{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:16:15Z","timestamp":1793146575026,"version":"4.5.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>People with misophonia experience strong negative emotional responses to sounds and associated stimuli\u2014mostly human produced\u2014to an extent that it may cause impairment in social functioning. The exact nature of the disorder remains a matter of ongoing research and debate. Here, we investigated the genetic etiology of misophonia to understand contributing genetic factors and shed light on individual differences in characteristics that are related to the disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For misophonia, we used an unpublished genome-wide association study (GWAS) from genetic service provider 23andMe, Inc., on a self-report item probing a single common misophonic symptom: the occurrence of rage when others produce eating sounds. First, we used gene-based and functional annotation analyses to explore neurobiological determinants of the rage-related misophonia symptom. Next, we calculated genetic correlations (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>G<\/jats:sub>\n                      ) of this rage-related misophonia symptom GWAS with a wide range of traits and disorders from audiology (tinnitus, hearing performance, and hearing trauma), psychiatry, neurology, and personality traits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rage-related misophonia symptom was significantly correlated with tinnitus, major depression disorder (MDD), post-traumatic stress disorder (PTSD), and generalized anxiety disorder (GAD; 0.12 &amp;lt;\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>G<\/jats:sub>\n                      &amp;lt; 0.22). Stronger genetic correlations (0.21 &amp;lt;\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>G<\/jats:sub>\n                      &amp;lt; 0.42) were observed for two clusters of personality traits: a guilt\/neuroticism and an irritability\/sensitivity cluster. Our results showed no genetic correlation with attention deficit and hyperactivity disorder, obsessive-compulsive disorder, and psychotic disorders. A negative correlation with autism spectrum disorder (ASD) was found, which may be surprising given the previously reported comorbidities and the sensory sensitivity reported in ASD. Clustering algorithms showed that rage-related misophonia consistently clustered with MDD, generalized anxiety, PTSD, and related personality traits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We conclude that\u2014based on the genetics of a common misophonia symptom\u2014misophonia most strongly clusters with psychiatric disorders and a personality profile consistent with anxiety and PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2022.971752","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T01:49:07Z","timestamp":1674524947000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["A genome-wide association study of a rage-related misophonia symptom and the genetic link with audiological traits, psychiatric disorders, and personality"],"prefix":"10.3389","volume":"16","author":[{"given":"Dirk J. A.","family":"Smit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Abdellaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Hoetink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"Vulink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiaan","family":"Denys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s41562-019-0757-5","article-title":"Genetic correlates of social stratification in Great Britain.","volume":"3","author":"Abdellaoui","year":"2019","journal-title":"Nat. Hum. Behav."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.08.20125732","article-title":"Genomic relationships across psychiatric disorders including substance use disorders.","author":"Abdellaoui","year":"2020","journal-title":"medRxiv"},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ijporl.2018.06.015","article-title":"Hyperacusis in children: The Edinburgh experience.","volume":"112","author":"Amir","year":"2018","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2019.103797","article-title":"An adult female with 5q34-q35.2 deletion: A rare syndromic presentation of left ventricular non-compaction and congenital heart disease.","volume":"63","author":"Arya","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41588-018-0320-8","article-title":"Multivariate genome-wide analyses of the well-being spectrum.","volume":"51","author":"Baselmans","year":"2019","journal-title":"Nat. Genet."},{"key":"B6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing.","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodological)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks.","volume":"2008","author":"Blondel","year":"2008","journal-title":"J. Stat. Mech."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00036","article-title":"Investigating misophonia: A review of the empirical literature. Clinical implications, and a research agenda.","volume":"12","author":"Brout","year":"2018","journal-title":"Front. Neurosci."},{"key":"B9","author":"Bruxner","year":"2016","journal-title":"\u2018Mastication rage\u2019: A review of misophonia \u2013 an under-recognised symptom of psychiatric relevance?."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits.","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ymgme.2004.01.020","article-title":"Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation.","volume":"82","author":"Bykhovskaya","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S1474-4422(14)70171-1","article-title":"Genetic determinants of common epilepsies: A meta-analysis of genome-wide association studies.","volume":"13","author":"Consortium","year":"2014","journal-title":"Lancet Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ng885","article-title":"Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy.","volume":"31","author":"Cossette","year":"2002","journal-title":"Nat. Genet."},{"key":"B14","first-page":"1","article-title":"The igraph software package for complex network research.","volume":"1695","author":"Csardi","year":"2006","journal-title":"Int. J. Complex Syst."},{"key":"B15","author":"Dawes","year":"2013","journal-title":"UK biobank normative data for the digit triplet test."},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41588-020-00754-2","article-title":"Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.","volume":"53","author":"Demange","year":"2021","journal-title":"Nat. Genet."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.223","article-title":"Obsessive\u2013compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs.","volume":"6","author":"den Braber","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"431","DOI":"10.5406\/amerjpsyc.130.4.0431","article-title":"Phenomenology of misophonia: Initial physical and emotional responses.","volume":"130","author":"Dozier","year":"2017","journal-title":"Am. J. Psychol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/010512","article-title":"Ancestry composition: A novel, efficient pipeline for ancestry deconvolution.","author":"Durand","year":"2014","journal-title":"bioRxiv"},{"key":"B20","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1016\/j.biopsych.2020.02.585","article-title":"Structural and functional brain abnormalities in misophonia.","volume":"87","author":"Eijsker","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.euroneuro.2017.10.014","article-title":"Misophonia, emotional dysregulation and affective disorders: A preliminary study.","volume":"28","author":"Erfanian","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/08039488.2019.1609086","article-title":"Misophonia and comorbid psychiatric symptoms: A preliminary study of clinical findings.","volume":"73","author":"Erfanian","year":"2019","journal-title":"Nord. J. Psychiatry"},{"key":"B23","article-title":"Genetic associations with traits in 23andme customers.","author":"Fayzullina","year":"2015","journal-title":"White Paper 23-08."},{"key":"B24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.schres.2020.04.027","article-title":"Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.","volume":"220","author":"Frajman","year":"2020","journal-title":"Schizophr. Res."},{"key":"B25","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4088\/JCP.v65n0711","article-title":"Prevalence, correlates, and disability of personality disorders in the united states: Results from the national epidemiologic survey on alcohol and related conditions.","volume":"65","author":"Grant","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6690","article-title":"The genetic architecture of the human cerebral cortex.","volume":"367","author":"Grasby","year":"2020","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41562-019-0566-x","article-title":"Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits.","volume":"3","author":"Grotzinger","year":"2019","journal-title":"Nat. Hum. Behav."},{"key":"B28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies.","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat. Genet."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231390","article-title":"Misophonia: Phenomenology, comorbidity and demographics in a large sample.","volume":"15","author":"Jager","year":"2020","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1012424","article-title":"Prevalence and clinical correlates of misophonia symptoms in the general population of Germany.","volume":"13","author":"Jakubovski","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B31","first-page":"5","article-title":"Components of decreased sound tolerance: Hyperacusis. misophonia, phonophobia.","volume":"2","author":"Jastreboff","year":"","journal-title":"ITHS News Lett."},{"key":"B32","author":"Jastreboff","year":"","journal-title":"Hyperacusis. Audiology Online."},{"key":"B33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1055\/s-0034-1372527","article-title":"Treatments for decreased sound tolerance (Hyperacusis and Misophonia).","volume":"35","author":"Jastreboff","year":"2014","journal-title":"Semin. Hear."},{"key":"B34","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/B978-0-444-62630-1.00021-4","article-title":"Chapter 21 - Decreased sound tolerance: Hyperacusis, misophonia, diplacousis, and polyacousis","author":"Jastreboff","year":"2015","journal-title":"Handbook of clinical neurology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000099025","article-title":"Susceptibility to tinnitus revealed at 2 kHz range by bilateral lower DPOAEs in normal hearing subjects with noise exposure.","volume":"12","author":"Job","year":"2007","journal-title":"AUD"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.978","article-title":"The prevalence and characteristics of misophonia in Ankara. Turkey: population-based study.","volume":"7","author":"K\u0131l\u0131\u00e7","year":"2021","journal-title":"BJPsych Open"},{"key":"B37","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants.","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/eat.22245","article-title":"Should we screen for misophonia in patients with eating disorders? A report of three cases.","volume":"47","author":"Kluckow","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"B39","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: Causes and clinical management.","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2016.59.11.S19","article-title":"Interstitial deletion of 5q33.3q35.1 in a boy with severe mental retardation.","volume":"59","author":"Lee","year":"2016","journal-title":"Korean J. Pediatr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","article-title":"Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.","volume":"50","author":"Lee","year":"2018","journal-title":"Nat. Genet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2019.11.020","article-title":"Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.","volume":"179","author":"Lee","year":"2019","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/sj.hdy.6800717","article-title":"Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix.","volume":"95","author":"Li","year":"2005","journal-title":"Heredity"},{"key":"B44","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00439-018-1910-3","article-title":"The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.","volume":"137","author":"Liu","year":"2018","journal-title":"Hum. Genet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project.","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog).","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B48","article-title":"Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci.","volume":"206","author":"Marees","year":"","journal-title":"Drug Alcohol Depend."},{"key":"B49","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1017\/S0033291719000357","article-title":"Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health.","volume":"50","author":"Marees","year":"","journal-title":"Psychol. Med."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000099","article-title":"How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing.","volume":"42","author":"McGeoch","year":"2020","journal-title":"BioEssays"},{"key":"B51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.heares.2016.10.030","article-title":"Lifetime leisure music exposure associated with increased frequency of tinnitus.","volume":"347","author":"Moore","year":"2017","journal-title":"Hear. Res."},{"key":"B52","year":"2018","journal-title":"FAQ - UK BIOBANK GWAS."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-0688-y","article-title":"Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits.","volume":"10","author":"Niarchou","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.832516","article-title":"Toward a multidimensional understanding of misophonia using cluster-based phenotyping.","volume":"16","author":"Norris","year":"2022","journal-title":"Front. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.","volume":"74","author":"Nyholt","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00325","article-title":"Towards the prevention of aminoglycoside-related hearing loss.","volume":"11","author":"O\u2019Sullivan","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.heares.2015.08.014","article-title":"Tinnitus and anxiety disorders: A review.","volume":"333","author":"Pattyn","year":"2016","journal-title":"Hear. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41588-021-00846-7","article-title":"Genetic analyses identify widespread sex-differential participation bias.","volume":"53","author":"Pirastu","year":"2021","journal-title":"Nat. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/hmg\/ddy327","article-title":"Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.","volume":"28","author":"Pulit","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"B100","year":"2022","journal-title":"R: A language and environment for statistical computing."},{"key":"B60","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.seizure.2021.10.013","article-title":"GABRA1 and GABRA6 gene mutations in idiopathic generalized epilepsy patients.","volume":"93","author":"Riaz","year":"2021","journal-title":"Seizure"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.941898","article-title":"Phenotyping misophonia: Psychiatric disorders and medical health correlates.","volume":"13","author":"Rosenthal","year":"2022","journal-title":"Front. Psychol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054706","article-title":"Misophonia: Diagnostic criteria for a new psychiatric disorder.","volume":"8","author":"Schr\u00f6der","year":"2013","journal-title":"PLoS One"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.110777","article-title":"Psychiatric and audiologic features of misophonia: Use of a clinical control group with auditory over-responsivity.","volume":"156","author":"Siepsiak","year":"2022","journal-title":"J. Psychosom. Res."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.841816","article-title":"Consensus definition of misophonia: A delphi study.","volume":"16","author":"Swedo","year":"2022","journal-title":"Front. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy.","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00938","article-title":"Teneurins: Domain architecture. Evolutionary origins, and patterns of expression.","volume":"12","author":"Tucker","year":"2018","journal-title":"Front. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.31234\/osf.io\/jwpeq","author":"Vitoratou","year":"2022","journal-title":"Misophonia in the UK: Norms of the selective sound sensitivity five factor model (S-Five) for misophonia and prevalence of the disorder using a large sample representative of the UK population."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1101\/110023","article-title":"FUMA: Functional mapping and annotation of genetic associations.","author":"Watanabe","year":"2017","journal-title":"bioRxiv"},{"key":"B70","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.genhosppsych.2015.03.019","article-title":"Toward a theoretical model of misophonia.","volume":"37","author":"Webber","year":"2015","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":".e1","DOI":"10.1016\/j.genhosppsych.2013.10.018","article-title":"Pediatric misophonia with comorbid obsessive\u2013compulsive spectrum disorders.","volume":"36","author":"Webber","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B72","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.heares.2006.09.003","article-title":"High-frequency tinnitus without hearing loss does not mean absence of deafferentation.","volume":"222","author":"Weisz","year":"2006","journal-title":"Hear. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2020.11.030","article-title":"A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms.","volume":"121","author":"Williams","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B74","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/jclp.22098","article-title":"Misophonia: Incidence, phenomenology, and clinical correlates in an undergraduate student sample.","volume":"70","author":"Wu","year":"2014","journal-title":"J. Clin. Psychol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.971752\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T16:41:10Z","timestamp":1728751270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.971752\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":75,"alternative-id":["10.3389\/fnins.2022.971752"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.971752","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.04.22279567","asserted-by":"object"}]},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"article-number":"971752"}}