{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:45:46Z","timestamp":1790613946135,"version":"4.1.0"},"reference-count":301,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Proteinopathies are a large group of neurodegenerative diseases caused by both genetic and sporadic mutations in particular genes which can lead to alterations of the protein structure and to the formation of aggregates, especially toxic for neurons. Autophagy is a key mechanism for clearing those aggregates and its function has been strongly associated with the ubiquitin-proteasome system (UPS), hence mutations in both pathways have been associated with the onset of neurodegenerative diseases, particularly those induced by protein misfolding and accumulation of aggregates. Many crucial discoveries regarding the molecular and cellular events underlying the role of autophagy in these diseases have come from studies using Drosophila models. Indeed, despite the physiological and morphological differences between the fly and the human brain, most of the biochemical and molecular aspects regulating protein homeostasis, including autophagy, are conserved between the two species.In this review, we will provide an overview of the most common neurodegenerative proteinopathies, which include PolyQ diseases (Huntington\u2019s disease, Spinocerebellar ataxia 1, 2, and 3), Amyotrophic Lateral Sclerosis (C9orf72, SOD1, TDP-43, FUS), Alzheimer\u2019s disease (APP, Tau) Parkinson\u2019s disease (a-syn, parkin and PINK1, LRRK2) and prion diseases, highlighting the studies using Drosophila that have contributed to understanding the conserved mechanisms and elucidating the role of autophagy in these diseases.<\/jats:p>","DOI":"10.3389\/fnins.2023.1082047","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T05:31:16Z","timestamp":1684387876000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies"],"prefix":"10.3389","volume":"17","author":[{"given":"Stefania","family":"Santarelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Londero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Soldano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Candelaresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Todeschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Vernizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bellosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1126\/science.aan6298","article-title":"Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes","volume":"358","author":"Abu-Remaileh","year":"2017","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"147291","DOI":"10.1016\/j.brainres.2021.147291","article-title":"Contribution of astrocytes to neuropathology of neurodegenerative diseases","volume":"1758","author":"Acioglu","year":"2021","journal-title":"Brain Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/bio.049692","article-title":"Age-dependent degeneration of an identified adult leg motor neuron in aDrosophilaSOD1 model of ALS","volume":"9","author":"Agudelo","year":"2020","journal-title":"Biology Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e234","DOI":"10.1371\/journal.pgen.0030234","article-title":"dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1","volume":"3","author":"Al-Ramahi","year":"2007","journal-title":"PLoS Genet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40478-019-0658-x","article-title":"ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles","volume":"7","author":"An","year":"2019","journal-title":"Acta Neuropathol. 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