{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:55:37Z","timestamp":1793663737751,"version":"4.5.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the effect of treatment zone (TZ) decentration on axial length growth (ALG) in adolescents after wearing the orthokeratology lenses (OK lenses).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This retrospective clinical study selected 251 adolescents who were fitted OK lenses at the Clinical College of Ophthalmology, Tianjin Medical University (Tianjin, China) from January 2018\u2013December 2018 and wore them continuously for &amp;gt;12 months. The age of the subjects was 8\u201315 years, spherical equivalent (SE): \u22121.00 to \u22125.00 diopter (D), and astigmatism \u2264 1.50 D. The corneal topography were recorded at baseline and 1-, 6-, and 12-month visits, and the axial length (AL) were recorded at baseline and 6-, 12-month visits. The data of the right eye were collected for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subjects were divided into three groups according to the decentration distance of the TZ after wearing lenses for 1 month: 56 cases in the mild (&amp;lt;0.5 mm), 110 in the moderate (0.5\u20131.0 mm), and 85 in the severe decentration group (&amp;gt;1.0 mm). A significant difference was detected in the ALG between the three groups after wearing lenses for 6 and 12 months (<jats:italic>F<\/jats:italic> = 10.223, <jats:italic>P<\/jats:italic> &amp;lt; 0.001; <jats:italic>F<\/jats:italic> = 13.380, <jats:italic>P<\/jats:italic> &amp;lt; 0.001, respectively). Among these, the 6- and 12-month ALG of the mild decentration group was significantly higher than that of the other two groups. Multivariable linear regression analysis showed that age, baseline SE, and 1-month decentration distance associated with the 12-month ALG (<jats:italic>P<\/jats:italic> &amp;lt; 0.001, <jats:italic>P<\/jats:italic> &amp;lt; 0.001, and <jats:italic>P<\/jats:italic> = 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decentration of the TZ of the OK lens affected the growth of the AL in adolescents, i.e., the greater the decentration, the slower the ALG.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2022.986364","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T07:02:25Z","timestamp":1666249345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of treatment zone decentration on axial length growth after orthokeratology"],"prefix":"10.3389","volume":"16","author":[{"given":"Shuxian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1364\/josaa.24.000578","article-title":"Three-dimensional relationship between high-order root-mean-square wavefront error, pupil diameter, and aging.","volume":"24","author":"Applegate","year":"2007","journal-title":"J. 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