{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:33:13Z","timestamp":1783027993090,"version":"3.54.6"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with primary dysmenorrhea (PDM) often present with abnormalities other than dysmenorrhea including co-occurrence with other chronic pain conditions and central sensitization. Changes in brain activity in PDM have been demonstrated; however, the results are not consistent. Herein, this study probed into altered intraregional and interregional brain activity in patients with PDM and expounded more findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 33 patients with PDM and 36 healthy controls (HCs) were recruited and underwent a resting-state functional magnetic resonance imaging scan. Regional homogeneity (ReHo) and mean amplitude of low-frequency fluctuation (mALFF) analysis were applied to compare the difference in intraregional brain activity between the two groups, and the regions with ReHo and mALFF group differences were used as seeds for functional connectivity (FC) analysis to explore the difference of interregional activity. Pearson's correlation analysis was conducted between rs-fMRI data and clinical symptoms in patients with PDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, patients with PDM showed altered intraregional activity in a series of brain regions, including the hippocampus, the temporal pole superior temporal gyrus, the nucleus accumbens, the pregenual anterior cingulate cortex, the cerebellum_8, the middle temporal gyrus, the inferior temporal gyrus, the rolandic operculum, the postcentral gyrus and the middle frontal gyrus (MFG), and altered interregional FC mainly between regions of the mesocorticolimbic pathway and regions associated with sensation and movement. The anxiety symptoms are correlated with the intraregional activity of the right temporal pole superior temporal gyrus and FC between MFG and superior frontal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed a more comprehensive method to explore changes in brain activity in PDM. We found that the mesocorticolimbic pathway might play a key role in the chronic transformation of pain in PDM. We, therefore, speculate that the modulation of the mesocorticolimbic pathway may be a potential novel therapeutic mechanism for PDM.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1098573","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T05:00:51Z","timestamp":1675054851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Altered brain activities in mesocorticolimbic pathway in primary dysmenorrhea patients of long-term menstrual pain"],"prefix":"10.3389","volume":"17","author":[{"given":"Ni","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s10194-021-01312-9","article-title":"Investigation of cortical thickness and volume during spontaneous attacks of migraine without aura: a 3-Tesla MRI study","volume":"22","author":"Amin","year":"2021","journal-title":"J. Headache Pain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/ejp.1140","article-title":"Assessment and manifestation of central sensitisation across different chronic pain conditions","volume":"22","author":"Arendt-Nielsen","year":"2018","journal-title":"Eur. J. Pain"},{"key":"B3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/00002508-200205000-00007","article-title":"A comparison of modality-specific somatosensory changes during menstruation in dysmenorrheic and nondysmenorrheic women","volume":"18","author":"Bajaj","year":"2002","journal-title":"Clin. J. Pain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.neuron.2015.06.005","article-title":"Nociception, pain, negative moods, and behavior selection","volume":"87","author":"Baliki","year":"2015","journal-title":"Neuron"},{"key":"B5","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1093\/brain\/awf022","article-title":"Imaging how attention modulates pain in humans using functional MRI","volume":"125","author":"Bantick","year":"2002","journal-title":"Brain"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3390\/ijerph17041191","article-title":"Inflammatory markers in dysmenorrhea and therapeutic options","volume":"17","author":"Barcikowska","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trsl.2021.06.004","article-title":"Brain mechanisms of chronic pain: critical role of translational approach","volume":"238","author":"Barroso","year":"2021","journal-title":"Transl. Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12311-014-0627-7","article-title":"Consensus paper: the role of the cerebellum in perceptual processes","volume":"14","author":"Baumann","year":"2015","journal-title":"Cerebellum"},{"key":"B9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neuroimage.2017.10.030","article-title":"Hippocampal morphology mediates biased memories of chronic pain","volume":"166","author":"Berger","year":"2018","journal-title":"Neuroimage"},{"key":"B10","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nrn.2016.68","article-title":"Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain","volume":"17","author":"Bliss","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.copsyc.2019.05.003","article-title":"Cortico-cerebellar networks for visual attention and working memory","volume":"29","author":"Brissenden","year":"2019","journal-title":"Curr. Opin. Psychol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neurobiolaging.2021.06.009","article-title":"Pain processing in older adults with dementia-related cognitive impairment is associated with frontal neurodegeneration","volume":"106","author":"Bunk","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"B14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.jogc.2016.12.023","article-title":"No. 345-primary dysmenorrhea consensus guideline","volume":"39","author":"Burnett","year":"2017","journal-title":"J. Obstet. Gynaecol. Can. JOGC"},{"key":"B15","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat. Rev. Neurosci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/pm\/pnaa425","article-title":"The relationship between corticomotor reorganization and acute pain severity: a randomized, controlled study using rapid transcranial magnetic stimulation mapping","volume":"22","author":"Cavaleri","year":"2021","journal-title":"Pain Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"046074","DOI":"10.1088\/1741-2552\/abed83","article-title":"A novel beamformer-based imaging of phase-amplitude coupling (BIPAC) unveiling the inter-regional connectivity of emotional prosody processing in women with primary dysmenorrhea","volume":"18","author":"Chan","year":"2021","journal-title":"J. Neural Eng"},{"key":"B18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jpain.2017.10.007","article-title":"Altered primary motor cortex structure, organization, and function in chronic pain: a systematic review and meta-analysis","volume":"19","author":"Chang","year":"2018","journal-title":"J. Pain"},{"key":"B19","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/j.pain.0000000000001428","article-title":"Whole-brain structural magnetic resonance imaging-based classification of primary dysmenorrhea in pain-free phase: a machine learning study","volume":"160","author":"Chen","year":"2019","journal-title":"Pain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/s12311-016-0832-7","article-title":"Altered Cerebellar activity in visceral pain-related fear conditioning in irritable bowel syndrome","volume":"16","author":"Claassen","year":"2017","journal-title":"Cerebellum"},{"key":"B21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s10194-017-0825-z","article-title":"Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features","volume":"18","author":"Coppola","year":"2017","journal-title":"J. Headache Pain"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000732","article-title":"Neuroimaging of pain in animal models: a review of recent literature","author":"Da Silva","year":"2019","journal-title":"Pain Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"18626","DOI":"10.1073\/pnas.0505210102","article-title":"Control over brain activation and pain learned by using real-time functional MRI","volume":"102","author":"deCharms","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1213\/01.ane.0000263280.49786.f5","article-title":"Disruption of attention and working memory traces in individuals with chronic pain","volume":"104","author":"Dick","year":"2007","journal-title":"Anesth. Analg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1590\/S1413-35552010000300003","article-title":"Revision of posturography based on force plate for balance evaluation","volume":"14","author":"Duarte","year":"2010","journal-title":"Rev. Bras. Fisioter."},{"key":"B26","doi-asserted-by":"publisher","first-page":"14223","DOI":"10.1523\/JNEUROSCI.3398-09.2009","article-title":"The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys","volume":"29","author":"Dum","year":"2009","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1365-2982.2007.00908.x","article-title":"Attentional modulation of visceral and somatic pain","volume":"19","author":"Dunckley","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"B28","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1080\/00222895.2017.1400947","article-title":"Association of fine motor loss and allodynia in fibromyalgia: an fNIRS study","volume":"50","author":"Eken","year":"2018","journal-title":"J. Mot. Behav"},{"key":"B29","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/j.pain.2013.09.001","article-title":"Pain matrices and neuropathic pain matrices: a review","volume":"154","author":"Garcia-Larrea","year":"2013","journal-title":"Pain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0228158","DOI":"10.1371\/journal.pone.0228158","article-title":"Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study","volume":"15","author":"Gentile","year":"2020","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0304-3959(97)03362-9","article-title":"Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men","volume":"71","author":"Giamberardino","year":"1997","journal-title":"Pain"},{"key":"B33","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/PHM.0000000000000859","article-title":"Association between sensorimotor impairments and functional brain changes in patients with low back pain: a critical review","volume":"97","author":"Goossens","year":"2018","journal-title":"Am. J. Phys. Med. Rehabil"},{"key":"B34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fnhum.2019.00333","article-title":"Correlation between thalamus-related functional connectivity and serum BDNF levels during the periovulatory phase of primary dysmenorrhea","volume":"13","author":"Han","year":"2019","journal-title":"Front. Hum. Neurosci"},{"key":"B35","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/S0140-6736(99)05003-5","article-title":"Cortical origin of pathological pain","volume":"354","author":"Harris","year":"1999","journal-title":"Lancet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1093\/brain\/awt211","article-title":"Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits","volume":"136","author":"Hashmi","year":"2013","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jpag.2019.09.004","article-title":"Prevalence and risk factors associated with primary dysmenorrhea among chinese female university students: a cross-sectional study","volume":"33","author":"Hu","year":"2020","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/ejp.832","article-title":"Altered fMRI resting-state connectivity in individuals with fibromyalgia on acute pain stimulation","volume":"20","author":"Ichesco","year":"2016","journal-title":"Eur. J. Pain"},{"key":"B39","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2147\/JPR.S121286","article-title":"Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea","volume":"10","author":"Jin","year":"2017","journal-title":"J. Pain Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.gaitpost.2021.01.019","article-title":"Primary dysmenorrhea and postural control: is it a problem only during menstruation","volume":"85","author":"Keklicek","year":"2021","journal-title":"Gait Posture"},{"key":"B41","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrn.2016.162","article-title":"Structural plasticity and reorganisation in chronic pain","volume":"18","author":"Kuner","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.pain.2012.11.018","article-title":"The importance of context: when relative relief renders pain pleasant","volume":"154","author":"Leknes","year":"2013","journal-title":"Pain"},{"key":"B43","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00540-018-2561-1","article-title":"Suppressed descending pain modulatory and enhanced sensorimotor networks in patients with chronic low back pain","volume":"32","author":"Li","year":"2018","journal-title":"J. Anesth"},{"key":"B44","doi-asserted-by":"publisher","first-page":"109411","DOI":"10.1016\/j.celrep.2021.109411","article-title":"Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation","volume":"36","author":"Li","year":"2021","journal-title":"Cell Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s11682-017-9730-y","article-title":"Changes of functional connectivity of the anterior cingulate cortex in women with primary dysmenorrhea","volume":"12","author":"Liu","year":"2018","journal-title":"Brain Imag. Behav"},{"key":"B46","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-981-13-1756-9_16","article-title":"Neuroimaging studies of primary dysmenorrhea","volume":"1099","author":"Low","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/brain\/awz204","article-title":"The functional neuroanatomy of emotion processing in frontotemporal dementias","volume":"142","author":"Marshall","year":"2019","journal-title":"Brain"},{"key":"B48","unstructured":"2021"},{"key":"B49","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00429-010-0262-0","article-title":"Saliency, switching, attention and control: a network model of insula function","volume":"214","author":"Menon","year":"2010","journal-title":"Brain Struct. Funct"},{"key":"B50","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12311-018-0930-9","article-title":"Pain experience is somatotopically organized and overlaps with pain anticipation in the human cerebellum","volume":"17","author":"Michelle Welman","year":"2018","journal-title":"Cerebellum"},{"key":"B51","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.jep.2014.01.002","article-title":"The traditional Chinese medicine prescription pattern of patients with primary dysmenorrhea in Taiwan: a large-scale cross sectional survey","volume":"152","author":"Pan","year":"2014","journal-title":"J. Ethnopharmacol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0987-7053(00)00227-6","article-title":"Functional imaging of brain responses to pain: a review and meta-analysis","volume":"30","author":"Peyron","year":"2000","journal-title":"Neurophysiol. Clin"},{"key":"B53","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol. Rev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.neuroimage.2009.05.068","article-title":"MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain","volume":"47","author":"Seminowicz","year":"2009","journal-title":"Neuroimage"},{"key":"B55","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jsams.2022.01.006","article-title":"A preliminary investigation of the effects of patellar displacement on brain activation and perceived pain in young females with patellofemoral pain","volume":"25","author":"Slutsky-Ganesh","year":"2022","journal-title":"J. Sci. Med. Sport"},{"key":"B56","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tics.2017.02.005","article-title":"The cerebellum: adaptive prediction for movement and cognition","volume":"21","author":"Sokolov","year":"2017","journal-title":"Trends Cogn. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.neubiorev.2018.04.018","article-title":"Brain changes after spinal cord injury, a quantitative meta-analysis and review","volume":"90","author":"Solstrand Dahlberg","year":"2018","journal-title":"Neurosci. Biobehav. Rev"},{"key":"B58","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/1753-6405.12484","article-title":"Health measurement scales: a practical guide to their development and use","volume":"40","author":"Steiner","year":"2016","journal-title":"Aust. N. Z. J. Public Health"},{"key":"B59","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cortex.2009.11.008","article-title":"Evidence for topographic organization in the cerebellum of motor control vs. cognitive and affective processing","volume":"46","author":"Stoodley","year":"2010","journal-title":"Cortex"},{"key":"B60","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fnhum.2015.00428","article-title":"Deficits in reflexive covert attention following cerebellar injury","volume":"9","author":"Striemer","year":"2015","journal-title":"Front. Hum. Neurosci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neubiorev.2016.04.001","article-title":"Functional reorganisation in chronic pain and neural correlates of pain sensitisation: a coordinate based meta-analysis of 266 cutaneous pain fMRI studies","volume":"68","author":"Tanasescu","year":"2016","journal-title":"Neurosci. Biobehav. Rev"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1097\/j.pain.0000000000000160","article-title":"A classification of chronic pain for ICD-11","volume":"156","author":"Treede","year":"2015","journal-title":"Pain"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4731","DOI":"10.3390\/jcm10204731","article-title":"Acupuncture treatment associated with functional connectivity changes in primary dysmenorrhea: a resting state fMRI study","volume":"10","author":"Tu","year":"2021","journal-title":"J. Clin. Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/AOG.0000000000004341","article-title":"Primary dysmenorrhea: diagnosis and therapy","volume":"137","author":"Tu","year":"2021","journal-title":"Obstet. Gynecol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1177\/0022034516638027","article-title":"The emotional brain as a predictor and amplifier of chronic pain","volume":"95","author":"Vachon-Presseau","year":"2016","journal-title":"J. Dent. Res"},{"key":"B66","doi-asserted-by":"publisher","first-page":"104735","DOI":"10.1016\/j.neubiorev.2022.104735","article-title":"The sensorimotor theory of pathological pain revisited","volume":"139","author":"Vitters\u00f8","year":"2022","journal-title":"Neurosci. Biobehav. Rev"},{"key":"B67","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/j.pain.0000000000000340","article-title":"Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea","volume":"157","author":"Wei","year":"2016","journal-title":"Pain"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1097\/j.pain.0000000000002279","article-title":"Activation of the dorsal, but not the ventral, hippocampus relieves neuropathic pain in rodents","volume":"162","author":"Wei","year":"2021","journal-title":"Pain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"B70","doi-asserted-by":"publisher","first-page":"24543","DOI":"10.1038\/srep24543","article-title":"Dynamic changes of functional pain connectome in women with primary dysmenorrhea","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1002\/ejp.1808","article-title":"Dynamic network topological properties for classifying primary dysmenorrhoea in the pain-free phase","volume":"25","author":"Wu","year":"","journal-title":"Eur. J. Pain"},{"key":"B72","doi-asserted-by":"publisher","first-page":"645616","DOI":"10.3389\/fneur.2021.645616","article-title":"Altered posterior cerebellar lobule connectivity with perigenual anterior cingulate cortex in women with primary dysmenorrhea","volume":"12","author":"Wu","year":"","journal-title":"Front Neurol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing and analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B74","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mri.2020.07.012","article-title":"Aberrant resting-state cerebral blood flow and its connectivity in primary dysmenorrhea on arterial spin labeling MRI","volume":"73","author":"Zhang","year":"2020","journal-title":"Magn. Reson. Imag."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.2147\/JPR.S177502","article-title":"Altered amplitude of low-frequency fluctuation and regional cerebral blood flow in females with primary dysmenorrhea: a resting-state fMRI and arterial spin labeling study","volume":"12","author":"Zhang","year":"2019","journal-title":"J. Pain Res"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.neuroimage.2009.09.037","article-title":"The oscillating brain: complex and reliable","volume":"49","author":"Zuo","year":"2010","journal-title":"Neuroimage"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1098573\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T05:00:55Z","timestamp":1675054855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1098573\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":76,"alternative-id":["10.3389\/fnins.2023.1098573"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1098573","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"article-number":"1098573"}}