{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:58:11Z","timestamp":1792277891942,"version":"4.4.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Cerebral small vessel disease (CSVD) is a common chronic and progressive disease that can lead to mental and cognitive impairment. Damage to brain structure and function may play an important role in the neuropsychiatric disorders of patients with CSVD. Increasing evidence suggests that functional changes are accompanied by structural changes in corresponding brain regions. Thus, normal structure\u2013function coupling is essential for optimal brain performance, and disrupted structure\u2013function coupling can be found in many neurological and psychiatric disorders. To date, most studies on patients with CSVD have focused on separate structures or functions, including reductions in white matter volume and blood flow, which lead to cognitive dysfunction. However, there are few studies on brain structure\u2013function coupling in patients with CSVD. In recent years, with the rapid development of multilevel (voxel-wise, neurovascular, regional level, and network level) brain structure\u2013functional coupling analysis methods based on multimodal magnetic resonance imaging (MRI), new evidence has been provided to reveal the correlation between brain function and structural abnormalities and cognitive impairment. Therefore, studying brain structure\u2013function coupling has a potential significance in the exploration and elucidation of the neurobiological mechanism of cognitive impairment in patients with CSVD. This article mainly describes the currently popular brain structure\u2013function coupling analysis technology based on multimodal MRI and the important research progress of these coupling technologies on CSVD and cognitive impairment to provide a perspective for the study of the pathogenesis and early diagnosis of CSVD.<\/jats:p>","DOI":"10.3389\/fnins.2023.1163274","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T16:32:20Z","timestamp":1686069140000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Brain structure\u2013function coupling associated with cognitive impairment in cerebral small vessel disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Na","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"119656","DOI":"10.1016\/j.neuroimage.2022.119656","article-title":"Heritability of hippocampal functional and microstructural organisation","volume":"264","author":"Bayrak","year":"2022","journal-title":"Neuroimage."},{"key":"B2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.17219\/acem\/131216","article-title":"Cerebral small vessel disease: a review","volume":"30","author":"Chojdak-Lukasiewicz","year":"2021","journal-title":"Adv Clin Exp Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.5853\/jos.2017.02922","article-title":"Cerebral small vessel disease: a review focusing on pathophysiology, biomarkers, and machine learning strategies","volume":"20","author":"Cuadrado-Godia","year":"2018","journal-title":"J Stroke."},{"key":"B4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41380-018-0067-8","article-title":"Changes in functional and structural brain connectome along the Alzheimer's disease continuum","volume":"25","author":"Filippi","year":"2020","journal-title":"Mol Psychiatry."},{"key":"B5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1176\/appi.ajp.2019.19050560","article-title":"Multimodal abnormalities of brain structure and function in major depressive disorder: a meta-analysis of neuroimaging studies","volume":"177","author":"Gray","year":"2020","journal-title":"Am J Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1073\/pnas.0811168106","article-title":"Predicting human resting-state functional connectivity from structural connectivity","volume":"106","author":"Honey","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1002\/hbm.25980","article-title":"Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition","volume":"43","author":"Hu","year":"2022","journal-title":"Hum Brain Mapp."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1002\/hbm.25536","article-title":"Function-structure coupling: white matter functional magnetic resonance imaging hyper-activation associates with structural integrity reductions in schizophrenia","volume":"42","author":"Jiang","year":"2021","journal-title":"Hum Brain Mapp."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.915164","article-title":"Structure\u2013function decoupling: a novel perspective for understanding the radiation-induced brain injury in patients with nasopharyngeal carcinoma","author":"Kang","year":"2022","journal-title":"Front. 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