{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:30:29Z","timestamp":1789025429073,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the differences in intra-regional brain activity and inter-regional functional connectivity between patients with recent-onset tinnitus (ROT) and persistent tinnitus (PT) using resting-state functional magnetic resonance imaging (rs-fMRI), including the amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and voxel-wise functional connectivity (FC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We acquired rs-fMRI scans from 82 patients (25 without recent-onset tinnitus, 28 with persistent tinnitus, and 29 healthy controls). Age, sex, and years of education were matched across the three groups. We performed ALFF, ReHo, and voxel-wise FC analyses for all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the control group, participants with ROT and PT manifested significantly reduced ALFF and ReHo activity within the left and right dorsolateral superior frontal gyrus (SFG) and gyrus rectus (GR). Additional voxel-wise FC revealed decreased connectivity between the dorsolateral SFG (left and right) and the right superior parietal gyrus (SPG), right middle frontal gyrus (MFG), and left medial superior frontal gyrus (mSFG) within these two groups. Significant differences were observed between the ROT and PT groups, with the ROT group demonstrating reduced FC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that patients with PT have more difficulty monitoring external stimuli and reorienting attention than patients with ROT. In addition, patients who perceive higher levels of disruption from tinnitus are more likely to develop persistent and debilitating tinnitus once the tinnitus lasts longer than six months. Therefore, we strongly recommend that clinicians implement effective tinnitus management strategies in patients with ROT as soon as possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2022.976095","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:42:13Z","timestamp":1666168933000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent-onset and persistent tinnitus: Uncovering the differences in brain activities using resting-state functional magnetic resonance imaging technologies"],"prefix":"10.3389","volume":"16","author":[{"given":"Haoliang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/s0140-6736(13)60142-7","article-title":"Tinnitus.","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/b978-0-444-63622-5.00001-2","article-title":"The history of the neurophysiology and neurology of the parietal lobe.","volume":"151","author":"Berlucchi","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e520","DOI":"10.1016\/j.wneu.2021.03.045","article-title":"Anatomy and White Matter Connections of the Middle Frontal Gyrus.","volume":"150","author":"Briggs","year":"2021","journal-title":"World Neurosurg."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00592","article-title":"Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss.","volume":"14","author":"Cai","year":"2020","journal-title":"Front. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.neuroimage.2005.09.011","article-title":"Contingency awareness in human aversive conditioning involves the middle frontal gyrus.","volume":"29","author":"Carter","year":"2006","journal-title":"NeuroImage"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/hbm.23525","article-title":"Tinnitus distress is linked to enhanced resting-state functional connectivity from the limbic system to the auditory cortex.","volume":"38","author":"Chen","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00034","article-title":"Connectivity-based structural and functional parcellation of the human cortex using diffusion imaging and tractography.","volume":"6","author":"Cloutman","year":"2012","journal-title":"Front. Neuroanat."},{"key":"B8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.cortex.2019.10.012","article-title":"Functional connectivity of the orbitofrontal cortex, anterior cingulate cortex, and inferior frontal gyrus in humans.","volume":"123","author":"Du","year":"2020","journal-title":"Cortex"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.621145","article-title":"The Neural Mechanisms of Tinnitus: A Perspective From Functional Magnetic Resonance Imaging.","volume":"15","author":"Hu","year":"2021","journal-title":"Front. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"12688","DOI":"10.1523\/jneurosci.1175-16.2016","article-title":"The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response.","volume":"36","author":"Hu","year":"2016","journal-title":"J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00023","article-title":"A role of right middle frontal gyrus in reorienting of attention: A case study.","volume":"9","author":"Japee","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7461\/jcen.2016.18.3.223","article-title":"Relationship between Gyrus Rectus Resection and Cognitive Impairment after Surgery for Ruptured Anterior Communicating Artery Aneurysms.","volume":"18","author":"Joo","year":"2016","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2019.00088","article-title":"Plasticity in Limbic Regions at Early Time Points in Experimental Models of Tinnitus.","volume":"13","author":"Kapolowicz","year":"2020","journal-title":"Front. Syst. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02908-6","article-title":"A large-scale diffusion imaging study of tinnitus and hearing loss.","volume":"11","author":"Khan","year":"2021","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3171\/2011.10.jns11434","article-title":"Association fibers connecting the Broca center and the lateral superior frontal gyrus: A microsurgical and tractographic anatomy.","volume":"116","author":"Kinoshita","year":"2012","journal-title":"J. Neurosurg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/7854_2020_213","article-title":"Psychosocial Variables That Predict Chronic and Disabling Tinnitus: A Systematic Review.","volume":"51","author":"Kleinst\u00e4uber","year":"2020","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s10162-021-00815-1","article-title":"Too Blind to See the Elephant? Why Neuroscientists Ought to Be Interested in Tinnitus.","volume":"22","author":"Knipper","year":"2021","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110459","article-title":"Topological features of limbic dysfunction in chronicity of tinnitus with intact hearing: New hypothesis for \u2018noise-cancellation\u2019 mechanism.","volume":"113","author":"Lan","year":"2022","journal-title":"Progress Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/hbm.25238","article-title":"Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.","volume":"42","author":"Lan","year":"2020","journal-title":"Hum. Brain Mapp."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep46088","article-title":"Dynamic Default Mode Network across Different Brain States.","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"E199","DOI":"10.1093\/ons\/opab174","article-title":"Anatomy and White Matter Connections of the Superior Parietal Lobule.","volume":"21","author":"Lin","year":"2021","journal-title":"Operat. Neurosurg."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027509","article-title":"Efficacy of sound therapy interventions for tinnitus management: A protocol for systematic review and network meta-analysis.","volume":"100","author":"Liu","year":"2021","journal-title":"Medicine"},{"key":"B23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.5935\/0946-5448.20210015","article-title":"Etiology and Pathophysiology of Tinnitus - A Systematic Review.","volume":"25","author":"Makar","year":"2021","journal-title":"Int. Tinnitus J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/mao.0000000000001626","article-title":"Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance.","volume":"39","author":"Minami","year":"2018","journal-title":"Otol. Neurotol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1006\/nimg.1999.0451","article-title":"Transient Neural Activity in the Medial Superior Frontal Gyrus and Precuneus Time Locked with Attention Shift between Object Features.","volume":"10","author":"Nagahama","year":"1999","journal-title":"NeuroImage"},{"key":"B26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.5935\/0946-5448.20210014","article-title":"Tinnitus, Use and Evaluation of Sound Therapy, Current Evidence and Area of Future Tinnitus Research.","volume":"25","author":"Osuji","year":"2021","journal-title":"Int. Tinnitus J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"14972","DOI":"10.1523\/jneurosci.4028-10.2010","article-title":"Ringing Ears: The Neuroscience of Tinnitus.","volume":"30","author":"Roberts","year":"2010","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jneumeth.2013.07.021","article-title":"A novel behavioral assay for the assessment of acute tinnitus in rats optimized for simultaneous recording of oscillatory neural activity.","volume":"219","author":"Stolzberg","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4081\/audiores.2019.222","article-title":"Tinnitus and suicide: An unresolved relation.","volume":"9","author":"Szibor","year":"2019","journal-title":"Audiol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599814545325","article-title":"Clinical practice guideline: Tinnitus.","volume":"151","author":"Tunkel","year":"2014","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067778","article-title":"Brain Regions Responsible for Tinnitus Distress and Loudness: A Resting-State fMRI Study.","volume":"8","author":"Ueyama","year":"2013","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137291","article-title":"Alterations of Regional Cerebral Blood Flow in Tinnitus Patients as Assessed Using Single-Photon Emission Computed Tomography.","volume":"10","author":"Ueyama","year":"2015","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01299","article-title":"Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.","volume":"13","author":"Xu","year":"2019","journal-title":"Front. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.joto.2014.10.001","article-title":"Regional homogeneity on resting state fMRI in patients with tinnitus.","volume":"9","author":"Yang","year":"2014","journal-title":"J. Otol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00405-016-4401-y","article-title":"A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.","volume":"274","author":"Zenner","year":"2016","journal-title":"Eur. Arch. Oto Rhino Laryngol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/cercor\/bhr088","article-title":"Resting-State Functional Connectivity of the Medial Superior Frontal Cortex.","volume":"22","author":"Zhang","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01010","article-title":"Disrupted Intraregional Brain Activity and Functional Connectivity in Unilateral Acute Tinnitus Patients With Hearing Loss.","volume":"13","author":"Zhou","year":"2019","journal-title":"Front. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"Zung","year":"1971","journal-title":"Psychosomatics"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.976095\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:42:16Z","timestamp":1666168936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.976095\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":38,"alternative-id":["10.3389\/fnins.2022.976095"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.976095","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.26.22276920","asserted-by":"object"},{"id-type":"doi","id":"10.1101\/2022.06.26.22276922","asserted-by":"object"}]},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"article-number":"976095"}}