{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:42:38Z","timestamp":1765888958703,"version":"3.41.2"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002386"],"award-info":[{"award-number":["82002386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["Incubating Program PX2021037"],"award-info":[{"award-number":["Incubating Program PX2021037"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Visual-spatial attention disorder after stroke seriously affects recovery and quality of life in stroke patients. Previous studies have shown that some patients recovery rapidly from visual-spatial neglect (VSN), but the brain networks underlying this recovery are not well understood. Using functional magnetic resonance imaging, we aimed to identify network differences between patients who rapidly recovered from VSN and those with persistent VSN. The study included 30 patients with VSN who suffered subacute stroke. Patients were examined 2\u20134 weeks after stroke onset and 4 weeks after the initial assessment. At the last evaluation, patients in the persistent VSN (<jats:italic>n<\/jats:italic> = 15) and rapid recovery (<jats:italic>n<\/jats:italic> = 15) groups underwent paper-and-pencil tests. We defined the bilateral frontal eye fields, bilateral intraparietal sulcus in the dorsal attention network, and right temporoparietal junction and ventral frontal cortex areas in the ventral attention network as regions of interest (ROI) and measured whole-brain ROI-based functional connectivity (FC) and amplitude of low-frequency fluctuations (ALFF) in subacute right-hemisphere stroke patients. VSN recovery was associated with changes in the activation of multiple bilateral attentional brain regions. Specifically, persistent VSN was associated with lower FC in the right superior frontal gyrus, right inferior temporal gyrus, right medial orbitofrontal cortex, left precuneus, right inferior parietal gyrus, right medial frontal gyrus, right rectus gyrus, left superior frontal gyrus, left middle cingulate gyrus, right superior temporal pole, right postcentral gyrus, and right posterior cingulate gyrus compared to that in those with rapid recovery, whereas ALFF in the left cerebellum were decreased in patients with persistent VSN. Our results demonstrate that the DAN rather than the VAN, plays a more important role in recovery from VSN, and that the cerebellum is involved in recovery. We believe that our results supplement those of previous studies on recovery from VSN.<\/jats:p>","DOI":"10.3389\/fnins.2022.974653","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T07:28:24Z","timestamp":1660807704000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Neural substrates in patients with visual-spatial neglect recovering from right-hemispheric stroke"],"prefix":"10.3389","volume":"16","author":[{"given":"Lei","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116339","article-title":"Functional reorganization during the recovery of contralesional target selection deficits after prefrontal cortex lesions in macaque monkeys.","volume":"207","author":"Adam","year":"2020","journal-title":"Neuroimage"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1126\/science.275.5308.1940","article-title":"Attentional activation of the cerebellum independent of motor involvement.","volume":"275","author":"Allen","year":"1997","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1093\/brain\/awu297","article-title":"Large-scale changes in network interactions as a physiological signature of spatial neglect.","author":"Baldassarre","year":"2014","journal-title":"Brain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1093\/brain\/aww107","article-title":"Dissociated functional connectivity profiles for motor and attention deficits in acute right-hemisphere stroke.","author":"Baldassarre","year":"2016","journal-title":"Brain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1523\/JNEUROSCI.0344-16.2016","article-title":"Functional Evidence for a cerebellar node of the dorsal attention network.","volume":"36","author":"Brissenden","year":"2016","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.08.059","article-title":"Topographic cortico-cerebellar networks revealed by visual attention and working memory.","volume":"336","author":"Brissenden","year":"2018","journal-title":"Curr. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1152\/jn.00339.2011","article-title":"The organization of the human cerebellum estimated by intrinsic functional connectivity.","volume":"106","author":"Buckner","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.apmr.2015.03.019","article-title":"Impact of spatial neglect on stroke rehabilitation: Evidence from the setting of an inpatient rehabilitation facility.","volume":"96","author":"Chen","year":"2015","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1146\/annurev-neuro-061010-113731","article-title":"Spatial neglect and attention networks.","volume":"34","author":"Corbetta","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1038\/nn1574","article-title":"Neural basis and recovery of spatial attention deficits in spatial neglect.","volume":"8","author":"Corbetta","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/0014-4886(83)90340-0","article-title":"Recovery from unilateral neglect.","volume":"81","author":"Deuel","year":"1983","journal-title":"Exp. Neurol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2020.10.010","article-title":"Prevalence of spatial neglect post-stroke: A systematic review.","volume":"64","author":"Esposito","year":"2020","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.dcn.2015.02.001","article-title":"Asymmetric development of dorsal and ventral attention networks in the human brain.","volume":"12","author":"Farrant","year":"2015","journal-title":"Dev. Cogn. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrn3901","article-title":"The connectomics of brain disorders.","volume":"16","author":"Fornito","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.691518","article-title":"Hemispheric difference of regional brain function exists in patients with acute stroke in different cerebral hemispheres: A resting-state fMRI study.","volume":"13","author":"Gao","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1111\/j.1460-9568.2004.03751.x","article-title":"Evidence for bilateral control of skilled movements: Ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions.","volume":"20","author":"Gonzalez","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jns.2017.11.007","article-title":"Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke.","volume":"384","author":"Lam","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.pjnns.2017.12.006","article-title":"BOLD fMRI signal in stroke patients and its importance for prognosis in the subacute disease period \u2013 Preliminary report.","volume":"52","author":"Lasek-Bal","year":"2018","journal-title":"Neurol. Neurochir. Pol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00072","article-title":"Contrasting evolutionary patterns of functional connectivity in sensorimotor and cognitive regions after stroke.","volume":"10","author":"Liu","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/brain\/awu389","article-title":"White matter lesional predictors of chronic visual neglect: A longitudinal study.","author":"Lunven","year":"2015","journal-title":"Brain"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2020.107356","article-title":"Behavioral deficits in left hemispatial neglect are related to a reduction of spontaneous neuronal activity in the right superior parietal lobule.","volume":"138","author":"Machner","year":"2020","journal-title":"Neuropsychologia"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/j.cortex.2012.11.006","article-title":"Time course of visuospatial neglect early after stroke: A longitudinal cohort study.","volume":"49","author":"Nijboer","year":"2013","journal-title":"Cortex"},{"key":"B23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/ana.24690","article-title":"Normalization of network connectivity in hemispatial neglect recovery.","volume":"80","author":"Ramsey","year":"2016","journal-title":"Ann. Neurol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00428","article-title":"Deficits in reflexive covert attention following cerebellar injury.","volume":"9","author":"Striemer","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1093\/brain\/aww226","article-title":"Intentional gaze shift to neglected space: A compensatory strategy during recovery after unilateral spatial neglect.","volume":"139","author":"Takamura","year":"2016","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.0000000000003843","article-title":"Distinct white matter alterations following severe stroke: Longitudinal DTI study in neglect.","volume":"88","author":"Umarova","year":"2017","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/ana.24614","article-title":"Predictors and signatures of recovery from neglect in acute stroke.","volume":"79","author":"Umarova","year":"2016","journal-title":"Ann. Neurol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134528","article-title":"Visual processing features in patients with visual spatial neglect recovering from right-hemispheric stroke.","volume":"714","author":"Ye","year":"2020","journal-title":"Neurosci. Lett."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052727","article-title":"Patterns in cortical connectivity for determining outcomes in hand function after subcortical stroke.","volume":"7","author":"Yin","year":"2012","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","article-title":"An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF.","volume":"172","author":"Zou","year":"2008","journal-title":"J. Neurosci. Methods"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.974653\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T07:28:26Z","timestamp":1660807706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.974653\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":30,"alternative-id":["10.3389\/fnins.2022.974653"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.974653","relation":{},"ISSN":["1662-453X"],"issn-type":[{"type":"electronic","value":"1662-453X"}],"subject":[],"published":{"date-parts":[[2022,8,18]]},"article-number":"974653"}}