic>APOE4+<\/jats:italic> genotype was associated with lower IAPF and lower relative power of the 11\u201313 Hz alpha subbands. The age related decrease in EEG IAPF was more pronounced in the <jats:italic>APOE4+<\/jats:italic> carriers than in the <jats:italic>APOE4+<\/jats:italic> non-carriers (<jats:italic>APOE4<\/jats:italic>-). The <jats:italic>APOE4+<\/jats:italic> carriers had a stronger fMRI positive rsFC of the interhemispheric regions of the frontoparietal, lateral visual and salience networks than the <jats:italic>APOE4\u2013<\/jats:italic> individuals. In contrast, the negative rsFC in the network between the left hippocampus and the right posterior parietal cortex was reduced in the <jats:italic>APOE4+<\/jats:italic> carriers compared to the non-carriers. Alpha rhythm slowing was associated with the dysfunction of hippocampal networks. Our results show that in adults without dementia <jats:italic>APOE4+<\/jats:italic> genotype is associated with alpha rhythm slowing and that this slowing is age-dependent. Our data suggest predominant alterations of inhibitory processes in large-scale brain network of non-demented <jats:italic>APOE4+<\/jats:italic> carriers. Moreover, dysfunction of large-scale hippocampal network can influence <jats:italic>APOE<\/jats:italic>-related alpha rhythm vulnerability.<\/jats:p>","DOI":"10.3389\/fnins.2022.931173","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T05:31:05Z","timestamp":1659331865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Genetic association of apolipoprotein E genotype with EEG alpha rhythm slowing and functional brain network alterations during normal aging"],"prefix":"10.3389","volume":"16","author":[{"given":"Natalya V.","family":"Ponomareva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana V.","family":"Andreeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Protasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodion N.","family":"Konovalov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Krotenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina P.","family":"Kolesnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria D.","family":"Malina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Kanavets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A.","family":"Mitrofanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly F.","family":"Fokin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey N.","family":"Illarioshkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny I.","family":"Rogaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jalz.2017.02.001","article-title":"2017 Alzheimer\u2019s disease facts and figures.","volume":"13","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ana.20724","article-title":"Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study.","volume":"59","author":"Babiloni","year":"2006","journal-title":"Ann. 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