{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:11:02Z","timestamp":1793041862632,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Andrographolide is a natural antibiotic that has the ability to dispel heat, detoxify, reduce inflammation, and relieve pain. Recent research has shown that it can exert anti-inflammatory effects <jats:italic>via<\/jats:italic> multiple pathways and multiple targets (mediated by NF-\u03baB, JAK\/STAT, T cell receptor, and other signaling pathways). It can inhibit human lung cancer cells, colon cancer cells, osteosarcoma cells, and other tumor cells, as well as reduce bacterial virulence and inhibit virus-induced cell apoptosis. It can also regulate inflammatory mediator expression to protect the nervous system and effectively prevent mental illness. Additionally, andrographolide regulates the immune system, treats cardiovascular and cerebral vascular diseases, protects the liver, and the gallbladder. It is clear that andrographolide has a huge range of potential applications. The mechanism of andrographolide\u2019s anti-inflammatory, antibacterial, antiviral, and nervous system defense in recent years have been reviewed in this article.<\/jats:p>","DOI":"10.3389\/fnins.2022.977376","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T09:40:06Z","timestamp":1663062006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Study on the mechanism of andrographolide activation"],"prefix":"10.3389","volume":"16","author":[{"given":"Qihan","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1517\/13543776.2014.956084","article-title":"Andrographolide: Progression in its modifications and applications\u2013a patent review (2012\u20132014).","volume":"24","author":"Aromdee","year":"2014","journal-title":"Exp. Opin. Ther. Pat."},{"key":"B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s0092-8674(00)81318-5","article-title":"Nf-kappa B: Ten years after.","volume":"87","author":"Baeuerle","year":"1996","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappaB in the immune system","volume":"12","author":"Baeuerle","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1164\/rccm.200809-1516oc","article-title":"A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway.","volume":"179","author":"Bao","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/13880209.2013.836544","article-title":"Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated Lc-Ms\/Ms method.","volume":"52","author":"Bera","year":"2014","journal-title":"Pharm. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s11892-016-0775-x","article-title":"Diabetes and cognitive impairment.","volume":"253","author":"Biessels","year":"2006","journal-title":"J. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/aje\/kwj008","article-title":"Chronic multisymptom illness complex in Gulf War I veterans 10 years later.","volume":"163","author":"Blanchard","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00702-011-0731-5","article-title":"Recent rodent models for Alzheimer\u2019s disease: Clinical implications and basic research.","volume":"119","author":"Braidy","year":"2012","journal-title":"J. Neural Transm (Vienna)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.bbadis.2014.06.010","article-title":"Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain.","volume":"1842","author":"Butterfield","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1055\/s-0030-1271019","article-title":"Andrographolide inhibits Pi3K\/Akt-dependent Nox2 and inos expression protecting mice against hypoxia\/ischemia-induced oxidative brain injury.","volume":"77","author":"Chern","year":"2011","journal-title":"Planta Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1177\/1947601910383416","article-title":"Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.","volume":"1","author":"Chun","year":"2010","journal-title":"Genes Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/jat.1211","article-title":"Role of nuclear factor-kappa B activation in the adverse effects induced by air pollution particulate matter (Pm2.5) in human epithelial lung cells (L132) in culture.","volume":"27","author":"Dagher","year":"2007","journal-title":"J. Appl. Toxicol. Jat"},{"key":"B14","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1124\/jpet.114.217968","article-title":"Andrographolide prevents high-fat diet-induced obesity in C57bl\/6 mice by suppressing the sterol regulatory element-binding protein pathway.","volume":"351","author":"Ding","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.micinf.2017.08.009","article-title":"Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-\u03baB and JAK-STAT signaling pathway.","volume":"19","author":"Ding","year":"2017","journal-title":"Microbes Infect."},{"key":"B16","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tem.2017.11.001","article-title":"Jak\/Stat\u2013emerging players in metabolism.","volume":"29","author":"Dodington","year":"2017","journal-title":"Trends Endocrinol. Metabolism"},{"key":"B17","first-page":"496","article-title":"Effect of andrographolide on apoptosis of human hepatoma HepG2 Cells by inhibiting PI3K\/AKT pathway.journal of oncology.","author":"Fan","year":"2020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106426","article-title":"Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis.","volume":"83","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jep.2006.12.031","article-title":"Indian medicinal plants as a source of antimycobacterial agents.","volume":"110","author":"Gautam","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114688","article-title":"Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.","volume":"379","author":"Geng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B21","author":"Geng","year":"2016","journal-title":"Andrographolide improves MPTP-induced Parkinson disease-like dyskinesia and protects rotenone-induced mitochondrial dysfunction."},{"key":"B22","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3109\/13880209.2011.558515","article-title":"Recent advances in herbal medicine for treatment of liver diseases.","volume":"49","author":"Ghosh","year":"2011","journal-title":"Pharm. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbi.2012.11.010","article-title":"Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression.","volume":"28","author":"Gibney","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"B24","author":"Gong","year":"2004","journal-title":"Medical immunology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/jdi.12087","article-title":"Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies.","volume":"4","author":"Gudala","year":"2013","journal-title":"J. Diabetes Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.bcp.2019.03.019","article-title":"Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice.","volume":"163","author":"Guo","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113022","article-title":"Andrographolide attenuates complete freund\u2019s adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines.","volume":"261","author":"Gupta","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2174\/1386207323999200818165029","article-title":"Andrographolide mitigates unfolded protein response pathway and apoptosis involved in Chikungunya virus infection.","volume":"24","author":"Gupta","year":"","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"B29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3109\/08923973.2012.744034","article-title":"Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and Nf-\u03baB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.","volume":"35","author":"He","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B30","first-page":"172","article-title":"Anti- inflammatory effect of andrographolide on adjuvant- induced inflammatory paw swelling in mice via the JAK2\/STAT3 signaling pathway.","volume":"37","author":"Huan","year":"2020","journal-title":"J. Guangxi Med. Univ."},{"key":"B31","article-title":"Study on growth inhibition and apoptosis induction effect of andrographolide on human glioma cell U87-MG.","volume":"42","author":"Huang","year":"2020","journal-title":"J. Youjiang Med. Coll. Natl."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00571","article-title":"Andrographolide, a new hope in the prevention and treatment of metabolic syndrome.","volume":"8","author":"Islam","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104259","article-title":"Screening cyclooxygenase-2 inhibitors from Andrographis paniculata to treat inflammation based on bio-affinity ultrafiltration coupled with Uplc-Q-Tof-Ms.","volume":"137","author":"Jiao","year":"2019","journal-title":"Fitoterapia"},{"key":"B34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.13412\/j.cnki.zyyl.2019.01.009","article-title":"Effect of andrographolide on amino acid and glucose metabolism of staphylococcus aureus.","volume":"35","author":"Jin","year":"2019","journal-title":"Chin. Med. Pharmacol. Clinic"},{"key":"B35","first-page":"47","article-title":"Chemical constituents of Andrographis paniculata.","volume":"43","author":"Jin","year":"2012","journal-title":"Chin. Herb. Med."},{"key":"B36","first-page":"1453","article-title":"Regulation of andrographolide on pathological lung injury, immune dysfuction and TLR4\/NF-\u03baB signaling pathway in klebsiella pneumoniae pneumoniae rats.","volume":"36","author":"Kang","year":"2020","journal-title":"Chin. J. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2174\/1871520620666200717143109","article-title":"Andrographolide inhibits proliferation of colon cancer Sw-480 cells via downregulating notch signaling pathway.","volume":"21","author":"Khan","year":"2021","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jep.2010.07.057","article-title":"Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines.","volume":"132","author":"Lee","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B39","author":"Li","year":"2021","journal-title":"Study on the inhibiton of Andrographolide on metastatic luminal-like breast cancer by targeting NF-\u03baB signaling pathway."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.643525","article-title":"Andrographolide suppresses the growth and metastasis of luminal-like breast cancer by inhibiting the Nf-\u03baB\/miR-21-5p\/Pdcd4 signaling pathway.","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00657","article-title":"Andrographolide alleviates acute brain injury in a rat model of traumatic brain injury: Possible involvement of inflammatory signaling.","volume":"12","author":"Li","year":"","journal-title":"Front. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.neuropharm.2018.09.015","article-title":"Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.","volume":"141","author":"Li","year":"","journal-title":"Neuropharmacol."},{"key":"B43","first-page":"1200","article-title":"Anti-inflammatory effects of andrographolide on LPS-induced mice mastitis.","volume":"47","author":"Li","year":"2017","journal-title":"Chin. Vet. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1440-1681.2011.05633.x","article-title":"Andrographolide and its analogues: Versatile bioactive molecules for combating inflammation and cancer.","volume":"39","author":"Lim","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B45","first-page":"2602","article-title":"Effect of andrographolide on immune function and intestinal microflora in mice infected with enterovirus 71.","volume":"35","author":"Lin","year":"2019","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"B46","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"Nf-\u03baB signaling in inflammation.","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"B47","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.intimp.2014.03.015","article-title":"Andrographolide sulfonate ameliorates experimental colitis in mice by inhibiting Th1\/Th17 response.","volume":"20","author":"Liu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"NF-kappaB in neuronal plasticity and neurodegenerative disorders.","volume":"107","author":"Mattson","year":"2001","journal-title":"J. Clin. Invest."},{"key":"B49","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/s0166-2236(96)01035-1","article-title":"NF-kappa B: A crucial transcription factor for glial and neuronal cell function.","volume":"20","author":"O\u2019Neill","year":"1997","journal-title":"Trends Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of Rel\/NF-kappaB transcription factors.","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.intimp.2010.08.002","article-title":"Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression.","volume":"10","author":"Parichatikanond","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"80262","DOI":"10.18632\/oncotarget.12918","article-title":"Andrographolide ameliorates Ova-induced lung injury in mice by suppressing Ros-mediated Nf-\u03baB signaling and NLRP3 inflammasome activation.","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"key":"B53","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jmgm.2015.07.001","article-title":"Andrographolide: A potent antituberculosis compound that targets aminoglycoside 2\u2019-N-acetyltransferase in mycobacterium tuberculosis.","volume":"61","author":"Prabu","year":"2015","journal-title":"J. Mol. Graph. Model."},{"key":"B54","author":"Ren","year":"2019","journal-title":"Study of antioxidative and anti-inflammation effects of andrographolide on the rat air pouch model of inflammation."},{"key":"B55","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.neurobiolaging.2016.06.021","article-title":"Andrographolide recovers cognitive impairment in a natural model of Alzheimer\u2019s disease (Octodon degus).","volume":"46","author":"Rivera","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11070905","article-title":"Andrographolide attenuates gut-brain-axis associated pathology in gulf war illness by modulating bacteriome-virome associated inflammation and microglia-neuron proinflammatory crosstalk.","volume":"11","author":"Saha","year":"2021","journal-title":"Brain Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1126\/science.1181886","article-title":"A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.","volume":"327","author":"Soliman","year":"2010","journal-title":"Science (New York, N.Y.)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1042\/bj20140207","article-title":"Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3\u03b2: Autoregulation of GSK-3\u03b2 invivo.","volume":"466","author":"Tapia-Rojas","year":"2015","journal-title":"Biochem. J."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1107107","article-title":"Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats.","author":"Thakur","year":"2016","journal-title":"Pharm. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ejphar.2006.09.052","article-title":"Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation.","volume":"553","author":"Thisoda","year":"2006","journal-title":"Eur. J Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nrneurol.2014.264","article-title":"Targeting secondary injury in intracerebral haemorrhage\u2014perihaematomal oedema.","volume":"11","author":"Urday","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"B62","first-page":"144","article-title":"A research progress of pharmacology of andrographolide and its derivatives.","volume":"9","author":"Wan","year":"2017","journal-title":"Clin. Res. Tcm"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151514","article-title":"Neuroprotective effects of andrographolide on chronic cerebral hypoperfusion-induced hippocampal neuronal damage in rats possibly via PTEN\/AKT signaling pathway.","volume":"122","author":"Wang","year":"2020","journal-title":"Acta Histochem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00210-019-01672-9","article-title":"Andrographolide enhances hippocampal Bdnf signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion.","volume":"392","author":"Wang","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"B65","first-page":"117","article-title":"Andrographolide ameliorates experimental Parkinson\u2019s disease in mice via induction of parkin-mediated mitophagy.","volume":"21","author":"Wang","year":"2022","journal-title":"J. Clin. Exp. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.08.007","article-title":"Endothelial function, inflammation, thrombosis, and basal ganglia perivascular spaces in patients with stroke.","volume":"25","author":"Wang","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.02.015","article-title":"A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt\/\u03b2-catenin signaling.","author":"Wta","year":"2022","journal-title":"J. Adv. Res."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.702885","article-title":"Effects of andrographolide on mouse intestinal microflora based on high-throughput sequence analysis.","volume":"8","author":"Wu","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s10753-018-0812-9","article-title":"Andrographolide ameliorates atherosclerosis by suppressing pro-inflammation and ROS generation-mediated foam cell formation.","volume":"41","author":"Wu","year":"2018","journal-title":"Inflammation"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081638","article-title":"Multi-targeting andrographolide, a Novel NF-\u03baB inhibitor, as a potential therapeutic agent for stroke.","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.phrs.2019.04.023","article-title":"Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: Involvement of Nrf2\/Ae and Tlr\/Nf-kappa B signaling.","volume":"144","author":"Yang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114420","article-title":"Protective effect of the effective part of Andrographis paniculata (Burm.f.) Nees on PM2.5-induced lung injury in rats by modulating the NF-\u03baB pathway.","volume":"280","author":"Yao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/ijnp\/pyz032","article-title":"Andrographolide exerts significant antidepressant-like effects involving the hippocampal BDNF system in mice.","volume":"22","author":"Zhang","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.3892\/mmr.2018.9599","article-title":"Andrographolide mitigates Il-1\u03b2\u2212induced human nucleus pulposus cells degeneration through the TLR4\/MyD88\/NF\u2212\u03baB signaling pathway.","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B75","first-page":"222","article-title":"Development of modern research on Andrographis paniculate.","volume":"24","author":"Zhang","year":"2018","journal-title":"Chin. J. Exp. Formulae"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.977376\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T09:40:22Z","timestamp":1663062022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2022.977376\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":74,"alternative-id":["10.3389\/fnins.2022.977376"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2022.977376","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]},"article-number":"977376"}}