{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:05Z","timestamp":1790009525358,"version":"4.0.1"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prior researches have identified distinct differences in neuroimaging characteristics between healthy controls (HCs) and patients with major depressive disorder (MDD). However, the correlations between homotopic connectivity and clinical characteristics in patients with MDD have yet to be fully understood. The present study aimed to investigate common and unique patterns of homotopic connectivity and their relationships with clinical characteristics in patients with MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 42 patients diagnosed with MDD and 42 HCs. We collected a range of clinical variables, as well as exploratory eye movement (EEM), event-related potentials (ERPs) and resting-state functional magnetic resonance imaging (rs-fMRI) data. The data were analyzed using correlation analysis, support vector machine (SVM), and voxel-mirrored homotopic connectivity (VMHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, patients with MDD showed decreased VMHC in the insula, and increased VMHC in the cerebellum 8\/vermis 8\/vermis 9 and superior\/middle occipital gyrus. SVM analysis using VMHC values in the cerebellum 8\/vermis 8\/vermis 9 and insula, or VMHC values in the superior\/middle occipital gyrus and insula as inputs can distinguish HCs and patients with MDD with high accuracy, sensitivity, and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated that decreased VMHC in the insula and increased VMHC values in the sensory-motor networks may be a distinctive neurobiological feature for patients with MDD, which could potentially serve as imaging markers to discriminate HCs and patients with MDD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1135337","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T05:36:16Z","timestamp":1678167376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder"],"prefix":"10.3389","volume":"17","author":[{"given":"Chunguo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaquan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangpan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuroimage.2015.11.030","article-title":"Anterior insula coordinates hierarchical processing of tactile mismatch responses.","volume":"127","author":"Allen","year":"2016","journal-title":"Neuroimage"},{"key":"B2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41380-018-0289-9","article-title":"Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report.","volume":"24","author":"Andersson","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.biopsych.2013.11.027","article-title":"Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula.","volume":"76","author":"Avery","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1176\/appi.ajp.161.12.2163","article-title":"The hamilton depression rating scale: has the gold standard become a lead weight?","volume":"161","author":"Bagby","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw0474","article-title":"Insular cortex processes aversive somatosensory information and is crucial for threat learning.","volume":"364","author":"Berret","year":"2019","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1006\/nimg.2002.1280","article-title":"Aging gracefully: compensatory brain activity in high-performing older adults.","volume":"17","author":"Cabeza","year":"2002","journal-title":"NeuroImage"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063148","article-title":"The interactive effects of cognition on coping styles among Chinese during the COVID-19 pandemic.","volume":"18","author":"Cai","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \u201cPipeline\u201d data analysis of resting-state fMRI.","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.799916","article-title":"Altered static and dynamic interhemispheric resting-state functional connectivity in patients with thyroid-associated ophthalmopathy.","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.815945","article-title":"Modulation of neuropathic pain by glial regulation in the insular cortex of rats.","volume":"15","author":"Choi","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.958294","article-title":"Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses.","volume":"13","author":"Chu","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cogbrainres.2004.12.002","article-title":"Take it to the bridge: an interhemispheric processing advantage for emotional faces.","volume":"24","author":"Compton","year":"2005","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nature14659","article-title":"Sparse whole-genome sequencing identifies two loci for major depressive disorder.","volume":"523","year":"2015","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic.","volume":"398","year":"2021","journal-title":"Lancet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nn1176","article-title":"Neural systems supporting interoceptive awareness.","volume":"7","author":"Critchley","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-022-01454-9","article-title":"Altered effective connectivity among the cerebellum and cerebrum in patients with major depressive disorder using multisite resting-state fMRI.","author":"Dai","year":"2022","journal-title":"Cerebellum"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1002\/hbm.23215","article-title":"Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder.","volume":"37","author":"Demirtas","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B18","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jad.2021.10.028","article-title":"A combination of P300 and eye movement data improves the accuracy of auxiliary diagnoses of depression.","volume":"297","author":"Diao","year":"2022","journal-title":"J. Affect. Disord."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138180","article-title":"Altered functional connectivity in patients with subcortical vascular cognitive impairment\u2013A resting-state functional magnetic resonance imaging study.","volume":"10","author":"Ding","year":"2015","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.833592","article-title":"Disrupted cerebellar-default mode network functional connectivity in major depressive disorder with gastrointestinal symptoms.","volume":"16","author":"Ding","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s10143-021-01602-5","article-title":"Anatomical aspects of the insula, opercula and peri-insular white matter for a transcortical approach to insular glioma resection.","volume":"45","author":"Dziedzic","year":"2022","journal-title":"Neurosurg. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s00234-022-02983-0","article-title":"Aberrant resting-state interhemispheric functional connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis.","volume":"64","author":"Fan","year":"2022","journal-title":"Neuroradiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/23279095.2016.1185426","article-title":"Depression and performance on the repeatable battery for the assessment of neuropsychological status.","volume":"24","author":"Faust","year":"2017","journal-title":"Appl. Neuropsychol. Adult."},{"key":"B24","doi-asserted-by":"publisher","first-page":"9673","DOI":"10.1073\/pnas.0504136102","article-title":"The human brain is intrinsically organized into dynamic, anticorrelated functional networks.","volume":"102","author":"Fox","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41380-022-01806-1","article-title":"Molecular pathways of major depressive disorder converge on the synapse.","volume":"28","author":"Fries","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.neuropsychologia.2004.12.016","article-title":"Task-related activity in prefrontal cortex and its relation to recognition memory performance in young and old adults.","volume":"43","author":"Grady","year":"2005","journal-title":"Neuropsychologia"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s11682-017-9794-8","article-title":"Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder.","volume":"12","author":"Guo","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"B28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pnpbp.2013.06.009","article-title":"Is there a cerebellar compensatory effort in first-episode, treatment-naive major depressive disorder at rest?","volume":"46","author":"Guo","year":"","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.pnpbp.2013.01.010","article-title":"Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression.","volume":"44","author":"Guo","year":"","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jad.2015.03.028","article-title":"Decreased insular connectivity in drug-naive major depressive disorder at rest.","volume":"179","author":"Guo","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jad.2011.06.048","article-title":"Abnormal neural activities in first-episode, treatment-naive, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study.","volume":"135","author":"Guo","year":"2011","journal-title":"J. Affect. Disord."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.642225","article-title":"Functional connectivity of the cognitive cerebellum.","volume":"15","author":"Habas","year":"2021","journal-title":"Front. Syst. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-clinpsy-050718-095457","article-title":"The utility of event-related potentials in clinical psychology.","volume":"15","author":"Hajcak","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States.","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/brain\/awaa405","article-title":"Depression, dementia and immune dysregulation.","volume":"144","author":"Hayley","year":"2021","journal-title":"Brain"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pscychresns.2016.07.011","article-title":"Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder.","volume":"255","author":"Hou","year":"2016","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.559729","article-title":"Decreased resting-state interhemispheric functional connectivity in medication-free obsessive-compulsive disorder.","volume":"11","author":"Jia","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.609866","article-title":"Integrating structural and functional interhemispheric brain connectivity of gait freezing in Parkinson\u2019s disease.","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1017\/S0033291721000441","article-title":"The genetic basis of major depression.","volume":"51","author":"Kendall","year":"2021","journal-title":"Psychol. Med."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00007","article-title":"Functional connectivity of brain structures correlates with treatment outcome in major depressive disorder.","volume":"2","author":"Kozel","year":"2011","journal-title":"Front. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpsychires.2022.07.040","article-title":"Altered functional connectivity in common resting-state networks in patients with major depressive disorder: a resting-state functional connectivity study.","volume":"155","author":"Krug","year":"2022","journal-title":"J. Psychiatr Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"8351","DOI":"10.1523\/JNEUROSCI.1074-21.2021","article-title":"Inner hemispheric and interhemispheric connectivity balance in the human brain.","volume":"41","author":"Krupnik","year":"2021","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.yebeh.2019.04.035","article-title":"Insular resection may lead to autonomic function changes.","volume":"97","author":"Lacuey","year":"2019","journal-title":"Epilepsy Behav."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1017\/S1461145714000947","article-title":"Decreased inter-hemispheric connectivity in anterior sub-network of default mode network and cerebellum: significant findings in major depressive disorder.","volume":"17","author":"Lai","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bandc.2008.08.013","article-title":"Neurophysiology and neuroanatomy of smooth pursuit in humans.","volume":"68","author":"Lencer","year":"2008","journal-title":"Brain Cogn."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-021-01575-w","article-title":"Risk factors for the frequent attendance of older patients at community health service centers in China: a cross-sectional study based on stratified sampling.","volume":"22","author":"Li","year":"2021","journal-title":"BMC Fam. Pract."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1007\/s11682-020-00299-2","article-title":"Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.","volume":"15","author":"Li","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/j.clinph.2014.11.014","article-title":"Disrupted cortical hubs in functional brain networks in social anxiety disorder.","volume":"126","author":"Liu","year":"2015","journal-title":"Clin. Neurophysiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-022-01475-9","article-title":"Baseline cognitive functioning can predict the trajectory of acute treatment in first-episode major depressive disorder.","author":"Liu","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jpsychires.2021.10.016","article-title":"Abnormal interhemispheric homotopic functional connectivity is correlated with gastrointestinal symptoms in patients with major depressive disorder.","volume":"144","author":"Liu","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00130","article-title":"Review of abnormal self-knowledge in major depressive disorder.","volume":"10","author":"Lou","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.3758\/s13428-021-01551-3","article-title":"Considerations for using the wisconsin card sorting test to assess cognitive flexibility.","volume":"53","author":"Miles","year":"2021","journal-title":"Behav. Res. Methods"},{"key":"B53","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/scan\/nst011","article-title":"The anterior insular and anterior cingulate cortices in emotional processing for self-face recognition.","volume":"9","author":"Morita","year":"2014","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.brs.2018.12.898","article-title":"Anterior insular cortex stimulation and its effects on emotion recognition.","volume":"224","author":"Motomura","year":"2019","journal-title":"Brain Stimul."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1038\/s41380-021-01413-6","article-title":"Genetic heterogeneity and subtypes of major depression.","volume":"27","author":"Nguyen","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3233\/JAD-191127","article-title":"Contributions of cerebro-cerebellar default mode connectivity patterns to memory performance in mild cognitive impairment.","volume":"75","author":"Pagen","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jad.2017.11.018","article-title":"Insular subdivisions functional connectivity dysfunction within major depressive disorder.","volume":"227","author":"Peng","year":"2018","journal-title":"J. Affect. Disord."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00132","article-title":"Medial prefrontal and anterior insular connectivity in early schizophrenia and major depressive disorder: a resting functional mri evaluation of large-scale brain network models.","volume":"10","author":"Penner","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1002\/hbm.24081","article-title":"The cerebellum after trauma: resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype.","volume":"39","author":"Rabellino","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.2147\/NDT.S245078","article-title":"Atrophic corpus callosum associated with altered functional asymmetry in major depressive disorder.","volume":"16","author":"Ran","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B61","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0165-1781(00)00153-0","article-title":"Eye movement task measures inhibition and spatial working memory in adults with schizophrenia, ADHD, and a normal comparison group.","volume":"95","author":"Ross","year":"2000","journal-title":"Psychiatry Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jad.2021.03.038","article-title":"Shared and distinct homotopic connectivity changes in melancholic and non-melancholic depression.","volume":"287","author":"Shan","year":"2021","journal-title":"J. Affect. Disord."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00323","article-title":"Major depressive disorder and alterations in insular cortical activity: a review of current functional magnetic imaging research.","volume":"6","author":"Sliz","year":"2012","journal-title":"Front. Hum. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1037\/0021-9010.87.2.211","article-title":"Substance versus style: a new look at social desirability in motivating contexts.","volume":"87","author":"Smith","year":"2002","journal-title":"J. Appl. Psychol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031","article-title":"REST: a toolkit for resting-state functional magnetic resonance imaging data processing.","volume":"6","author":"Song","year":"2011","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.924431","article-title":"Abnormal reginal homogeneity in left anterior cingulum cortex and precentral gyrus as a potential neuroimaging biomarker for first-episode major depressive disorder.","volume":"13","author":"Song","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1523\/JNEUROSCI.5173-08.2009","article-title":"Roles of the insular cortex in the modulation of pain: insights from brain lesions.","volume":"29","author":"Starr","year":"2009","journal-title":"J. Neurosci."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00588","article-title":"Application of support vector machine on fMRI data as biomarkers in schizophrenia diagnosis: a systematic review.","volume":"11","author":"Steardo","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.neuroscience.2020.05.028","article-title":"Cerebellar dysfunction, cerebro-cerebellar connectivity and autism spectrum disorders.","volume":"462","author":"Su","year":"2021","journal-title":"Neuroscience"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1955-9","article-title":"Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder.","volume":"18","author":"Teng","year":"2018","journal-title":"BMC Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1093\/cercor\/bhn014","article-title":"Functional coactivation map of the human brain.","volume":"18","author":"Toro","year":"2008","journal-title":"Cereb. Cortex"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85235-0","article-title":"Event-related components are structurally represented by intrinsic event-related potentials.","volume":"11","author":"Tsai","year":"2021","journal-title":"Sci. Rep."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00041","article-title":"Whole brain resting-state analysis reveals decreased functional connectivity in major depression.","volume":"4","author":"Veer","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jad.2019.06.010","article-title":"The P300 event-related potential in bipolar disorder: a systematic review and meta-analysis.","volume":"256","author":"Wada","year":"2019","journal-title":"J. Affect. Disord."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004043","article-title":"Clinical significance of increased cerebellar default-mode network connectivity in resting-state patients with drug-naive somatization disorder.","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine"},{"key":"B76","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/hbm.26099","article-title":"Functional connectivity gradients of the insula to different cerebral systems.","volume":"44","author":"Wang","year":"2022","journal-title":"Hum. Brain Mapp."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1021365","article-title":"P300 event-related potentials in patients with different subtypes of depressive disorders.","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Psychiatry"},{"key":"B78","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/15622975.2022.2025616","article-title":"The similar eye movement dysfunction between major depressive disorder, bipolar depression and bipolar mania.","volume":"23","author":"Wang","year":"2022","journal-title":"World J. Biol. Psychiatry"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.01620","article-title":"Voxel-mirrored homotopic connectivity of resting-state functional magnetic resonance imaging in blepharospasm.","volume":"9","author":"Wei","year":"2018","journal-title":"Front. Psychol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.972939","article-title":"The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy.","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.906534","article-title":"Abnormal spontaneous neural activity in hippocampal-cortical system of patients with obsessive-compulsive disorder and its potential for diagnosis and prediction of early treatment response.","volume":"16","author":"Yan","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8555","article-title":"Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders.","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00842","article-title":"Decreased functional connectivity in insular subregions in depressive episodes of bipolar disorder and major depressive disorder.","volume":"12","author":"Yin","year":"2018","journal-title":"Front. Neurosci."},{"key":"B84","first-page":"1541","article-title":"Difference in resting-state fractional amplitude of low-frequency fluctuation between bipolar depression and unipolar depression patients.","volume":"21","author":"Yu","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045476","article-title":"Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura.","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2022.108426","article-title":"Altered functional connectivity in emotional subregions of the anterior cingulate cortex in young and middle-aged patients with major depressive disorder: a resting-state fMRI study.","volume":"175","author":"Zhang","year":"2022","journal-title":"Biol. Psychol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.852330","article-title":"Aberrant inter-hemispheric connectivity in patients with recurrent major depressive disorder: a multimodal MRI study.","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Neurol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jad.2020.06.062","article-title":"Cerebellar-cerebral dynamic functional connectivity alterations in major depressive disorder.","volume":"275","author":"Zhu","year":"2020","journal-title":"J. Affect. Disord."},{"key":"B89","doi-asserted-by":"publisher","first-page":"15034","DOI":"10.1523\/JNEUROSCI.2612-10.2010","article-title":"Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.","volume":"30","author":"Zuo","year":"2010","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1135337\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T05:36:20Z","timestamp":1678167380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1135337\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":89,"alternative-id":["10.3389\/fnins.2023.1135337"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1135337","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,7]]},"article-number":"1135337"}}