{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:17:22Z","timestamp":1790813842912,"version":"4.1.0"},"reference-count":233,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Although the identification of numerous genes involved in neurodevelopmental disorders (NDDs) has reshaped our understanding of their etiology, there are still major obstacles in the way of developing therapeutic solutions for intellectual disability (ID) and other NDDs. These include extensive clinical and genetic heterogeneity, rarity of recurrent pathogenic variants, and comorbidity with other psychiatric traits. Moreover, a large intragenic mutational landscape is at play in some NDDs, leading to a broad range of clinical symptoms. Such diversity of symptoms is due to the different effects DNA variations have on protein functions and their impacts on downstream biological processes. The type of functional alterations, such as loss or gain of function, and interference with signaling pathways, has yet to be correlated with clinical symptoms for most genes. This review aims at discussing our current understanding of how the molecular changes of group I <jats:italic>p21-activated kinases<\/jats:italic> (<jats:italic>PAK1<\/jats:italic>, <jats:italic>2<\/jats:italic> and <jats:italic>3<\/jats:italic>), which are essential actors of brain development and function; contribute to a broad clinical spectrum of NDDs. Identifying differences in <jats:italic>PAK<\/jats:italic> structure, regulation and spatio-temporal expression may help understanding the specific functions of each group I <jats:italic>PAK<\/jats:italic>. Deciphering how each variation type affects these parameters will help uncover the mechanisms underlying mutation pathogenicity. This is a prerequisite for the development of personalized therapeutic approaches.<\/jats:p>","DOI":"10.3389\/fnins.2023.1123784","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T04:37:01Z","timestamp":1677731821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype"],"prefix":"10.3389","volume":"17","author":[{"given":"Manon","family":"Dobrigna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Po\u00eba-Guyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Toutain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Vianney","family":"Barnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1182\/blood-2008-06-160861","article-title":"P21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.","volume":"113","author":"Allen","year":"2009","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/1675","article-title":"PAK3 mutation in nonsyndromic X-linked mental retardation.","volume":"20","author":"Allen","year":"1998","journal-title":"Nat. Genet."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.930966","article-title":"Protein-activated kinase 3 (PAK3)-related intellectual disability associated with combined immunodeficiency: a case report.","volume":"22","author":"Almutairi","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/ddab026","article-title":"Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2.","volume":"31","author":"Antonarakis","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1042\/BC20070109","article-title":"A tale of two paks.","volume":"100","author":"Arias-Romero","year":"2008","journal-title":"Biol. Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.1523\/JNEUROSCI.1501-13.2013","article-title":"PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and A\u03b2.","volume":"33","author":"Arsenault","year":"2013","journal-title":"J. Neurosci. Offi. J. Soc. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuropharm.2008.06.055","article-title":"Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1).","volume":"56","author":"Asrar","year":"2009","journal-title":"Neuropharmacology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"23633","DOI":"10.1074\/jbc.273.37.23633","article-title":"A novel regulator of p21-activated kinases.","volume":"273","author":"Bagrodia","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/s0960-9822(02)00956-9","article-title":"Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis.","volume":"12","author":"Banerjee","year":"2002","journal-title":"Curr. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ajhg.2020.01.018","article-title":"Opposite modulation of RAC1 by mutations in TRIO is associated with distinct, domain-specific neurodevelopmental disorders.","volume":"106","author":"Barbosa","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.594998","article-title":"The role of ADF\/cofilin in synaptic physiology and Alzheimer\u2019s disease.","volume":"8","author":"Ben Zablah","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/1096-8628(20000814)93:4<294::AID-AJMG8<3.0.CO;2-F","article-title":"Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation.","volume":"93","author":"Bienvenu","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/31940","article-title":"Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.","volume":"392","author":"Billuart","year":"1998","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"10816","DOI":"10.1523\/JNEUROSCI.2931-04.2004","article-title":"The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.","volume":"24","author":"Boda","year":"2004","journal-title":"J. Neurosci. Offi. J. Soc. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.conb.2010.03.012","article-title":"Signaling mechanisms regulating synapse formation and function in mental retardation.","volume":"20","author":"Boda","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev.biochem.72.121801.161742","article-title":"Biology of the p21-activated kinases.","volume":"72","author":"Bokoch","year":"2003","journal-title":"Ann. Rev. Biochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1093\/hmg\/ddy200","article-title":"PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.","volume":"27","author":"Bondar","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.18632\/aging.101239","article-title":"Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer\u2019s disease.","volume":"9","author":"Bories","year":"2017","journal-title":"Aging"},{"key":"B19","year":"2022","journal-title":"Developmental transcriptome: brainspan: atlas of the developing human brain."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1091\/mbc.02-02-0015","article-title":"Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway.","volume":"13","author":"Brown","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.764756","article-title":"Wnt\/\u03b2-catenin-dependent transcription in autism spectrum disorders.","volume":"14","author":"Caracci","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/MCD.0000000000000154","article-title":"Short case report: Xq23 deletion involving PAK3 as a novel cause of developmental delay in a 6-year-old boy","volume":"26","author":"Cartwright","year":"2017","journal-title":"Clin. Dysmorphol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1093\/hmg\/ddz296","article-title":"The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.","volume":"29","author":"Castillon","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/cercor\/bhn133","article-title":"The p21-activated kinase is required for neuronal migration in the cerebral cortex.","volume":"19","author":"Causeret","year":"2009","journal-title":"Cerebral Cortex"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/35088558","article-title":"Monogenic causes of X-linked mental retardation.","volume":"2","author":"Chelly","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1523\/JNEUROSCI.0164-07.2007","article-title":"Changes in synaptic morphology accompany actin signaling during LTP.","volume":"27","author":"Chen","year":"2007","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jgg.2021.03.010","article-title":"Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice.","volume":"48","author":"Cheng","year":"2021","journal-title":"J. Genet. Genom."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7134.1","article-title":"Advances in understanding\u2014genetic basis of intellectual disability.","volume":"5","author":"Chiurazzi","year":"2016","journal-title":"F1000 Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.bbadis.2017.11.005","article-title":"PAKs in the brain: function and dysfunction.","volume":"1864","author":"Civiero","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.neuron.2007.05.024","article-title":"Dlx transcription factors promote migration through repression of axon and dendrite growth.","volume":"54","author":"Cobos","year":"2007","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"30084","DOI":"10.1074\/jbc.M112.355073","article-title":"The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.","volume":"287","author":"Combeau","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B32","author":"Crocq","year":"2015","journal-title":"DSM-5: manuel diagnostique et statistique des troubles mentaux."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1021\/acssynbio.6b00359","article-title":"Engineering pak1 allosteric switches.","volume":"6","author":"Dagliyan","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/ejn.12413","article-title":"Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression.","volume":"39","author":"Dai","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1016\/j.bbamcr.2015.05.031","article-title":"PAK1 modulates a PPAR\u03b3\/NF-\u03baB cascade in intestinal inflammation.","volume":"1853","author":"Dammann","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1093\/emboj\/17.3.754","article-title":"Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells.","volume":"17","author":"Daniels","year":"1998","journal-title":"EMBO J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1101\/gad.1880510","article-title":"A FOXO-Pak1 transcriptional pathway controls neuronal polarity.","volume":"24","author":"de la Torre-Ubieta","year":"2010","journal-title":"Genes Dev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1056\/NEJMoa1206524","article-title":"Diagnostic exome sequencing in persons with severe intellectual disability.","volume":"367","author":"de Ligt","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.chembiol.2008.03.005","article-title":"An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.","volume":"15","author":"Deacon","year":"2008","journal-title":"Chem. Biol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00119","article-title":"Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.","volume":"8","author":"Deidda","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3233\/JAD-160167","article-title":"Partial amelioration of synaptic and cognitive deficits by inhibiting cofilin dephosphorylation in an animal model of Alzheimer\u2019s disease.","volume":"53","author":"Deng","year":"2016","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"B42","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/(sici)1096-8628(19971031)72:3<324::aid-ajmg14<3.0.co;2-v","article-title":"Gene for nonspecific X-linked mental retardation (MRX 47) is located in Xq22.3-q24.","volume":"72","author":"des Portes","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/653487","article-title":"Structure-functional prediction and analysis of cancer mutation effects in protein kinases.","volume":"2014","author":"Dixit","year":"2014","journal-title":"Comput. Mathe. Methods Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.1073\/pnas.1219383110","article-title":"Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.","volume":"110","author":"Dolan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B45","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/(SICI)1096-8628(19960712)64:1<113::AID-AJMG19<3.0.CO;2-Q","article-title":"Regional localization of two non-specific X-linked mental retardation genes (MRX30 and MRX31).","volume":"64","author":"Donnelly","year":"1996","journal-title":"Am. J. Med. Genet."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104709","article-title":"PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.","volume":"136","author":"Duarte","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1523\/JNEUROSCI.3252-11.2012","article-title":"Alteration of synaptic network dynamics by the intellectual disability protein PAK3.","volume":"32","author":"Dubos","year":"2012","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jns.2009.11.003","article-title":"Alpha pix enhances mutant huntingtin aggregation.","volume":"290","author":"Eriguchi","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.tins.2016.03.001","article-title":"Proliferation and differentiation deficits are a major convergence point for neurodevelopmental disorders.","volume":"39","author":"Ernst","year":"2016","journal-title":"Trends Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.tibs.2008.06.002","article-title":"UnPAKing the class differences among p21-activated kinases.","volume":"33","author":"Eswaran","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuroscience.2020.01.041","article-title":"Seizures in mouse models of rare neurodevelopmental disorders.","volume":"445","author":"Fallah","year":"2020","journal-title":"Neuroscience"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1002\/ajmg.a.36559","article-title":"Cerebral palsy, epilepsy, and severe intellectual disability in a patient with 3q29 microduplication syndrome.","volume":"164","author":"Fern\u00e1ndez-Ja\u00e9n","year":"2014","journal-title":"Am. J. Med. Genet."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209015","article-title":"Unique and overlapping substrate specificities of caspase-8 and caspase-10.","volume":"25","author":"Fischer","year":"2006","journal-title":"Oncogene"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/schbul\/sbx164","article-title":"The psychiatric risk gene transcription factor 4 (TCF4) regulates neurodevelopmental pathways associated with schizophrenia, autism, and intellectual disability.","volume":"44","author":"Forrest","year":"2018","journal-title":"Schizophr. Bull."},{"key":"B55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0092-8674(00)80077-X","article-title":"LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.","volume":"86","author":"Frangiskakis","year":"1996","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"publisher","first-page":"19693","DOI":"10.1074\/jbc.M909860199","article-title":"Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.","volume":"275","author":"Frost","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1111\/cns.13907","article-title":"Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder.","volume":"28","author":"Fuchs","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"B58","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.neuroscience.2016.07.037","article-title":"Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.","volume":"333","author":"Fuchsova","year":"2016","journal-title":"Neuroscience"},{"key":"B59","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.tig.2009.05.002","article-title":"The genetic landscape of intellectual disability arising from chromosome X.","volume":"25","author":"G\u00e9cz","year":"2009","journal-title":"Trends Genetics TIG"},{"key":"B60","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/ajmg.a.20131","article-title":"X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3.","author":"Gedeon","year":"2003","journal-title":"Am. J. Med. Genet. Part A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nn.4589","article-title":"Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.","volume":"20","author":"Geisheker","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040603","article-title":"Control of synapse structure and function by actin and its regulators.","volume":"11","author":"Gentile","year":"2022","journal-title":"Cells"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.jaac.2020.01.006","article-title":"Systematic review and meta-analysis: mental health in children with neurogenetic disorders associated with intellectual disability.","volume":"59","author":"Glasson","year":"2020","journal-title":"J. Am. Acad. Child Adoles. Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0869-4","article-title":"The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes.","volume":"17","author":"Gussow","year":"2016","journal-title":"Geno. Biol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146206","article-title":"Identification of the most damaging nsSNPs in the human CFL1 gene and their functional and structural impacts on cofilin-1 protein.","volume":"819","author":"Halder","year":"2022","journal-title":"Gene"},{"key":"B66","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.ajhg.2018.09.005","article-title":"Activating mutations in PAK1, encoding p21-activated kinase 1, cause a neurodevelopmental disorder.","volume":"103","author":"Harms","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"B67","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.1074\/jbc.M005854200","article-title":"Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3","volume":"276","author":"Hashimoto","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/dneu.20363","article-title":"Pak1 regulates dendritic branching and spine formation.","volume":"67","author":"Hayashi","year":"2007","journal-title":"Dev. Neurobiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.neuron.2004.05.003","article-title":"Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.","volume":"42","author":"Hayashi","year":"2004","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","first-page":"6461","DOI":"10.1073\/pnas.1321109111","article-title":"PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.","volume":"111","author":"Hayashi-Takagi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B71","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ejmg.2017.01.004","article-title":"A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins.","volume":"60","author":"Hertecant","year":"2017","journal-title":"Eur. J. Med. Genet."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.747785","article-title":"Dysregulation of NF-\u03baB-associated LncRNAs in autism spectrum disorder.","volume":"14","author":"Honarmand Tamizkar","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1093\/brain\/awz264","article-title":"De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures.","volume":"142","author":"Horn","year":"2019","journal-title":"Brain J. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1177\/0883073817740443","article-title":"Improvement of self-injury with dopamine and serotonin replacement therapy in a patient with a hemizygous PAK3 mutation: a new therapeutic strategy for neuropsychiatric features of an intellectual disability syndrome.","volume":"33","author":"Horvath","year":"2018","journal-title":"J. Child Neurol."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006290","article-title":"Tuning PAK activity to rescue abnormal myelin permeability in HNPP.","volume":"12","author":"Hu","year":"2016","journal-title":"PLoS Genet."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0322-3","article-title":"MicroRNA-455-3p promotes TGF-\u03b2 signaling and inhibits osteoarthritis development by directly targeting PAK2.","volume":"51","author":"Hu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1128\/MCB.00969-10","article-title":"P21-activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.","volume":"31","author":"Huang","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"E5883","DOI":"10.1073\/pnas.1518382112","article-title":"Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation.","volume":"112","author":"Hussain","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a003988","article-title":"A novel PAK3 pathogenic variant identified in two siblings from a Japanese family with X-linked intellectual disability: case report and review of the literature.","volume":"5","author":"Iida","year":"2019","journal-title":"Cold Spring Harbor Mol. Case Stud."},{"key":"B80","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature13908","article-title":"The contribution of de novo coding mutations to autism spectrum disorder.","volume":"515","author":"Iossifov","year":"2014","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.ajhg.2022.05.009","article-title":"Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: an emerging neurodevelopmental syndrome.","volume":"109","author":"Ismail","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1016\/j.celrep.2020.01.079","article-title":"CtBP1-mediated membrane fission contributes to effective recycling of synaptic vesicles.","volume":"30","author":"Ivanova","year":"2020","journal-title":"Cell Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/s1357-2725(01)00158-3","article-title":"p21-activated kinases: three more join the pak.","volume":"34","author":"Jaffer","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"38675","DOI":"10.1074\/jbc.M306494200","article-title":"Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation*.","volume":"278","author":"Jakobi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/genes13101795","article-title":"Profiling genome-wide DNA methylation in children with autism spectrum disorder and in children with fragile X syndrome.","volume":"13","author":"Jasoliya","year":"2022","journal-title":"Genes"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144991","article-title":"Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.","volume":"760","author":"Kanumuri","year":"2020","journal-title":"Gene"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114316","article-title":"Rac is required for the survival of cortical neurons.","volume":"361","author":"Katayama","year":"2023","journal-title":"Exp. Neurol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/cge.13618","article-title":"P21 protein-activated kinase 1 is associated with severe regressive autism, and epilepsy.","volume":"96","author":"Kernohan","year":"2019","journal-title":"Clin. Genet."},{"key":"B89","doi-asserted-by":"publisher","first-page":"C624","DOI":"10.1152\/ajpcell.00303.2020","article-title":"MiRNA degradation in the mammalian brain.","volume":"319","author":"Kim","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"21512","DOI":"10.1074\/jbc.273.34.21512","article-title":"Structural requirements for PAK activation by Rac GTPases.","volume":"273","author":"Knaus","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1242\/jcs.114.23.4239","article-title":"Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles.","volume":"114","author":"Koh","year":"2001","journal-title":"J. Cell Sci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neuron.2016.05.025","article-title":"A postsynaptic AMPK\u2192p21-activated kinase pathway drives fasting-induced synaptic plasticity in AgRP neurons.","volume":"91","author":"Kong","year":"2016","journal-title":"Neuron"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0100-x","article-title":"MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3.","volume":"9","author":"Koo","year":"2018","journal-title":"Cell Death Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jphysparis.2014.08.007","article-title":"Participation of group I p21-activated kinases in neuroplasticity.","volume":"108","author":"Koth","year":"2014","journal-title":"J. Physiol. Paris"},{"key":"B95","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cellsig.2008.11.001","article-title":"PAK signalling in neuronal physiology.","volume":"21","author":"Kreis","year":"2009","journal-title":"Cell. Sign."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/j.1471-4159.2008.05474.x","article-title":"The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.","volume":"106","author":"Kreis","year":"2008","journal-title":"J. Neurochem."},{"key":"B97","doi-asserted-by":"publisher","first-page":"21497","DOI":"10.1074\/jbc.M703298200","article-title":"The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.","volume":"282","author":"Kreis","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/bs.acr.2016.01.002","article-title":"PAKs in human cancer progression: from inception to cancer therapeutic to future oncobiology.","volume":"130","author":"Kumar","year":"2016","journal-title":"Adv. Cancer Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/80002","article-title":"Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.","volume":"26","author":"Kutsche","year":"2000","journal-title":"Nat. Genet."},{"key":"B100","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/bpa.12779","article-title":"Synaptic actin stabilization protein loss in down syndrome and alzheimer disease.","volume":"30","author":"Lauterborn","year":"2020","journal-title":"Brain Pathol."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2021.103623","article-title":"Operative list of genes associated with autism and neurodevelopmental disorders based on database review.","volume":"113","author":"Leblond","year":"2021","journal-title":"Mol. Cell. Neurosci."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101123","article-title":"Rare genetic diseases: nature\u2019s experiments on human development.","volume":"23","author":"Lee","year":"2020","journal-title":"IScience"},{"key":"B103","first-page":"611","article-title":"A theory of X-linkage of major intellectual traits.","volume":"76","author":"Lehrke","year":"1972","journal-title":"Am. J. Mental Deficiency"},{"key":"B104","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/s0092-8674(00)00043-x","article-title":"Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.","volume":"102","author":"Lei","year":"2000","journal-title":"Cell"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34264-y","article-title":"Systematic analysis and prediction of genes associated with monogenic disorders on human chromosome X.","volume":"13","author":"Leit\u00e3o","year":"2022","journal-title":"Nat. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1038\/nn.4352","article-title":"Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.","volume":"19","author":"Lelieveld","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1016\/j.celrep.2018.04.073","article-title":"Activation of entorhinal cortical projections to the dentate gyrus underlies social memory retrieval.","volume":"23","author":"Leung","year":"2018","journal-title":"Cell Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1002\/2211-5463.12738","article-title":"MicroRNA-7-5p induces cell growth inhibition, cell cycle arrest and apoptosis by targeting PAK2 in non-small cell lung cancer.","volume":"9","author":"Li","year":"2019","journal-title":"FEBS Open Bio."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00289-0","article-title":"The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism.","volume":"2","author":"Li","year":"2020","journal-title":"Nat. Metab."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116167","article-title":"Neuronal cytoskeleton in intellectual disability: from systems biology and modeling to therapeutic opportunities.","volume":"22","author":"Liaci","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/ajmg.a.32190","article-title":"3q29 interstitial microduplication: a new syndrome in a three-generation family.","author":"Lisi","year":"2008","journal-title":"Am. J. Med. Genet. Part A"},{"key":"B112","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ebiom.2019.10.060","article-title":"Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1\/Cdc42-PAK signalling pathway.","volume":"50","author":"Liu","year":"2019","journal-title":"EBioMedicine"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.641381","article-title":"The role of p21-activated kinases in cancer and beyond: where are we heading?","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0418-y","article-title":"Paxillin: A crossroad in pathological cell migration","volume":"10","author":"L\u00f3pez-Colom\u00e9","year":"2017","journal-title":"J. Hematol. Oncol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.ajhg.2012.02.018","article-title":"Fragile X and X-Linked intellectual disability: four decades of discovery.","volume":"90","author":"Lubs","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B116","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/hmg\/ddm362","article-title":"P21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity.","volume":"17","author":"Luo","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B117","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1242\/jcs.050013","article-title":"Huntingtin promotes cell survival by preventing Pak2 cleavage.","volume":"122","author":"Luo","year":"2009","journal-title":"J. Cell Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"14132","DOI":"10.1074\/jbc.M708034200","article-title":"P21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.","volume":"283","author":"Ma","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B119","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4161\/cl.21602","article-title":"PAK in alzheimer disease. Huntington disease and X-linked mental retardation.","volume":"2","author":"Ma","year":"2012","journal-title":"Cell. Logist."},{"key":"B120","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1093\/hmg\/ddu070","article-title":"A mutation in PAK3 with a dual molecular effect deregulates the RAS\/MAPK pathway and drives an X-linked syndromic phenotype.","volume":"23","author":"Magini","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B121","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.nbd.2016.12.004","article-title":"The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation.","volume":"98","author":"Maglorius Renkilaraj","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s13402-021-00635-8","article-title":"PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.","volume":"44","author":"Magne","year":"2021","journal-title":"Cell. Oncol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/10409238.2020.1810621","article-title":"Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.","volume":"55","author":"Majumder","year":"2020","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"8887","DOI":"10.1074\/jbc.M112.428904","article-title":"Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and rho GTPases*.","volume":"288","author":"Malecka","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"25070","DOI":"10.1074\/jbc.270.42.25070","article-title":"Molecular cloning of a new member of the p21-Cdc42\/Rac-activated kinase (PAK) family.","volume":"270","author":"Manser","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B126","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/s1097-2765(00)80019-2","article-title":"PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.","volume":"1","author":"Manser","year":"1998","journal-title":"Mol. Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroscience.2020.07.034","article-title":"Modelling learning and memory in drosophila to understand intellectual disabilities.","volume":"445","author":"Mariano","year":"2020","journal-title":"Neuroscience"},{"key":"B128","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s00335-011-9326-6","article-title":"Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34.","volume":"22","author":"Marlin","year":"2011","journal-title":"Mammalian Geno. Offi. J. Int. Mammalian Geno. Soc."},{"key":"B129","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajhg.2017.12.015","article-title":"Functional dysregulation of CDC42 causes diverse developmental phenotypes.","volume":"102","author":"Martinelli","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"B130","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/mp.2014.189","article-title":"Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.","volume":"20","author":"McMichael","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B131","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1523\/JNEUROSCI.23-17-06914.2003","article-title":"DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.","volume":"23","author":"McPhie","year":"2003","journal-title":"J. Neurosci. Offi. J. Soc. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1007\/s00429-018-1621-5","article-title":"Multiple roles of sonic hedgehog in the developing human cortex are suggested by its widespread distribution.","volume":"223","author":"Memi","year":"2018","journal-title":"Brain Struct. Funct."},{"key":"B133","doi-asserted-by":"publisher","first-page":"6641","DOI":"10.1523\/JNEUROSCI.0028-05.2005","article-title":"Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.","volume":"25","author":"Meng","year":"2005","journal-title":"J. Neurosci. Offi. J. Soc. Neurosci."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105856","article-title":"Synaptic genes and neurodevelopmental disorders: from molecular mechanisms to developmental strategies of behavioral testing.","volume":"173","author":"Michetti","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"B135","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nature13185","article-title":"Transcriptional landscape of the prenatal human brain.","volume":"508","author":"Miller","year":"2014","journal-title":"Nature"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/nn.3822","article-title":"Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.","volume":"17","author":"Molosh","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1016\/j.neuron.2022.10.006","article-title":"The neurobiology of long COVID.","volume":"110","author":"Monje","year":"2022","journal-title":"Neuron"},{"key":"B138","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.pnpbp.2017.09.014","article-title":"Glutamatergic synapses in neurodevelopmental disorders.","volume":"84","author":"Moretto","year":"2018","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B139","doi-asserted-by":"publisher","first-page":"65","DOI":"10.31887\/DCNS.2020.22.1\/macrocq","article-title":"Neurodevelopmental disorders-the history and future of a diagnostic concept.","volume":"22","author":"Morris-Rosendahl","year":"2020","journal-title":"Dial. Clin. Neurosci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ajhg.2020.06.018","article-title":"Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum.","volume":"107","author":"Motta","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"B141","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000453266","article-title":"Neurodevelopmental perspectives on wnt signaling in psychiatry.","volume":"2","author":"Mulligan","year":"2017","journal-title":"Mol. Neuropsychiatry"},{"key":"B142","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1089\/omi.2017.0009","article-title":"Next-generation sequencing reveals novel mutations in X-linked intellectual disability.","volume":"21","author":"Muthusamy","year":"2017","journal-title":"Omics J. Int. Biol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00424-007-0385-1","article-title":"Rho-linked genes and neurological disorders.","volume":"455","author":"Nadif Kasri","year":"2008","journal-title":"Pfl\u00fcgers Archiv Eur. J. Physiol."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2019.103800","article-title":"Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: identification of a novel missense mutation and review of literature.","volume":"63","author":"Nagy","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1111\/j.1471-4159.2007.05031.x","article-title":"Signal transduction in alzheimer disease: P21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.","volume":"104","author":"Nguyen","year":"2008","journal-title":"J. Neurochem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.1093\/emboj\/17.15.4328","article-title":"PAK promotes morphological changes by acting upstream of Rac.","volume":"17","author":"Obermeier","year":"1998","journal-title":"EMBO J."},{"key":"B147","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s10038-020-0728-8","article-title":"A novel PAK1 variant causative of neurodevelopmental disorder with postnatal macrocephaly.","volume":"65","author":"Ohori","year":"2020","journal-title":"J. Hum. Genet."},{"key":"B148","year":"2022"},{"key":"B149","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wps.20440","article-title":"Schizophrenia and the neurodevelopmental continuum: evidence from genomics.","volume":"16","author":"Owen","year":"2017","journal-title":"World Psychiatry"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0124-z","article-title":"PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.","volume":"8","author":"Pan","year":"2015","journal-title":"Mol. Brain"},{"key":"B151","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.tins.2020.05.004","article-title":"Neurodevelopmental disorders: from genetics to functional pathways.","volume":"43","author":"Parenti","year":"2020","journal-title":"Trends Neurosci."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066892","article-title":"P21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.","volume":"8","author":"Parker","year":"2013","journal-title":"PLoS One"},{"key":"B153","doi-asserted-by":"publisher","first-page":"24133","DOI":"10.1074\/jbc.M109.015271","article-title":"Dissecting activation of the PAK1 kinase at protrusions in living cells*.","volume":"284","author":"Parrini","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B154","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s1097-2765(01)00428-2","article-title":"Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.","volume":"9","author":"Parrini","year":"2002","journal-title":"Mol. Cell"},{"key":"B155","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1007\/s12031-021-01868-w","article-title":"Clinical and molecular aspects of the neurodevelopmental disorder associated with PAK3 perturbation.","volume":"71","author":"Pascolini","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neubiorev.2021.01.024","article-title":"The postnatal GABA shift: a developmental perspective.","volume":"124","author":"Peerboom","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B157","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1002\/ajmg.a.31956","article-title":"PAK3 related mental disability: further characterization of the phenotype.","author":"Peippo","year":"2007","journal-title":"Am. J. Med. Genet. Part A"},{"key":"B158","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/cm.21015","article-title":"Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines.","volume":"69","author":"Penzes","year":"2012","journal-title":"Cytoskeleton"},{"key":"B159","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2337\/db13-0384","article-title":"Pak3 promotes cell cycle exit and differentiation of \u03b2-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.","volume":"63","author":"Piccand","year":"2014","journal-title":"Diabetes"},{"key":"B160","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jmb.2006.06.017","article-title":"A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.","volume":"361","author":"Pirruccello","year":"2006","journal-title":"J. Mol. Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ajhg.2013.06.013","article-title":"XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.","volume":"93","author":"Piton","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"B162","doi-asserted-by":"publisher","first-page":"9388","DOI":"10.1074\/jbc.M208414200","article-title":"P21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.","volume":"278","author":"Puto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B163","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1016\/j.devcel.2022.09.011","article-title":"Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.","volume":"57","author":"Qian","year":"2022","journal-title":"Dev. Cell"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10100747","article-title":"Comprehensive analysis of RNA-seq gene expression profiling of brain transcriptomes reveals novel genes, regulators, and pathways in autism spectrum disorder.","volume":"10","author":"Rahman","year":"2020","journal-title":"Brain Sci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ajhg.2017.08.007","article-title":"RAC1 missense mutations in developmental disorders with diverse phenotypes.","volume":"101","author":"Reijnders","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/ejhg.2008.103","article-title":"A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features.","volume":"16","author":"Rejeb","year":"2008","journal-title":"Eur. J. Hum. Genet."},{"key":"B167","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1080\/09540261.2018.1450229","article-title":"Co-occurring psychiatric conditions in autism spectrum disorder.","volume":"30","author":"Rosen","year":"2018","journal-title":"Int. Rev. Psychiatry"},{"key":"B168","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuroscience.2020.02.017","article-title":"Angelman syndrome: from mouse models to therapy.","volume":"445","author":"Rotaru","year":"2020","journal-title":"Neuroscience"},{"key":"B169","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1074\/jbc.M207251200","article-title":"A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases.","volume":"278","author":"Rousseau","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1126\/science.276.5318.1571","article-title":"Membrane and Morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.","volume":"276","author":"Rudel","year":"1997","journal-title":"Science"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.neuron.2015.09.016","article-title":"Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci.","volume":"87","author":"Sanders","year":"2015","journal-title":"Neuron"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/s41591-019-0581-5","article-title":"A framework for the investigation of rare genetic disorders in neuropsychiatry.","volume":"25","author":"Sanders","year":"2019","journal-title":"Nat. Med."},{"key":"B173","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.gpb.2019.10.003","article-title":"Schizophrenia-associated MicroRNA-gene interactions in the dorsolateral prefrontal cortex.","volume":"17","author":"Santarelli","year":"2019","journal-title":"Genom. Proteom. Bioinform."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1242\/jcs.112607","article-title":"PAK\u2013PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth.","volume":"126","author":"Santiago-Medina","year":"2013","journal-title":"J. Cell Sci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.molcel.2010.04.004","article-title":"A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.","volume":"38","author":"Say","year":"2010","journal-title":"Mol. Cell"},{"key":"B176","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1093\/brain\/awac106","article-title":"Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes.","volume":"145","author":"Scala","year":"2022","journal-title":"Brain J. Neurol."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3216-y","article-title":"Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development.","volume":"17","author":"Schachtschneider","year":"2016","journal-title":"BMC Genom."},{"key":"B178","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.neuroscience.2015.08.034","article-title":"Genomic approach to selective vulnerability of the hippocampus in brain ischemia-hypoxia.","volume":"309","author":"Schmidt-Kastner","year":"2015","journal-title":"Neuroscience"},{"key":"B179","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1083\/jcb.145.4.837","article-title":"P21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts.","volume":"145","author":"Sells","year":"1999","journal-title":"J. Cell Biol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/s0960-9822(97)70091-5","article-title":"Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.","volume":"7","author":"Sells","year":"1997","journal-title":"Curr. Biol. CB"},{"key":"B181","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1042\/BST20160134","article-title":"Targeting PAK1.","volume":"45","author":"Semenova","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"B182","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1158\/1541-7786.MCR-21-0837","article-title":"Inactivation of p21-activated kinase 2 (Pak2) inhibits the development of Nf2-deficient tumors by restricting downstream hedgehog and Wnt signaling.","volume":"20","author":"Sementino","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105067","article-title":"Targeting PI3K-AKT\/mTOR signaling in the prevention of autism.","volume":"147","author":"Sharma","year":"2021","journal-title":"Neurochem. Int."},{"key":"B184","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pharmthera.2017.02.031","article-title":"Peptide regulation of cofilin activity in the CNS: a novel therapeutic approach for treatment of multiple neurological disorders.","volume":"175","author":"Shaw","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/cercor\/bhy051","article-title":"Foxg1 regulates the postnatal development of cortical interneurons.","volume":"29","author":"Shen","year":"2019","journal-title":"Cerebral Cortex"},{"key":"B186","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41397-021-00215-x","article-title":"Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms.","volume":"21","author":"Sinha","year":"2021","journal-title":"Pharmacogen. J."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1042\/BCJ20180867","article-title":"Solution structures and biophysical analysis of full-length group a PAKs reveal they are monomeric and auto-inhibited in cis.","volume":"476","author":"Sorrell","year":"2019","journal-title":"Biochem. J."},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142406","article-title":"The retinoblastoma tumor suppressor transcriptionally represses pak1 in osteoblasts.","volume":"10","author":"Sosa-Garc\u00eda","year":"2015","journal-title":"PLoS One"},{"key":"B189","doi-asserted-by":"publisher","first-page":"6429","DOI":"10.1093\/emboj\/cdf644","article-title":"XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis.","volume":"21","author":"Souopgui","year":"2002","journal-title":"EMBO J."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06008-4","article-title":"A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.","volume":"9","author":"Srivastava","year":"2018","journal-title":"Nat. Commun."},{"key":"B191","doi-asserted-by":"publisher","first-page":"14319","DOI":"10.1074\/jbc.RA119.007692","article-title":"The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.","volume":"294","author":"Sun","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B192","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1074\/jbc.M406013200","article-title":"Adhesion stimulates direct PAK1\/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.","volume":"280","author":"Sundberg-Smith","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B193","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.tig.2020.11.002","article-title":"To NMD or Not To NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases.","volume":"37","author":"Supek","year":"2021","journal-title":"Trends Genet."},{"key":"B194","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/pcn.12774","article-title":"Estimating contribution of rare non-coding variants to neuropsychiatric disorders.","volume":"73","author":"Takata","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24898-9","article-title":"Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.","volume":"12","author":"Tan","year":"2021","journal-title":"Nat. Commun."},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135763","article-title":"DSCAM\/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with down syndrome.","volume":"131","author":"Tang","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B197","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ajmg.c.32012","article-title":"The molecular genetics of RASopathies: an update on novel disease genes and new disorders.","volume":"190","author":"Tartaglia","year":"2022","journal-title":"Am. J. Med. Genet. Part C Sem. Med. Genet."},{"key":"B198","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuroscience.2018.12.017","article-title":"LIMK2-1 is a hominidae-specific isoform of LIMK2 expressed in central nervous system and associated with intellectual disability.","volume":"399","author":"Tastet","year":"2019","journal-title":"Neuroscience"},{"key":"B199","doi-asserted-by":"publisher","first-page":"26690","DOI":"10.1074\/jbc.270.44.26690","article-title":"Identification and molecular cloning of a p21cdc42\/rac1-activated serine\/threonine kinase that is rapidly activated by thrombin in platelets.","volume":"270","author":"Teo","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B200","doi-asserted-by":"publisher","first-page":"40044","DOI":"10.1074\/jbc.M111.262246","article-title":"P21-activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2\/Grb4 protein adaptor.","volume":"286","author":"Th\u00e9venot","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B201","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1128\/MCB.19.1.602","article-title":"Genetic evidence for pak1 autoinhibition and its release by Cdc42.","volume":"19","author":"Tu","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/ejhg.2015.5","article-title":"Next-generation sequencing in X-linked intellectual disability.","volume":"23","author":"Tzschach","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"B203","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev-genet-110410-132512","article-title":"Genetic and epigenetic networks in intellectual disabilities.","volume":"45","author":"van Bokhoven","year":"2011","journal-title":"Ann. Rev. Genet."},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.932305","article-title":"Disease similarity network analysis of autism spectrum disorder and comorbid brain disorders.","volume":"15","author":"Vilela","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"B205","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrg3999","article-title":"Genetic studies in intellectual disability and related disorders.","volume":"17","author":"Vissers","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.str.2011.10.013","article-title":"Structural insights into the autoactivation mechanism of p21-activated protein kinase.","volume":"19","author":"Wang","year":"2011","journal-title":"Structure"},{"key":"B207","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/brv.12815","article-title":"Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how.","volume":"97","author":"Wang","year":"2022","journal-title":"Biol. Rev."},{"key":"B208","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1016\/j.celrep.2018.07.061","article-title":"PAK2 haploinsufficiency results in synaptic cytoskeleton impairment and autism-related behavior.","volume":"24","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"B209","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1002\/cne.24712","article-title":"Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.","volume":"527","author":"Wei","year":"2019","journal-title":"J. Comparat. Neurol."},{"key":"B210","first-page":"1663","article-title":"A familial 3q28q29 duplication induced mild intellectual disability: case presentation and literature review.","volume":"14","author":"Wen","year":"2022","journal-title":"Am. J. Trans. Res."},{"key":"B211","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2741\/3724","article-title":"Signalling to cancer cell invasion through PAK family kinases.","volume":"16","author":"Whale","year":"2011","journal-title":"Front. Biosci."},{"key":"B212","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.neuron.2017.04.024","article-title":"De novo coding variants are strongly associated with tourette disorder.","volume":"94","author":"Willsey","year":"2017","journal-title":"Neuron"},{"key":"B213","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/S0140-6736(14)61705-0","article-title":"Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.","volume":"385","author":"Wright","year":"2015","journal-title":"Lancet"},{"key":"B214","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1080\/21541248.2016.1228793","article-title":"PAK1 regulates inhibitory synaptic function via a novel mechanism mediated by endocannabinoids.","volume":"9","author":"Xia","year":"2018","journal-title":"Small GTPases"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01643-2","article-title":"Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-\u03b2-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.","volume":"27","author":"Yamahashi","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B216","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1111\/febs.15872","article-title":"Interneuron development and dysfunction.","volume":"289","author":"Yang","year":"2022","journal-title":"FEBS J."},{"key":"B217","doi-asserted-by":"publisher","first-page":"9741","DOI":"10.7150\/thno.46913","article-title":"P21-activated kinase 1: emerging biological functions and potential therapeutic targets in cancer.","volume":"10","author":"Yao","year":"2020","journal-title":"Theranostics"},{"key":"B218","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4161\/cl.21882","article-title":"PAK signaling in cancer.","volume":"2","author":"Ye","year":"2012","journal-title":"Cell. Logist."},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00027","article-title":"Aberrant NF-KappaB expression in autism spectrum condition: a mechanism for neuroinflammation.","volume":"2","author":"Young","year":"2011","journal-title":"Front. Psychiatry"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00562-1","article-title":"Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects.","volume":"31","author":"Yu","year":"2021","journal-title":"Cell Res."},{"key":"B221","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.3892\/mmr.2016.5477","article-title":"MicroRNA-7 regulates cell growth, migration and invasion via direct targeting of PAK1 in thyroid cancer.","volume":"14","author":"Yue","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B222","doi-asserted-by":"publisher","first-page":"18392","DOI":"10.1074\/jbc.M400084200","article-title":"P21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.","volume":"279","author":"Zenke","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B223","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1523\/JNEUROSCI.3553-04.2005","article-title":"A GIT1\/PIX\/Rac\/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.","volume":"25","author":"Zhang","year":"2005","journal-title":"J. Neurosci."},{"key":"B224","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s13238-020-00812-9","article-title":"The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders.","volume":"13","author":"Zhang","year":"2022","journal-title":"Protein Cell"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154241","article-title":"Decreased microRNA-125b-5p disrupts follicle steroidogenesis through targeting PAK3\/ERK1\/2 signalling in mouse preantral follicles.","volume":"107","author":"Zhang","year":"2020","journal-title":"Metabolism"},{"key":"B226","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"B227","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nn1630","article-title":"Role of p21-activated kinase pathway defects in the cognitive deficits of alzheimer disease.","volume":"9","author":"Zhao","year":"2006","journal-title":"Nat. Neurosci."},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.927796","article-title":"MiR-7 regulates pathogen-induced immune response via PAK1 in the sea cucumber apostichopus japonicus.","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/mp.2014.82","article-title":"Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.","volume":"20","author":"Zhao","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B230","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1128\/MCB.20.11.3906-3917.2000","article-title":"Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.","volume":"20","author":"Zhao","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113010","article-title":"Disruption of PAK3 signaling in social interaction induced CFOS positive cells impairs social recognition memory.","volume":"10","author":"Zhou","year":"2021","journal-title":"Cells"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1242\/jcs.179465","article-title":"Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.","volume":"129","author":"Zhou","year":"2016","journal-title":"J. Cell Sci."},{"key":"B233","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.molcel.2020.07.004","article-title":"GIT\/PIX condensates are modular and ideal for distinct compartmentalized cell signaling","volume":"79","author":"Zhu","year":"2020","journal-title":"Mol. Cell"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1123784\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T04:37:17Z","timestamp":1677731837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1123784\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":233,"alternative-id":["10.3389\/fnins.2023.1123784"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1123784","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"article-number":"1123784"}}