{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:26:23Z","timestamp":1769855183246,"version":"3.49.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Diffusion magnetic resonance imaging (dMRI) studies have revealed microstructural abnormalities in white matter resulting from sleep deprivation (SD). This study aimed to adopt neurite orientation dispersion and density imaging (NODDI) to investigate the effect of SD on gray matter (GM) microstructural properties and its association to visuospatial memory (VSM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-four healthy women underwent two sessions of dMRI scanning and visuospatial ability assessment by Complex Figure Test (CFT), once during rested wakefulness (RW) and once after 24 h of SD. We calculated NODDI metrics, including intracellular volume fraction (ICVF), orientation dispersion index (ODI), and isotropic volume fraction (ISO). Differences in NODDI-related metrics between RW and SD were determined using a voxel-wise paired <jats:italic>t-<\/jats:italic>test. We identified an association between NODDI metrics and CFT results using Spearman\u2019s correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sleep deprivation worsened subjects\u2019 performance in the delayed-CFT trial. We observed no significant difference in ICVF and ODI between RW and SD. After SD, subjects showed decreases in ISO, primarily in the prefrontal cortex and temporal lobe, while exhibiting ISO increases in the anterior and posterior cerebellar lobe and cerebellar vermis. Furthermore, ISO change in the left superior, middle and inferior frontal gyrus was significantly correlated with completion time change in delayed-CFT trial performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggested that SD hardly affected the density and spatial organization of neurites in GM, but the extra-neurite water molecule diffusion process was affected (perhaps resulting from neuroinflammation), which contributed to VSM dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1144802","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:44:49Z","timestamp":1679546689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered isotropic volume fraction in gray matter after sleep deprivation and its association with visuospatial memory: A neurite orientation dispersion and density imaging study"],"prefix":"10.3389","volume":"17","author":[{"given":"Jia-Hui","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Bin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao-Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/syn.21779","article-title":"Sleep deprivation induces differential morphological changes in the hippocampus and prefrontal cortex in young and old rats.","volume":"69","author":"Acosta-Pena","year":"2015","journal-title":"Synapse"},{"key":"B2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system - a technical review.","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.1523\/JNEUROSCI.3981-16.2017","article-title":"Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex.","volume":"37","author":"Bellesi","year":"2017","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13198","article-title":"Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex.","volume":"5","author":"Buchta","year":"2017","journal-title":"Physiol. Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11065-011-9156-z","article-title":"Sleep and the brain.","volume":"21","author":"Colrain","year":"2011","journal-title":"Neuropsychol. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuroimage.2014.11.035","article-title":"Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation.","volume":"106","author":"Cui","year":"2015","journal-title":"Neuroimage"},{"key":"B7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neuroimage.2014.10.026","article-title":"Accelerated microstructure imaging via convex optimization (AMICO). from diffusion MRI data.","volume":"105","author":"Daducci","year":"2015","journal-title":"Neuroimage"},{"key":"B8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.sleep.2011.09.019","article-title":"Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: a resting-state fMRI study.","volume":"13","author":"Dai","year":"2012","journal-title":"Sleep Med."},{"key":"B9","article-title":"DTI detection of microstructural changes induced by sleep deprivation","author":"Ding","year":"2012","journal-title":"Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012"},{"key":"B10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1055\/s-2005-867080","article-title":"Neurocognitive consequences of sleep deprivation.","volume":"25","author":"Durmer","year":"2005","journal-title":"Semin. Neurol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127351","article-title":"Widespread changes in white matter microstructure after a day of waking and sleep deprivation.","volume":"10","author":"Elvsashagen","year":"2015","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58613","article-title":"Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis.","volume":"9","author":"Fujita","year":"2020","journal-title":"Elife"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01607","article-title":"Novel measures to assess the effects of partial sleep deprivation on sensory, working, and permanent memory.","volume":"8","author":"Gosselin","year":"2017","journal-title":"Front. Psychol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"12506","DOI":"10.1523\/JNEUROSCI.2306-12.2012","article-title":"Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures.","volume":"32","author":"Hinard","year":"2012","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.998541","article-title":"Altered stability of brain functional architecture after sleep deprivation: a resting-state functional magnetic resonance imaging study.","volume":"16","author":"Huang","year":"2022","journal-title":"Front. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.803066","article-title":"White matter abnormalities and cognitive deficit after mild traumatic brain injury: comparing DTI, DKI, and NODDI.","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.neuroimage.2017.04.024","article-title":"An emergent functional parcellation of the temporal cortex.","volume":"170","author":"Jackson","year":"2018","journal-title":"Neuroimage"},{"key":"B18","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl.","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108908","article-title":"NODDI in clinical research.","volume":"346","author":"Kamiya","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/mrm.26054","article-title":"Gibbs-ringing artifact removal based on local subvoxel-shifts.","volume":"76","author":"Kellner","year":"2016","journal-title":"Magn. Reson. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/B978-0-444-53702-7.00007-5","article-title":"Effects of sleep deprivation on cognition.","volume":"185","author":"Killgore","year":"2010","journal-title":"Prog. Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3174\/ajnr.A4720","article-title":"Nonmotor functions of the cerebellum: an introduction.","volume":"37","author":"Klein","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bpsgos.2021.12.012","article-title":"Neurite orientation dispersion and density imaging in psychiatric disorders: a systematic literature review and a technical note.","volume":"3","author":"Kraguljac","year":"2022","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.642411","article-title":"Relation of decreased functional connectivity between left thalamus and left inferior frontal gyrus to emotion changes following acute sleep deprivation.","volume":"12","author":"Li","year":"2021","journal-title":"Front. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neurobiolaging.2016.03.026","article-title":"Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging.","volume":"43","author":"Merluzzi","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1002\/hbm.24760","article-title":"Neurite orientation dispersion and density imaging (NODDI). and free-water imaging in Parkinsonism.","volume":"40","author":"Mitchell","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"B27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.tins.2017.02.002","article-title":"The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology.","volume":"40","author":"Namkung","year":"2017","journal-title":"Trends Neurosci."},{"key":"B28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70410-6","article-title":"Anatomy and white matter connections of the fusiform gyrus.","volume":"10","author":"Palejwala","year":"2020","journal-title":"Sci. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsx213","article-title":"Effects of sleep deprivation on component processes of working memory in younger and older adults.","volume":"41","author":"Pasula","year":"2018","journal-title":"Sleep"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000356727","article-title":"Cognitive impairment assessment through visuospatial memory can be performed with a modified walking corsi test using the \u2018Magic Carpet\u2019.","volume":"4","author":"Perrochon","year":"2014","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"key":"B31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion tensor MR imaging of the human brain.","volume":"201","author":"Pierpaoli","year":"1996","journal-title":"Radiology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/sleep\/32.8.1100","article-title":"White matter differences predict cognitive vulnerability to sleep deprivation.","volume":"32","author":"Rocklage","year":"2009","journal-title":"Sleep"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3687","DOI":"10.1002\/hbm.22872","article-title":"Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology.","volume":"36","author":"Sepehrband","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"B34","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/nprot.2006.115","article-title":"Clinical and empirical applications of the rey-osterrieth complex figure test.","volume":"1","author":"Shin","year":"2006","journal-title":"Nat. Protoc."},{"key":"B35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jmri.25930","article-title":"A study of neurite orientation dispersion and density imaging in wilson\u2019s disease.","volume":"48","author":"Song","year":"2018","journal-title":"J. Magn. Reson. Imaging"},{"key":"B36","doi-asserted-by":"crossref","first-page":"W26","DOI":"10.2214\/AJR.13.11365","article-title":"Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain.","volume":"202","author":"Steven","year":"2014","journal-title":"AJR Am. J. Roentgenol."},{"key":"B37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-0-444-63956-1.00004-7","article-title":"Functional topography of the human cerebellum.","volume":"154","author":"Stoodley","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"B38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1365-2869.2000.00225.x","article-title":"Neural basis of alertness and cognitive performance impairments during sleepiness. i. effects of 24 h of sleep deprivation on waking human regional brain activity.","volume":"9","author":"Thomas","year":"2000","journal-title":"J. Sleep Res."},{"key":"B39","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction.","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"B40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/sleep\/26.2.117","article-title":"The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.","volume":"26","author":"Van Dongen","year":"2003","journal-title":"Sleep"},{"key":"B41","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/mrm.26059","article-title":"Diffusion MRI noise mapping using random matrix theory.","volume":"76","author":"Veraart","year":"","journal-title":"Magn. Reson. Med."},{"key":"B42","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","article-title":"Denoising of diffusion MRI using random matrix theory.","volume":"142","author":"Veraart","year":"","journal-title":"Neuroimage"},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117540","article-title":"Sleep and sleep deprivation differentially alter white matter microstructure: a mixed model design utilising advanced diffusion modelling.","volume":"226","author":"Voldsbekk","year":"2021","journal-title":"Neuroimage"},{"key":"B44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2147\/NSS.S345328","article-title":"Predicting attentional vulnerability to sleep deprivation: a multivariate pattern analysis of DTI data.","volume":"14","author":"Wang","year":"2022","journal-title":"Nat. Sci. Sleep"},{"key":"B45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuroimage.2018.06.019","article-title":"Investigation into local white matter abnormality in emotional processing and sensorimotor areas using an automatically annotated fiber clustering in major depressive disorder.","volume":"181","author":"Wu","year":"2018","journal-title":"Neuroimage"},{"key":"B46","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain.","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.616132","article-title":"Brain development from newborn to adolescence: evaluation by neurite orientation dispersion and density imaging.","volume":"15","author":"Zhao","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"B48","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2017.09.047","article-title":"White matter microstructural properties are related to inter-individual differences in cognitive instability after sleep deprivation.","volume":"365","author":"Zhu","year":"2017","journal-title":"Neuroscience"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1144802\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T14:20:34Z","timestamp":1681914034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1144802\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":48,"alternative-id":["10.3389\/fnins.2023.1144802"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1144802","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]},"article-number":"1144802"}}