{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:11:35Z","timestamp":1778080295951,"version":"3.51.4"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>\n                    It is well-known that morphological features in the brain undergo changes due to traumatic events and associated disorders such as post-traumatic stress disorder (PTSD). However, existing approaches typically offer group-level comparisons, and there are limited predictive approaches for modeling behavioral outcomes based on brain shape features that can account for heterogeneity in PTSD, which is of paramount interest. We propose a comprehensive shape analysis framework representing brain sub-structures, such as the hippocampus, amygdala, and putamen, as parameterized surfaces and quantifying their shape differences using an elastic shape metric. Under this metric, we compute shape summaries (mean, covariance, PCA) of brain sub-structures and represent individual brain shapes by their principal scores under a shape-PCA basis. These representations are rich enough to allow visualizations of full 3D structures and help understand localized changes. In order to validate the elastic shape analysis, we use the principal components (PCs) to reconstruct the brain structures and perform further evaluation by performing a regression analysis to model PTSD and trauma severity using the brain shapes represented\n                    <jats:italic>via<\/jats:italic>\n                    PCs and in conjunction with auxiliary exposure variables. We apply our method to data from the Grady Trauma Project (GTP), where the goal is to predict clinical measures of PTSD. The framework seamlessly integrates accurate morphological features and other clinical covariates to yield superior predictive performance when modeling PTSD outcomes. Compared to vertex-wise analysis and other widely applied shape analysis methods, the elastic shape analysis approach results in considerably higher reconstruction accuracy for the brain shape and reveals significantly greater predictive power. It also helps identify local deformations in brain shapes associated with PTSD severity.\n                  <\/jats:p>","DOI":"10.3389\/fnins.2022.954055","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T02:09:11Z","timestamp":1661998151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Elastic shape analysis of brain structures for predictive modeling of PTSD"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuexuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suprateek","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Fani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuj","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2470547017724069","DOI":"10.1177\/2470547017724069","article-title":"The association of PTSD symptom severity with localized hippocampus and amygdala abnormalities","volume":"1","author":"Akiki","year":"2017","journal-title":"Chronic Stress"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1007\/s11682-019-00127-2","article-title":"Volume and shape analysis of the hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder","volume":"14","author":"Bae","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"B3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1117\/12.57955","article-title":"\u201cMethod for registration of 3-D shapes,\u201d","volume-title":"Sensor Fusion IV: Control Paradigms and Data Structures, Vol. 1611","author":"Besl","year":"1992"},{"key":"B4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/B978-0-12-810493-4.00012-2","article-title":"\u201cShapeworks: particle-based shape correspondence and visualization software,\u201d","volume-title":"Statistical Shape and Deformation Analysis","author":"Cates","year":"2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/da.22833","article-title":"Smaller hippocampal ca1 subfield volume in posttraumatic stress disorder","volume":"35","author":"Chen","year":"2018","journal-title":"Depress. 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