{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:55Z","timestamp":1792798795527,"version":"4.5.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intermittent energy restriction (IER) is an effective weight loss strategy. However, the accompanying changes in spontaneous neural activity are unclear, and the relationship among anthropometric measurements, biochemical indicators, and adipokines remains ambiguous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty-five obese adults were recruited and received a 2-month IER intervention. Data were collected from anthropometric measurements, blood samples, and resting-state functional magnetic resonance imaging at four time points. The regional homogeneity (ReHo) method was used to explore the effects of the IER intervention. The relationships between the ReHo values of altered brain regions and changes in anthropometric measurements, biochemical indicators, and adipokines (leptin and adiponectin) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that IER significantly improved anthropometric measurements, biochemical indicators, and adipokine levels in the successful weight loss group. The IER intervention for weight loss was associated with a significant increase in ReHo in the bilateral lingual gyrus, left calcarine, and left postcentral gyrus and a significant decrease in the right middle temporal gyrus and right cerebellum (VIII). Follow-up analyses showed that the increase in ReHo values in the right LG had a significant positive correlation with a reduction in Three-factor Eating Questionnaire (TFEQ)-disinhibition and a significant negative correlation with an increase in TFEQ-cognitive control. Furthermore, the increase in ReHo values in the left calcarine had a significant positive correlation with the reduction in TFEQ-disinhibition. However, no significant difference in ReHo was observed in the failed weight loss group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study provides objective evidence that the IER intervention reshaped the ReHo of some brain regions in obese individuals, accompanied with improved anthropometric measurements, biochemical indicators, and adipokines. These results illustrated that the IER intervention for weight loss may act by decreasing the motivational drive to eat, reducing reward responses to food cues, and repairing damaged food-related self-control processes. These findings enhance our understanding of the neurobiological basis of IER for weight loss in obesity.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1201169","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:03:04Z","timestamp":1691056984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Intermittent energy restriction changes the regional homogeneity of the obese human brain"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhonglin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziya","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.neubiorev.2021.02.014","article-title":"Sensory cue reactivity: sensitization in alcohol use disorder and obesity","volume":"124","author":"Agarwal","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.physbeh.2017.11.003","article-title":"Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder","volume":"184","author":"Aviram-Friedman","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis","volume":"360","author":"Beckmann","year":"2005","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/1028415X.2016.1191165","article-title":"Implications of oxidative stress in the brain plasticity originated by fasting: a BOLD-fMRI study","volume":"20","author":"Bela\u00efch","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12311-012-0360-z","article-title":"Effects of leptin deficiency and replacement on cerebellar response to food-related cues","volume":"12","author":"Berman","year":"2013","journal-title":"Cerebellum"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1053\/j.gastro.2017.03.045","article-title":"Advances in obesity: causes, consequences, and therapy","volume":"152","author":"Berthoud","year":"2017","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1053\/j.gastro.2016.12.050","article-title":"Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms [J]","volume":"152","author":"Berthoud","year":"2017","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1016\/j.clnme.2013.07.005","article-title":"Alternate day fasting with or without exercise: effects on endothelial function and adipokines in obese humans","volume":"8","author":"Bhutani","year":"2013","journal-title":"e-SPEN J."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1159\/000437157","article-title":"Diet-induced weight loss alters functional Brain responses during an episodic memory task","volume":"8","author":"Boraxbekk","year":"2015","journal-title":"Obes. Facts"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e60393","DOI":"10.1371\/journal.pone.0060393","article-title":"Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies","volume":"8","author":"Brooks","year":"2013","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1467-789X.2011.00927.x","article-title":"Neuroimaging and obesity: current knowledge and future directions","volume":"13","author":"Carnell","year":"2012","journal-title":"Obes. Rev."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.bbr.2017.09.017","article-title":"Correlation between brain circuit segregation and obesity","volume":"337","author":"Chao","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-09874-y","article-title":"Altered cross-talk between the hypothalamus and non-homeostatic regions linked to obesity and difficulty to lose weight","volume":"7","author":"Contreras-Rodr\u00edguez","year":"2017","journal-title":"Sci. Rep."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/ajcn\/86.4.965","article-title":"Effects of overfeeding on the neuronal response to visual food cues","volume":"86","author":"Cornier","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.tem.2012.02.009","article-title":"Functional brain imaging of appetite","volume":"23","author":"Dagher","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1056\/NEJMra1905136","article-title":"Effects of intermittent fasting on health, aging, and disease [J]","volume":"381","author":"De Cabo","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/ijo.2016.28","article-title":"Brain regulation of food craving: relationships with weight status and eating behavior","volume":"40","author":"Dietrich","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/oby.22731","article-title":"Altered interactions among resting\u2010state networks in individuals with obesity","volume":"28","author":"Ding","year":"2020","journal-title":"Obesity"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.biopsycho.2015.05.003","article-title":"Spontaneous regional brain activity links restrained eating to later weight gain among young women","volume":"109","author":"Dong","year":"2015","journal-title":"Biol. Psychol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroscience.2014.01.062","article-title":"Altered regional homogeneity and efficient response inhibition in restrained eaters","volume":"266","author":"Dong","year":"2014","journal-title":"Neuroscience"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3389\/fnins.2018.01027","article-title":"The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer\u2019s disease","volume":"12","author":"Forny-Germano","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2014.10.023","article-title":"20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium","volume":"64","author":"Friedman","year":"2015","journal-title":"Metabolism"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.appet.2018.04.024","article-title":"Decreased resting-state BOLD regional homogeneity and the intrinsic functional connectivity within dorsal striatum is associated with greater impulsivity in food-related decision-making and BMI change at 6-month follow up","volume":"127","author":"Gao","year":"2018","journal-title":"Appetite"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.pscychresns.2015.05.017","article-title":"Functional network centrality in obesity: a resting-state and task fMRI study","volume":"233","author":"Garc\u00eda-Garc\u00eda","year":"2015","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/EP161365.GL","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity","volume":"22","author":"Garvey","year":"2016","journal-title":"Endocr. Pract."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e12604","DOI":"10.1111\/ijpo.12604","article-title":"Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight\/obesity","volume":"15","author":"Gracia-Marco","year":"2020","journal-title":"Pediatr. Obes."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.11124\/JBISRIR-2016-003248","article-title":"Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis [J]","volume":"16","author":"Harris","year":"2018","journal-title":"JBI Evid. Synth."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/ijo.2010.171","article-title":"The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women","volume":"35","author":"Harvie","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101803","DOI":"10.1016\/j.nicl.2019.101803","article-title":"Efficacy of weight loss intervention can be predicted based on early alterations of fMRI food cue reactivity in the striatum","volume":"23","author":"Hermann","year":"2019","journal-title":"Neuro Image"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/obr.12799","article-title":"Grey matter alterations in obesity: a meta\u2010analysis of whole\u2010brain studies","volume":"20","author":"Herrmann","year":"2019","journal-title":"Obes. Rev."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/cercor\/bhaa294","article-title":"Brain connectivity, and hormonal and Behavioral correlates of sustained weight loss in obese patients after laparoscopic sleeve gastrectomy","volume":"31","author":"Hu","year":"2021","journal-title":"Cereb. Cortex"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/osp4.149","article-title":"Early predictors of weight loss in a 1\u2010year behavioural weight\u2010loss programme","volume":"4","author":"James","year":"2018","journal-title":"Obes. Sci. Pract."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"394","DOI":"10.2337\/dc12-1112","article-title":"Neural correlates of stress- and food cue\u2013induced food craving in obesity","volume":"36","author":"Jastreboff","year":"2013","journal-title":"Diabetes Care"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/jn\/nxz049","article-title":"Intermittent energy restriction is a feasible, effective, and acceptable intervention to treat adolescents with obesity","volume":"149","author":"Jebeile","year":"2019","journal-title":"J. Nutr."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/hbm.21268","article-title":"The obese brain: association of body mass index and insulin sensitivity with resting state network functional connectivity","volume":"33","author":"Kullmann","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1002\/hbm.22021","article-title":"Relationships between gray matter, body mass index, and waist circumference in healthy adults","volume":"34","author":"Kurth","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fpsyt.2022.863056","article-title":"Improved regional homogeneity in chronic insomnia disorder after amygdala-based real-time fMRI neurofeedback training","volume":"13","author":"Li","year":"2022","journal-title":"Front. Psych."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.orcp.2019.11.005","article-title":"Fast track to health \u2014 intermittent energy restriction in adolescents with obesity. A randomised controlled trial study protocol","volume":"14","author":"Lister","year":"2020","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"879513","DOI":"10.3389\/fnhum.2022.879513","article-title":"Altered intrinsic regional spontaneous Brain activity in patients with severe obesity and meibomian gland dysfunction: a resting-state functional magnetic resonance imaging study","volume":"16","author":"Liu","year":"2022","journal-title":"Front. Hum. Neurosci."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/osp4.417","article-title":"Differences in brain structure and function in children with the FTO obesity\u2010risk allele","volume":"6","author":"Lugo-Candelas","year":"2020","journal-title":"Obes. Sci. Pract."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.orcp.2018.01.003","article-title":"Abnormal of inter-hemispheric functional connectivity in elderly subjects with overweight\/obesity","volume":"12","author":"Luo","year":"2018","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.nicl.2016.07.005","article-title":"Disrupted functional connectivity in adolescent obesity","volume":"12","author":"Moreno-Lopez","year":"2016","journal-title":"Neuro Image"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cmet.2018.09.024","article-title":"Neurocognitive and hormonal correlates of voluntary weight loss in humans","volume":"29","author":"Neseliler","year":"2019","journal-title":"Cell Metab."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.physbeh.2013.07.009","article-title":"Biological mechanisms that promote weight regain following weight loss in obese humans","volume":"120","author":"Ochner","year":"2013","journal-title":"Physiol. Behav."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.neuroimage.2006.01.047","article-title":"Brain abnormalities in human obesity: a voxel-based morphometric study","volume":"31","author":"Pannacciulli","year":"2006","journal-title":"NeuroImage"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/ajcn\/nqx002","article-title":"Comparison of self-reported dietary intakes from the automated self-administered 24-h recall, 4-d food records, and food-frequency questionnaires against recovery biomarkers","volume":"107","author":"Park","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s11154-021-09665-x","article-title":"A systematic review of resting-state functional connectivity in obesity: refining current neurobiological frameworks and methodological considerations moving forward","volume":"23","author":"Parsons","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.clnu.2019.07.014","article-title":"Intermittent energy restriction is comparable to continuous energy restriction for cardiometabolic health in adults with central obesity: a randomized controlled trial; the Met-IER study","volume":"39","author":"Pinto","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1093\/cercor\/bhw008","article-title":"Caloric restriction in older adults-differential effects of weight loss and reduced weight on Brain structure and function","volume":"27","author":"Prehn","year":"2017","journal-title":"Cereb. Cortex"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fnut.2014.00007","article-title":"Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies","volume":"1","author":"Pursey","year":"2014","journal-title":"Front. Nutr."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1172\/JCI35055","article-title":"Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli","volume":"118","author":"Rosenbaum","year":"2008","journal-title":"J. Clin. Invest."},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.14.22273867","article-title":"The cerebellum plays more than one role in appetite control: evidence from typical and pathological populations","author":"Sader","year":"2022","journal-title":"med Rxiv"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1080\/10408398.2020.1757616","article-title":"Impact of intermittent energy restriction on anthropometric outcomes and intermediate disease markers in patients with overweight and obesity: systematic review and meta-analyses","volume":"61","author":"Schwingshackl","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/nu14071509","article-title":"The role of intermittent energy restriction diet on metabolic profile and weight loss among obese adults","volume":"14","author":"Stanek","year":"2022","journal-title":"Nutrients"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/s41366-021-00920-4","article-title":"Homeostasis and food craving in obesity: a functional MRI study","volume":"45","author":"Stopyra","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0022-3999(85)90010-8","article-title":"The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger [J]","volume":"29","author":"Stunkard","year":"1985","journal-title":"J. Psychosom. Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/s41430-018-0370-0","article-title":"Effects of intermittent versus continuous energy restriction for weight loss on diet quality and eating behavior. A randomized trial [J]","volume":"73","author":"Sundf\u00f8r","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/osp4.403","article-title":"Modeling interactions between brain function, diet adherence behaviors, and weight loss success","volume":"6","author":"Szabo-Reed","year":"2020","journal-title":"Obes. Sci. Pract."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/osp4.363","article-title":"Changes in brain activity after weight loss","volume":"5","author":"Van Opstal","year":"2019","journal-title":"Obes. Sci. Pract."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"8368","DOI":"10.1093\/cercor\/bhad122","article-title":"Multivariate resting-state functional connectomes predict and characterize obesity phenotypes","volume":"33","author":"Wang","year":"2023","journal-title":"Cereb. Cortex"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3389\/fneur.2019.01006","article-title":"Abnormal functional connectivity in cognitive control network, default mode network, and visual attention network in internet addiction: a resting-state fMRI study","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Neurol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.3390\/nu14112315","article-title":"Comparison of the effects of intermittent energy restriction and continuous energy restriction among adults with overweight or obesity: an overview of systematic reviews and meta-analyses","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"eaai 8700","DOI":"10.1126\/scitranslmed.aai8700","article-title":"Fasting-mimicking diet and markers\/risk factors for aging, diabetes, cancer, and cardiovascular disease","volume":"9","author":"Wei","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1177\/10998004221078079","article-title":"Intermittent energy restriction for weight loss: a systematic review of cardiometabolic, inflammatory and appetite outcomes","volume":"24","author":"Wei","year":"2022","journal-title":"Biol. Res. Nurs."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3945\/ajcn.116.141143","article-title":"Elevated reward response to receipt of palatable food predicts future weight variability in healthy-weight adolescents","volume":"105","author":"Winter","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/oby.23629","article-title":"Perigenual anterior cingulate cortex and its structural covariance as predictors for future body fat gain in young adults [J]","volume":"31","author":"Yang","year":"2023","journal-title":"Obesity"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/brainsci11121587","article-title":"Brain responses to high-calorie visual food cues in individuals with normal-weight or obesity: an activation likelihood estimation meta-analysis [J]","volume":"11","author":"Yang","year":"2021","journal-title":"Brain Sci."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"NeuroImage"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"118419","DOI":"10.1016\/j.neuroimage.2021.118419","article-title":"Spontaneous neural activity changes after bariatric surgery: a resting-state fMRI study","volume":"241","author":"Zeighami","year":"2021","journal-title":"NeuroImage"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S2213-8587(21)00047-4","article-title":"Clinical management and treatment of obesity in China","volume":"9","author":"Zeng","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/ijo.2016.98","article-title":"Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery","volume":"40","author":"Zhang","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"105055","DOI":"10.1016\/j.appet.2020.105055","article-title":"Hierarchical integrated processing of reward-related regions in obese males: a graph-theoretical-based study","volume":"159","author":"Zhang","year":"2021","journal-title":"Appetite"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.neulet.2014.10.020","article-title":"Altered baseline brain activities before food intake in obese men: a resting state fMRI study","volume":"584","author":"Zhang","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1002\/oby.22839","article-title":"Abnormal regional neural activity and reorganized neural network in obesity: evidence from resting\u2010state fMRI","volume":"28","author":"Zhang","year":"2020","journal-title":"Obesity"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s11682-015-9491-4","article-title":"Intrinsic brain subsystem associated with dietary restraint, disinhibition and hunger: an fMRI study","volume":"11","author":"Zhao","year":"2017","journal-title":"Brain Imaging Behav."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s11682-021-00542-4","article-title":"Alteration of regional heterogeneity and functional connectivity for obese undergraduates: evidence from resting-state fMRI","volume":"16","author":"Zhao","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10571-007-9236-z","article-title":"The cerebellum in feeding control: possible function and mechanism [J]","volume":"28","author":"Zhu","year":"2008","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1201169\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:03:09Z","timestamp":1691056989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1201169\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,3]]},"references-count":79,"alternative-id":["10.3389\/fnins.2023.1201169"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1201169","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,3]]},"article-number":"1201169"}}