{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:45:49Z","timestamp":1793295949173,"version":"4.5.0"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>The use of medicinal plants has grown in popularity in recent decades because, as natural ingredients, they have fewer adverse effects and are more effective than synthetic alternatives. As a small perennial herb, <jats:italic>Glycyrrhiza glabra<\/jats:italic> L. (Licorice) has been investigated for its therapeutic efficacy against neural disorders mainly ischemic stroke as well as the neurodegenerative diseases such as dementia and Alzheimer\u2019s disease, and Parkinson\u2019s disease which has been attributed to its HMGB inhibitory function, reactive oxygen scavenging and anti-inflammatory activity. The objective of current review is to review the evidence for the pharmacological effects of licorice and its vital active components on neurological disorders and the underlying signaling networks. We reviewed Papers published from 2000.1.1 up to 2 January 2023 in web of science, Google Scholar and PubMed data bases using key words including \u201cLicorice,\u201d \u201c<jats:italic>Glycyrrhiza glabra<\/jats:italic> L.,\u201d \u201cGlycyrrhizic acid,\u201d \u201cbrain,\u201d \u201cneurodegenerative disease,\u201d \u201cAlzheimer\u2019s,\u201d and \u201cParkinson\u201d were used to search in title\/abstracts. Licorice extract and\/or its active components can be used safely in therapeutic doses for optimizing the management of a multiple neurodegenerative disorders, and hampering the extent of neural tissue injury and neurologic deficits subsequent to cerebrovascular accidents.<\/jats:p>","DOI":"10.3389\/fnins.2023.1148258","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:50:08Z","timestamp":1678078208000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Parvin","family":"Zulfugarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayebeh","family":"Zivari-Ghader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevinj","family":"Maharramova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ahmadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Eftekhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rovshan","family":"Khalilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vugar Ali","family":"Turksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gvozden","family":"Rosi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragica","family":"Selakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27206804","article-title":"Alzheimer\u2019s disease as a major public health concern: Role of dietary saponins in mitigating neurodegenerative disorders and their underlying mechanisms.","volume":"27","author":"Abduljawad","year":"2022","journal-title":"Molecules"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s10068-010-0198-4","article-title":"Effect of licorice (Glycyrrhiza uralensis Fisch) on amyloid-\u03b2-induced neurotoxicity in PC12 cells.","volume":"19","author":"Ahn","year":"2010","journal-title":"Food Sci. 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