{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:18:08Z","timestamp":1764829088916,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the long-term safety, efficacy, and binocular balance of monovision surgery using Implantable Collamer Lens (ICL) V4c implantation and Femtosecond Laser-Assisted <jats:italic>in situ<\/jats:italic> Keratomileusis (FS-LASIK) for the treatment of myopic patients with presbyopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case series study involved 90 eyes of 45 patients (male\/female\u2009=\u200919\/26; average age:46.27\u2009\u00b1\u20095.54 years; average follow-up time:48.73\u2009\u00b1\u200914.65\u2009months) who underwent the aforementioned surgery to treat myopic presbyopes. Data on manifest refraction, corrected distance visual acuity, dominant eye, presbyopic addition, intraocular pressure, and anterior segment biometric parameters were collected. The visual outcomes and binocular balance at 0.4\u2009m, 0.8\u2009m, and 5\u2009m were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The safety index for the ICL V4c and FS-LASIK groups were 1.24\u2009\u00b1\u20090.27 and 1.04\u2009\u00b1\u20090.20 (<jats:italic>p<\/jats:italic>\u2009=\u20090.125), respectively. Binocular visual acuity (logmar) for 0.4\u2009m, 0.8\u2009m, and 5\u2009m were\u2009\u22120.03\u2009\u00b1\u20090.05, \u22120.03\u2009\u00b1\u20090.02, and 0.10\u2009\u00b1\u20090.03 for the ICL V4c group, and\u2009\u22120.02\u2009\u00b1\u20090.09, \u22120.01\u2009\u00b1\u20090.02, and 0.06\u2009\u00b1\u20090.04 for the FS-LASIK group, respectively. The proportions of all patients with imbalanced vision at 0.4\u2009m, 0.8\u2009m, and 5\u2009m distances were 68.89, 71.11, and 82.22%, respectively (all <jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05 between the two groups). There were significant differences in refraction between the balanced and imbalanced vision for patients at 0.4\u2009m distance (for non-dominant eye spherical equivalent [SE]: \u22121.14\u2009\u00b1\u20090.17D and\u2009\u22121.47\u2009\u00b1\u20090.13D, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), 0.8\u2009m distance (for preoperative ADD:0.90\u2009\u00b1\u20090.17D and 1.05\u2009\u00b1\u20090.11D, <jats:italic>p<\/jats:italic>\u2009=\u20090.041), and 5\u2009m distance (for non-dominant SE: \u22121.13\u2009\u00b1\u20090.33D and\u2009\u22121.42\u2009\u00b1\u20090.11D, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICL V4c implantation and FS-LASIK monovision treatment demonstrated good long-term safety and binocular visual acuity at various distances. After the procedure, the imbalanced patients\u2019 vision is primarily related to the age-related presbyopia and anisometropia progression caused by the monovision design.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1204792","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T04:24:46Z","timestamp":1685593486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Binocular imbalance in patients after implantable collamer lens V4c implantation or femtosecond laser-assisted in situ keratomileusis for myopia with presbyopia"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuhao","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanru","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"55890","DOI":"10.1038\/s41598-019-55890-5","article-title":"Age-dependency in binocular rivalry is reflected by exclusive percepts, not mixed percepts","volume":"9","author":"Arani","year":"2019","journal-title":"Sci. Rep. UK"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14811","DOI":"10.1073\/pnas.1905174116","article-title":"Evidence for neural rhythms embedded within binocular rivalry","volume":"116","author":"Cha","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12886-016-0336-8","article-title":"Comparison of early changes in and factors affecting vault following posterior chamber phakic implantable collamer lens implantation without and with a central hole (ICL V4 and ICL V4c)","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Ophthalmol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"112603","DOI":"10.1016\/j.bbr.2020.112603","article-title":"Binocular rivalry dynamics associated with high levels of self-reported autistic traits suggest an imbalance of cortical excitation and inhibition","volume":"388","author":"Dunn","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12886-018-0794-2","article-title":"Safety and satisfaction of myopic small-incision lenticule extraction combined with monovision","volume":"18","author":"Fu","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/S0886-3350(03)00065-8","article-title":"Implantable contact lens for moderate to high myopia","volume":"29","author":"Gonvers","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1136\/bjophthalmol-2018-312140","article-title":"Three-year outcomes of small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for myopia and myopic astigmatism","volume":"103","author":"Han","year":"2019","journal-title":"Brit. J. Ophthalmol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0039-6257(96)82015-7","article-title":"Success of monovision in presbyopes: review of the literature and potential applications to refractive surgery","volume":"40","author":"Jain","year":"1996","journal-title":"Surv. Ophthalmol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.62.12.9","article-title":"Binocular interactions in Glaucoma patients with nonoverlapping visual field defects: contrast summation, rivalry, and phase combination","volume":"62","author":"Joao","year":"2021","journal-title":"Invest. Ophth. Vis. Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"11539","DOI":"10.1038\/s41598-017-11539-9","article-title":"Monovision by implantation of posterior chamber Phakic intraocular Lens with a central hole (hole ICL) for early presbyopia","volume":"7","author":"Kamiya","year":"2017","journal-title":"Sci. Rep. UK"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e100156","DOI":"10.1371\/journal.pone.0100156","article-title":"Assessing binocular interaction in amblyopia and its clinical feasibility","volume":"9","author":"Kwon","year":"2014","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1097\/OPX.0000000000000002","article-title":"Monovision surgery in myopic Presbyopes: visual function and satisfaction","volume":"90","author":"Levinger","year":"2013","journal-title":"Optometry Vision Sci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"160273","DOI":"10.1098\/rsos.160273","article-title":"Monocular blur alters the tuning characteristics of stereopsis for spatial frequency and size","volume":"3","author":"Li","year":"2016","journal-title":"Roy. Soc. Open Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.5301\/ejo.5001069","article-title":"Small incision lenticule extraction (SMILE) monovision for presbyopia correction","volume":"28","author":"Luft","year":"2018","journal-title":"Eur. J. Ophthalmol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.61.8.7","article-title":"Binocular imbalance in amblyopia depends on spatial frequency in binocular combination","volume":"61","author":"Mao","year":"2020","journal-title":"Invest. Ophth. Vis. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.62.2.12","article-title":"Contrast rivalry paradigm reveals suppression of monocular input in keratoconus","volume":"62","author":"Marella","year":"2021","journal-title":"Invest. Ophth. Vis. Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ophtha.2020.10.040","article-title":"Reducing the global burden of myopia by delaying the onset of myopia and reducing myopic progression in children","volume":"128","author":"Modjtahedi","year":"2021","journal-title":"Ophthalmology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ophtha.2018.10.029","article-title":"Potential lost productivity resulting from the global burden of myopia","volume":"126","author":"Naidoo","year":"2019","journal-title":"Ophthalmology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/bjophthalmol-2020-316865","article-title":"Influence of age on small incision lenticule extraction outcomes","volume":"106","author":"Primavera","year":"2020","journal-title":"Brit. J. Ophthalmol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/6158520","article-title":"Intentional Undercorrection by implantation of posterior chamber Phakic intraocular Lens with a central hole (hole ICL) for early presbyopia","volume":"2018","author":"Takahashi","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7457902","article-title":"Posterior-chamber Phakic intraocular Lens implantation in patients over 40 years of age","volume":"2020","author":"Ta\u00f1\u00e1-Rivero","year":"2020","journal-title":"J. Ophthalmol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1089\/cyber.2022.0162","article-title":"Exploring the relationship between binocular imbalance and myopia: Refraction with a virtual reality platform","volume":"25","author":"Tao","year":"2022","journal-title":"Cyberpsychol. Behav. Soc. Netw."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/18.11.17","article-title":"Binocular temporal visual processing in myopia","volume":"18","author":"Vera-Diaz","year":"2018","journal-title":"J. Vis."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/iovs.62.12.10","article-title":"Balanced binocular inputs support superior stereopsis","volume":"62","author":"Wang","year":"2021","journal-title":"Invest. Ophth. Vis. Sci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1167\/iovs.61.6.50","article-title":"Suppression rather than visual acuity loss limits Stereoacuity in amblyopia","volume":"61","author":"Webber","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1097\/APO.0000000000000236","article-title":"Epidemiology of myopia","volume":"5","author":"Wu","year":"2016","journal-title":"Asia-Pacific J. Ophthalmol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1089\/cyber.2019.0020","article-title":"Assessment of binocular imbalance with an augmented virtual reality platform in a Normal population","volume":"22","author":"Xu","year":"2019","journal-title":"Cyberpsychol. Behav. Soc. Netw."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e8119","DOI":"10.1097\/MD.0000000000008119","article-title":"Comparison of perceptual eye positions among patients with different degrees of anisometropia","volume":"96","author":"Yang","year":"2017","journal-title":"Medicine"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-023-06010-7","article-title":"A novel quick contrast sensitivity function test in Chinese adults with myopia and its related parameters","author":"Ye","year":"2023","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1136\/bjophthalmol-2021-319205","article-title":"Long-term evaluation of anterior lens density after implantable collamer lens V4c implantation in patients with myopia over 40 years old","volume":"106","author":"Ye","year":"2021","journal-title":"Brit. J. Ophthalmol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1007\/s00417-021-05545-x","article-title":"Long-term follow-up for monovision surgery by implantable collamer Lens V4c implantation for myopia correction in early presbyopia","volume":"260","author":"Ye","year":"2022","journal-title":"Graefe's Arch. Clin. Exp. Ophthalmol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/15.6.17","article-title":"The role of sensory ocular dominance on through-focus visual performance in monovision presbyopia corrections","volume":"15","author":"Zheleznyak","year":"2015","journal-title":"J. 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