{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:52:45Z","timestamp":1788979965648,"version":"build-2803163510"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS122751"],"award-info":[{"award-number":["R01-NS122751"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by a CAG repeat expansion in the <jats:italic>ATXN3<\/jats:italic> gene. Though the ATXN3 protein is expressed ubiquitously throughout the CNS, regional pathology in SCA3 patients is observed within select neuronal populations and more recently within oligodendrocyte-rich white matter tracts. We have previously recapitulated these white matter abnormalities in an overexpression mouse model of SCA3 and demonstrated that oligodendrocyte maturation impairments are one of the earliest and most progressive changes in SCA3 pathogenesis. Disease-associated oligodendrocyte signatures have recently emerged as significant contributors to several other neurodegenerative diseases, including Alzheimer\u2019s disease, Huntington\u2019s disease, and Parkinson\u2019s disease, but their role in regional vulnerability and disease progression remains unexplored. Here, we are the first to comparatively assess myelination in human tissue in a region-dependent manner. Translating these findings to SCA3 mouse models of disease, we confirmed endogenous expression of mutant <jats:italic>Atxn3<\/jats:italic> leads to regional transcriptional dysregulation of oligodendrocyte maturation markers in Knock-In models of SCA3. We then investigated the spatiotemporal progression of mature oligodendrocyte transcriptional dysregulation in an overexpression SCA3 mouse model and how it relates to the onset of motor impairment. We further determined that regional reduction in mature oligodendrocyte cell counts in SCA3 mice over time parallels the onset and progression of brain atrophy in SCA3 patients. This work emphasizes the prospective contributions of disease-associated oligodendrocyte signatures to regional vulnerability and could inform timepoints and target regions imperative for biomarker assessment and therapeutic intervention in several neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnins.2023.1118429","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T08:46:59Z","timestamp":1676450819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3"],"prefix":"10.3389","volume":"17","author":[{"given":"Kristen H.","family":"Schuster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"DiFranco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Putka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Mato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina I.","family":"Jarrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Stec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram O.","family":"Sundararajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley S.","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s12311-020-01137-3","article-title":"Volumetric MRI changes in spinocerebellar ataxia (SCA3 and SCA10) patients.","volume":"19","author":"Arruda","year":"2020","journal-title":"Cerebellum"},{"key":"B2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.pediatrneurol.2007.12.006","article-title":"Homozygosity enhances severity in spinocerebellar ataxia type 3.","volume":"38","author":"Carvalho","year":"2008","journal-title":"Pediatr. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/hmg\/11.9.1075","article-title":"YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.","volume":"11","author":"Cemal","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/mt.2013.144","article-title":"Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease.","volume":"21","author":"Costa","year":"2013","journal-title":"Mol. Ther."},{"key":"B5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pneurobio.2011.11.006","article-title":"Toward understanding Machado-Joseph disease.","volume":"97","author":"Costa","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/mds.28140","article-title":"In vivo molecular signatures of cerebellar pathology in spinocerebellar ataxia type 3.","volume":"35","author":"Costa","year":"2020","journal-title":"Mov. Disord."},{"key":"B7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.celrep.2016.03.069","article-title":"Developmental origin of oligodendrocyte lineage cells determines response to demyelination and susceptibility to age-associated functional decline.","volume":"15","author":"Crawford","year":"2016","journal-title":"Cell Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1552-6569.2011.00614.x","article-title":"Neocortical atrophy in Machado-Joseph disease: a longitudinal neuroimaging study.","volume":"22","author":"D\u2019Abreu","year":"2012","journal-title":"J. Neuroimaging"},{"key":"B9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.410390411","article-title":"Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.","volume":"39","author":"Durr","year":"1996","journal-title":"Ann. Neurol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28393","article-title":"Oligodendrocytes, a new player in the etiology of Parkinson\u2019s disease.","volume":"36","author":"Errea","year":"2021","journal-title":"Mov. Disord."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/mds.28610","article-title":"Regional brain and spinal cord volume loss in spinocerebellar ataxia type 3.","volume":"36","author":"Faber","year":"2021","journal-title":"Mov. Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/s41591-018-0236-y","article-title":"Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis.","volume":"24","author":"Falcao","year":"2018","journal-title":"Nat. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"9622","DOI":"10.1073\/pnas.1818042116","article-title":"Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease.","volume":"116","author":"Ferrari Bardile","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19453-x","article-title":"Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury.","volume":"11","author":"Floriddia","year":"2020","journal-title":"Nat. Commun."},{"key":"B15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41593-018-0221-2","article-title":"Selective vulnerability in neurodegenerative diseases.","volume":"21","author":"Fu","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature02033","article-title":"A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.","volume":"425","author":"Gong","year":"2003","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/mds.25451","article-title":"A multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3.","volume":"28","author":"Guimaraes","year":"2013","journal-title":"Mov. Disord."},{"key":"B18","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s12035-021-02610-8","article-title":"A Novel SCA3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities especially in oligodendrocytes.","volume":"59","author":"Haas","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/jnnp.2009.190702","article-title":"The progression of regional atrophy in premanifest and early Huntington\u2019s disease: a longitudinal voxel-based morphometry study.","volume":"81","author":"Hobbs","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.neuron.2015.02.026","article-title":"Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.","volume":"85","author":"Huang","year":"2015","journal-title":"Neuron"},{"key":"B21","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00234-020-02528-3","article-title":"Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.","volume":"63","author":"Inada","year":"2020","journal-title":"Neuroradiology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1001\/archneur.58.6.899","article-title":"Neurologic findings in Machado-Joseph disease: relation with disease duration, subtypes, and (CAG)n.","volume":"58","author":"Jardim","year":"2001","journal-title":"Arch. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/ana.25212","article-title":"Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.","volume":"83","author":"Joers","year":"2018","journal-title":"Ann. Neurol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-482","article-title":"CellProfiler Analyst: data exploration and analysis software for complex image-based screens.","volume":"9","author":"Jones","year":"2008","journal-title":"BMC Bioinform."},{"key":"B25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00415-013-7186-6","article-title":"White matter damage is related to ataxia severity in SCA3.","volume":"261","author":"Kang","year":"2014","journal-title":"J. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ng1194-221","article-title":"CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.","volume":"8","author":"Kawaguchi","year":"1994","journal-title":"Nat. Genet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/s41593-022-01104-7","article-title":"A shared disease-associated oligodendrocyte signature among multiple CNS pathologies.","volume":"25","author":"Kenigsbuch","year":"2022","journal-title":"Nat. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3174\/ajnr.A4760","article-title":"MR imaging in spinocerebellar ataxias: a systematic review.","volume":"37","author":"Klaes","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ana.410360318","article-title":"Homozygous inheritance of the Machado-Joseph disease gene.","volume":"36","author":"Lang","year":"1994","journal-title":"Ann. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000472162","article-title":"Machado-Joseph disease: correlation between the clinical features, the CAG repeat length and homozygosity for the mutation.","volume":"4","author":"Lerer","year":"1996","journal-title":"Eur. J. Hum. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1007\/s00415-021-10890-2","article-title":"Brain structural abnormalities in the preclinical stage of Machado-Joseph disease\/spinocerebellar ataxia type 3 (MJD\/SCA3): evaluation by MRI morphometry, diffusion tensor imaging and neurite orientation dispersion and density imaging.","volume":"269","author":"Li","year":"2022","journal-title":"J. Neurol."},{"key":"B32","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.1314","article-title":"Clinical features and genetic characteristics of homozygous spinocerebellar ataxia type 3.","volume":"8","author":"Li","year":"2020","journal-title":"Mol. Genet. Genomic Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neulet.2006.09.007","article-title":"Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study.","volume":"408","author":"Lukas","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B34","first-page":"54","article-title":"Correlation between CAG repeat length and clinical features in Machado-Joseph disease.","volume":"57","author":"Maciel","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41593-019-0581-2","article-title":"Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation.","volume":"23","author":"Marisca","year":"2020","journal-title":"Nat. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"504.e7","DOI":"10.1016\/j.devcel.2018.07.005","article-title":"Transcriptional convergence of oligodendrocyte lineage progenitors during development.","volume":"46","author":"Marques","year":"2018","journal-title":"Dev. Cell."},{"key":"B37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/ana.25264","article-title":"Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.","volume":"84","author":"McLoughlin","year":"2018","journal-title":"Ann. Neurol."},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104635","article-title":"Pathogenesis of SCA3 and implications for other polyglutamine diseases.","volume":"134","author":"McLoughlin","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.omtn.2017.04.005","article-title":"Evaluation of antisense oligonucleotides targeting ATXN3 in SCA3 mouse models.","volume":"7","author":"Moore","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00411","article-title":"Assessment of cerebral and cerebellar white matter microstructure in spinocerebellar ataxias 1, 2, 3, and 6 using diffusion MRI.","volume":"11","author":"Park","year":"2020","journal-title":"Front. Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0896-6273(00)80943-5","article-title":"Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.","volume":"19","author":"Paulson","year":"1997","journal-title":"Neuron"},{"key":"B42","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/brain\/aws339","article-title":"Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.","volume":"136","author":"Philips","year":"2013","journal-title":"Brain"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1002\/mds.28113","article-title":"A 5-year longitudinal clinical and magnetic resonance imaging study in spinocerebellar ataxia type 3.","volume":"35","author":"Piccinin","year":"2020","journal-title":"Mov. Disord."},{"key":"B44","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cortex.2022.03.009","article-title":"Regional changes of brain structure during progression of idiopathic Parkinson\u2019s disease - A longitudinal study using deformation based morphometry.","volume":"151","author":"Pieperhoff","year":"2022","journal-title":"Cortex"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/hmg\/ddu532","article-title":"A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.","volume":"24","author":"Ramani","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1093\/hmg\/ddx224","article-title":"Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.","volume":"26","author":"Ramani","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/ana.25297","article-title":"Structural signature of SCA3: from presymptomatic to late disease stages.","volume":"84","author":"Rezende","year":"2018","journal-title":"Ann. Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12311-008-0013-4","article-title":"SCA3: neurological features, pathogenesis and animal models.","volume":"7","author":"Riess","year":"2008","journal-title":"Cerebellum"},{"key":"B49","doi-asserted-by":"publisher","first-page":"11080","DOI":"10.1021\/bi026173d","article-title":"Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer\u2019s disease.","volume":"41","author":"Roher","year":"2002","journal-title":"Biochemistry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/WCO.0b013e3282f7673d","article-title":"New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease).","volume":"21","author":"R\u00fcb","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.pneurobio.2013.01.001","article-title":"Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.","volume":"104","author":"Rub","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1073\/pnas.052587399","article-title":"Mapping the evolution of regional atrophy in Alzheimer\u2019s disease: unbiased analysis of fluid-registered serial MRI.","volume":"99","author":"Scahill","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162615","article-title":"Pathogenetic mechanisms underlying spinocerebellar ataxia type 3 are altered in primary oligodendrocyte culture.","volume":"11","author":"Schuster","year":"","journal-title":"Cells"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1101\/2022.07.18.500473v1","article-title":"ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice.","author":"Schuster","year":"","journal-title":"bioRxiv"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1523\/JNEUROSCI.1954-20.2021","article-title":"Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis.","volume":"42","author":"Schuster","year":"","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jns.2018.04.026","article-title":"Homozygote of spinocerebellar ataxia type 3 correlating with severe phenotype based on analyses of clinical features.","volume":"390","author":"Shang","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"459.e5","DOI":"10.1016\/j.neuron.2018.12.020","article-title":"Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age.","volume":"101","author":"Spitzer","year":"2019","journal-title":"Neuron"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00749","article-title":"MR Imaging of SCA3\/MJD.","volume":"14","author":"Wan","year":"2020","journal-title":"Front. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000617","article-title":"Revealing the timeline of structural MRI changes in premanifest to manifest huntington disease.","volume":"7","author":"Wijeratne","year":"2021","journal-title":"Neurol. Genet."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00714","article-title":"Microstructural alterations in asymptomatic and symptomatic patients with spinocerebellar ataxia type 3: a tract-based spatial statistics study.","volume":"8","author":"Wu","year":"2017","journal-title":"Front. Neurol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s004010000277","article-title":"Involvement of the cerebral cortex and autonomic ganglia in Machado-Joseph disease.","volume":"101","author":"Yamada","year":"2001","journal-title":"Acta Neuropathol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165540","article-title":"Progression of regional microstructural degeneration in parkinson\u2019s disease: a multicenter diffusion tensor imaging study.","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1118429\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T08:47:14Z","timestamp":1676450834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1118429\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":63,"alternative-id":["10.3389\/fnins.2023.1118429"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1118429","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"article-number":"1118429"}}